Ongoing Activity Research Articles

The recovery of parabolic avalanches in spatially subsampled neuronal networks at criticality.

Scaling relationships are key in characterizing complex systems at criticality. In the brain, they are evident in neuronal avalanches-scale-invariant cascades of neuronal activity quantified by power laws. Avalanches manifest at the cellular level as cascades of neuronal groups that fire action potentials simultaneously. Such spatiotemporal synchronization is vital to theories on brain function yet avalanche synchronization is often underestimated when only a fraction of neurons is observed. Here, we investigate biases from fractional sampling within a balanced network of excitatory and inhibitory neurons with all-to-all connectivity and critical branching process dynamics. We focus on how mean avalanche size scales with avalanche duration. For parabolic avalanches, this scaling is quadratic, quantified by the scaling exponent, , reflecting rapid spatial expansion of simultaneous neuronal firing over short durations. However, in networks sampled fractionally, is significantly lower. We demonstrate that applying temporal coarse-graining and increasing a minimum threshold for coincident firing restores , even when as few as 0.1% of neurons are sampled. This correction crucially depends on the network being critical and fails for near sub- and supercritical branching dynamics. Using cellular 2-photon imaging, our approach robustly identifies over a wide parameter regime in ongoing neuronal activity from frontal cortex of awake mice. In contrast, the common 'crackling noise' approach fails to determine under similar sampling conditions at criticality. Our findings overcome scaling bias from fractional sampling and demonstrate rapid, spatiotemporal synchronization of neuronal assemblies consistent with scale-invariant, parabolic avalanches at criticality.

Enabling efficient satellite mission design with rule-based collision avoidance

The growing number of operational spacecraft in Earth's orbit entails an increasing operational effort for collision avoidance (COLA), particularly regarding the coordination of evasive measures. To reduce the associated workload, COLA operations should already be considered in the early planning phases of space missions. The Mission Analysis Software (MAS) is a web-based application developed within the ESA-funded CASCADE (Collision avoidance, satellite coordination assessment demonstration environment) project by OKAPI:Orbits and TU Darmstadt for this purpose. The software follows a data-driven approach to offer satellite operators, mission designers, service providers, agencies, and authorities two services: conjunction assessment and rule analysis. The conjunction assessment provides an estimation of the number and type of conjunctions to be expected on the targeted orbit and identifies frequently conjuncting parties for the current population of active satellites as well as for conceivable future scenarios. The rule analysis follows a rule-based approach to coordinate COLA between individual operators, allowing users to build custom hierarchical rule sets from pre-defined rule building blocks to achieve a desired split of effort between the conjunction parties. The MAS enables the assessment of the operational consequences for a chosen rule set, empowering users to reach bilateral agreements with identified frequently conjuncting parties to determine the obligation to take evasive measures for future conjunctions. The approach of the MAS allows for the pre-emptive reduction of the expected number of conjunctions enabling operators to optimize orbit parameters within their mission constraints as well as the automatization of COLA coordination during operations. Through this, the MAS optimizes propellant needs, mission time, and required workforce associated with COLA for space missions.This paper presents the MAS, showcasing the key features and use cases that have been developed closely with stakeholders and the European Space Agency. Furthermore, the data-based simulation approach of the MAS will be explained, covering the data sources and design choices for the conjunction detection and propagation module. The paper also presents the results of a preliminary rule analysis conducted for the population of active satellites in low Earth orbit as of April 2023. As an intermediate result of an on-going research activity involving the authoring entities, a major goal of this paper is to engage with satellite operators, mission designers, service providers, agencies, and authorities in order to tailor the results of the activity to their actual needs.

