Onion Extract Gel Research Articles

The Efficacy of Onion Extract on the Prevention or Treatment of Scars: A Systemic Review.

Scars are common and debilitating outcomes of burn injury, with no current consensus regarding the gold standard in scar management. Non-invasive interventions such as silicone gels are popular adjuvant treatments due to ease of application. Onion extract (OE) has been proposed as a potential scar treatment modality due to its anti-microbial and anti-inflammatory properties. A systematic search of the literature was conducted using PubMed, Scopus, and Cochrane for articles published between January 2000 and December 2021. Inclusion criteria were studies: (a) involved OE gel or OE treatment, and (b) those assessing scar prevention or treatment outcomes. Patient and physician reported scar outcomes after treatment and adverse effects were recorded. A total of 21 articles were included in the final review. Five studies found statistically significant improvements in overall scores and individual VSS components in the OE treatment group compared to the silicone groups. Several studies found combined treatment of OE with other topical treatment modalities such as triamcinolone or silicone gel produced significant improvements in scar symptoms. In this review, reported adverse effects were minimal, often consisting of self-resolving pruritus, irritation, and erythema. This review supports OE's potential utility in scar prevention and treatment. Most studies reported minimal adverse events with OE application and significant benefits in specific scar characteristics. Further research is needed to investigate scar outcomes after treatment with OE with larger sample sizes and a follow up period greater than a year.

Role of onion extract in preventing abnormal scarring in scald injury

It has been suggested that using an onion extract and silicone derivative can stop aberrant scarring. In order to prevent aberrant post-burn scars, our study showed the prophylactic usage of silicone derivative and onion extract gel. Along with silicone-based treatments, onion extract or capelin has received attention recently as a potential contributor to scarring. According to various studies, onion extract itself may help with wound healing and may help avoid new scars. Patients evaluated their level of pain and itching at each visit, and surgeons used the Vancouver Scar Scale to assess the scarring process. Ratings for pain and itchiness in patients applying onion extract gel. No side effects were reported by any patients. Gel made from onion extract is secure and useful for avoiding unnatural burn scars.

Role of Onion Extract in Post Electrical Burn Scar

An imbalance of collagen synthesis and degradation is the most common cause of scarring. Onion extract inhibits fibroblast activity, which helps to reduce scar formation. Despite the fact that onion extract is used in a variety of commercial products, the precise molecular mechanisms by which onion extract reduces scar development in the skin are yet unknown. The aim of this study is to evaluate the effectiveness of onion extract gel in improving the post electrical burn scar.

The compound losartan cream inhibits scar formation via TGF-β/Smad pathway

The role of angiotensin receptor blocker in wound healing and cutaneous fibrosis has become a hotspot in recent years. We have developed a losartan cream that is comparable to triamcinolone ointment in inhibiting scarring. Considering the effects of chitosan and asiaticoside on wound healing and scarring, we added them to the losartan cream this time and improved the formula, expecting to get a better anti-scarring effect. The effects of creams were investigated on mouse scar model with triamcinolone ointment, onion extract gel, and commercial asiaticoside cream set as positive controls. A preliminary exploration of the mechanism involved in TGF-β/Smad pathway was performed in vivo and in vitro. With all results of anti-scarring, the compound losartan cream (containing chitosan, asiaticoside, and losartan) shows the best effect, followed by the chitosan asiaticoside cream. The treatment of the compound losartan cream inhibited expression of TGF-β1, collagen, and Smads, and decreased phosphorylation of Smad in vivo. These inhibitory effects were also confirmed in vitro. Our findings indicated that the compound losartan cream could inhibit scarring via TGF-β/Smad pathway. This cream might be an effective option for scar treatment.

