One-sample Test Research Articles

Gender differences in long-term survival after coronary artery bypass surgery is womens cardiovascular health at risk?

Abstract Introduction Cardiovascular healthcare for women tends to be influenced by various factors. This patient group is generally associated with a worse prognosis following coronary artery bypass surgery (CABG). Aims To assess the impact of gender on long-term survival after CABG and the potential effect of age on this association; to compare the survival of these patients with the expected survival of the general national population, and to compare immediate postoperative outcomes between genders. Methods Longitudinal, retrospective, single center study, involving consecutive patients who underwent isolated primary CABG between 2004 and 2014. Exclusion criteria included emergency/salvage surgeries or the use of extracorporeal circulation without aortic clamping. Included patients were categorized into age subgroups: ≤60, 60-70, and ≥70 years. All-cause mortality was assessed in February 2023, and a time-to-event analysis was performed using Kaplan-Meier curves, Log-Rank tests, and multivariable Cox regressions. To compare expected mortality (matched for sex and age with the general population) with observed mortality in the patient cohort, survival tables for the years 2004-2022 were consulted. Kaplan-Meier curves for the reference population, stratified by gender, were constructed and compared to the surgical cohort using one-sample Log-Rank tests with specific software. Standardized mortality ratios (SMR) were estimated. The mean follow-up time was 11 years, with a maximum of 19 years. Results From 3978 patients included patient’s, 21% were women (W). W were older (mean age 67±9 vs. 63±10 years, p<0.001) and had a higher prevalence of cardiovascular risk factors and severe chronic kidney disease compared to men (M). M more frequently had peripheral arterial disease and smoking habits. Although three-vessel disease was similar between sexes (p=0.111), W were less frequently implanted with ≥3 grafts (p<0.001). At 5,10 and 15 years of follow-up, cumulative survival for MvsW was 89%vs88%, 73%vs68%, and 57%vs46%, respectively (Log-rank test p<0.001). After stratification by age, Log-Rank tests showed no differences between sexes. Multivariable adjustment did not identify gender as an independent predictor of long-term survival in any age subgroup. However, a time-stratified analysis at 10 years of follow-up in the ≥70 years subgroup showed that W had a higher risk than M after 10 years of follow-up (HR:0.7[0.5-0.9],p=0.03). Comparing with the survival of the Portuguese population, CABG allowed M to equalize the risk of mortality to what was expected (SMR =1.1;95%CI:0.9-1.1), but W showed a higher risk of mortality after CABG than W in the reference population (SMR =1.6,95%CI:1.3-1.8). Conclusion Women undergoing isolated primary CABG at an age >70 years, with longest periods follow-up, exhibited poorer long-term survival than men of the same age.Women demonstrated inferior survival outcomes compared to the general population.

Survival penalty in patients undergoing transcatheter versus surgical aortic valve replacement: is it just a question of frailty? Insights from a large cohort with demographic matching

Abstract Background Transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) are the reference treatments for aortic stenosis. Conflicting data exist on late survival results of these two techniques. While randomised controlled trials (with highly selected patients) assert the non-inferiority of TAVR, real-world data from large registries (with potential uncorrected confounders) suggest the opposite. Comparing the survival rates of SAVR and TAVR with those of a matched reference population could help circumvent potential biases of direct procedural comparisons and quantify the impact of frailty on post-operative survival. Purpose Our study aims to compare the 5-year overall survival rates of SAVR, non-frail TAVR, and frail TAVR patients with the survival of their demographically matched reference population. Methods This study included all consecutive patients undergoing either SAVR or TAVR at a tertiary hospital between January 2010 and December 2021. Each patient underwent a comprehensive geriatric assessment by an experienced geriatric team, from which a Clinical Frailty Scale (CFS) was derived using a validated classification tree. Frailty was defined as a CFS ≥ 6, in accordance with ESC guidelines. The patients were stratified into 3 subgroups: SAVR, non-frail TAVR, and frail TAVR patients. For each subgroup, a corresponding reference population was generated using national actuarial tables to ensure individual-level matching based on age, gender, and year of observation. Survival of each subgroup was then compared to its corresponding reference population over a 5-year period using standardized mortality ratios (SMR) and one-sample logrank tests. Results Our cohort included 1183 SAVR, 254 non-frail TAVR, and 151 frail TAVR patients, with mean ages of 74.1, 85.4, and 85.7 years, and median EuroSCORE II of 2.0%, 4.2%, and 5.4%, respectively. Survival of SAVR patients was equivalent to the reference population (80.1 vs 80.9% survival; SMR = 1.06 [0.89 – 1.25]; p = 0.454; Figure 1A). Similarly, non-frail TAVR patients also achieved survival rates comparable to those of the reference population (50.9 vs 54.0% survival; SMR = 0.94 [0.76 – 1.18]; p = 0.549; Figure 1B). However, frail TAVR patients faced a significantly reduced survival rate (41.7% vs 54.0% survival; SMR = 1.48 [1.15 – 1.90]; p < 0.001; Figure 1C). The frailty of this subgroup could therefore explain a 48% increase in mortality risk compared with their reference population after 5 years. Conclusions Treating non-frail patients with aortic stenosis through TAVR or SAVR restores life expectancy to levels comparable with their reference population, challenging results from other real-world registries. In contrast, TAVR in frail patients is associated with worse survival, raising the question of treatment futility in this specific subgroup. Refining the selection of frail patients who may benefit from TAVR remains an important clinical challenge.