Mind-wandering contents and characteristics: an exploratory study comparing between work and non-work contexts

ABSTRACT Mind-wandering, where thoughts drift away from the immediate environment or task to self-generated thoughts, is a common human experience. Despite the growing research on its antecedents and consequences, the content and characteristics of mind-wandering across different contexts, such as work-related and non-work-related settings, remain poorly understood. This study, guided by the Context and Content Regulation Hypothesis, explores the nuances of mind-wandering by examining both its content and characteristics, such as deliberateness and temporal orientation. Over five working days, we prompted 131 workers three times daily to report the content and characteristics of their current thoughts. Our findings indicate that mind-wandering occurred less frequently during work but was predominantly populated with work-related content, regardless of the ongoing activity. Furthermore, while most mind-wandering events were future-oriented and spontaneous, those centred on work exhibited a more deliberate and pronounced future bias. Challenging the prevailing notion of mind-wandering as a mere distraction, our findings align with the Context and Content Regulation Hypothesis, emphasizing its strategic role in foreseeing and preparing for future work-related events.

Cloud-Connected Bracelet for Continuous Monitoring of Parkinson’s Disease Patients: Integrating Advanced Wearable Technologies and Machine Learning

Parkinson’s disease (PD) is one of the most unremitting and dynamic neurodegenerative human diseases. Various wearable IoT devices have emerged for detecting, diagnosing, and quantifying PD, predominantly utilizing inertial sensors and computational algorithms. However, their proliferation poses novel challenges concerning security, privacy, connectivity, and power optimization. Clinically, continuous monitoring of patients’ motor function is imperative for optimizing Levodopa (L-dopa) dosage while mitigating adverse effects and motor activity decline. Tracking motor function alterations between visits is challenging, risking erroneous clinical decisions. Thus, there is a pressing need to furnish medical professionals with an ecosystem facilitating comprehensive Parkinson’s stage evaluation and disease progression monitoring, particularly regarding tremor and bradykinesia. This study endeavors to establish a holistic ecosystem centered around an energy-efficient Wi-Fi-enabled wearable bracelet dubbed A-WEAR. A-WEAR functions as a data collection conduit for Parkinson’s-related motion data, securely transmitting them to the Cloud for storage, processing, and severity estimation via bespoke learning algorithms. The experimental results demonstrate the resilience and effectiveness of the suggested technique, with 86.4% accuracy for bradykinesia and 90.9% accuracy for tremor estimation, along with good sensitivity and specificity for each scoring class. The recommended approach will support the timely determination of the severity of PD and ongoing patient activity monitoring. The system helps medical practitioners in decision making when initially assessing patients with PD and reviewing their progress and the effects of any treatment.

Repetition for real-time coordination of action: Lexical and non-lexical vocalizations in collaborative time management

Repetition has often been argued to be a semiotic device that iconically signifies ‘more content’, such as intensity and plurality. However, through multimodal interaction analysis of materials in English, Estonian, and Swedish, this paper demonstrates how self-repetition is used to coordinate actions across participants and temporally organize the ongoing activity. The data are taken from infant mealtimes, pilates classes, dance training, boardgames, rock climbing, and opera rehearsals. Repetition of both lexical and non-lexical tokens can prolong, postpone, and generally organize segments of action as well as co-create rhythms and moves in a moment-by-moment reflexive relationship with other (non-vocalizing) participants. A crucial feature of repetitions is that they can be flexibly extended to fit the other’s public performance, its launching, continuation, and projectable completion. We argue that the iconicity of repetition emerges through its indexical relationship to other bodies, as a real-time jointly achieved phenomenon.

Queering the Poster: Disruptive Knowledge at the AACN Diversity Symposium.

This article advances theory to practice by describing the application of queer norm-critical pedagogy to a poster given as part of a virtual session at the 2021 American Association of Colleges of Nursing Diversity Symposium. The authors created and facilitated the experience of a queered, conceptual poster, inviting a critical appraisal of both the limits and the possibilities of knowledge sharing and co-creation among nurse educators and nursing scholars. The poster was and remains a multimodal, democratic, space/time-transgressing performance whose reach extended well beyond the Symposium in both time and (virtual) space. Inviting learners into this co-created, ongoing educational activity up-ends the hierarchies of conference participation, breaking the fourth wall. This kind of work also has potential for the classroom. With planning and creativity, nursing educators can use the methods described here to queer their teaching. [J Nurs Educ. 2024;63(4):265-267.].

