One-pot Synthesis Method Research Articles

Bi2Te3/Carbon Nanotube Hybrid Nanomaterials as Catalysts for Thermoelectric Hydrogen Peroxide Generation

Harnessing waste heat from environmental or industrial sources presents a promising approach to eco-friendly and sustainable chemical synthesis. In this study, we introduce a thermoelectrocatalytic (TECatal) system capable of utilizing even small amounts of heat for hydrogen peroxide (H2O2) production. We developed a nanohybrid structure, combining carbon nanotubes (CNTs) and Bi2Te3 nanoflakes (Bi2Te3/CNTs), through a one-pot synthesis method. Bi2Te3, as a thermoelectric (TE) material, generates charge carriers under a temperature gradient via the Seebeck effect, enabling them to participate in surface redox reactions. However, the rapid recombination of these charge carriers greatly limits the TECatal activity. In the Bi2Te3/CNTs nanohybrid system, the introduction of CNTs substantially enhances the efficiency of H2O2 production, as the strong bonding between CNTs and Bi2Te3, along with the excellent conductivity of CNTs, facilitates charge carrier separation and transport, as confirmed by TE electrochemical tests. This study underscores the significant potential of thermoelectric nanomaterials for converting waste heat into green chemical synthesis.

A facile one-pot synthesis of hierarchical porous carbon for supercapacitor electrodes

This study presents a facile, environmentally friendly approach to fabricate hierarchical porous carbon for supercapacitor electrodes. The one-pot synthesis of PFO/silica/PTFE via co-pyrolysis generates ideal hierarchical porous carbon. Compared with traditional methods, this method eliminates toxic solvents and complex cleaning steps. PPC-2 obtained under the optimized activation time has the highest specific surface area (2657 m2 g−1) and a remarkable total pore volume (2.96 cm3 g−1). These properties result in a remarkable specific capacitance of 335.9–210.8 F g−1 at current densities of 0.5–10 A g−1 in KOH electrolyte. The electrochemical performance of the PPC-2 electrode in a symmetric supercapacitor device was measured in aqueous (6 M KOH) and ionic liquid (EMIM-TFSI) electrolytes. In EMIM-TFSI, PPC-2//PPC-2 provides an energy density of 48.5 Wh/kg even at a power density of 750 W kg−1. This facile one-pot synthesis method offers a sustainable and scalable approach to produce high-performance hierarchical porous carbon for supercapacitor applications.

Rapid adsorptive removal of congo red using Cu/Fe/Al mixed metal oxides obtained from layered double hydroxide nanomaterial: Performance and optimization evaluation using BBD-RSM approach

This work utilized a one-pot synthesis method to synthesize Cu/Fe/Al mixed metal oxide (MMO) from layered double hydroxide (LDH) calcination. The adsorption potentials of Cu/Fe/Al LDH and Cu/Fe/Al MMOs were evaluated using Congo Red (CR) aqueous solution. Various advanced techniques were used to characterize the synthesized nanomaterial. XRD confirmed the successful synthesis of trimetallic carbonate intercalated LDH and MMO, while FE-SEM revealed their flaky morphology. EDX and FT-IR analyses supported the dye removal mechanism, showing that MMOs had greater adsorptive removal of CR molecules than LDH. This was primarily due to the MMOs' larger surface area and microporous structure (132 m²/g) which favoured greater adsorption. The adsorption kinetics reveal that the adsorptive removal of CR on LDH and MMOs follows a pseudo-second-order reaction. Moreover, as predicted by Freundlich the maximum adsorptive removal was obtained by LDH-derived MMO (96%) which was higher than the LDH (90%). The thermodynamics indicates that adsorption was exothermic and thus more favorable at room temperature. In addition, the Box-Behnken Design (BBD) was adopted for Response Surface Methodology (RSM) due to its simplicity in analysis and effectiveness in systematically evaluating the impact of pH, dosage of adsorbent, dye concentration, contact period, and temperature variables. The pHzpc of 7.9 indicated that lower pH enhances adsorption, and a +5.1 mV charge on the MMO surface, measured by zeta potential, supported electrostatic interaction with the anionic dye. Lastly, LDH and LDH-derived MMO were regenerated using 1 M NaOH and effectively reused for up to 5 cycles. MMOs demonstrated superior reusability compared to LDH for anionic dye removal. Thus, the synthesised Cu/Fe/Al MMO, with its large surface area, offers a superior adsorbent for removing organic pollutants.

