We report a numerical study on the mixed electroosmotic and pressure-driven transport of an Oldroyd-B fluid through a microchannel having high surface charge modulated walls. We report an augmentation in the net-throughput for higher surface potentials and thinner electrical double layers. We have shown that the enhanced fluid elasticity is responsible for the generation of asymmetric flow structures inside the micro-channel. A great augmentation in the streaming current is achieved by increasing the strength of surface potential or reducing the thickness of the electrical double layer. By accounting for the nonlinear fluid behavior and nonlinear nature of ionic transport, we show that the electrochemical parameters such as zeta potential, the relative strength of the applied electric field and pressure gradient, followed by the thickness of the electrical double layer, contribute largely toward altering the net-throughput inside the micro-channel. We observe the formation and shifting of re-circulation zones due to the complex interaction of the fluid rheology and asymmetric surface potential at the channel walls. The results of the present study hold the key toward understanding the complex fluid flow mimicking bio-fluid transport in the microfluidic platform under the mixed influence of electroosmotic forcing and pressure gradient.