One-pot Reaction Of Aldehydes Research Articles

A facile electrosynthesis of N-acyl benzotriazoles from aldehydes and benzotriazole

An electrochemical synthesis of N-acylbenzotriazoles has been developed under mild conditions with good to excellent yields using aldehydes and benzotriazole as starting materials. In addition, a one-pot reaction of aldehyde, benzotriazole and phenol has been achieved affording phenolic esters in moderate yields under the combination of electricity-on/off conditions, where N-acyl benzotriazole acted as the benign acylating reagent. It is noteworthy the research provided environmental friendly syntheses in that no superstoichiometric hazardous chemical oxidants were required, corrosive/toxic reagents have been avoided and waste production has significantly been reduced. The key of the electrochemical synthesis involves the oxidation of benzotriazole-aldehyde adduct by phthalimido-N-oxy (PINO), which was generated by N-hydroxyphthalimide (NHPI) as a redox mediator.

Biosynthesized Selenium nanoparticles as a new catalyst in the synthesis of quinazoline derivatives in pentacyclic system with docking validation as (TRPV1) inhibitor

In recent years, a lot of benefits of Selenium have been discovered for humans, animals and chemical uses. Nano-Selenium was biosynthesized and characterized by using FTIR, UV/Vis., TEM/SAED, and mapping to ensure their crystallinity. The N-bridged imidazo-quinazoline derivatives were successfully synthesized in pentacyclic nonlinear ortho fused polynuclear by a one-pot reaction of aldehyde, β-naphthol, and 2-aminobenzoimidazole in the presence of a catalytic amount of aqueous nano-Se as a highly efficient and facile catalyst at 70–80 °C. The molecular docking study as TRPV1 inhibitor compared with Rutaecarpine and Evodiamine as reference alkaloids ligands.

Impact of an aryl bulky group on a one-pot reaction of aldehyde with malononitrile and N-substituted 2-cyanoacetamide.

In this study, we successfully explored the effect of steric hindrance on the one-pot reaction of different aryl aldehydes with malononitrile and N-substituted 2-cyanoacetamide in the presence of piperidinium acetate as the catalyst. It involved the Knoevenagel condensation of the aldehyde and malononitrile to produce arylidene malononitrile as an intermediate, which was further treated with N-substituted 2-cyanoacetamide to give 6-amino-2-pyridone-3,5-dicarbonitrile derivatives when the less steric bulky group was involved. High steric hindrance changed the earlier reaction route and gave N-substituted 2-cyanoacrylamides via a slower route.

An Efficient One-Pot Synthesis of α-Amino Phosphonates Catalyzed by Bismuth Nitrate Pentahydrate

Correction to: An Efficient One-Pot Synthesis of α-Amino Phosphonates Catalyzed by Bismuth Nitrate PentahydrateSynlett 2007; 2007(05): 0745-0748DOI: 10.1055/s-2007-970762

One-pot oxidative bromination – Esterification of aldehydes to 2-bromoesters using cerium (IV) ammonium nitrate and lithium bromide

A two-step, one-pot reaction of aldehydes with the CAN/LiBr oxidation system under solvent-free conditions followed by the addition of methanol affords methyl α-bromocarboxylates. The oxidation of aldehydes with methanol using this system gives only methyl esters. A facile method, which does not require special equipment, was developed for the synthesis of 2-bromoesters from aliphatic aldehydes with carbon chain lengths of 5–10 atoms.

Selective pyrone functionalization: reductive alkylation of triacetic acid lactone

The one-pot reaction of aldehydes, triacetic acid lactone, and Hantzsch 1,4-dihydropyridine affords 3-alkyl pyrones via a reductive alkylation strategy.

A straightforward synthesis of alkyl 1H-tetrazol-5-yl thioethers via a one-pot reaction of aldehydes and 1H-tetrazole-5-thiols mediated by N-tosylhydrazones

A method for the straightforward synthesis of alkyl 1H-tetrazol-5-yl thioethers from aldehydes and 1H-tetrazole-5-thiols through a one-pot procedure is presented.

An Efficient and Convenient Procedure for the One-Pot Synthesis of α-Aminophosphonates from Aryl Azides under Solvent-Free Conditions

A novel and simple approach to the multicomponent one-pot reaction of aldehydes, diethyl phosphite, and azides to form α-aminophosphonates under solvent-free conditions at room temperature has been developed. In the presence of iodine and iron, aryl azides were, for the first time, used as substrates for the synthesis of α-aminophosphonates. The reactions were completed within 5 minutes to 12 hours and afforded the corresponding products in good yields.

Synthesis, characterization and catalytic properties of magnetic nanoparticle supported guanidine in base catalyzed synthesis of α-hydroxyphosphonates and α-acetoxyphosphonates

Magnetic nanoparticle Fe3O4-immobilized guanidine (MNPs-Guanidine) as a novel magnetically interphase nanocatalyst was synthesized and characterized. MNPs-Guanidine catalyzed the synthesis of α-hydroxyphosphonates from aldehydes and dimethyl phosphite in solvent-free condition at 80°C. The synthesis of α-acetoxyphosphonates through a one-pot reaction of aldehydes, dimethyl phosphite and acetic anhydride was also achieved using this catalyst in PEG at room temperature. The catalyst was recycled up to 10 times with little loss of activity.