One-pot synthesis of chiral cysteine-capped gold nanoparticles for use as vaccine adjuvants in mice

The influence of chirality on the biological activity of nanoparticles, including their interaction with the immune system, is a growing area of interest. This study presents a one-pot synthesis method for 15 nm L-cysteine or D-cysteine capped gold nanoparticles (L/D-Cys-GNPs) and evaluates their immunological potential as adjuvants in mice. The synthesized GNPs were comprehensively characterized using UV–visible absorption spectroscopy, FTIR, CD spectra, and TEM, revealing enhanced stability and effective internalization by human umbilical vein endothelial cells (HUVEC), with L-Cys-GNPs exhibiting a higher uptake rate. In vivo immunization studies demonstrated that L-Cys-GNPs significantly boosted the production of anti-ovalbumin(OVA) IgG antibodies compared to D-Cys-GNPs (>66 folds), underscoring the importance of chiral surface properties in modulating immune responses. However, the encapsulation of GNPs in liposomes negated the chiral effect, suggesting that delivery methods may influence the interaction of GNPs with the immune system. The findings highlight the role of chirality in vaccine development and provide insights into targeted antigen delivery systems. This work contributes to the understanding of chirality in vaccine development and paves the way for the design of more effective vaccines against challenging diseases.

Construction of an Innovative Nanogel and Its Applications for Achieving Chemo-Immunotherapy of Tumors.

Malignant tumors, also known as cancers, are a global public health problem. Nanogels are promising carriers for the delivery of anticancer medicines. Therefore, based on the unique microenvironment of tumor cells and the advantages of nanogels, a simple and economical one-pot synthesis method was designed to construct natural polysaccharide-based redox-responsive nanogels (LDD NGs). The enhanced permeability and retention (EPR) effect enriched LDD NGs in tumor cells, which then rapidly collapsed and released the natural antitumor drug diosgenin (DG) and the natural polysaccharide lentinan (LNT) via the depletion of a high level of reduced glutathione (GSH) in tumor cells, resulting in a synergistic therapeutic effect of chemotherapy and immunotherapy. In vivo antitumor experiments showed that LDD NGs could inhibit the proliferation and metastasis of the A549 lung cancer cells. Further studies indicated that LDD NGs could increase the production of ROS and induce apoptosis of A549 cells. In addition, LNT released from LDD NGs could promote the proliferation of dendritic cells, increase the production of NO, and upregulate the expressions of the costimulatory molecules CD40, CD80, CD86, and MHC-II. The construction of LDD NGs was a novel drug synthesis approach that could provide fresh ideas for the development of polysaccharide-based redox-responsive drug delivery systems.

Mechanism study on the influence of surface properties on the synthesis of dimethyl carbonate from CO2 and methanol over ceria catalysts

The direct synthesis of dimethyl carbonate (DMC) from CO2 and methanol has attracted much attention as an environmentally benign and alternative route for conventional routes. Herein, a series of cerium oxide catalysts with various textural features and surface properties were prepared by the one-pot synthesis method for the direct DMC synthesis from CO2 and methanol, and the structure-performance relationship was investigated in detail. Characterization results revealed that both of surface acid-base properties and the oxygen vacancies contents decreased with the rising crystallinity at increasingly higher calcination temperature accompanied by an unexpectedly volcano-shaped trend of DMC yield observed on the catalysts. In situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) studies indicated that the adsorption rate of methanol is slower than that of CO2 and the methanol activation state largely influences the formation of key intermediate. Although the enhanced surface acidity-basicity and oxygen vacancies brought by low-temperature calcination could facilitate the activation of CO2, the presence of excess strongly basic sites on low-crystallinity sample was detrimental to DMC synthesis due to the preferred formation of unreactive mono/polydentate carbonates as well as the further impediment of methanol activation. Moreover, with the use of 2-cyanopyridine as a dehydration reagent, the DMC synthesis was found to be both influenced by the promotion from the rapid in situ removal of water and the inhibition from the competitive adsorption of hydration products on the same active sites.

