Optical Attenuation Research Articles

PM2.5 carbonaceous components and mineral dust at a COALESCE network site - Bhopal, India: Assessing the impacts of COVID-19 lockdowns on site-specific optical properties

Thermal elemental carbon (EC), optical black carbon (BC), organic carbon (OC), mineral dust (MD), and 7-wavelength optical attenuation of 24-hour ambient PM2.5 samples were measured/estimated at a regionally representative site (Bhopal, central India) during a business-as-usual year (2019) and the COVID-19 lockdowns year (2020). This dataset was used to estimate the influence of emissions source reductions on the optical properties of light-absorbing aerosols. During the lockdown period, the concentration of EC, OC, BC880 nm, and PM2.5 increased by 70 % ± 25 %, 74 % ± 20 %, 91 % ± 6 %, and 34 % ± 24 %, respectively, while MD concentration decreased by 32 % ± 30 %, compared to the same time period in 2019. Also, during the lockdown period, the estimated absorption coefficient (babs) and mass absorption cross-section (MAC) values of Brown Carbon (BrC) at 405 nm were higher (42 % ± 20 % and 16 % ± 7 %, respectively), while these quantities for MD, i.e., babs-MD and MACMD values were lower (19 % ± 9 % and 16 % ± 10 %), compared to the corresponding period during 2019. Also, babs-BC-808 (115 % ± 6 %) and MACBC-808 (69 % ± 45 %) values increased during the lockdown period compared with the corresponding period during 2019. It is hypothesized that although anthropogenic emissions (chiefly industrial and vehicular) reduced drastically during the lockdown period compared to the business-as-usual period, an increase in the values of optical properties (babs and MAC) and concentrations of BC and BrC, were likely due to the increased local and regional biomass burning emissions during this period. This hypothesis is supported by the CBPF (Conditional Bivariate Probability Function) and PSCF (Potential Source Contribution Function) analyses for BC and BrC.

Decreased Central Macular Choriocapillaris Perfusion Correlates With Increased Low Luminance Visual Acuity Deficits

Correlations between low luminance visual acuity deficits (LLVADs) and central choriocapillaris perfusion deficits were investigated to help explain how increases in LLVAD scores at baseline predict annual growth rates of geographic atrophy (GA). Prospective cross-sectional study. Photopic luminance best-corrected visual acuity (PL-BCVA) and low luminance BCVA (LL-BCVA) were measured using the Early Treatment Diabetic Retinopathy Study chart. LL-BCVA was measured using a 2.0-log unit neutral density filter. LLVADs were calculated as the difference between PL-BCVA and LL-BCVA. Within a fovea-centered 1-mm circle, the percentage of choriocapillaris flow deficits (CC FD%), drusen volume, optical attenuation coefficient (OAC) elevation volume, and outer retinal layer (ORL) thickness were assessed. In all 90 eyes (30 normal eyes; 31 drusen-only eyes; 29 non-foveal GA eyes), significant correlations were found between the central CC FD% and PL-BCVA (r=-0.393, P < .001), LL-BCVA (r=-0.534, P < .001), and the LLVAD (r=0.439, P < .001). Central cube root (cubrt) drusen volume, cubrt OAC elevation volume, and ORL thickness were correlated with PL-BCVA, LL-BCVA, and LLVADs (all P < .05). Stepwise regression models showed that central cubrt OAC elevation volume and ORL thickness were associated with PL-BCVA (R2=0.24, P < .05); central CC FD%, cubrt OAC elevation volume, and ORL thickness were associated with LL-BCVA (R2=0.44, P < .01); and central CC FD% and ORL thickness were associated with LLVAD (R2=0.24, P < .01). The significant correlations between central CC FD% and LLVAD support the hypothesis that the ability of LLVAD to predict the growth of GA is mediated through a decrease in macular choriocapillaris perfusion.

