One-pot Reaction For Synthesis Research Articles

Bio-based Hyperbranched Ester Plasticizers from Woody Oil Based on Cohesive Energy via a One-Pot Synthesis Reaction

Bio-based Hyperbranched Ester Plasticizers from Woody Oil Based on Cohesive Energy via a One-Pot Synthesis Reaction

Hybrid rGO-AgNPs Conductive Ink for Inkjet Printed Flexible Humidity Sensor

Due to the challenging dispersion of graphene in aqueous media, organic solvents are commonly used in conductive graphene inks. This will result in safety issues and environmental pollution. In this study, we demonstrated a green approach of graphene ink preparation through one-pot synthesis reaction that produce a hybrid reduced graphene oxide (rGO)-silver nanoparticles (AgNPs), with deionized water as solvent. The synthesized rGO-AgNPs was monitored using ultraviolet–visible (UV-Vis) spectroscopy and fourier transform infrared (FTIR). A stable dispersion of rGO-AgNPs ink was confirmed through UV-Vis analysis. FTIR result showed the removal and the reduction in the intensities of absorption bands of oxygen-containing functional groups, which indicated that graphene oxide (GO) has been successfully reduced to rGO in the hybrid ink. The printed film of rGO-AgNPs exhibited a high conductivity of 1.50 × 104 S/cm, proven that the electrical performance of the hybrid ink has been improved as compared to previously reported GO-based ink. Printed into interdigitated electrode (IDE), the impressive characteristic of our hybrid ink performed well as a high-sensitivity flexible humidity sensor.

Synthesis, molecular docking, and in silico ADME studies of dihydropyrimidine derivatives using tetrabutylphosphonium methanesulphonate ionic liquid as a catalyst under solvent-free conditions

This paper describes the synthesis and characterization of tetrabutylphosphonium methanesulphonate ionic liquid and its use for the first time as a catalyst in a multicomponent reaction for one-pot synthesis of dihydropyrimidine derivatives from various aromatic aldehydes, methyl or ethyl acetoacetate, and urea or thio-urea under solvent-free conditions at 120 °C. About 21 different dihydropyrimidine derivatives have been synthesized in excellent yields. The advantages of this method are the following: solvent-free conditions, a small amount of catalyst required, shorter reaction time, easy workup procedure, and no hazardous organic solvents or toxic catalysts. This catalyst was easily prepared and showed an excellent level of reusability. The molecular docking study was performed to evaluate interactions between the active compounds with Leishmania pteridine reductase 1 (PTR1). Using theoretical evaluation, ADME properties in silico were investigated for their oral bioavailability to predict the safer efficacy of the synthesized compounds.

Synthesis of Pd supported on 3,4-diaminobenzoic acid functionalized Fe3O4 nanoparticles as a magnetic catalyst for synthesis of 2-methoxy-2-phenylacetonitrile derivative via a strecker-type reaction under ambient and solvent-free conditions

Pd supported on 3,4-diaminobenzoic acid functionalized Fe3O4 magnetic nanoparticles as an organic-inorganic hybrid heterogeneous catalyst was fabricated and characterized by FT-IR, XRD, SEM, TEM, TGA, VSM, EDX, and ICP-AES techniques. The catalytic activity of the magnetic catalyst was probed through a Strecker-type reaction for one-pot synthesis of 2-methoxy-2-phenylacetonitrile derivatives under ambient and solvent-free conditions. Simple procedure, high yields, short reaction time, and environmentally benign method are advantages of this protocol. The catalyst was readily separated using an external magnet and reusable without significant loss of its catalytic efficiency.

Synthesis and characterization of Pd supported on methane diamine (propyl silane) functionalized Fe3O4 nanoparticles as a magnetic catalyst for synthesis of α-aminonitriles and 2-methoxy-2-phenylacetonitrile derivative via Strecker-type reaction under ambient and solvent-free conditions

Pd supported on methane diamine (propyl silane) functionalized Fe3O4 magnetic nanoparticles as an organic–inorganic hybrid heterogeneous catalyst was fabricated and characterized by FT-IR, XRD, SEM, TEM, TGA, VSM, EDX, and ICP-AES techniques. The catalytic activity of the magnetic catalyst was probed through the Strecker-type reaction for one-pot synthesis of α-aminonitriles and 2-methoxy-2-phenylacetonitrile derivatives under ambient and solvent-free conditions. Simple procedure, high yields, short reaction time, and the environmentally benign method are advantages of this protocol. The catalyst was readily separated using an external magnet and reusable without significant loss of its catalytic efficiency.