Deuterated-alkylation reagents based on sulfonium salts as cation and radical sources

Abstract The replacement of C–H bonds with more stable C–D bonds at the α-position of heteroatoms, which is the typical metabolic site for cytochrome P450, is important in drug discovery. Recently, we have developed dn (deuterated)-alkylated sulfonium salts (1a-dn), which were easily prepared by deuteration (H/D exchange reaction) with D2O of the corresponding alkyl diphenylsulfonium salts (1a), as electrophilic dn-alkylating reagents (cation sources). Herein, we newly report an improved preparation method of 1a and one-pot synthesis of dn-alkylated compounds via the deuteration of 1a with D2O and the subsequent nucleophilic substitution under basic conditions. Additionally, dn-alkyl thianthrenium salts (1b-dn) were also found to work as dn-alkylating reagents (cation sources). Furthermore, 1b-dn served as radical sources under photo-induced reaction conditions with Ir photocatalyst, Hantzsch ester, or triphenylamine to obtain various regioselectively deuterium-incorporated alkyl compounds. These dn-alkylating reagents will contribute to advance the drug discovery.

Machine learning-assisted identification of potential cancer inhibitors: Multifunctional biomineralized CaCO3-polyethyleneimine nanoparticle carriers and their application in lung cancer therapy

Cancer, as a prevalent phenomenon among malignant tumors, has a late-stage diagnosis rate approaching half, significantly limiting treatment efficacy and imposing substantial physiological and psychological burdens on patients. Therefore, developing innovative therapeutic platforms that simultaneously optimize diagnostic accuracy, enhance therapeutic efficacy, and minimize side effects is a critical scientific challenge in the field of precision cancer medicine. In this study, we employed a simple and efficient one-pot synthesis method combined with polyethyleneimine (PEI)-mediated biomineralization technology to successfully prepare calcium carbonate-polyethyleneimine (CaCO3-PEI) composite nanoparticles. These nanoparticles exhibit high pH sensitivity and can rapidly degrade under the mildly acidic conditions that mimic the tumor microenvironment, providing potential for targeted tumor therapy. Subsequently, we encapsulated compound 1, which has potential for lung cancer treatment, within the CaCO3-PEI nanoparticles, successfully constructing the CaCO3-PEI@1 composite system. Structural analysis of this composite system was conducted through characterization techniques. In vitro cell experiments demonstrated that the CaCO3-PEI@1 composite system exhibited significant anticancer effects by effectively inhibiting cancer cell proliferation through the regulation of apoptosis-related protein Bax expression. This provides new insights and experimental evidence for the development of cancer treatment strategies. Based on the experiment and molecular docking identified activity against lung cancer, the compound 1 was used as the initiator for the machine learning model, and up to 10,000 episodes were generated, after thorough examination, it was found about two-thirds of the generated episodes were entirely different from each other, which demonstrated that the machine learning model was a powerful tool for designing of potential inhibitors against lung cancer.

Detection of urea in milk by urease-inorganic hybrid nanoflowers combined with portable colorimetric microliter tube.