Simulation analysis of underwater wireless optical communication based on Monte Carlo method and experimental research in complex hydrological environment

This paper aims to address the challenges of short optical communication distances and high Bit Error Rates (BERs) caused by seawater absorption, scattering, and underwater turbulence. This paper establishes an optical communication channel model based on the Monte Carlo method and simulates and analyzes the process of received optical power attenuation when light is transmitted underwater due to absorption and scattering. The simulation model focuses on the influence of seawater type, transmission distance, receiver position, and angle on the received optical power attenuation. The results of this simulation will provide theoretical support for the development of prototype underwater optical communication systems and experiments in complex environments. To solve the long-range weak signal reception and processing issues in underwater optical wireless communication systems, this paper proposes the design and implementation of an underwater optical wireless communication system using optimized on-off keying high-power light-emitting diode/laser diode modulation technology and avalanche photodiode (APD)/photomultiplier (PMT) receiver modules. In addition, this paper describes the design of the underwater optical communication host computer software, which provides functions such as mode selection, BER monitoring, and file transfer. To test the performance of the proposed system, this paper conducts experiments in a 35 m long pool, fixed platform, and underwater mobile platform, as well as cross-air-water interface optical communication performance test experiments in a complex hydrological environment. The results show that the system achieved a 35 m underwater medium communication distance, transmission rate of 5–20 Mbps, and cross-domain wireless optical communication function under the condition of a BER of less than 10−6. The experiments also revealed that the communication distance decreases as the turbidity of the water body increases and the PMT receiver module selected at the receiver end has a longer communication distance than the APD receiver module. Overall, this paper demonstrates the feasibility of the proposed technology for underwater optical communication systems in complex waters, providing theoretical and data support for the next engineering practice.

Intensity Equalization of Bidirectional Fiber Laser Based on a Non-Reciprocal Optical Attenuator.

The application of a bidirectional laser requires the laser intensity in both directions to be balanced. However, the CW and CCW light intensities in current bidirectional erbium-doped fiber laser experiments differ due to the gain competition effect. There is no report on equalizing the intensity in the CW and CCW directions. This paper proposes a bidirectional non-reciprocal optical attenuator using the Faraday optical rotation effect. Continuous attenuation adjustment is realized by changing the angle between the polarizer's transmission axis and the linear polarized light. In this study, we analyzed the influence of different parameters on the device's performance, built a non-reciprocal attenuator, and tested the bidirectional attenuation curve, which was consistent with the simulation results. The device was integrated into a bidirectional fiber laser, and the light intensity in both directions was balanced through non-reciprocal adjustment. Combined with closed-loop control, the average intensity difference fluctuation between the two directions was controlled at 0.28% relative to the average power, realizing stable long-term bidirectional fiber laser intensity equalization.

Tunable MEMS-based metamaterial nanograting coupler for C-band optical communication application

A tunable metamaterial nanograting coupler (MNC) is presented that is composed of a one-dimensional surface nanograting coupler with a bottom reflector and the metamaterial atop. For a single nanograting coupler, by introducing a reflector and optimizing nanograting parameters, the spatial coupling efficiency exceeds 97% around near-infrared wavelength of 1.43 μm. The metamaterial can be tuned by using micro-electro-mechanical system (MEMS) technique. The relative height or lateral offset between metamaterial and coupling nanograting can be controlled, that the light-emitting efficiency can be separated into two different directions. In addition, the coupling efficiency is as high as 91% at the optical C-band communication window. Therefore, the proposed MEMS-based MNC not only has the possibility of coupling optical fibers with high-density integrated optoelectronic chips, but also has potential application prospects in light path switching, variable optical attenuation, and optical switch.

Optical attenuation coefficient of skin under low compression.

In various biomedical optics therapies, knowledge of how light is absorbed or scattered by tissues is crucial. Currently, it is suspected that a low compression applied to the skin surface may improve light delivery into tissue. However, the minimum pressure needed to be applied to significantly increase the light penetration into the skin has not been determined. In this study, we used optical coherence tomography (OCT) to measure the optical attenuation coefficient of the human forearm dermis in a low compression regime (<8k P a). Our results show low pressures such as 4kPa to 8kPa are sufficient to significantly increase light penetration by decreasing the attenuation coefficient by at least 1.0m m -1.

