In this study, multiple tuned mass dampers (MTMDs) were studied to understand their impact on the human-induced vibration response and comfort level of a pedestrian cable-supported suspension bridge. A spatial finite element model based on a specific engineering case was established. The dynamic characteristics of the bridge under human-induced loads were investigated, and its comfort level under human-induced vibrations was analyzed using the time-history method. Then, this study adjusted the design parameters of the dampers based on various optimal damper parameter expressions. Furthermore, the damping effectiveness of MTMD under different mass ratios (μ) was evaluated, and it was found that increasing the mass ratio significantly impacts damping performance. Finally, determinant-TMD (TMDD) was introduced, and a comparison between the damping effect, robustness, and performance of TMDD and MTMD was conducted. The results indicate that while increasing the mass ratio does not linearly affect maximum vibration acceleration, the damping effect increases initially and then stabilizes, with a damping rate converging at approximately 55%. However, with the TMDD approach, the maximum damping rate can reach approximately 70%, enhancing comfort levels from the “minimum CL3” achieved with MTMD to the “medium CL2” level. Additionally, while TMDD’s robustness is slightly inferior to MTMD at lower mass ratios, it demonstrates superior robustness at higher mass ratios.