Asimple one-pot green synthesis method was used to prepare urease-inorganic hybrid nanoflowers (UE-HNFs), which had a high surface-to-volume ratio to improve enzyme catalytic efficiency and make urease reusable. A portable colorimetric microliter tube based on urease-inorganic hybrid nanoflowers (UE-HNFs-PCMT), as an urea colorimetric biosensor, was developed for determining urea concentration in milk. The combination of urea colorimetric biosensor and asmartphone is usedfor capturingthe colour change of milk after reaction. There was a good linear relationship between colour intensity of the image (Δ intensity) and urea concentration (43-600mg L-1), with a detection limit of 12.81mg L-1. UE-HNFs-PCMT has the advantages of no need for complex equipment, easy operation, reusability, low detection cost, good portability, and environmental friendliness and can achieve urea detection in milk.

Enhanced electrocatalytic CO2 reduction into formate: Unleashing the effect of engineered bimetallic oxides supported on activated carbon

The excessive concentration of anthropogenic CO2 continuously harms the atmosphere. Consequently, deploying CO2 via the electrochemical reduction approach has become a highly sought-after research thrust area. In this study, a facile, one-pot solution combustion synthesis method (SCSM) was employed for the synthesis of various mixed-metal oxides supported on porous activated carbon (SnO2-CuO@AC). The prepared materials are characterized by analytical and spectroscopic techniques. Electrochemical studies were performed for the SnO2-CuO@AC catalyst to reduce CO2 into formic acid via an electrochemical approach. The in-depth properties of the designed catalysts were analysed by theoretical calculations using FT-IR and XRD data. The SnO2-CuO@AC exhibited improved electrochemical performance with a high current density of −10.77 mAcm−2, a low overpotential of −1.29 V, a lower Tafel slope value of 100 mV/dec. The faradaic efficiency for formic acid was 78.8 % at 1.3 V vs. RHE, with high stability for 9 h. The presence of coordinated active sites and oxygen vacancies, and a lower Tafel slope, also endorses CO2 adsorption and activation, faster electron transfer and boosts CO2 reduction. The significant reactivity toward CO2 reduction is attributed to the intensity of interaction between CO2∗- and the electrocatalyst, followed by kinetic activation toward protonation to obtain the desired product.

Catalytic activity insight into sustainable Fe-hydroxyapatite application using an experimental design approach

Combining experimental design with advanced characterisation methods provides a valuable opportunity to deepen our understanding of catalytic processes and their underlying mechanisms. Here, a series of hydroxyapatite doped with Fe2+ at different molar loadings noted HAP-FeX% (X = 1; 5.5 and 10; Ca/Fe molar ratio) were elaborated using a one-pot synthesis method. Characterization of these catalysts by various techniques such as ICP, BET/BJH, TGA/DSC, XRD, Raman, UV–visible, TPD-NH3, SEM, and TEM revealed substantial Fe2+ oxidation during synthesis, inducing changes in the morphological and physical-chemical characteristics of HAP caused by Fe3+/Ca2+ substitution. Furthermore, the synthesis produced nanoparticles (approximately 0.30 nm in size) on the hydroxyapatite surface, resulting from the precipitation of Fe/O phases. The catalysts exhibited good catalytic performance in methylene blue (MB) degradation through the photo-Fenton process (95 %). The Ca/Fe molar ratio = 8.8 %, [H2O2] = 2.8 mmol L−1, and pH = 8.8 were optimized using the design of experiments (DOE) via response surface methodology (RSM). A mathematical model was developed to determine the influence of the Ca2+/Fe3+ substitution and the Fe/O phase on the catalytic activity. The results revealed the role of the Fe/O phase in the reaction initiation and the surface modification induced by Ca2+/Fe3+ substitution to facilitate the reaction chain.