Substituted Imidazole-Pyrazole Clubbed Scaffolds: Microwave Assisted Synthesis and Examined Their In-vitro Antimicrobial and Antituberculosis Effects

A series of substituted imidazole-pyrazole fused compounds were designed & fused synthesized by employing Debus-Radziszewski one-pot synthesis reaction. Azoles are an extensive and comparatively new class of synthetic compounds including imidazoles and pyrazoles. The current clinical treatment uses compounds of azole framework. Azoles act by inhibiting ergosterol synthesis pathway (a principal component of the fungal cell wall). In addition, a literature review shows that the compounds that include imidazoles and pyrazoles have significant anti-bacterial and anti-mycobacterial effects. In light of the above findings, a series of compounds with imidazole and pyrazole scaffolds were sketched and developed to examine anti-bacterial, antifungal and antimycobacterial activities. The structures of the synthesized compounds were characterized using <sup>1</sup>HNMR, <sup>13</sup>CNMR, elemental analysis, and MS spectral data. The target compounds were screened for their in-vitro antimicrobial activity against gram-positive and gram-negative bacterial species by disc diffusion method according to the NCCLS (National Committee for Clinical Laboratory Standards) and anti-mycobacterial activity against the Mycobacterium tuberculosis H37Rv strain. The results revealed that imidazole-pyrazole fused scaffold compounds have potential antibacterial, antifungal and anti-mycobacterial activities which can be further optimized to get a lead compound.

Thiol-Bromo Click Reaction for One-Pot Synthesis of Star-Shaped Polymers.

Star-shaped polymers have unique physical properties and they are sought after materials in industry. However, the ease of synthesis is essential for translation of these materials into large-scale applications. Herein, a highly efficient synthetic method to prepare star-shaped polymers by combination of Cu-mediated reversible deactivation radical polymerization (Cu-RDRP) and thiol-bromo click reaction is described. Well-defined linear and block polymers with a very high bromine chain end fidelity are obtained via Cu-RDRP and subsequently react with multi-functional thiol compounds. High coupling efficiencies of larger than 90% are obtained owing to the quick and efficient reaction between thiols and alkyl bromides. Moreover, the arms of the obtained star-shaped polymers are linked via thioether bonds to the core, making them susceptible for oxidative degradation.

Condensation–cyclization reaction for one-pot synthesis of 1,3-thiazolidin-4-one derivatives by poly(p-phenylenediamine) grafted on LDHs as a catalyst with green tool

The three-component reaction between amine, carbonyl compound and thioglycolic acid is now considered as a major strategy for synthesis of 1,3-thiazolidin-4-ones, which consists of the following steps: (i) condensation of aldehyde and amine which results the formation of an imine; (ii) the reaction between thioglycolic acid and the imine which is followed by an intramolecular cyclization reaction, which leads to the formation of the final product. In this way, if no suitable catalyst is employed, the completion of the reaction will not be achieved. Hence, it is of great importance to select an appropriate catalyst so that these compounds can be successfully synthesized. Herein, we employed LDHs@PpPDA as a versatile catalyst for the fabrication of novel derivatives of 1,3-thiazolidin-4-one.

Palladium complexes with an annellated mesoionic carbene (MIC) ligand: catalytic sequential Sonogashira coupling/cyclization reaction for one-pot synthesis of benzofuran, indole, isocoumarin and isoquinolone derivatives.

Two Pd(ii) complexes (1 and 2) featuring a fused π-conjugated imidazo[1,2-a][1,8]naphthyridine-based mesoionic carbene ligand have been synthesized and structurally characterized. Both complexes effectively catalyze the one-pot synthesis of benzofuran starting from phenylacetylene and 2-iodophenol under mild conditions. Complex 1 is found to be an excellent catalyst for the straightforward access to a library of benzofuran, indole, isocoumarin and isoquinolone derivatives by the reaction of terminal alkynes with 2-iodo derivates of phenol, N-methyl aniline, benzoic acid and N-methyl benzamide, respectively. The general utility of the catalytic method is demonstrated using a variety of diversely substituted terminal alkynes and the corresponding desired products are obtained in good to excellent yields. On the basis of control experiments, a two-cycle mechanism is proposed which involves the Sonogashira coupling of 2-iodo derivatives with alkynes and the subsequent cyclization of the corresponding 2-alkynyl compounds.

