This study empirically explores the Quadruple Helix model’s potential in facilitating an urgent open innovation project. By examining the life cycle of the project, developed during the COVID-19 pandemic crisis in Brazil, it reveals complex interactions among government, academia, industry, and civil society stakeholders, while also shedding light on the various risks arising from their dynamic collaboration. Employing an approach that combines case study analysis, risk assessment, and theoretical framework development, we unravel the project’s evolution, highlighting pivotal elements such as trust, collaboration, communication, agile mindset, stakeholder partnerships, scale, and logistics. Additionally, the study underscores concerns related to finance, time, reputation, and health, which warrant consideration. Risk analysis uncovers internal and external risks and categorizes thirty-two risks, with one deemed unacceptable, thus revealing valuable insights into stakeholders’ partnerships, institutional image, public equipment, manufacturing, project management, human resources, intellectual property, regulation, and sanitation risks. Building on these findings, we develop a new framework illustrating the management of the urgent open innovation project through the fast-paced Quadruple Helix formation. By exploring stakeholder collaboration and risk management, this research provides insights into the adaptability and speed required to successfully execute an emergency project, as well as presenting practical strategies for risk management and mitigation, significantly contributing to the domains of the Quadruple Helix and project management research.
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