Urea-induced low crystallization of Rh nanoparticles for efficient H2 production

Developing highly efficient catalysts for the hydrogen evolution reaction (HER) is crucial for advancing renewable hydrogen energy technologies. Heterophase nanomaterials have shown great promise in catalysis, owing to the synergistic effect among various phases and the abundance of active sites located at the phase boundaries or interfaces. However, achieving precise control over these phase structures during synthesis remains a significant challenge. In this work, we explored a one-pot synthesis method for amorphous/crystalline heterophase Rh nanoparticles, with crystallinity tunable by adjusting the quantity of urea and reaction duration. Due to the increased electrochemical active sites, enhanced electron transport, the resulting amorphous/crystalline heterophase Rh exhibits superior HER activities in both acidic (with an overpotential of 27 mV) and alkaline media (with an overpotential of 21 mV), surpassing that of commercial Pt/C and crystalline Rh. Theoretical calculations indicate that the amorphous/crystalline structure reduces the kinetic barrier for water splitting and optimizes adsorption free energy of hydrogen (ΔGH∗), thereby enabling the catalyst to exhibit significantly enhanced HER performance. This exploration offers a valuable reference for designing amorphous/crystalline heterophase structures and demonstrates the great potential of phase engineering strategy in the development of electrocatalysts.

In situ-grown nitrogen-sulfur co-doped carbon nanotubes encapsulated with FeS particles as cathode materials for zinc-air batteries

Transition metal sulfides as ideal oxygen reduction reaction (ORR) catalysts have great potential to regulate multiple reaction pathways and understand their corresponding internal reaction mechanisms at cathode in zinc-air batteries (ZABS), effectively. This work adopted a facile one-pot synthesis method based on chemical vapor deposition (CVD), which utilizes the synergistic effect of zeolite imidazolium ester skeleton (ZIF-8) and polypyrrole (PPY) to grow nitrogen-sulfur co-doped carbon nanotubes (NS-CNT) in the shape of colonic with a relatively uniform size and encapsulated with FeS nanoparticles as the main active sites. The synthesized purpose catalyst noted as FeS-NS-CNT-900, in which that the FeS nanoparticles were tightly encapsulated in carbon nanotubes, and this special structure ensures that the FeS particles do not detach during the reaction, thus greatly enhancing their electrochemical activity and stability. As expected, the FeS-NS-CNT-900 catalyst exhibited a half-wave potential of 0.877 V which is higher than that of commercial platinum charcoal (0.847 V), at 0.1 mol KOH. More importantly, the formation of abundant FeS catalytic active sites, the optimal conditions for NS-CNT growth, and the covered mechanisms of the enhanced ORR reaction activity of FeS-NS-CNT-900 were thoroughly investigated. Additionally, whileFeS-NS-CNT-900 was used as an air cathode material for the assembly of a zinc-air battery, it exhibited a peak power density and specific capacity of 123 mW cm−2 and 785.81 mA h g−1, respectively, which were significantly better than that of platinum-carbon cathode (92.8 mW cm−2 and 740.4 mA h g−1). And surprisingly, the battery with FeS-NS-CNT-900 cathode exhibited (delivered/showed) a high cycle stability of 260 h at 5 mA cm−2. Conclusively, present work provides a feasible method for in situ growth of sulfur and nitrogen co-doped carbon nanotube encapsulated transition metal sulfide nanoparticle catalysts, which may pave a new avenue for the preparation of high ORR performance air cathode material for ZABS.

Photocatalytic CO2 Reduction to Solar Fuels by a Chemically Stable Bimetallic Porphyrin-Based Framework.

Porphyrin-based photocatalysts have emerged as promising candidates for facilitating carbon dioxide (CO2) reduction due to their exceptional light-harvesting properties. However, their performance is hindered by complex synthesis procedures, limited structural stability, inadequate CO2 activation capabilities, and a lack of comprehensive structure-property relationships. This study investigates the performance of a porphyrin-based bimetallic framework, [Cu(TPP)Cu2Mo3O11] (TPP = tetrapyridylporphyrin), termed MoCu-1 for photocatalytic CO2 reduction. In addition to its straightforward one-pot synthesis method, the framework shows remarkable chemical stability, particularly notable in alkaline reaction conditions, making it a compelling option for sustainable catalytic applications. By harnessing the superior photoabsorption properties of the porphyrin linker and the abundance of catalytic sites provided by the bimetallic structure, this framework exhibits the potential for enhancing CO2 reduction efficiency. MoCu-1 demonstrates excellent activity in converting CO2 into CO, achieving a maximum yield of 3.21 mmol g-1 with a selectivity of ∼93%. We unravel the intricate interplay of structural features and catalytic activity through systematic characterization techniques and an in situ diffuse reflectance Fourier transform study, which provided insights into the mechanism governing CO2 conversion and was supported by density functional theory calculations. This work contributes to advancing our understanding of photocatalytic processes and offers guidance for designing robust materials for CO2 utilization in renewable energy applications.

