Depression In Old Age Research Articles

Senior Theater Projects: Enhancing Physical Health and Reducing Depression in Older Adults.

The aim of this study was to clarify the effects of a theater training program intervention on the physical and cognitive functions in community-dwelling older people. Of the 59 participants, 30 were the control group, and 29 were the intervention group. We assessed physical and mental/cognitive functions and criteria of physical frailty. Statistical analysis showed that the usual walking speed (UWS) (p < 0.01), grip strength (GS) (p < 0.01), and GDS-15 (p < 0.05) improved significantly in the intervention group, whereas the Geriatric Depression Scale short-form (GDS-15) (p < 0.01) worsened significantly in the control group. Cognitive function was not significantly different between the two groups. Physical frailty was unchanged in the control group but significantly improved in the intervention group (p < 0.05), and a significant interaction was found for GDS-15 in ANOVA (F = 5.76, p < 0.05). The results of this study suggest that a theater intervention for the older adults may be effective in preventing and improving depression and physical frailty in old age.

(Interfering) Cortical mechanisms of standing balance and cognition in old-age depression: A functional near-infrared spectroscopy (fNIRS) study

Major depressive disorder in old age can cause changes in the cerebral cortex that might lead to postural imbalance and thus increase fall risk. We aim to examine cortical activation during standing balance in depressed older patients compared to healthy controls and to determine how an additional cognitive task affects this activation. Eleven older patients (age ≥65 years) diagnosed with major depressive disorder and sixteen age-matched healthy controls participated in the study. Functional near-infrared spectroscopy (fNIRS) was used to assess cortical activation of the prefrontal (PFC) and motor (MC) cortex during standing balance with eyes closed under single and dual task (counting backwards). The present study generally revealed tendencies in the MC – and partly the PFC too – for more activation whilst balancing compared to baseline. Also, in the MC, patients tended to show more cortical activation compared to controls and dual task tended to elicit more activation. The results suggest that depressed older patients, to compensate for their illness, may require increased cortical activation to perform motor and cognitive tasks than healthy controls. The absence of PFC activation in the main analyses may be related to the small participant number and possibly to too simple task conditions.

Exploring the interplay between control beliefs, cortisol levels and depression in old age: Is feeling in control always beneficial?

ObjectivesWe investigated the relationship between levels of mastery/conscientiousness and cortisol response in older adults, considering depression status. Based on former research we hypothesized that high and low and not intermediate levels of mastery/conscientiousness would correlate with high cortisol response, particularly in depressed individuals. MethodsData from the Netherlands Study of Depression in Older Persons (NESDO) were analyzed. Respondents were categorized into low, intermediate, and high mastery/conscientiousness groups. Regression analyses examined associations between mastery/conscientiousness and evening cortisol (N=412) and cortisol awakening response (N=370), stratified by depression status. Histograms were created to visualize the results. ResultsNo significant associations were found between mastery/conscientiousness and cortisol response, irrespective of depression status. ConclusionsOur findings do not suggest that low or high levels of mastery/conscientiousness increase stress in depressed older adults compared to those with intermediate levels, nor do they differ from non-depressed individuals.

활동적 노화가 노년기의 우울 및 인지에 미치는 영향

The purpose of this study was to analyze how active aging affects depression and cognition in old age. For this purpose, the raw data from the 『2020 Survey on the Status of the Elderly』 were reanalyzed using descriptive statistics, t-Test, Pearson correlation analysis, and hierarchical multiple regression analysis. The main results were as follows : 1) The average depression score of the subjects was 3.37, the average cognition score was 24.32, and the average active aging score was 2.01. 2) The participating group in social activities had lower depression and higher cognitive function than the non-participating group. 3) As a result of hierarchical multiple regression analysis of depression, in Model 1, gender, education, health status, household income, and marital status were significant factors affecting depression, and the explanatory power of the model was 19.4%. In Model 2, gender, education, health status, household income, marital status, and active aging were significant factors of depression in old age, and the explanatory power of Model 2 was 19.8%, 0.4% more than Model 1. 4) In the hierarchical multiple regression analysis of cognition, age, education, health status, household income, and household type were significant factors affecting cognition in Model 1, and the explanatory power of the model was 17.4%. In Model 2, age, education, health status, household income, household type, and active aging were significant factors, and the explanatory power was 18.9%, 1.5% higher than Model 1. Based on the above results, several suggestions were added for elderly welfare policies and practices.

활동적 노화가 노년기의 우울 및 인지에 미치는 영향

The purpose of this study was to analyze how active aging affects depression and cognition in old age. For this purpose, the raw data from the 『2020 Survey on the Status of the Elderly』 were reanalyzed using descriptive statistics, t-Test, Pearson correlation analysis, and hierarchical multiple regression analysis. The main results were as follows : 1) The average depression score of the subjects was 3.37, the average cognition score was 24.32, and the average active aging score was 2.01. 2) The participating group in social activities had lower depression and higher cognitive function than the non-participating group. 3) As a result of hierarchical multiple regression analysis of depression, in Model 1, gender, education, health status, household income, and marital status were significant factors affecting depression, and the explanatory power of the model was 19.4%. In Model 2, gender, education, health status, household income, marital status, and active aging were significant factors of depression in old age, and the explanatory power of Model 2 was 19.8%, 0.4% more than Model 1. 4) In the hierarchical multiple regression analysis of cognition, age, education, health status, household income, and household type were significant factors affecting cognition in Model 1, and the explanatory power of the model was 17.4%. In Model 2, age, education, health status, household income, household type, and active aging were significant factors, and the explanatory power was 18.9%, 1.5% higher than Model 1. Based on the above results, several suggestions were added for elderly welfare policies and practices.