UJI EFEKTIVITAS ANTIINFLAMASI GEL EKSTRAK PINING BAWANG (Hornstedtia alliacea) PADA MENCIT (Mus musculus) YANG DIINDUKSI KARAGENAN 1%

The purpose of this study was to determine the concentration of onion pining extract gel which has anti-inflammatory activity in carrageenan-induced male mice. Pining onion (Horstedtia alliacea) is a member of the ginger plant (Zingiberaceae) that grows in tropical areas including Halmanera. Pining onion is usually used as an energy supplier for hunting in the forest, treating wounds and infections, the seeds are consumed by children and adults. The benefit of this research is that this research can provide scientific and truthful information to the public regarding the anti-inflammatory effects of the pining onion plant, so that it can be used as an alternative inflammatory treatment. Pining onions contain flavonoid compounds, essential oils and several other compounds that are useful as anti-inflammatory. This study made three sample formulas with the active ingredient of pining onion extract with composition 0 (negative control), formula I 5%, formula II 10%, formula III 15% and diclofenac sodium (positive control) using the maceration method, with an interval of 30 minutes. for 8 repetitions of each suspension. Inhibition of edema in the FIII group (15% pining onion extract) had the same tendency as the K+ group (Na-Diclofenac). Meanwhile, at the lowest test dose the inhibition of edema was in the FI group (5% onion pining extract). The conclusion of this study is that administration of pining onion extract gel can show anti-inflammatory activity in carrageenan-induced mice. Pining onion extract gel at a concentration of 15% is the concentration that has the best anti-inflammatory activity compared to concentrations of 10% and 5%.

Onion extract gel is not better than other topical treatments in scar management: A meta-analysis from randomised controlled trails.

To evaluate the efficacy and safety of onion extract (OE) gel on scar management, a systematic review was performed by searching Embase, PubMed, Medline, and the Cochrane Library databases, and a meta‐analysis was conducted according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement guidelines. Finally, 13 randomised controlled trails were enrolled for meta‐analysis. OE gel increased the total improvement scores assessed by investigators (P < .00001) and patients (P < .00001) than no treatment, but no differences were detected between OE gel and other commonly used topical treatments assessed by investigators (P = .56) and patients (P = .39). Moreover, OE in silicone gel increased the total improvement scores assessed by investigators (P < .00001) and patients (P = .0007) than other treatments. OE gel increased the incidence of total adverse effects compared with no treatment (P < .0001) and other treatments (P = .008) by a fixed‐effects model, and increased the incidence of dropping out caused by intolerance of treatments (P = .0002). OE gel not only has no superiority to commonly used topical treatments, but also has the potential to increase the incidence of adverse effects on scar management; OE in silicone gel might be the optimal topical choice for scar treatment; however, more evidences are needed to strength these conclusions.

The effect of silicone gel versus contractubex gel on the upper-extremity postsurgical scars: A randomized, double-blinded, controlled trial.

Background: Wound healing is a process that has three overlapping inflammatory, proliferative, and reconstruction phases. Silicone gel and Contractubex (onion extract gel) are two main topical agents used for the prevention and treatment of hypertrophic scars. This clinical trial study aimed to evaluate the efficacy and safety of onion extract and silicone gel on hypertrophic scars of the upper extremity and compare it to non-treated patients. Methods: This randomized, double-blind, parallel, clinical trial was done on 120 male patients who had undergone upper extremity sharp injury repair. Patients were assigned to three groups, i.e., Silicone gel (Kelo-cortTM; WA, USA) (group 1; 40 patients), Onion extract (ContractubexTM, Merz Pharma, Frankfurt, Germany) gel (group 2; 40 patients), and No Intervention (group 3; 40 patients), using drawing sealed envelopes and a computer-based table of randomization. Data were recorded using the Vancouver scale in each visit by two surgeons who were blinded to the study groups. IBM SPSS Statistics for Windows, Version 22.0. (Armonk, NY: IBM Corp). Data were compared using the ANOVA test. A P-value of less than 0.05 was considered statistically significant. Results: Vascularity (p=0.200), pliability (p=0.058), pigmentation (p=0.701), and height (p=0.438) as subjective scar parameters were approximately similar in post-upper extremity sharp injury wound hypertrophic scar among the three groups. Conclusion: Vascularity, pliability, pigmentation and height, as subjective scar parameters, were not statistically different in post-upper extremity sharp injury wound hypertrophic scar among the groups. Even though onion extract gel and Silicone gel show preventive effects in the literature, especially in burns wounds, further studies are recommended to be conducted to prove the topical effects of above-mentioned gels in patients.