Cerium-Organic Framework UiO-66(Ce) as a Support for Nanoparticulate Gold for Use in Oxidation Catalysis.

An optimised synthesis of the metal-organic framework (MOF) UiO-66(Ce) is reported using a modulator-free route, yielding ~5 g of material with high crystallinity and 22% ligand defect. Two methods developed for loading gold nanoparticles onto the MOF. The first uses a double-solvent method to introduce HAuCl4 onto UiO-66(Ce), followed by reduction under 5% H2 in N2, while the second is a novel one-pot method where HAuCl4 is added to the synthesis mixture, forming Au nanoparticles within the pores of the UiO-66(Ce) during crystallisation. Analysis using powder X-ray diffraction (PXRD), nitrogen adsorption isotherms, transmission electron microscopy and small-angle X-ray scattering (SAXS) reveals that the two-step double-solvent method yields gold crystallites on the external surface of the MOF particles that are visible by PXRD. In contrast, the one-pot method forms smaller gold crystallites, with a distribution of sizes centred on ~4 nm diameter as seen by SAXS, with evidence from PXRD for the smallest particles being present within the MOF structure. The Au-loaded UiO-66(Ce) materials are evaluated for the catalytic oxidation of vanillyl alcohol to vanillin at 60 °C. Our findings indicate that incorporating Au nanoparticles via the one-pot synthesis method, enhances redox activity, achieving 43% conversion and 90% selectivity towards vanillin.

Construction of PANI@V2O5-ZnIn2S4 Z-scheme heterojunction photocatalysts for highly effective degradation of industrial dyes and antibiotics

From an environmental protection, the highly effective photodegradation of organic dyes and antibiotics in wastewater needs to be solved expeditiously. Fortunately, the construction of Z-scheme heterojunction for photocatalytic degradation is considered to be an effective method. In this paper, after the fabrication of V2O5 by calcination and loading of PANI on its surface by aniline polymerization, a novel PANI@V2O5-ZnIn2S4 composite photocatalysts prepared by one-pot synthesis method and used for the degradation of industrial dyes (crystalline violet, Congo red) and antibiotics (tetracycline-TC). Under the optimal photodegradation conditions, the 30 wt% PANI@V2O5-ZnIn2S4 heterojunction photocatalysts resulted in more than 95 % degradation of CR, CV and TC solutions after 32 min of irradiation. The optimal photodegradation conditions of the simulated pollutants in real aqueous environments catalyzed by the as-synthesized photocatalysts were explored via response surface methodology (RSM). Multiple material characterization techniques, such as FESEM, HRTEM, XPS valence band spectrum, photoelectrochemistry, radical trapping experiments and EPR tests verified the existence of Z-scheme heterojunction. Especially, the coating of conductive PANI on the V2O5 surface can further improve the separation and transfer efficiency of photogenerated charge carriers, thereby enhancing the photocatalytic activity of the semiconductor photocatalyst. This study will provide a robust option for the design and construction of Z-scheme heterojunctions photocatalysts for environmental pollution remediation.

One Pot Synthesis of Alkyl Nitriles

A one-pot synthesis method to produce alkyl nitriles using the corresponding aliphatic carboxylic acid has been developed. The process involves treating the aliphatic acid with thionyl chloride to obtain the corresponding aliphatic acid chloride, which is then further treated with anhydrous ammonia gas to yield the respective aliphatic acid amide. The intermediate corresponding amide is dehydrated with thionyl chloride to obtain alkyl nitrile with a quantitative yield.