Efficient one-pot three-component method for the synthesis of highly fluorescent coumarin-containing 3,5-disubstituted-2,6-dicyanoaniline derivatives under microwave irradiation

ABSTRACTA simple and concise approach to the synthesis of coumarin-containing highly fluorescent asymmetric/symmetric 3,5-diaryl/heteroaryl-2,6-dicyanoaniline derivatives are reported. The compounds were synthesized through base catalyzed three-component one-pot synthesis reaction of 2-(1-(7-(diethylamino)-2-oxo-2H-chromen-3-yl)ethylidene)malononitrile, aliphatic, aromatic/heteroaromatic aldehydes, and malononitrile in solvent-free reaction medium, catalyzed by piperidine under microwave irradiation method. The reaction gave the novel, highly fluorescent coumarin-containing 3,5-disubstituted-2,6-dicyanoaniline derivatives in good yields at 300 W, 80 °C in 2 min. This method provides several advantages; such as shorter reaction time, environmental friendliness, simple workup procedure, lower energy consumption and, generally, good yields with high purity. In addition, the synthesized compounds are fluorescently active dyes even in day light, except for compounds including nitro substituent, and show maximum absorption wavelengths (λabs.max) in the visible region in DMSO at room temperature. Thermal properties of all the synthesized compounds were also evaluated with thermal gravimetric analysis for usability as optic dye. Optical and thermal screening studies of the compounds showed that the dyes have excellent photophysical and thermal stability properties.

Correction: An efficient and rapid intramolecular cyclization of a quadruple Mannich reaction for one-pot synthesis of pentaazaphenalenes and their antimicrobial activities

Correction for ‘An efficient and rapid intramolecular cyclization of a quadruple Mannich reaction for one-pot synthesis of pentaazaphenalenes and their antimicrobial activities’ by Ahmed F. M. EL-Mahdy et al., RSC Adv., 2016, 6, 92134–92143.

Molecular structure and spectroscopic investigations combined with hypoglycemic/anticancer and docking studies of a new barbituric acid derivative

The one-pot synthesis reaction of barbituric acid derivative, 1,3-cyclohexandione, and 4-fluorobenzaldehyde in water mediated by NHEt2 as base afforded 4 with excellent yield. The synthesized compound was characterized by spectrophotometric tools as well as X-ray single crystal diffraction technique. The stability of the nine possible isomers of the synthesized compound was studied using the B3LYP method and 6-31G(d,p) basis set. The electronic and spectroscopic properties of the most stable isomer were predicted. The UV–Vis absorption spectrum displayed two bands at 203 and 257 nm in the solvent chloroform. The latter was calculated at 235.6 nm (f = 0.1995) in the gas phase due to H-2→L (42%) and H-1→L+2 (14%) excitations. In solution, using chloroform as a solvent, a slight bathochromic shift to 237.6 nm with an increase in the absorption intensity (f = 0.2898) was predicted. The molecular orbital energy level diagram of this transition band was characterized mainly by π-π* transitions. The 13C and 1H NMR chemical shifts correlated well with the experimental data. The correlations had higher correlation coefficients (R2) when solvent effects were considered. The atomic charges were calculated using natural population analysis and the charged regions were presented using a molecular electrostatic potential (MEP) map. The synthesized compound was examined as a hypoglycemic agent via inhibition of α-glucosidase and β-glucuronidase enzymes. Its inhibitory activity against α-glucosidase was 10 times greater than the inhibitory activity of the standard drug acarbose (IC50 77.9 ± 0.3 μM and 840 ± 1.73 μM, respectively). Moreover, the target compound was evaluated for anticancer activity against MCF-7, H460, 3T3, and Hela cell lines. It demonstrated inhibitory activity against the MCF-7 and H460 cell lines with IC50 5.80 ± 0.12 and 19.6 ± 0.5 μM, respectively, in comparison to doxorubicin. The docking study was performed using the OpenEye program.