Activation of Students' Cognitive Activity through Physical and Health-Improving Activities

The methodology for developing cognitive activity through physical and health-improving activities is thoroughly examined for primary school students. Regarding the methodology for developing cognitive activity through physical and health-improving activities for middle school students, there are practically few developments, and recommendations are often given in a general form. Thus, the issue of the impact of physical and health- improving activities on the cognitive activity of middle school students is still largely unexplored and has not yet received scientific substantiation. The article determines the influence of the level of physical working capacity on the cognitive activity of 6th-grade students. A method for activating cognitive activity through small forms of physical culture is presented. The study involved the analysis of literary sources and internet resources; analysis of students' academic performance; research on physical working capacity; speed of thinking; determination of the average academic score; mathematical statistics methods using the SPSS program: the Kolmogorov-Smirnov one-sample test; Pearson correlation.

SHR-8068 combined with adebrelimab and bevacizumab in the treatment of refractory advanced colorectal cancer: study protocol for a single-arm, phase Ib/II study.

The third-line treatment for refractory colorectal cancer (CRC) has limited efficacy. This study aimed to evaluate the safety and efficacy of SHR-8068 (an anti-CTLA-4 antibody), combined with adebrelimab (an anti-PD-L1 antibody), and bevacizumab in refractory non-microsatellite instability-high (MSI-H) or proficient mismatch repair (pMMR) CRC. This study is a prospective, open-label, single-center phase Ib/II clinical trial. Patients with pathologically confirmed pMMR/non-MSI-H metastatic colorectal adenocarcinoma who have failed ≥2 lines prior standard systemic treatments will be enrolled (n=36). The Ib phase will evaluate two dosing regimens of SHR-8068 in combination therapy (n=9 each dosage): SHR-8068 (1 mg per kilogram, every six weeks, intravenously) or SHR-8068 (4 mg per kilogram, every twelve weeks, intravenously) combined with adebrelimab (1200 mg, every three weeks, intravenously) and bevacizumab (7.5 mg per kilogram, every three weeks, intravenously). The efficacy and adverse events (AEs) of these regimens will be assessed to determine the recommended phase II dose (RP2D) of SHR-8068. Those of RP2D group from the phase Ib will be included in the phase II. The study will go to include 18 additional patients according to the one-sample log-rank test design in the phase II. The primary endpoint of the Ib phase is safety, with secondary endpoints including the objective response rate (ORR), progression-free survival (PFS), overall survival (OS), disease control rate (DCR), and quality of life (QOL). The primary endpoint for phase II was PFS, with secondary endpoints including ORR, OS, DCR, safety, and QOL. Identifying biomarkers to predict the efficacy of this regimen is the exploratory study endpoint. This proof-of-concept study would provide safety and efficacy signals of this novel combination treatment for the MSS CRCs in the late-line setting. And it may offer new insights on the clinical application of dual immunotherapy combined with anti-angiogenic therapy in the MSS CRC.