Development of polarization-sensitive optical coherence tomography imaging platform and metrics to quantify electrostimulation-induced peripheral nerve injury in vivo in a small animal model.

Neuromodulation devices are rapidly evolving for the treatment of neurological diseases and conditions. Injury from implantation or long-term use without obvious functional losses is often only detectable through terminal histology. New technologies are needed that assess the peripheral nervous system (PNS) under normal and diseased or injured conditions. We aim to demonstrate an imaging and stimulation platform that can elucidate the biological mechanisms and impacts of neurostimulation in the PNS and apply it to the sciatic nerve to extract imaging metrics indicating electrical overstimulation. A sciatic nerve injury model in a 15-rat cohort was observed using a newly developed imaging and stimulation platform that can detect electrical overstimulation effects with polarization-sensitive optical coherence tomography. The sciatic nerve was electrically stimulated using a custom-developed nerve holder with embedded electrodes for 1h, followed by a 1-h recovery period, delivered at above-threshold Shannon model -values in experimental groups: sham control (SC, , ), stimulation level 1 (SL1, , , and ), and stimulation level 2 (SL2, , , and ). The stimulation and imaging system successfully captured study data across the cohort. When compared to a SC after a 1-week recovery, the fascicle closest to the stimulation lead showed an average change of (SL1/SL2) in phase retardation and in optical attenuation relative to SC. Analysis of immunohistochemistry (IHC) shows a difference in myelin pixel counts and difference in axon pixel counts, and an overall increase in cell nuclei pixel count of . These metrics were consistent with IHC and hematoxylin/eosin tissue section analysis. The poststimulation changes observed in our study are manifestations of nerve injury and repair, specifically degeneration and angiogenesis. Optical imaging metrics quantify these processes and may help evaluate the safety and efficacy of neuromodulation devices.

Optical Attenuation Coefficient Optimization Algorithm for Deep Tissue Signals in Optical Coherence Tomography Based on Kalman Filter

Optical coherence tomography (OCT) attenuation imaging is a technique that uses the optical attenuation coefficient (OAC) to distinguish the types or pathological states of tissues and has been increasingly used in basic research and clinical diagnosis. With the increasing application of swept-source OCT, scholars are increasingly inclined to explore deep tissues. Unfortunately, the accuracy of OAC calculation when exploring deep tissues has yet to be improved. Existing methods generally have the following problems: overestimation error, underestimation error, severe fluctuation, or stripe artifacts in the OAC calculation of the OCT tail signal. The main reason for this is that the influence of the noise floor on the OCT weak signal at the tail-end is not paid enough attention. The noise floor can change the attenuation pattern of the OCT tail signal, which can lead to severe errors in the OAC. In this paper, we proposed a Kalman filter-based OAC optimal algorithm to solve this problem. This algorithm can not only eliminate the influence of the noise floor, but can also effectively protect the weak signal at the tail-end from being lost. The OAC of deep tissues can be calculated accurately and stably. Numerical simulation, phantom, and in vivo experiments were tested to verify the algorithm’s effectiveness in this paper. This technology is expected to play an essential role in disease diagnosis and in the evaluation of the effectiveness of treatment methods.

Dual-Mode Variable Optical Attenuator Based on Polymer Waveguide Mach–Zehnder Interferometer

The variable optical attenuator is one of the key components in optical communication system, but it is scarce for mode division multiplexing system. Here, we designed and experimentally demonstrated an ultra-broadband dual-mode variable optical attenuator based on Mach–Zehnder interferometer with thermo-optic phase shifters. We fabricated the device with polymer waveguide and characterized the function of the variable optical attenuator. The presented device can attenuate E11 and E12 modes simultaneously at a low power-consumption ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\sim $ </tex-math></inline-formula> 4.8 mW) over 1500 - 1620 nm, which proves that our device is mode-insensitive and wavelength-insensitive. The presented variable optical attenuator can be widely used in mode division multiplexing system where mode-insensitive attenuating or switching is needed.