Efficacy of a Silicone-Based Gel Containing Pracaxi Oil (Pentaclethra macroloba) for Treating Post-Surgical Scars

Scars are an unavoidable consequence of cutaneous surgery. Healing with an excellent cosmetic outcome is a crucial component to any surgical wound to avoid any negative impact on quality of life. Various products exist which claim to improve post-surgical scar appearance and texture. In this blinded, randomized pilot study, we compared the efficacy of a silicone-based topical gel containing Pracaxi oil (PO Gel; Serica™ Moisturizing Scar Formula; Cynova Laboratories, Houston, TX) against a second silicone-based gel containing Cepalin onion extract (OE Gel; Mederma® Advanced Scar Gel, Merz, North America). The Vancouver Scar Scale (VSS), Physician and Subject Global Assessment of Scar Treatment, and digital photography were used to determine efficacy and superior post-surgical care treatment outcomes. Forty healthy subjects (18-75 years old) with recent surgical scar (1 to 4 months old) were randomized to PO gel or OE gel and asked to apply a topical solution three times daily for 8 weeks. There were six study visits (Baseline and Weeks 2, 4, 8, 12 and 16). The results of this study showed that subjects with post-surgical scars achieved significant improvements at 8 and 12 weeks following application of a product with either Pracaxi oil or onion extract gel, based on mean Vancouver Scar Scale scores. Both products generally improved the individual scar signs and symptoms. Subjects using the onion extract product did not achieve improvement in Pain or Itch at the 8-week evaluation or Pain at the 12-week evaluation.

Randomised comparison of silicone gel and onion extract gel for post-surgical scars

To compare the efficacy of silicone gel and onion extract gel on new surgical wounds, we performed a randomised controlled trial evaluating the appearance of the laparoscopic surgical scars of 60 subjects after 12 weeks of two times daily application of either silicone gel or onion extract gel. Objective scar assessment by the Vancouver Scar Scale (VSS) and the Image Panel Scale (IPS) and subjective scar assessment by the Body Image Scale (BIS) and Cosmetic Scale (CS) were performed after 12 weeks of treatment. Safety was also evaluated by gathering adverse events related to application of the gel. After 12 weeks of applying the assigned gel, there were no differences between the two groups in VSS (p = .779), IPS (p = .621), BIS (p = .924), or CS (p = .843). Subject compliance and safety with the assigned gel was similar between the two study groups. Our conclusion was that silicone gel and onion extract gel had similar compliance, side effects and efficacy in making surgical scars less distinct.Impact StatementWhat is already known on this subject: There are commercially available, topical scar emollients for prevention of surgical scarring. Despite their popularity, data demonstrating the efficacy of these scar emollients are lacking.What do the results of this study add: After 12 weeks of applying the assigned topical scar emollients, there were no differences between the two groups in terms of cosmesis and satisfaction.What are the implications of these findings for clinical practice and/or further research: Silicone gel and onion extract gel had similar compliance, side effects and efficacy in making surgical scars less distinct.

The ability of a new proprietary onion extract gel to reduce the appearance of scars: A randomized, controlled study

The ability of a new proprietary onion extract gel to reduce the appearance of scars: A randomized, controlled study

THE UTILITY OF ONION EXTRACT GEL CONTAINING TOPICAL ALLANTOIN AND HEPARIN AFTER SURGICAL TREATMENT OF UPPER EXTREMITY BURN SCAR