Penalized canonical correlation analysis reveals a relationship between temperament traits and brain oscillations during mind wandering.

There has been a growing interest in studying brain activity under naturalistic conditions. However, the relationship between individual differences in ongoing brain activity and psychological characteristics is not well understood. We investigated this connection, focusing on the association between oscillatory activity in the brain and individually characteristic dispositional traits. Given the variability of unconstrained resting states among individuals, we devised a paradigm that could harmonize the state of mind across all participants. We constructed task contrasts that included focused attention (FA), self-centered future planning, and rumination on anxious thoughts triggered by visual imagery. Magnetoencephalography was recorded from 28 participants under these 3 conditions for a duration of 16min. The oscillatory power in the alpha and beta bands was converted into spatial contrast maps, representing the difference in brain oscillation power between the two conditions. We performed permutation cluster tests on these spatial contrast maps. Additionally, we applied penalized canonical correlation analysis (CCA) to study the relationship between brain oscillation patterns and behavioral traits. The data revealed that the FA condition, as compared to the other conditions, was associated with higher alpha and beta power in the temporal areas of the left hemisphere and lower alpha and beta power in the parietal areas of the right hemisphere. Interestingly, the penalized CCA indicated that behavioral inhibition was positively correlated, whereas anxiety was negatively correlated, with a pattern of high oscillatory power in the bilateral precuneus and low power in the bilateral temporal regions. This unique association was found in the anxious-thoughts condition when contrasted with the focused-attention condition. Our findings suggest individual temperament traits significantly affect brain engagement in naturalistic conditions. This research underscores the importance of considering individual traits in neuroscience and offers an effective method for analyzing brain activity and psychological differences.

Taxonomic and chorological novelties in Blakea (Melastomataceae: Pyxidantheae) from Peru with a list of species for the country

Seven new Peruvian species of Blakea are described and illustrated here: Blakea eden, Blakea quinta, Blakea wilderi and Blakea yumi from the Department of Amazonas, Blakea pavida and Blakea rojasiae from the Departments of Amazonas and Cajamarca, and Blakea leoniae from the Departments of Amazonas and San Martin. Following IUCN criteria, we propose that most species should be considered as Endangered (EN) but for B. pavida, B. quinta and B. yumi, that should be recognized as Critically Endangered (CR) due to their restricted distributions and the intense ongoing human activity (agriculture and livestock) in their habitats. Additionally, we provide notes on the new records and species that have been published since Brako & Zarucchi’s checklist of the Peruvian flora in 1993, including the lectotypifications of Blakea brasiliensis, B. nareliana, and Topobea pittieri (B. henripittierii). Blakea gracilis and B. parvifolia are suggested to be excluded from Peru. Based on this, we present a list of 33 Blakea species currently accepted for Peru, 14 of which are endemic.

Tacrolimus versus mycophenolate for AutoImmune hepatitis patients with incompLete response On first-line therapy (TAILOR study): a study protocol for a phase III, open-label, multicentre, randomised controlled trial