Real-time adaptive optical self-interference cancellation for in-band full-duplex transmission using SARSA(λ) reinforcement learning.

Self-interference (SI) due to signal leakage from a local transmitter is an issue in an in-band full-duplex (IBFD) transmission system, which would cause severe distortions to a receiving signal of interest (SOI). By superimposing a local reference signal with the same amplitude and opposite phase, the SI signal can be fully canceled. However, as the manipulation of the reference signal is usually operated manually, it is difficult to ensure a high speed and high accurate cancellation. To overcome this problem, a real-time adaptive optical SI cancellation (RTA-OSIC) scheme using a SARSA(λ) reinforcement learning (RL) algorithm is proposed and experimentally demonstrated. The proposed RTA-OSIC scheme can automatically adjust the amplitude and phase of a reference signal by adjusting a variable optical attenuator (VOA) and a variable optical delay line (VODL) achieved through an adaptive feedback signal, which is generated by evaluating the quality of the received SOI. To verify the feasibility of the proposed scheme, a 5 GHz 16QAM OFDM IBFD transmission experiment is demonstrated. By using the proposed RTA-OSIC scheme, for an SOI at three different bandwidths of 200, 400, and 800 MHz, the signal can be adaptively and correctly recovered within 8 time periods (TPs), which is the required time of a single adaptive control step. The cancellation depth for the SOI with a bandwidth of 800 MHz is 20.18 dB. The short- and long-term stability of the proposed RTA-OSIC scheme is also evaluated. The experimental results indicate that the proposed approach could be a promising solution for real-time adaptive SI cancellation in future IBFD transmission systems.

459 Neuro-Oncology Spectral Fingerprint Biorepository: A Novel Approach Leveraging a Surgical and Clinical Detailed Repository in a Diverse Patient Population

INTRODUCTION: Despite advances in the understanding of brain cancer, surgery and extent of resection (EOR) continue to be the main predictors of patient outcome. However, currently available public biorepositories do not include extent of resection for individual patients raising important questions regarding confounding effects for some molecular markers. Further, emerging data has supported important novel biomarkers in tumor’s lipidome and optical attenuation properties which could serve as new therapeutic opportunities. METHODS: All neuro-oncology surgical cases at our institution were eligible for collection since 2016. Blood was collected from every patient pre-operatively. Cerebrospinal fluid was collected whenever surgically safe. Genomic and transcriptomic analysis was performed. Intra-operative spectral and optical attenuation data was obtained through desorption electrospray ionization mass spectrometry (DESI-MS) over 0 to 1000 m/z and optical coherence tomography, respectively, for biomarker discovery. RESULTS: A total of 912 unique patient collections have been performed including 286 gliomas and 205 other rare brain tumors. Demographic, clinical, imaging, surgical and survival data was curated for each individual patient. Extent of resection (EOR) was determined for each patient, with an average of 78.6% for chordomas, 85.9% in glioblastoma, 88.3% in other high-grade gliomas and 72% in low-grade gliomas with predictive of progression-free survival (p &lt; 0.01) and overall survival (p &lt; 0.01). Comprehensive sequencing has been completed for 131 gliomas. Of those, lipid and optical profiling has been completed for multiple tumor samples (330) from a total of 79 patients. CONCLUSIONS: We have curated a large biorepository of neuro-oncology tumors with detailed patient information including for the first time to our knowledge detailed surgical, imaging, spectral and optical information. Efforts are ongoing at large-scale biomarker discovery leveraging the unique spectral and optical fingerprint of each tumor to their genomic/transcriptomic profile.

Arterial pulsation modulates the optical attenuation coefficient of skin.