Background: The development of hypertrophic scars after burns can lead to esthetic as well as functional disorders. The aim of the study was to determine the functional and cosmetic effects of Contractubex® (onion extract, heparin, allantoin) gel applied in burn scar patients after surgery for scar excision and skin grafts. Patients and Methods: The study included seven male patients who presented to our clinic between 2005 and 2012 for the treatment of hypertrophic burn scar and were administered either single or combined medical hypertrophic scar treatments. Patients who had scars on the right upper extremity were included in group 1 and those with left upper extremity scars in group 2. In group 1, all scars were excised and closed with medium thickness skin graft. After surgery, the onion extract gel was applied to the right upper extremities. In group 2, only surgical treatment was applied. The results were evaluated with Vancouver scar scale. Results: Vascularity, flexibility, and height of the scars improved significantly in both groups. In addition, hyperpigmentation was observed on the skin grafts of all patients. Scar flexibility was less often observed in patients’ left upper extremities. However, no statistical difference between groups 1 and 2 was found. Conclusion: Although no significant difference was obtained with Contractubex gel treatment in this study, cosmetic and functional success can be achieved through excision of the scar and use of medium thickness skin graft in patients with upper extremity hypertrophic burn scarring that is resistant to conservative treatments.

Effectiveness of Onion Extract Gel on Surgical Scars in Asians

Background. Onion extracts have been shown in vitro to accelerate wound healing. Results from clinical studies on surgical scars in Caucasians were disappointing. The aim of this study is to evaluate the effectiveness of onion extract gel in improving the cosmetic and symptoms of surgical scars in Asians. Patients/Methods. Twenty Asians who had new Pfannenstiel's cesarean section scars were recruited in this prospective double-blinded, split-scar study. Each side was randomly assigned treatment with onion extract gel or placebo at 7 days after surgery. The product was applied three times daily for 12 weeks. Subjects were evaluated at baseline and 4th and 12th weeks. Scar redness was assessed by calorimeter, scar height and pliability were assessed by blinded investigators, and scar symptoms and overall cosmetic improvement were assessed by subjects. Results. Sixteen subjects completed the study. A statistically significant difference between two sides of scar in terms of scar height and scar symptoms was found. There was no statistically significant difference in scar redness, scar pliability, and overall cosmetic appearance between two sides. Conclusions. The early use of topical 12% onion extract gel on Pfannenstiel's cesarean section scar in Asians resulted in the improvement of scar height and scar symptoms.

Role of silicone derivative plus onion extract gel in presternal hypertrophic scar protection: a prospective randomized, double blinded, controlled trial

Use of silicone derivative and onion extract had been reported in the prevention of hypertrophic scarring. Our experience showed the preventive use of silicone derivative plus onion extract gel on hypertrophic scars after median sternotomy. In a randomized, double blinded, placebo-controlled study, 60 patients after median sternotomy incisions were separated into two groups. All patients were treated either with silicone derivative plus onion extract gel (Cybele(®) scagel) or placebo gel twice daily for a total treatment period of 12 weeks. During each visit, pain and itching scores were graded by the patients and scar characteristics were observed by surgeons using the Vancouver scar scale. Pain and itch score values from patients' who applied silicone derivative plus onion extract gel was less than another group (P < 0·05). Pigmentation was significantly different between two groups (P < 0·05) and the reduction of scores on vascularity, pliability, height in treated group was not superior to the untreated group. No adverse events were reported by any of the patients. A silicone derivative plus onion extract gel is safe and effective for the preventing the hypertrophic scarring after median sternotomy.

An Open, Randomized, Controlled, Comparative Study of the Combined Effect of Intralesional Triamcinolone Acetonide and Onion Extract Gel and Intralesional Triamcinolone Acetonide Alone in the Treatment of Hypertrophic Scars and Keloids

An Open, Randomized, Controlled, Comparative Study of the Combined Effect of Intralesional Triamcinolone Acetonide and Onion Extract Gel and Intralesional Triamcinolone Acetonide Alone in the Treatment of Hypertrophic Scars and Keloids

A comparison of onion extract gel with onion extract cream for the improvement of the appearance of postsurgical scars

A comparison of onion extract gel with onion extract cream for the improvement of the appearance of postsurgical scars

An Open, Randomized, Controlled, Comparative Study of the Combined Effect of Intralesional Triamcinolone Acetonide and Onion Extract Gel and Intralesional Triamcinolone Acetonide Alone in the Treatment of Hypertrophic Scars and Keloids