BackgroundAutoimmune hepatitis (AIH) is a rare, chronic inflammatory disease of the liver. The treatment goal is reaching complete biochemical response (CR), defined as the normalisation of aspartate and alanine aminotransferases and immunoglobulin gamma. Ongoing AIH activity can lead to fibrosis and (decompensated) cirrhosis. Incomplete biochemical response is the most important risk factor for liver transplantation or liver-related mortality. First-line treatment consists of a combination of azathioprine and prednisolone. If CR is not reached, tacrolimus (TAC) or mycophenolate mofetil (MMF) can be used as second-line therapy. Both products are registered for the prevention of graft rejection in solid organ transplant recipients. The aim of this study is to compare the effectiveness and safety of TAC and MMF as second-line treatment for AIH.MethodsThe TAILOR study is a phase IIIB, multicentre, open-label, parallel-group, randomised (1:1) controlled trial performed in large teaching and university hospitals in the Netherlands. We will enrol 86 patients with AIH who have not reached CR after at least 6 months of treatment with first-line therapy. Patients are randomised to TAC (0.07 mg/kg/day initially and adjusted by trough levels) or MMF (max 2000 mg/day), stratified by the presence of cirrhosis at inclusion. The primary endpoint is the difference in the proportion of patients reaching CR after 12 months. Secondary endpoints include the difference in the proportion of patients reaching CR after 6 months, adverse effects, difference in fibrogenesis, quality of life and cost-effectiveness.DiscussionThis is the first randomised controlled trial comparing two second-line therapies for AIH. Currently, second-line treatment is based on retrospective cohort studies. The rarity of AIH is the main issue in clinical research for alternative treatment options. The results of this trial can be implemented in existing international clinical guidelines.Trial registrationClinicalTrials.gov NCT05221411. Retrospectively registered on 3 February 2022; EudraCT number 2021–003420-33. Prospectively registered on 16 June 2021.

Perception of near-threshold visual stimuli is influenced by prestimulus alpha-band amplitude but not by alpha phase.

Ongoing brain activity preceding visual stimulation has been suggested to shape conscious perception. According to the pulsed inhibition framework, bouts of functional inhibition arise in each alpha cycle (every ~100 ms), allowing information to be processed in a pulsatile manner. Consequently, it has been hypothesized that perceptual outcome can be influenced by the specific phase of alpha oscillations prior to the stimulus onset, although empirical findings are controversial. In this study, we aimed to shed light on the role of prestimulus alpha oscillations in visual perception. To this end, we recorded electroencephalographic activity, while participants performed three near-threshold visual detection tasks with different attentional involvement: a no-cue task, a noninformative cue task (50% validity), and an informative cue task (100% validity). Cluster-based permutation statistics were complemented with Bayesian analyses to test the effect of prestimulus oscillatory amplitude and phase on visual awareness. We additionally examined whether these effects differed in trials with low and high oscillatory amplitude, as expected from the pulsed inhibition theory. Our results show a clear effect of prestimulus alpha amplitude on conscious perception, but only when alpha fluctuated spontaneously. In contrast, we did not find any evidence that prestimulus alpha phase influenced perceptual outcome, not even when differentiating between low- and high-amplitude trials. Furthermore, Bayesian analysis provided moderate evidence in favor of the absence of phase effects. Taken together, our results challenge the central theoretical predictions of the pulsed inhibition framework, at least for the particular experimental conditions used here.

The mode of delivery does not influence the occurrence of post-partum perianal disease flares in patients with inflammatory bowel disease

IntroductionPerianal disease occurs in up to 34% of inflammatory bowel disease (IBD) patients. An estimated 25% of women will become pregnant after the initial diagnosis, thus introducing the dilemma of whether mode of delivery affects perianal disease. The aim of our study was to analyze whether a cesarean section (C-section) or vaginal delivery influence perianal involvement. We hypothesized the delivery route would not alter post-partum perianal manifestations in the setting of previously healed perianal disease.MethodsAll consecutive eligible IBD female patients between 1997 and 2022 who delivered were included. Prior perianal involvement, perianal flare after delivery and delivery method were noted.ResultsWe identified 190 patients with IBD who had a total of 322 deliveries; 169 (52%) were vaginal and 153 (48%) were by C-section. Nineteen women (10%) experienced 21/322 (6%) post-partum perianal flares. Independent predictors were previous abdominal surgery for IBD (OR, 2.7; 95% CI, 1–7.2; p = 0.042), ileocolonic involvement (OR, 3.3; 95% CI, 1.1–9.4; p = 0.030), previous perianal disease (OR, 22; 95% CI, 7–69; p < 0.001), active perianal disease (OR, 96; 95% CI, 21–446; p < 0.001) and biologic (OR, 4.4; 95% CI,1.4–13.6; p < 0.011) or antibiotic (OR, 19.6; 95% CI, 7–54; p < 0.001) treatment. Negative association was found for vaginal delivery (OR, 0.19; 95% CI, 0.06–0.61; p < 0.005). Number of post-partum flares was higher in the C-section group [17 (11%) vs. 4 (2%), p = 0.002].ConclusionsDelivery by C-section section was not protective of ongoing perianal disease activity post-delivery, but should be recommended for women with active perianal involvement.