Photoplethysmographic (PPG) signals arise from the modulation of light reflectivity on the skin due to changes of physiological origin. Imaging plethysmography (iPPG) is a video-based PPG method that can remotely monitor vital signs in a non-invasive manner. iPPG signals result from skin reflectivity modulation. The origin of such reflectivity modulation is still a subject of debate. Here, we have used optical coherence tomography (OCT) imaging to find whether iPPG signals may result from skin optical properties being directly or indirectly modulated by arterial transmural pressure propagation. The light intensity across the tissue was modeled through a simple exponential decay (Beer-Lambert law) to analyze in vivo the modulation of the optical attenuation coefficient of the skin by arterial pulsation. The OCT transversal images were acquired from a forearm of three subjects in a pilot study. The results show that the optical attenuation coefficient of skin changes at the same frequency as the arterial pulsation due to transmural pressure propagation (local ballistographic effect), but we cannot discard the contribution of global ballistographic effects.

Quantitative photoacoustic tomography with light fluence compensation based on radiance Monte Carlo model

Objective. Photoacoustic tomography (PAT) is a rapidly evolving imaging modality that provides images with high contrast and spatial resolution showing the optical properties of biological tissues. The photoacoustic pressure is proportional to the product of the optical absorption coefficient and the local light fluence. The essential challenge in reconstructing quantitative images representing spatially varying absorption coefficients is the unknown light fluence. In addition, optical attenuation induces spatial variations in the light fluence, and the heterogeneity of the fluence determines the limits of reconstruction quality and depth. Approach. In this work, a reconstruction enhancement scheme is proposed to compensate for the variation in the light fluence in the absorption coefficient recovery. The inverse problem of the radiance Monte Carlo model describing light transport through the tissue is solved by using an alternating optimization strategy. In the iteration, the absorption coefficients and photon weights are alternately updated. Main results. The method provides highly accurate quantitative images of absorption coefficients in simulations, phantoms, and in vivo studies. The results show that the method has great potential for improving the accuracy of absorption coefficient recovery compared to conventional reconstruction methods that ignore light fluence variations. Comparison with state-of-the-art fluence compensation methods shows significant improvements in root mean square error, normalized mean square absolute distance, and structural similarity metrics. Significance. This method achieves high precision quantitative imaging by compensating for nonuniform light fluence without increasing the complexity and operation of the imaging system.

Capacity Enhancement Analysis of an OAM-OFDM-SMM Multiplexed Free Space Communication System in Atmospheric Turbulence

To overcome atmospheric turbulence (AT) distortion during signal propagation through the optical link, orbital angular momentum (OAM) mode states employing multiple inputs and multiple outputs (MIMO) techniques have recently gained prominence in free space optical communication (FSO). As the various OAM modes propagate through the free space optical link, signal attenuation and crosstalk may occur, reducing system capacity and increasing the likelihood of bit errors. In this work, our objective is to propose a spectrally efficient, high-speed and channel capacity efficient crosstalk FSO communication system by combining the features of orthogonal frequency division multiplexing (OFDM), spatial mode multiplexing (SMM), and a mode diversity scheme into an existing OAM-FSO communication system. The incorporation of the OFDM-MIMO concept and spatial mode diversity into the existing OAM-MIMO-FSO system is extremely beneficial in enhancing the transmission capacity, mitigating multipath fading and atmospheric turbulence distortions. The Gamma–Gamma (GG) model is used to assess the performance of the proposed system under various atmospheric turbulence conditions in terms of the performance metrics such as BER vs. number of OAM states for different refractive index structure and Rytov constants, link distance, and an optical signal to noise ratio (OSNR). A FEC limit of 3.8 × 10−3 and a maximum link distance of 2 km are set to evaluate these performance parameters. Finally, the transmission capacity of the proposed system is compared to that of the existing MIMO and OAM-SMM-MIMO systems for different OSNR values under atmospheric turbulence conditions for the OAM state of l = +1, yielding an overall improvement of 3.3 bits/s/Hz compared to conventional MIMO systems and 1.6 bits/s/Hz for the OAM-SMM-MIMO system.

Intraoperative application of optical coherence tomography for lung tumor.