The Spatial Variation of Soil Structure Fractal Derived from Particle Size Distributions at the Basin Scale

The accurate characterization of soil structure is fundamental to groundwater science, environmental ecology, and Earth systems science. To address the challenge of quantifying the high spatial variability of large-scale soil structures, this study used a laser particle size analyzer to measure the distribution of soil particle size in 207 samples from ten profiles across the Daqing and Ziya River basins in the North China Plain. The quantified soil structure, expressed as soil fractal dimension D, was derived using monofractal theory. Various spatial analysis techniques, including Moran’s I index, correlation analysis heat maps, the Kolmogorov–Smirnov one-sample test, and geostatistical semivariogram function, were jointly applied to investigate the spatial variability of soil structural fractals across different depths in the piedmont plain–coastal areas of the two river basins. The results indicate the following: (1) Quantitative analysis confirms that under the influence of piedmont alluvial and fluvial dynamics, soil D values homogenize from the piedmont to the coastal areas, with decreasing particle size differences closer to the coast. However, the spatial variability of the soil structural fractals in the Ziya River Basin was greater than that in the Daqing River Basin. (2) The combined effects of climate change, regional differences, and human activity led to greater spatial variability in the soil structural fractals in the Ziya River Basin than in the Daqing River Basin. The correlation between D values and burial depth was strongest in the Xianxian profile (−0.78), whereas the spatial correlation was strongest in the Hengshui and Dacheng profiles (−0.47). (3) The greatest spatial variability in soil D values occurred at depths of 1–2 m, with a coefficient of variation of 23.595%, which was significantly higher than those at depths of 0–1 (14.569%) and 2–3 m (16.284%).

Investigating the discrepancy between students’ self-efficacy and their performance regarding computational thinking

ABSTRACT Background and context There were few studies indicating if students’ computational thinking (CT) self-efficacy and their CT performance were aligned with each other. Objectives The study was to investigate if there was a discrepancy between students’ CT self-efficacy and their CT performance. Method Involving 104 non-CS undergraduate students as participants, this study employed descriptive statistics, one-sample tests, and prediction modules to perceive if a discrepancy existed. Findings The findings revealed that students’ CT self-efficacy and their performance on understanding CT showed an opposite pattern and failed to meet instructors’ expectations. Moreover, students’ CT self-efficacy did not significantly predict their CT performance on application or understanding. Implications The detected discrepancy suggests that students’ CT understanding needs to be improved . A variety of approaches should be employed to evaluate their CT self-efficacy. CT self-efficacy surveys need to be refined to enhance the validity of CT self-efficacy measurement.

Profile of Pancasila Students Through Culture-Based Learning in Elementary Schools within the Independent Curriculum in Indonesia

The profile of Pancasila students is an essential characteristic that students must possess. However, in real-world conditions, it is still observed that students lack knowledge and appreciation of their own cultures, and interactions among students often lead to conflicts. The purpose of this research is to assess the application of culture-based learning in relation to the Pancasila Student Profile. This research is experimental in nature. The population as well as the sample consists of 15 fourth-grade students. The design used is a one-group posttest design. The instrument used is a questionnaire. Data analysis was conducted using the One-Sample Test, resulting in a t-value of 5.041 and a t-table value of 1.76131. Since the t-value is greater than the t-table value, it can be concluded that culture-based learning has a positive impact on the Pancasila student profile, particularly in the aspect of global diversity.

Clinical application of prone position to suppress respiratory movement artifacts in supine position during magnetic resonance cholangiopancreatography/MRI.

To compare the image quality of magnetic resonance cholangiopancreatography (MRCP) in the supine position and prone position under the conditions of the same equipment, the same sequence (3D Navigator Triggered Sampling Perfection with Application-Optimized Contrast Using Different Flip-angle Evolutions, 3D-NT-SPACE) and the same patient, and to explore the clinical application value of prone position in MRCP examination to suppress respiratory motion artifacts. 53 participants who underwent MRCP in our hospital from April 2020 to August 2022 were prospectively collected. The 3D-NT-SPACE sequence was used in these patients. The visibility of the common bile duct, common hepatic duct, main pancreatic duct, and first- and second- and third-level branches of the intrahepatic bile duct and the comfort of the participants in two positions were subjective-evaluated. The Signal-to-noise ratio (SNR) and contrast-to-noise ratio were objective-evaluated. Statistical analysis was performed using Shapiro-Wilk, Levene's, Mann Whitney U test, Pearson chi-square test, and one-sample chi-square test. 53 patients (51.92years ± 2.02, 20 men) were evaluated. There were significant differences in the second- and third-level branches visibility score, the main pancreatic duct visibility score, the image quality score of the pancreaticobiliary tree, the blur and motion artifact score, the total image quality score, and SNR between the two positions (p < 0.05). The overall image quality of the prone position was better than that of the supine position. The prone position is a useful complement to the supine position.