Enhancing dental remineralization and antimicrobial properties with Ag nanoparticles-loaded mesoporous bioactive glass in reinforced dental resins: A one-pot synthesis approach

Secondary caries develops between the dental filling and the tooth surface because the filling materials lack antibacterial properties. In our study, we successfully created Ag-mesoporous bioactive glass (MBG) with antibacterial properties using a one-pot synthesis method and modified its surface with bisphenol A-glycidyl methacrylate (Bis-GMA). We tested the antibacterial and remineralizing abilities of the resin matrix. The 10 wt% Bis-GMA-Ag-MBG composite resin showed excellent remineralizing and antibacterial abilities, and the presence of Ag nanoparticles did not affect these properties during the photocuring process. Cell viability experiments confirmed that the 10 wt% Bis-GMA-Ag-MBG composite resin is biocompatible. This study emphasizes the potential of Bis-GMA-Ag-MBG (10 wt%) as a new dental composite resin with bioactive, remineralizing, and antibacterial properties, addressing the critical need for durable and preventive dental materials against secondary caries.

In vitro and in silico DNA interaction studies of a series of 3-carboxamide-4-quinolone derivatives prepared from an one-pot stepwise synthesis (OPSS) method

The 3-carboxamide-4-quinolone framework is highly regarded in the fields of Medicinal and Bioorganic Chemistry mainly due to its widespread bioactive properties. This versatile scaffold allows for the development of compounds with various pharmacological effects. In this sense, the present work explores a novel one-pot stepwise (OPPS) method for synthesizing fifteen 3-carboxamide-4-quinolone derivatives, some of which exhibit antitumor profiles in previous works. These compounds were synthesized using the OPPS methodology with yields ranging from 35 % to 88 %, streamlining the synthetic process and reducing solvent usage. Furthermore, interaction studies with calf-thymus DNA were done by UV–Vis absorption and steady-state fluorescence measurements combined with molecular docking calculations. Compounds 10a-b, 10d-g, 10k, and 10n were selected for the CT-DNA interaction assays, from which it was possible to demonstrate their DNA-binding property through peripheral secondary interactions. Molecular docking results suggested van der Waals and hydrogen bonds as the main binding forces responsible for the interactive profile between the nucleobases and the 3-carboxamide-4-quinolone derivatives. All these results unveiled promising insights into their role as DNA replication inhibitors, highlighting their potential in developing antiproliferative drugs.

Development of MnWO4:Ag nanodilute magnetic semiconductors with tunable magnetic and optoelectronic properties

The bandgap engineered MnWO4 nanoparticles doped with Ag were developed using a facile one-pot synthesis method. The impurity doping concentration of Ag was varied from 1 to 5 wt percentages to tune the interactions between manganese tungstate and silver ions to obtain desirable magnetic and optoelectronic properties. The structural properties of the MnWO4 particles with various concentrations of Ag were investigated using X-ray diffraction. The optical properties of the pristine and Ag-doped MnWO4 particles were determined using UV‒Vis and photoluminescence spectroscopy. The impurity concentration-dependent structural transformations and changes in the vibrational modes, lattice dynamics, electronic transitions and optoelectronic properties of the prepared materials were analyzed using Raman spectroscopy. The topology, morphology and elemental analysis of the synthesized nanoparticles were elucidated using HRTEM, SAED, SEM and EDX techniques. The magnetic properties of the MnWO4:Ag nanoparticles were measured using a vibrating sample magnetometer (VSM). The obtained results suggested that Ag-doped MnWO4 nanosystems show enhanced and tunable magnetic properties suitable for nanodilute magnetic semiconductor (nDMS) applications. The presented work opens a range of possibilities for the development of advanced materials with applications in optoelctronics, nanomedicine, energy-efficient electronic devices and energy conversion.