A Simple and Green Tandem Knoevenagel–Phospha-Michael Reaction for One-Pot Synthesis of 2-Oxindol-3-ylphosphonates Catalyzed by a DABCO-Based Ionic Liquid

A simple, clean, and efficient approach for the one-pot synthesis of 2-oxindol-3-ylphosphonates has been successfully developed. With 7 mol% loading of the 1,4-diazabicyclo[2.2.2]octane-based ionic liquid catalyst, 2-oxindol-3-ylphosphonates form in good to excellent yields within short times. This tandem reaction involves a phospha-Michael­ addition to the activated alkenes, which form <i>in situ</i> by Knoevenagel­ condensation. The corresponding products are easily separated and purified by simple crystallization. The catalyst can be recycled five times without significant activity loss. This approach is readily amenable to large-scale synthesis.

Nano isopolyoxomolybdate catalyzed Biginelli reaction for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones under solvent-free conditions

The Biginelli reaction of β-ketoesters with aryl aldehyde and urea or thiourea in the presence of a Keplerate type giant nanoporous isopolyoxomolybdate, (NH4)42[Mo 72 VI Mo 60 V O372(CH3COO)30(H2O)72], presented as {Mo132}, as an efficient catalyst under solvent free conditions is reported. The catalyst was synthesized according to the earlier published procedure using inexpensive and readily available starting materials. The catalyst could be recovered and reused efficiently in six cycles. Other beneficial features of this new synthetic approach include short reaction time, high yields, clean reaction profiles, and a simple work-up procedure.

A mild acid-free one-pot reaction for synthesis of new phenanthridine dyes

A series of new phenylphenanthridin dyes have been synthesized in the yields of 52–75% by a mild strategy in one-pot reaction. This is the first successful attempt to perform efficient soft acid-free reaction for phenanthridine ring construction. A large substrate scope was well demonstrated.

An efficient and rapid intramolecular cyclization of a quadruple Mannich reaction for one-pot synthesis of pentaazaphenalenes and their antimicrobial activities

An efficient, regioselective and one-pot synthesis of pentaazaphenalenes has been developed via a quadruple Mannich reaction. Most of the synthesized compounds showed significant antimicrobial activities.

One-Pot Reactions for Synthesis of 2,5-Substituted Tetrazoles from Aryldiazonium Salts and Amidines.

One-pot sequential reactions of aryldiazonium salts with amidines followed by the treatment of I2/KI under basic conditions provide 2,5-disubstituted tetrazoles in moderate to excellent yields. This one-pot synthesis has several advantages such as mild reaction conditions, short reaction time, convenient workup, and high yields, making this methodology practical.

One-pot synthesis of (R)-2-acetoxy-1-indanone from 1,2-indanedione combining metal catalyzed hydrogenation and chemoenzymatic dynamic kinetic resolution

A heterogeneously catalyzed one-pot reaction for synthesis of (R)-2-acetoxy-1-indanone is described.

One-pot synthesis of polysubstituted 2-piperidinones from aromatic aldehydes, nitromethane, ammonium acetate, and dialkyl malonates

A pseudo-five-component reaction for one-pot synthesis of polysubstituted 2-piperidinones from two equivalent aromatic aldehydes, nitromethane, ammonium acetate, and dialkyl malonates is reported. Interestingly, the formation of products was highly stereoselective. Two different stereochemical classes of polysubstituted 2-piperidinones were provided depending on the substituent position of the aromatic aldehydes.

Synthesis and Cyclization of 8‐Formyl‐2‐(phenoxymethyl)quinoline‐3‐carboxylic Acids

AbstractA facile synthesis of a series of new quinoline‐8‐carbaldehyde compounds, namely 8‐formyl‐2‐(phenoxymethyl)quinoline‐3‐carboxylic acids (4a–4h) and 13‐oxo‐6,13‐dihydro[1]benzoxepino[3,4‐b]quinoline‐8‐carbaldehyde (5a–5g) is described, involving the one‐pot synthesis reaction of ethyl 2‐(chloromethyl)‐8‐formylquinoline‐3‐carboxylate (3) with substituted phenols followed by the intramolecular cyclization reaction via the treatment with polyphosphoric acid (PPA). Quinoline‐8‐carbaldehydes 4a–4h and 5a–5g are novel and their structures were supported by IR, 1H NMR, 13C NMR, MS and elemental analysis.