The impact of online learning on basketball courses: A true experimental design study in sports students

This study explores the implementation of online learning for basketball courses at STKIP PGRI Bangkalan compared to offline basketball courses. Employing a true experimental design with a posttest-only control setup, the research gathers data through pretest and posttest scores. The study ensures validity through expert validation and assesses reliability using product-moment correlation. Normality tests are performed with the one-sample Kolmogorov-Smirnov test, while differences are evaluated using an independent sample t-test. This research reveals significant differences between online and offline learning environments. The analysis highlights a decrease in performance during online courses with a mean difference of 9.29870, underscoring the challenges faced by students in adapting to online learning platforms. The study contributes valuable insights into the effectiveness of online learning in physical education, providing a basis for future educational strategies and interventions.

Chronological age, relative age, pubertal development, and their impact on countermovement jump performance in adolescent football players: An integrative analysis

This paper examined the relationship among countermovement jump (CMJ), football category, chronological age, relative age, and pubertal development status to investigate which parameter could be better associated with jumping performance. We tested 259 young male football players (14.9 ± 1.8 yrs; 169.7 ± 9.8 cm; 60.6 ± 11.3 kg; 20.9 ± 2.6 kg m−2) belonging to elite football academies. One-sample chi-square tests were used to test the uniformity of distributions of the proportions of players in each year quarter (relative age effect, RAE) for the whole sample and stratified for each football age category (U14, U15, U17, and U19). One-way ANOVAs were used to test the associations among a) categories, RAE, and CMJ, and b) the pubertal status category and CMJ. Pearson's correlation assessed the relationship among variables. The birth distribution among the year's quarters significantly differed from the expected proportion of 25 % of participants each quarter (χ2 = 41.74; p < 0.001), highlighting the presence of a relative age effect. Results indicate that age significantly influences CMJ (F(6,231) = 8.85, p < 0.001, η2p = 0.187), and a significant interaction effect (age × birth quarter) was found. Coaches, strength and conditioning trainers, and scouts should be aware of physical and biological players' maturation.

Test for the mean of high-dimensional functional time series

The one-sample test and two-sample test for the mean of high-dimensional functional time series are considered in this study. The proposed tests are built on the dimension-wise max-norm of the sum of squares of diverging projections. The null distribution of the test statistics is investigated using normal approximation, and the asymptotic behavior under the alternative is studied. The approach is robust to the cross-series dependence of unknown forms and magnitude. To approximate the critical values, a blockwise wild bootstrap method for functional time series is employed. Both fully and partially observed data are analyzed in theoretical research and numerical studies. Evidence from simulation studies and an IT stock data case study demonstrates the usefulness of the test in practice. The proposed methods have been implemented in a R package.

Pain Experience and Image Quality with Curved versus Standard Compression for Breast Cancer Screening Mammography: A Randomized Controlled Trial.

Background A curve-shaped compression paddle could reduce the pain experienced by some women at breast cancer screening. Purpose To compare curved and standard compression systems in terms of pain experience and image quality in mammography screening. Materials and Methods In this randomized controlled trial conducted between October 2021 and February 2022, participants screened at three screening sites in the Netherlands were randomized to either a curved-paddle or sham-paddle group. The sham paddle was a standard paddle that was presented as a new paddle. At a standard screening examination, one additional image was acquired with a curved or sham paddle. Pain was measured on a numerical rating scale (range, 0-10). Participants provided a pain score after compression with the standard and test paddles, resulting in two scores per participant. Differences in pain scores were compared between groups using analysis of covariance, adjusting for pain score after standard-paddle compression. Two radiographers and two radiologists performed unblinded paired comparisons of curved-paddle vs standard-paddle images, using standard image quality criteria (radiographers evaluated 1246 image pairs using 12 criteria; radiologists evaluated 320 image pairs using six criteria). The one-sample Wilcoxon signed-rank test was used to determine if there was a significant preference for either paddle. Results In total, 2499 female participants (mean age, 61.6 years ± 7.1 [SD]) were studied; 1250 in the curved-paddle group and 1249 in the sham-paddle group. The mean pain score decreased by an additional 0.19 points in the curved-paddle group compared with the sham-paddle group (95% CI: 0.09, 0.28; P < .001). In terms of image quality, the observers showed no preference or a preference for the standard paddle. Decreased image contrast (range Bonferroni-corrected P values: P < .001 to P > .99) and visibility of structures were the main concerns for curved-paddle images. Conclusion The use of the curved paddle resulted in a minimal pain reduction during mammography breast compression but image quality was reduced. © RSNA, 2024 Supplemental material is available for this article.