An Open, Randomized, Controlled, Comparative Study of the Combined Effect of Intralesional Triamcinolone Acetonide and Onion Extract Gel and Intralesional Triamcinolone Acetonide Alone in the Treatment of Hypertrophic Scars and Keloids

An Open, Randomized, Controlled, Comparative Study of the Combined Effect of Intralesional Triamcinolone Acetonide and Onion Extract Gel and Intralesional Triamcinolone Acetonide Alone in the Treatment of Hypertrophic Scars and Keloids

Various treatment regimens have been used in scars. The literature offers little consensus about appropriate therapy. To compare intralesional triamcinolone acetonide (TAC) alone or combined with onion extract in keloidal and hypertrophic scars. Fourteen patients were treated with intralesional TAC and onion extract gel, and 13 patients were treated with intralesional TAC alone. Findings were recorded and graded at each visit (weeks 0, 4, 12, and 20). The scores before treatment and at week 20 were compared. Twenty-seven patients [17 men (63%) and 10 women (37%) aged 15 to 73 (average age 28.1 +/- 11.7)] were enrolled in the study. At baseline, the difference in the two treatment groups was not statistically significant (p>.05). At week 20, there was statistically significant improvement in both treatment groups (p<.05). TAC with onion extract was more effective than TAC alone in terms of pain-sensitiveness, itching, and elevation but not in erythema and induration. Treatment was well tolerated, without any adverse effect. Treatment with intralesional TAC and onion extract and TAC alone were effective. Combined with onion extract gel, intralesional TAC appears to be superior to TAC alone in the treatment of keloids and hypertrophic scars.

The ability of onion extract gel to improve the cosmetic appearance of postsurgical scars

Superior wound healing with excellent cosmesis is critical in superficial dermal wounds created when cosmetically unacceptable lesions are removed from the body. Dermatologists frequently remove seborrheic keratoses, nevi, and angiomas from the body with a superficial shave excision. The excision is designed to minimize dermal scarring while removing the unsightly skin growth. This study was undertaken to evaluate the ability of an onion extract gel to improve the appearance of scars following excision. Sixty subjects with symmetrical seborrheic keratoses at least 8 mm in diameter on the right and left upper chest were enrolled. The lesions were removed with a scalpel shave, following local anesthesia with 2% lidocaine plus epinephrine. The surgical sites were allowed to heal for 2 to 3 weeks, at which time the subjects returned to the research center for randomization to either the onion gel treatment group or the no-treatment group. Forty-seven subjects in the active treatment group were further randomized as to the site of study product application. Thirteen control subjects applied nothing to either side. Subjects returned to the study center at weeks 2, 4, 6, and 10 for photography, subject evaluations, and investigator assessments. The study showed that the onion extract gel significantly improved scar softness, redness, texture, and global appearance at the excision site at study weeks 4, 6, and 10 as assessed by the blinded investigator.

The effects of onion extract on hypertrophic and keloid scars

To evaluate the therapeutic activity of topical onion extract in gel form on hypertrophic and keloid scars, focusing on problems such as elevation, redness, hardness, itching and pain. This comparative prospective study assigned 60 patients to three groups. Group I was treated with onion extract alone, group 2 with silicon gel sheet alone and 3 group with a combination of onion extract and silicon gel sheet. In the group comparisons, a significant difference was observed at the end of six months in the colour parameter between group I and group 2 and in the height parameter between group I and group 3 (ANOVA post-hoc Tukey's test, p<0.01 and p<0.05 respectively). The onion extract was more effective in relation to scar colour, while the silicon gel sheet was superior in decreasing the height of scar (paired sample t-test, p<0.001). In addition, the most effective therapeutic results were obtained when the silicon gel sheet treatment was combined with onion extract in group 3. Onion extract improved hypertrophic and keloids scars via multiple mechanisms. However, it was statistically ineffective in improving scar height and itching. For this reason, onion extract therapy should be used in combination with an occlusive silicon dressing to achieve a satisfying decrease in scar height.

Appeal of Onion Is Weak for Scar Treatment

Onion extract gel (Mederma) has been promoted by its manufacturer to improve the appearance and texture of surgical scars. To confirm or refute this