On-site instant determination of benign or malignant tumors for deciding the types of resection is crucial during pulmonary surgery. We designed a portable spectral-domain optical coherence tomography (SD-OCT) system to do real-time scanning intraoperatively for the distinction of fresh tumor specimens in the lung. A total of 12 ex vivo lung specimens from six patients were enrolled. Three patients were diagnosed with invasive adenocarcinoma (IA), while the others were benign. After OCT-imaged reconstruction, we compared the qualitative morphology of OCT and histology among malignant, benign, and normal tissues. In addition, through analysis of the quantitative data, a discrete difference in optical attenuation coefficients around the junctional surface was shown by our data processing. This study demonstrated a feasible OCT-assisted resection guide by a rapid on-site tumor diagnosis. The results indicate that future deep learning of OCT-captured image systems able to improve diagnostic and therapeutic efficiency is warranted.

Derivation of chromophore concentrations in turbid media using the rate of change of optical attenuation with respect to wavelength

A spectroscopic method is investigated for estimating the concentrations of absorbers in highly scattering media using measurements of the rate of change of optical attenuation with wavelength. Such measurements are independent of absolute intensity and thus may be significantly less influenced by changes in coupling which often cause artefacts in medical applications of near-infrared spectroscopy. The method has been explored using a combination of stochastic (Monte Carlo) and analytical (diffusion-based) models and experiments on samples of turbid fluids. Results suggest that the method is highly tolerant of changes in the measurement geometry. The accuracy of the derived concentrations of absorbers can be strongly influenced by the wavelength dependence of scattering, and an ad-hoc, empirically-derived correction for this dependency has been investigated and implemented with some success.

Optical frequency transfer with below 10−21 uncertainty using a DFB–laser-based fiber Brillouin amplifier

Exploiting the outstanding performance of optical atomic clocks for improved timekeeping, relativistic geodesy, and fundamental physics beyond the standard model demands comparing distant state-of-the-art optical clocks. Interferometric optical fiber links have been demonstrated as an eminent method for such frequency comparisons over distances up to thousands of kilometers. However, for such distances, the optical fiber attenuation mandates signal amplification. Fiber Brillouin amplification (FBA) has been proven as an efficient amplification technique for coherent frequency transfer. Demonstrated FBA schemes have been designed based on costly narrow-linewidth pump lasers and analog pump-to-signal phase locking schemes. Furthermore, the high pump power requirement of these FBAs hinders the integration of FBA-based frequency dissemination on fiber connections for shared telecommunication signals in the C-band. In this paper, we propose and experimentally demonstrate a novel FBA module (FBAM) employing cost-effective distributed feedback (DFB) pump lasers assisted by a digital phase locking scheme based on a field programmable gated array. The new FBAM is compact, cost-effective, and directly applicable to different bands, which opens up new opportunities to establish a frequency metrology infrastructure within existing telecommunication fiber networks. Additionally, the small-footprint of the DFB-FBAM allows for frequent amplification stages with lower pump power to reach continental scale optical metrology links with an optimized signal-to-noise ratio. We characterized the DFB-FBAM’s frequency transfer uncertainty using a two-way layout over an in-lab 100 km long optical fiber link and reach a fractional frequency instability of 9.3 × 10−22 at a 10 ks integration time. The DFB-FBAM characterizations show uncertainty contributions of (−2.1 ± 3.3) × 10−22 and below for averaging times &amp;gt;100 ks. For the first time, we assess the temporal Brillouin frequency shift variations in an underground fiber link and implement a scheme to track these changes in a remote FBAM.

Automated segmentation and quantification of calcified drusen in 3D swept source OCT imaging.