Ultrasound-guided retromammillary injections in dogs: a feasibility, descriptive and anatomical study

ObjectiveTo evaluate the feasibility of an ultrasound-guided technique targeting the medial branches of the dorsal ramus of the spinal nerves (DRSN) by injecting a dye solution at the caudal aspect of the base of lumbar mammillary processes [i.e. the retromammillary (RM) space]. Study designFeasibility, descriptive, anatomical study. AnimalsEleven canine cadavers. MethodsUsing anatomical dissections, the relationship between the mammillary processes and the branches of the DRSN of the thoracolumbar and lumbar spine was studied in two cadavers. Subsequently, ultrasound-guided RM injections were administered in nine cadavers, randomly assigned to low volume (LV; 0.01 mL kg–1) of a dye solution at multiple points from L3 to L6 on one side, and high volume (HV; 0.4 mL kg–1) at a single L4 point on the contralateral side. Gross anatomical dissections were immediately performed after the injections. The RM injections were feasible if ultrasonographic landmarks were identifiable in at least 80% of cases, and 80% of LV injections showed medial branch staining. A one-sample binomial test was used for testing feasibility. ResultsThe medial branches emerged shortly after the DRSN exited the intervertebral foramen and traveled towards the caudal aspect of the base of the mammillary process, which served as the target injection point. With LV, 36 out of 36 (100%) injected medial branches were stained, meeting the criteria of feasibility (p < 0.001). The median (range) number of stained medial branches per cadaver were 4 (4–4) and 2 (1–3), with LV and HV, respectively. Although no lateral branches were stained with LV, 1 (0–2) was stained with HV. Neither ventral branch staining nor epidural spread was noted in any cadaver. Conclusions and clinical relevanceUltrasound-guided RM injections are feasible and allow for selective staining of the medial branch of the DRSN in canine cadavers at the lumbar spine.

Conducting Multivariate One- and Two-Sample Statistical tests using SPSS Syntax

The availability of multivariate one-sample and two-sample testing procedures is often restricted or merged with other statistical tests in many statistical applications. SPSS software, known for its user-friendly Graphical User Interface (GUI) for statistical analysis, also provides a specialised programming language called SPSS syntax. This syntax allows users to execute statistical procedures by writing commands, providing an alternative to the GUI interface. The purpose of this paper is to create new dialogs written in the SPSS syntax language using custom dialog builder for extensions. These dialogs are designed to test multivariate one- and two-sample data when ∑ is unknown by applying Hotelling’s T2 test statistic, especially in situations where the GUI lacks these particular functionalities. In the case of two-sample data, both independent and paired multivariate testing methods are employed. Examples are supplied to demonstrate the key analyses performed using Hotelling's T2 tests. The syntax written for the analyses was performed using SPSS software v.27. The adoption of the developed dialogs is recommended for researchers requiring analysis of multivariate one- and two-sample data with limited or no programming experience, with potential future incorporation of the dialogs into forthcoming SPSS versions by IBM. Extending the scope of statistical analyses supported by SPSS dialogs through future research that encourages their use and supports wider acceptance of additional statistical methods not included in standard versions of SPSS.

Effects of Chitosan as a Novel Obturation Material for Pulpectomized Teeth on Periapical Inflammation, Periodontal Ligament Widening, and Hard Tissue Resorption: A Preliminary Exploratory Study on Dogs.