Quantitative Detection of VBNC State Pseudomonas aeruginosa Contributing to Accurate Assessment of Microbial Inactivation in Drinking Water Disinfection

In harsh environments, bacteria often enter a viable but nonculturable (VBNC) state, which cannot be detected using heterotrophic plate counting (HPC). Importantly, VBNC bacteria can potentially resuscitate under favorable conditions, posing a risk to drinking water safety. This study introduces an innovative approach, combining improved quantitative polymerase chain reaction (qPCR) with propidium monoazide (PMA) dye and HPC to accurately quantify VBNC Pseudomonas aeruginosa (P. aeruginosa). The method was applied to assess the ability of various disinfection techniques to induce P. aeruginosa into the VBNC state. Different disinfection methods, including ultraviolet radiation (UV), sodium hypochlorite (NaClO), and peracetic acid (PAA), significantly reduced bacterial culturability (&gt;99.9%), with the majority entering the VBNC state. Notably, under favorable conditions, UV-induced VBNC cells were resuscitated faster than those induced by NaClO. VBNC P. aeruginosa exhibited relatively high intracellular adenosine triphosphate (ATP) levels, indicating ongoing metabolic activity. Scanning electron microscopy (SEM) reveals that some bacteria maintained cellular integrity for UV and PAA treatment, while evident membrane disruption was observed after NaClO disinfection. This study represents a significant advancement in quantitatively detecting VBNC state P. aeruginosa, contributing to an accurate assessment of microbial inactivation during drinking water disinfection.

The frequency and cueing mechanisms of involuntary autobiographical memories while driving

ABSTRACT Involuntary autobiographical memories (IAMs) have been typically studied with paper diaries, kept for a week or longer. However, such studies are unable to capture the true frequency of IAMs, nor the level of detail that would give new insights into the mechanisms of IAMs. To address this gap, a new audio-recording method was developed and tested on the first author who recorded 674 IAMs while driving a car on a 30–40-minute-long habitual route on 20 occasions. Results revealed very high frequency of IAMs (almost 34 per journey) that were reported more often in response to dynamic (one-off) than static cues. Moreover, a substantial number of memory chains and long-term priming of IAMs by previously encountered incidental stimuli were also recorded. Based on these results, a new theoretical model is proposed in which the occurrence of IAMs is determined by an interplay of factors at the time of the IAM, such as the type of ongoing activity and internal or external triggers, as well as different types of long-term priming. The results also have practical implications for studying mind-wandering and safety issues in driving and aircraft-flying, where periods of concentration are followed by monotony and less demanding tasks.

Fractal Neurodynamics.

The neuronal ongoing electrical activity in the brain network, the neurodynamics, reflects the structure and functionality of generating neuronal pools. The activity of neurons due to their excitatory and inhibitory projections is associated with specific brain functions. Here, the purpose was to investigate if the local ongoing electrical activity exhibits its characteristic spectral and fractal features in wakefulness and sleep across and within subjects. Moreover, we aimed to show that measures typical of complex systems catch physiological features missed by linear spectral analyses. For this study, we concentrated on the evaluation of the power spectral density (PSD) and Higuchi fractal dimension (HFD) measures. Relevant clinical impact of the specific features of neurodynamics identification stands primarily in the potential of classifying cortical parcels according to their neurodynamics as well as enhancing the effectiveness of neuromodulation interventions to cure symptoms secondary to neuronal activity unbalances.