Natrolite zeolite: A natural and reusable catalyst for one-pot synthesis of α-aminophosphonates under solvent-free conditions

α-Aminophosphonates are synthesized efficiently by one-pot reaction of aldehydes or ketones, amines, trialkyl phosphites in the presence of Natrolite zeolite as a natural catalyst under solvent-free conditions. Furthermore, the catalyst can be reused several times without any significant loss of catalytic activity.

Simple synthesis of 4-aryl-9-furylnaphtho[2,3-b]furan

Naphthofuran (III) is obtained in a simple one-pot reaction of aldehyde (I) and 2-methylfuran (II) in the presence of a catalytic amount of perchloric acid.

ChemInform Abstract: CuCl/DABCO/4‐HO‐TEMPO‐Catalyzed Aerobic Oxidative Synthesis of 2‐Substituted Quinazolines and 4H‐3,1‐Benzoxazines.

The Cu/N-ligand/TEMPO catalytic system was first applied to the aerobic oxidative synthesis of heterocycles. As demonstrated, 2-substituted quinazolines and 4H-3,1-benzoxazines were synthesized efficiently from the one-pot reaction of aldehydes with 2-aminobenzylamines and 2-aminobenzyl alcohols, respectively, by employing CuCl/DABCO/4-HO-TEMPO as the catalysts and oxygen as the terminal oxidant.

CuCl/DABCO/4-HO-TEMPO-Catalyzed Aerobic Oxidative Synthesis of 2-Substituted Quinazolines and 4H-3,1-Benzoxazines

The Cu/N-ligand/TEMPO catalytic system was first applied to the aerobic oxidative synthesis of heterocycles. As demonstrated, 2-substituted quinazolines and 4H-3,1-benzoxazines were synthesized efficiently from the one-pot reaction of aldehydes with 2-aminobenzylamines and 2-aminobenzyl alcohols, respectively, by employing CuCl/DABCO/4-HO-TEMPO as the catalysts and oxygen as the terminal oxidant.

ChemInform Abstract: Efficient Synthesis of α‐Aminophosphonates via One‐Pot Reactions of Aldehydes, Amines, and Phosphates in Ionic Liquid.

Ionic liquids such as 1,3-dialkylimidazolium bromides make excellent solvents for synthesis of α-aminophosphonates from aldehydes, amines, and phosphites. The ionic liquids are successfully regenerated and reused. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 22:625–629, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20724

Mechanistic Studies on a New Catalyst System (CuI-NaHSO4×SiO2) Leading to the One-Pot Synthesis of Imidazo[1,2-a]pyridines from Reactions of 2-Aminopyridines, Aldehydes, and Terminal Alkynes

One-pot reactions of aldehydes, 2-aminopyridines, and terminalalkynes, in the presence of the copper(I) iodide-NaHSO 4 ˙SiO 2 combinationcatalyst in refluxing toluene, generate the corresponding imidazo[1,2- A]pyridines in high to excellent yields;the mechanism has been studied.

Ytterbium pentafluorobenzoate as a novel fluorous Lewis acid catalyst in the synthesis of 2,4-disubstituted quinolines

A series of simple, efficient, stable and recoverable rare earth metal pentafluorobenzoates [RE(Pfb) 3] have been synthesized for the first time. A highly efficient and environmentally friendly synthesis of 2,4-disubstituted quinolines catalyzed by Yb(Pfb) 3 via one-pot reaction of aldehydes, alkynes and amines under solvent-free conditions has been explored.

Eco-Friendly One-Pot Synthesis of 2,4-Disubstituted Thiazoles by Grinding Under Catalyst- and Solvent-Free Conditions

An efficient and facile synthesis of 2,4-disubstituted thiazoles is achieved by a one-pot reaction of aldehydes and α-bromoketones with thiosemicarbazide by grinding under catalyst- and solvent-free conditions. This method has notable advantages in terms of simple workup, neat conditions, high yield, reasonably rapid reaction rate, and environmental friendliness.Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.GRAPHICAL ABSTRACT

Cascade cyclization, dipolar cycloaddition of azomethine imines for the synthesis of pyrazolidines

A tandem multi-step, one-pot reaction of aldehydes with hydrazines has been used for the preparation of tetrahydropyrazoles and dihydropyrazoles. The chemistry involves condensation then cyclization, followed by inter- or intramolecular dipolar cycloaddition of the resulting azomethine imine intermediates. The intramolecular cycloaddition gives fused tricyclic compounds as single diastereoisomers. The intermolecular cycloaddition was successful with a variety of activated alkene and alkyne dipolarophiles.

ChemInform Abstract: General Procedure for the Synthesis of α-Amino Phosphonates from Aldehydes and Ketones Using Indium(III) Chloride as a Catalyst.

A simple, efficient, and general method has been developed for the synthesis of α-amino phosphonates through a one-pot reaction of aldehydes and ketones with amines in the presence of indium(III) chloride as a catalyst.

Synthesis of Stilbenes Promoted by the Mixture of Zinc and Iron Powder

Stilbenes have been synthesised by a one-pot reaction of aldehydes with benzyl bromide. The reaction was promoted by both triphenylphosphine and the mixture of zinc and iron together in sealed tube. The yields ranged from moderate to excellent.