Proactive Mobile Network (PMN) has been proposed to support extremely low latency communications with multi-tier computing architectures, machine-centricity, and data-driven operation features. Nevertheless, the communication reliability of the PMN introduces new substantial technological challenges. As PMN employs unique proactive open-loop communication, any feedback-based control is avoided to enhance end-to-end latency. This paper focuses on machine-initiated uplink transmission in PMN and proposes a reliability-guaranteed resource management scheme. Without requiring feedback control information, our scheme uniquely decomposes conventional resource management into two collaborative decision processes: predictive resource allocation suggested by network anchor nodes (ANs) and proactive smart resource utilization by smart equipment (SE). These two decision-making processes are constructed as independent reinforcement learning (RL) problems, but implicitly share the states of radio resources according to operating environments. Different algorithms for different operating scenarios have been investigated for this dual-decision solution. Simulation results in various scenarios show that our scheme enables PMN’s reliability close to the theoretical optimal value and successfully serves radio resource utilization in the PMNs.