Heat-driven thermoacoustic refrigerator (HDTR) emerges as a pivotal solution to global energy challenges and carbon emissions. This study introduces a simplified single-unit HDTR as a new supplement to the heat-driven thermoacoustic refrigeration process. Featuring only one simple, direct-coupled thermoacoustic energy conversion core unit, it is designed to reduce overall system complexity. Initially, the simulation model of the single-unit system is established in Sage and compared with a two-unit HDTR, indicating that reducing the number of thermoacoustic core units decreases system complexity without compromising system performance. The onset characteristics and steady-state operational characteristics of the proposed single-unit HDTR are then experimentally tested, revealing a cooling power of 895 W with a coefficient of performance (COP) of 0.43 when the ambient and cooling temperature is 25 °C and 0 °C, respectively. Notably, a minimal onset temperature difference of 61.6 °C is obtained for the single-unit HDTR. These results showcase the possible application potential for low-grade heat recovery. A comparative analysis against existing loop HDTR systems establishes its superior performance, offering a valuable reference for contemporary HDTR assessments. This study significantly advances HDTR development, emphasizing efficiency and sustainable cooling applications.