The title of the research is "The chronology of the application of open source information system Koha in the library of Muhammadiyah University of Surakarta from 2006 to 2010. "The background of this research is that the development of the information technology demands the library to use the technology. UMS' library was the first and its private-university library using Koha system as the automatic system in Indonesia. Koha's complete features and its development raised confusion UMS' library staff. The use od English language and the small number of the community of Koha users in Indonesia sometimes lead to misinterpretation.The method used in this research was the qualitative method, and its approach was the case study. The reason of using these was that the case happened was unique and the forms of the questions were how and why.The result of the research was that there were 3 periods of the chronology of Koha application in UMS library, namely: pre-Koha, whilst using Koha, and developing of Koha system. The application of Koha system in UMS library had been in accordance with the cycle of the development of the information system. This cycle includes influential factors were: (1) the rectorat's supports, (2) human resource and leadership, (3) trend in the library, (4) integration, (5) theneed of the system, (6) the data analyze, (7) conmunication, (8) good cooperation, (9) socialization, (10) open source, (11) financial condition, (12) the quality of the system, (13) the readiness of the facilities. Besides, the research found that were some factors as the theoretical contributors namely: good communication and cooperation, socialization, abd the readiness of the facilities. It also found that there were one was lost factor, namely: user interface.