Qualitative and quantitative assessments of calcified drusen are clinically important for determining the risk of disease progression in age-related macular degeneration (AMD). This paper reports the development of an automated algorithm to segment and quantify calcified drusen on swept-source optical coherence tomography (SS-OCT) images. The algorithm leverages the higher scattering property of calcified drusen compared with soft drusen. Calcified drusen have a higher optical attenuation coefficient (OAC), which results in a choroidal hypotransmission defect (hypoTD) below the calcified drusen. We show that it is possible to automatically segment calcified drusen from 3D SS-OCT scans by combining the OAC within drusen and the hypoTDs under drusen. We also propose a correction method for the segmentation of the retina pigment epithelium (RPE) overlying calcified drusen by automatically correcting the RPE by an amount of the OAC peak width along each A-line, leading to more accurate segmentation and quantification of drusen in general, and the calcified drusen in particular. A total of 29 eyes with nonexudative AMD and calcified drusen imaged with SS-OCT using the 6 × 6 mm2 scanning pattern were used in this study to test the performance of the proposed automated method. We demonstrated that the method achieved good agreement with the human expert graders in identifying the area of calcified drusen (Dice similarity coefficient: 68.27 ± 11.09%, correlation coefficient of the area measurements: r = 0.9422, the mean bias of the area measurements = 0.04781 mm2).

Effect of particle and pore morphology on optical transmission of yttria based laser host ceramics: A small-angle scattering investigation

Transparent and nearly opaque Nd: YAG and Nd: Y2O3 laser host ceramics synthesized by both co-precipitation (COP) and solid-state reaction (SS) routes are investigated using the scanning electron microscopy (SEM) and small-angle scattering (SAS) technique. Studies revealed that ceramic pellets of Nd: YAG and Nd: Y2O3 contain bi-modal pores with 〈D〉 ∼ 120 nm-230 nm and 28–58 nm and the pore structure is independent of the method of preparation. The porosity values of all the ceramic pellets are calculated and it is found that SS-synthesized pellets remained nearly 10 times more porous than those obtained from the COP method. These results are attributed to the presence of hard non-sinterable aggregates in the SS ceramic pellets as observed in SEM pictures. Further, the optical attenuation coefficients (at λ = 300 nm, 450 nm, 645 nm and 1000 nm) are also calculated using the parameters obtained from SAS results and the values are found to be 22.2 cm−1, 4.5 cm−1, 0.87 cm−1, 0.48 cm−1 for YAG and 34.8 cm−1, 3.5 cm−1, 1.20 cm−1, 0.78 cm−1 for Y2O3 ceramic pellets synthesized by COP method. These attenuation coefficient well corroborate with the optical transmission studies. Our study shows that SAS as an excellent technique to calculate porosity of the technologically important laser host ceramics and correlate optical properties with their pore morphology.

In vivo characterization of cerebrovascular impairment induced by amyloid β peptide overload in glymphatic clearance system using swept-source optical coherence tomography.

Antiamyloid ( ) immunotherapy is a promising therapeutic strategy for Alzheimer's disease (AD) but generates large amounts of soluble peptides that could overwhelm the clearance pathway, leading to serious side effects. Direct implications of in glymphatic drainage transport for cerebral vasculature and tissue are not well known. Studies are needed to resolve this issue and pave the way to better monitoring abnormal vascular events that may occur in -modifying therapies for AD. The objective is to characterize the modification of cerebral vasculature and tissue induced by soluble abundantly present in the glymphatic clearance system. peptide was injected intracerebroventricularly and swept-source optical coherence tomography (SS-OCT) was used to monitor the progression of changes in the brain microvascular network and tissue in vivo over 14 days. Parameters reflecting vascular morphology and structure as well as tissue status were quantified and compared before treatment. Vascular perfusion density, vessel length, and branch density decreased sharply and persistently following peptide administration. In comparison, vascular average diameter and vascular tortuosity were moderately increased at the late stage of monitoring. Endpoint density gradually increased, and the global optical attenuation coefficient value decreased significantly over time. burden in the glymphatic system directly contributes to cerebrovascular structural and morphological abnormalities and global brain tissue damage, suggesting severe deleterious properties of soluble cerebrospinal fluid- . We also show that OCT can be used as an effective tool to monitor cerebrovascular dynamics and tissue property changes in response to therapeutic treatments in drug discovery research.