Objectives: This preliminary animal study was conducted to assess the effects of chitosan as a novel obturation material for pulpectomized teeth on periapical inflammation, periodontal ligament (PDL) widening, and hard tissue resorption. Materials and Methods: Forty premolar root canals in two mature dogs were obturated with zinc oxide eugenol (ZOE) and an experimental 3% chitosan paste (n=20 in each group). The teeth were then restored with amalgam. After 28 days, the dogs were sacrificed, and histopathological assessment was performed. The amount of resorbed obturation material, degree of inflammatory response, degree of PDL widening, and the number of bone/cementum/dentin resorption defects were recorded under ×40 and ×200 magnifications. Data were analyzed using the Mann-Whitney U test, one-sample Wilcoxon signed-rank test, and Fisher's exact test (α=0.05). Results: Bone, cementum, and dentin resorption were seen in 6, 10, and 1 chitosan-obturated canals and 14, 15, and 0 ZOE-obturated canals, respectively. Only the bone resorption defects were significantly fewer in the chitosan group (P=0.026). Mild, moderate, and severe inflammation were observed in 17, 3, and 0 chitosan-obturated canals, and 7, 9, and 4 ZOE-filled canals, respectively (P=0.004). Mild, moderate, and severe PDL widening were seen around 15, 5, and 0 chitosan-filled canals and 7, 12, and 1 ZOE-filled canals, respectively (P=0.025). Conclusion: The 3% chitosan was superior to ZOE in terms of causing less inflammation and PDL widening. It also decreased bone resorption and acted similar to ZOE in terms of dentin and cementum resorption.

Sperm extraction in nonmosaic Klinefelter syndrome patients: A case series and literature review of sperm extraction in Klinefelter syndrome patients.

Klinefelter syndrome (KF) is a group of chromosomal disorders with at least one extra X chromosome in male individuals that leads to infertility and diminished hair growth in affected males. In this study, we present a case series of 16 nonmosaic KF and an extensive literature review. This is a retrospective study including 16 nonmosaic Klinefelter Syndrome patients that underwent micro-testicular sperm extraction (m-TESE) at our center between January 2016 and December 2022. Frequencies and percentages were used to present categorical variables, whereas continuous variables were presented as the median and interquartile range (IQR). The sperm retrieval rate (SRR) was assessed using a one-sample proportions test with continuity correction. Fisher's exact test was to assess the differences between patients with negative and positive retrieval in terms of the categorical variables. A Wilcoxon rank-sum test was applied to explore the between-group differences in the numerical variables. A literature search was performed for additional publications of discussing m-TESE among KF patients. The median (IQR) age of patients was 40.0 years (34.5-47.0). All of the patients had nonobstructive azoospermia, and the majority of them (93.8%) had primary infertility. The most common histopathological findings were atrophic tubules (57.1%), followed by Sertoli cell-only (28.6%). Sperm retrieval was positive for two patients with a rate of 12.5% (95% confidence interval 2.2 to 39.6). Patients with positive sperm retrieval were significantly younger than their peers with negative retrieval (median = 28.0, IQR = 27.5 to 28.5 vs. median = 41.5, IQR = 35.8 to 47.0, P = 0.031). The successful conception rate was 100% (n = 2) using intracytoplasmic sperm injection with a birth rate of 100% (n = 2). Our observed SRR among nonmosaic KF patients was marginally lower than the reported literature. Younger-age patients were significantly more likely to benefit from the procedure.

EFFECTIVENESS OF POSTPARTUM EXERCISE FOR POSPARTUM WOMEN ON UTERINE INVOLUTION

Postpartum exercise plays an important role in the process of uterine involution. The involution process will proceed well if uterine contractions are strong, so action must be taken to improve uterine contractions. Efforts to control bleeding from the placenta by improving strong contractions and retraction of myometrial fibers with postpartum exercises. The aim of this research is to determine the effectiveness of postpartum exercises for postpartum mothers. on Uterine Involution at the Pujud Community Health Center, Rokan Hilir Regency. This type of research is a quasi-experimental design. The population in this study were postpartum mothers, who were taken using a purposive sampling technique. Of the 17 postpartum mothers in the Pujud Community Health Center Working Area, Rokan Hilir Regency, before postpartum exercise there was a decrease in Rapid TFU of 0 (0%), a decrease in Normal TFU of 8 (47.1), a decrease in Slow TFU of 9 (52.9) and after After postpartum exercise was carried out, there was a rapid decrease in TFU in 11 people (64.7%), there was a decrease in normal TFU in 6 (35.3), there was a slow decrease in TFU in 0 (0). There was a significant influence between postpartum exercise and uterine involution as seen from the height measurement. Uterine fundus with the One-Sample Test results above show that the P value is 0.000 &lt; 0.05. So, in accordance with the basis for decision making in statistical tests, it can be concluded that postpartum exercise carried out before and after is effective in reducing the fundal height of the uterus (TFU) of postpartum mothers at the Pujud Community Health Center, Rokan Hilir Regency. It is hoped that all postpartum mothers can understand the benefits of postpartum exercise for uterine involution process. .