Dynamic activity model of movement disorders: a unified view to understand their pathophysiology

Malfunction of the basal ganglia leads to movement disorders such as Parkinson's disease, dystonia, Huntington's disease, dyskinesia, and hemiballism, but their underlying pathophysiology is still subject to debate. To understand their pathophysiology in a unified manner, we propose the "dynamic activity model", on the basis of alterations of cortically induced responses in individual nuclei of the basal ganglia. In the normal state, electric stimulation in the motor cortex, mimicking cortical activity during initiation of voluntary movements, evokes a triphasic response consisting of early excitation, inhibition, and late excitation in the output stations of the basal ganglia of monkeys, rodents, and humans. Among three components, cortically induced inhibition, which is mediated by the direct pathway, releases an appropriate movement at an appropriate time by disinhibiting thalamic and cortical activity, whereas early and late excitation, which is mediated by the hyperdirect and indirect pathways, resets on-going cortical activity and stops movements, respectively. Cortically induced triphasic response patterns are systematically altered in various movement disorder models and could well explain the pathophysiology of their motor symptoms. In monkey and mouse models of Parkinson's disease, cortically induced inhibition is reduced and prevents the release of movements, resulting in akinesia/bradykinesia. On the other hand, in a mouse model of dystonia, cortically induced inhibition is enhanced and releases unintended movements, inducing involuntary muscle contractions. Moreover, after blocking the subthalamic nucleus activity in a monkey model of Parkinson's disease, cortically induced inhibition is recovered and enables voluntary movements, explaining the underlying mechanism of stereotactic surgery to ameliorate parkinsonian motor signs. The "dynamic activity model" gives us a more comprehensive view of the pathophysiology underlying motor symptoms of movement disorders and clues for their novel therapies.

Treatment of Thyroid Eye Disease-Associated Ophthalmopathy and Myopathy With Intraorbital Injection of 5-Fluorouracil and Triamcinolone Acetonide.

The authors report a technique of local application of anti-metabolite and corticosteroid mixture in the orbit for treatment of thyroid orbitopathy with moderate-severe inflammation and muscle involvement. Patients of one orbital surgeon seen between March 2019 and May 2020 with active thyroid eye disease and restrictive strabismus were considered for local treatment of the myopathic component of the disease. A mixture of 1 ml 5-FU 50 mg/ml, 0.25 ml triamcinolone 40 mg/ml, and 1 ml lidocaine 2% is injected through the skin using a 25-gauge, 1.5-inch needle into the orbit adjacent to the affected extraocular muscle. Six patients were treated in the outpatient setting and 3 patients have been treated with this intervention intraoperatively at the time of orbital decompression. One was treated with the mixture reconstituted with hyaluronic acid (Healon GV) to address postoperative medial rectus fibrosis to the medial wall, this mixture was applied topically in the operative field and not injected. All patients had subjective improvement in the eye movement limitation and 2 patients had a change in motility on exam that was temporally correlated to injections. One patient did not disclose high-dose aspirin intake before injection and experienced a retrobulbar hemorrhage immediately following injection which was successfully treated. No complications were noted as a result of the medication itself. The combination of 5-fluorouracil and triamcinolone acetonide for orbital treatment may be a useful adjunct in treating patients with ongoing inflammatory activity, both in the office and in the operating room. The novel combination may optimize ophthalmic outcomes, modifying disease course in some patients.

Ensuring delivery of medical education in conflict-affected nations

Medical education refers to the process wherein freshly passed school students are transformed into competent healthcare professionals after being subjected to a structured training program. The emergence or continuation of a conflict is expected to interrupt the ongoing civic activity, and is expected to result in the delay, decline, or complete interruption of the training activities and delivery of medical education in the medical institutions. All the above factors and existing realities call for the need to ensure that the process of medical education has to continue even during the conflicts and this essentially will require understanding and mutual agreement between the conflicting stakeholders. To conclude, conflicts have become a part of the current era with millions of people experiencing them. As these conflicts tend to influence each and every sector, even the area of medical education has been significantly affected. However, as most of the affected nations cannot afford the shortage of healthcare providers, there is an indispensable need to continue the training process even during conflicts and expose the medical students to conflict-related curriculum.

