The aim of the article is to analyze the ontological foundations of quantum mechanics and the relationship of various interpretations of quantum mechanics with the question of truth in scientific knowledge. The theoretical material (various interpretations of quantum mechanics) was analyzed. The research methods were analysis, comparative-historical and institutional approaches. On the basis of the study, it can be concluded that physicists are only able to predict the probabilities of physical phenomena or processes, without any knowledge of the structure of entity in itself. The study helps to complement the theoretical picture of the ontology of quantum mechanics and to get an idea about the development prospects of the methodology of physical sciences. We should not ascribe properties that are unobservable in experience to the entity because science can truly interpret only the representation of entity in itself in experience and the ways of dealing with it, not future events or possible states of the entity. Otherwise, science “slides” down to the level of dialectical (rhetorical) exercises based not on true premises, but on generally accepted or “authoritative” biases, which gives room to extreme forms of relativism and takes natural scientists away from studying nature to inventing empirically unsupported hypotheses. When, in accordance with the Cartesian ontology, the scientist assumes that the entity is as the “subject” observes it (that is, the “reflection” of the entity in consciousness is identified with entity in itself), this assumption leads the scientist to attempts to “scientifically” describe the future events or the possible states of the entity. The criterion for the truth of a scientific theory put forward by Einstein in his dispute with Bohr remains a fundamentally unattainable ideal. Cognition of nature is probabilistically and fundamentally incomplete since a person can consciously comprehend natural phenomena only within the framework of their representation in the existing being. The probabilistic nature of quantum mechanics is due to the impossibility of knowing things as they exist by themselves, that is, as they exist outside of representation in the mind of the observer. This does not mean that physical entities did not exist before their knowledge: they existed potentially, but were not valid for the observer, that is, conscious. Quantum physics is as incomplete as any other physical theory when compared with an unattainable ideal, but this fact does not negate its truth for modern scientists since quantum theory is based on the results of verified experiments.
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