One-pot Synthesis Of Primary Amides Research Articles

Hydrosilane Reduction of Nitriles to Primary Amines by Cobalt-Isocyanide Catalysts.

Reduction of nitriles to silylated primary amines was achieved by combination of 1,1,3,3-tetramethyldisiloxane (TMDS) as the hydrosilane and a catalytic amount of Co(OPiv)2 (Piv = CO tBu) associated with isocyanide ligands. The resulting silylated amines were subjected to acid hydrolysis or treatment with acid chlorides to give the corresponding primary amines or imides in good yields. One-pot synthesis of primary amides to primary amines with hydrosilanes was also achieved by iron-cobalt dual catalyst systems.

An efficient catalyst-free one-pot synthesis of primary amides from the aldehydes of the Baylis–Hillman reaction

Herein, a facile and efficient method for the preparation of allyl amides from the aldehydes of Baylis–Hillman adducts has been developed using a hydroxylamine/methanol system under a catalyst-free condition.

One-pot synthesis of primary amides on bifunctional Rh(OH)x/TS-1@KCC-1 catalysts

A new microporous/mesoporous composite with a core-shell structure, [email protected], was fabricated in a microemulsion system by coating flower-like mesoporous silica (KCC-1) on the crystal surface of TS-1 zeolite. The synthesis conditions and a possible formation mechanism were studied in detail for the [email protected] material. A suitable temperature and assembly time were found to be 373–393 K and 4 h, respectively. The shell thickness of [email protected] was conveniently tuned in the range 25–80 nm. Rh(OH)x species were supported on [email protected], giving rise to a novel bifunctional tandem catalyst Rh(OH)x/[email protected], which effectively catalyzed the one-pot synthesis of primary amides directly from aldehydes, ammonia, and hydrogen peroxide.

Ruthenium-catalyzed one-pot synthesis of primary amides from aldehydes in water

The readily available arene–ruthenium(II) complex [RuCl2(η6-C6Me6){P(NMe2)3}] (5 mol%) proved to be an efficient catalyst for the direct synthesis of primary amides from aldehydes and hydroxylamine hydrochloride (NH2OH·HCl) in water at 100 °C. The process, which requires the presence of NaHCO3 to catch the HCl released during the formation of the key aldoxime intermediates, was operative with both aromatic, heteroaromatic, α,β-unsaturated and aliphatic aldehydes, and tolerated several functional groups. A greener approach using commercially available NH2OH solution (50 wt.% in water) is also presented.

ChemInform Abstract: Highly Efficient One‐Pot Synthesis of Primary Amides Catalyzed by Scandium(III) Triflate under Controlled MW.

The present Letter highlights a versatile synthetic protocol for the one-pot synthesis of primary amides employing scandium(III) triflate as a catalyst in water under controlled MW. This methodology offers excellent yields in shorter reaction times with enhanced selectivity.

Highly efficient one-pot synthesis of primary amides catalyzed by scandium(III) triflate under controlled MW

The present Letter highlights a versatile synthetic protocol for the one-pot synthesis of primary amides employing scandium(III) triflate as a catalyst in water under controlled MW. This methodology offers excellent yields in shorter reaction times with enhanced selectivity.