Target lysis by cholesterol extraction is a rate limiting step in the resolution of phagolysosomes

The ongoing phagocytic activity of macrophages necessitates an extraordinary capacity to digest and resolve incoming material. While the initial steps leading to the formation of a terminal phagolysosome are well studied, much less is known about the later stages of this process, namely the degradation and resolution of the phagolysosomal contents. We report that the degradation of targets such as splenocytes and erythrocytes by phagolysosomes occurs in a stepwise fashion, requiring lysis of their plasmalemmal bilayer as an essential initial step. This is achieved by the direct extraction of cholesterol facilitated by Niemann-Pick protein type C2 (NPC2), which in turn hands off cholesterol to NPC1 for export from the phagolysosome. The removal of cholesterol ulimately destabilizes and permeabilizes the membrane of the phagocytic target, allowing access of hydrolases to its internal compartments. In contrast, we found that saposins, which activate the hydrolysis of sphingolipids, are required for lysosomal tubulation, yet are dispensable for the resolution of targets by macrophages. The extraction of cholesterol by NPC2 is therefore envisaged as rate-limiting in the clearance of membrane-bound targets such as apoptotic cells. Selective cholesterol removal appears to be a primary mechanism that enables professional phagocytes to distinguish the target membrane from the phagolysosomal membrane and may be conserved in the resolution of autolysosomes.

Sensory input to cortex encoded on low-dimensional periphery-correlated subspaces.

As information about the world is conveyed from the sensory periphery to central neural circuits, it mixes with complex ongoing cortical activity. How do neural populations keep track of sensory signals, separating them from noisy ongoing activity? Here, we show that sensory signals are encoded more reliably in certain low-dimensional subspaces. These coding subspaces are defined by correlations between neural activity in the primary sensory cortex and upstream sensory brain regions; the most correlated dimensions were best for decoding. We analytically show that these correlation-based coding subspaces improve, reaching optimal limits (without an ideal observer), as noise correlations between cortex and upstream regions are reduced. We show that this principle generalizes across diverse sensory stimuli in the olfactory system and the visual system of awake mice. Our results demonstrate an algorithm the cortex may use to multiplex different functions, processing sensory input in low-dimensional subspaces separate from other ongoing functions.

DEMENTIA-FOCUSED ADULT DAY CARE IN AN URBAN SETTING: PROGRAM STAKEHOLDERS’ VIEWS OF CRUCIAL COMPONENTS

Abstract Dementia focused adult day centers (ADCs) provide socialization, physical activity, and cognitive activities for participants, and respite for caregivers. This study reports findings from a process evaluation of an ADC serving a predominantly African American population in a large midwestern city. The evaluation examined whether the program was being implemented as intended, what was working/not working, and participant engagement. We conducted in-depth interviews of staff, volunteers, and student interns and surveyed caregivers (n=17). Thematic analysis of the interviews revealed themes such as “structured flexibility” in running the daily activities, an ethos of care that mixes encouragement of participation with respect for autonomy, ongoing and positive activity, and individualized attention to participants. Other findings revealed the value of consistent and experienced staff and reliance upon and benefits for students and volunteers. Quantitative and qualitative responses to caregiver surveys supported the interview themes. Caregivers valued the socialization and creative stimuli provided to participants. Guidance from program personnel included modeling communication strategies and being “in the moment” with the participants. The findings suggest that further work to inform the development of quality care and programming to improve the quality of life of older African Americans with dementia and their caregivers is needed. Specifically, there is a need to 1) identify essential components of ADCs; 2) document the ways that key ADC service philosophies are realized and communicated; and 3) explore the key role of volunteers and students in terms of their roles, activities, and motivations for working with older adults with dementia.