Exploring the Influence of Students' Anxiety on English Language Learning in Online Integrated Instruction

This research explores the influence of online integrated learning on students’ anxiety within the English Language Education Program at Muhammadiyah University of East Kalimantan (UMKT). The study investigates the impact of online integrated learning in the English General Course on students' anxiety levels. It examines significant differences in anxiety levels between students actively using online platforms and those who do not. The sample consisted of 117 freshmen, with data collected via questionnaires assessing comfort with technology, perceptions of its effectiveness, and its impact on anxiety levels. Statistical analyses, including descriptive statistics, the One-Sample Kolmogorov-Smirnov Test, ANOVA, and Bonferroni multiple comparisons, were employed to provide a comprehensive understanding of the findings. Key results indicate a mean anxiety score of 41.55 and a mean achievement score of 78.21, reflecting moderate anxiety and relatively high academic performance. The One-Sample Kolmogorov-Smirnov Test confirmed the normal distribution of the data (p &gt; 0.05), justifying the use of parametric methods. ANOVA results showed significant differences in anxiety levels and English scores based on online integrated learning (F = 166.159, p &lt; 0.001). Bonferroni multiple comparisons revealed that lower anxiety was associated with higher English scores, with significant mean differences observed between low, medium, and high anxiety groups (p &lt; 0.001). These findings suggest that online integrated learning significantly impacts students' anxiety levels, which in turn affects their academic performance. The study provides valuable insights for educators and policymakers on the importance of creating supportive and anxiety-reducing learning environments in technology-enhanced settings

Examining the Attitudes of Hypertension Patients Toward Using Complementary Treatments.

The present study was conducted in a cross-sectional and descriptive design to examine the attitudes of hypertension patients toward using complementary treatments. The study was conducted with 173 patients who had the diagnosis of hypertension who applied to the Cardiology Clinics of a University Health Practice and Research Hospital between 15.12.2021 and 10.03.2022. Before starting the study, permission was obtained from the ethics committee, institution, and patients. The data of the study were collected through face-to-face interviews, a questionnaire, and the Attitude Scale Toward Using Complementary Treatments (ASUCT). The score to be obtained from the scale varies between 0 and 39 and a high score indicates a positive attitude toward complementary treatments. One-Sample Kolmogorov-Smirnov test was used to evaluate the homogeneity of the data. The Student t, Mann-Whitney U test, correlation, and ANOVA tests were also used to evaluate the data, and P <.05 was considered statistically significant. It was found that 55.0% of the patients were women, 31.2% were between the ages of 44 to 56, 63.0% had other chronic diseases, and 68.2% preferred herbal applications in the management of hypertension. It was also found that the mean ASUCT score of hypertensive individuals was 21.13±2.99, and there was a statistically significant relationship between the mean ASUCT score of the patients and their gender, education level, and reasons for applying to herbal therapy (P <.05). Patients frequently preferred the consumption of pomegranate syrup (43.4%), garlic (36.4%), and quince leaf tea (30.8%) as non-drug applications in the management of hypertension. It was found that the attitudes of the hypertension patients toward using complementary treatments were at a "moderate" level and there was a relationship between their level of attitude toward using complementary treatments and gender, education, and the reasons for applying herbal therapy. In this respect, it is recommended to evaluate the attitudes of hypertension patients toward using complementary treatments, to learn the practices they prefer for disease management through patient-health care professional interaction, and to support patients for hypertension management.

On Misuses of the Kolmogorov–Smirnov Test for One-Sample Goodness-of-Fit

The Kolmogorov–Smirnov (KS) test is widely employed to assess the goodness-of-fit of a hypothesized continuous distribution to a sample. Despite its popularity, the test is frequently misused in the literature and practice. While originally intended for independent, continuous data with precisely specified hypothesized distributions, it is erroneously applied to scenarios with dependent, discrete, or rounded data, with hypothesized distributions requiring estimated parameters. For example, it has been “discovered” multiple times that the test is too conservative when the hypothesized distribution has parameters that need to be estimated. We demonstrate misuses of the one-sample KS test in three scenarios through simulation studies: (a) the hypothesized distribution has unspecified parameters; (b) the data are serially dependent; and (c) a combination of the first two scenarios. For each scenario, we provide remedies for practical applications using appropriate bootstrap approaches. The whole demonstration can be used as hands-on education materials on both goodness-of-fit tests and bootstrap.