IntroductionOpen lower limb fractures are severe injuries long-lasting consequences. Limited research has been done on the impact of these on quality of life, internationally. MethodsThe Quality of Life after Open Extremity Trauma (QUINTET) study was designed as an international, multi-centre, observational, cohort study of patients admitted with open lower limb fractures. Demographic and clinical information was collected, along with repeated validated quality of life measures. Primary outcomes were SF-12 and EQ-5D-3L and secondary outcomes were soft tissue infection, deep infection, non-union and amputation. ResultsA total 92 patients were enrolled in 8 centres, based in the UK, Spain, Chile and Sudan. Mean age at presentation of 54 years, 47 years for males and 64 years for females. Males presented a higher proportion of road traffic accidents as the underlying mechanism, while for females this was the case for low-energy falls. Participant retention was 71.7% and 73.9% for the 3 and 12-months assessments, respectively. There was a substantial reduction in quality of life after open fracture, which only partially recovered at 12 months. Participants recruited in the UK presented lower quality of life scores compared with patients treated in Spain and Chile. DiscussionFor this study, international patient recruitment proved challenging, leading to most patients being recruited in the UK. Despite this limitation we found significant a statistically significant detriment in self-reported quality of life which did not recover after a year. This study highlights differences in quality-of-life outcomes from a gender and international perspective.