노년기 우울과 삶의 만족도의 관계에서 사회활동 참여의 매개 및 사회적지지의 조절된 매개효과

This study aims to empirically verify the mediating effect of social activity participation and the moderated mediating effect of social support in the relationship between depression and life satisfaction in old age. For this purpose, raw data from Lee et al.'s (2020) were re-analyzed. A total of 10,097 subjects were used for the analysis, and data analysis was performed using SPSS 21.0 for Windows and SPSS PROCESS macro 4.2 version. For statistical analysis, Pearson correlation analysis, mediating effect, moderating effect, and moderated mediating effect were analyzed. The main results from the results were as follows: First, depression was negatively correlated with life satisfaction in old age, social activity participation, and social support. Social activity participation and social support was positively correlated with life satisfaction. Second, participation in social activities had a mediating effect in the relationship between depression and life satisfaction. Third, social support significantly moderated the relationship between depression and social activity participation. Fourth, a significant moderating effect of social support was confirmed in the relationship between depression and life satisfaction. Fifth, social support was found to moderate and mediate the effect of depression on life satisfaction through participation in social activities. Finally, based on the above research results, some suggestions were added for education and welfare services for the elderly and for follow-up research.

Prevention of depression in old age: individual and societal relevance

Prevention of depression in old age: individual and societal relevance

The longitudinal reciprocal association between depression and physical activity in old age: The role of lifetime cumulative adversity

ObjectiveThis study investigated the reciprocal nature of the depression–physical activity relationship with reference to lifetime cumulative adversity (LCA), over a period of 8 years across 5 time points in aging. MethodBased on data from the Survey of Health Ageing and Retirement in Europe (SHARE), the sample included 21,996 participants between the ages of 50 and 100 years (M = 65.5, SD = 9.1). The analysis was designed as a random intercept cross-lagged panel model. The trajectories measured were depression and physical activity. The independent variable, LCA, was created by the sum of stressful events, and the analyses controlled for background characteristics. ResultsThe findings revealed that physical activity significantly reduced the risk for depression at two time points along the study, whereas depression significantly reduced future physical activity during the entire period examined. Further, a higher level of LCA was associated with lower baseline levels of physical activity and higher levels of depression (β = −0.04, p < 0.001; β = 0.12, p < 0.001; respectively). ConclusionsThe results support a bidirectional relation between physical activity and depression, with stronger evidence for depression to physical activity. Interventions targeting the vulnerable population with a history of cumulative adversity, and utilizing techniques to mitigate depressive symptoms, may help to decrease the risk for physical inactivity and other health consequences in this population.

Profiles of met and unmet care needs in the oldest-old primary care patients with depression – results of the AgeMooDe study

BackgroundUnmet care needs have been associated with an increased risk of depression in old age. Currently, the identification of profiles of met and unmet care needs associated with depressive symptoms is pending. Therefore, this exploratory study aimed to identify profiles of care needs and analyze associated factors in oldest-old patients with and without depression. MethodsThe sample of 1092 GP patients aged 75+ years is based on the multicenter study “Late-life depression in primary care: needs, health care utilization and costs (AgeMooDe)”. Depression (i.e. clinically meaningful depressive symptoms) was determined using the Geriatric Depression Scale (GDS) (cutoff score ≥ 4). Needs of patients were assessed using the Camberwell Assessment of Need for the Elderly (CANE). Associated sociodemographic and clinical factors were examined, and latent class analysis identified the need profiles. ResultsThe main result of the study indicates three need profiles: ‘no needs’, ‘met physical needs’, and ‘unmet social needs’. Members of the ‘met physical needs’ (OR = 3.5, 95 %-CI: 2.5–4.9) and ‘unmet social needs’ (OR = 17.4, 95 %-CI: 7.7–39.7) profiles were significantly more likely to have depression compared to members of the ‘no needs’ profile. LimitationsBased on the cross-sectional design, no conclusions can be drawn about the causality or direction of the relationships between the variables. ConclusionsThe study results provide important insights for the establishment of needs-based interventions for GPs. Particular attention should be paid to the presence of unmet social needs in the oldest-old GP patients with underlying depressive symptoms.

Effectiveness of Pet Therapy on Depression among Elderly Residing In Selected Old Age Homes at Bangalore

Introduction: Depression is prevalent among elderly individuals, significantly affecting their quality of life. Pet therapy, or animal-assisted therapy, is gaining attention as a potential intervention to alleviate these symptoms. This study aims to assess pet therapy's impact on depression among elderly residents in selected Bangalore old age homes. The findings suggest implications for geriatric care and mental health interventions, underscoring pet therapy's potential as a complementary approach to enhancing emotional well-being in institutional settings. Background of the study: Depression in seniors can result from factors like bereavement, retirement, social isolation, health issues, or traumatic events such as strokes or falls. Prompt identification and treatment are crucial to alleviate symptoms and prevent severe outcomes like physical illness, strained relationships, neglect, self-harm, or suicide. Late-onset depression in old age is a significant aspect of geriatric major depression, differing from early-onset depression experienced earlier in life. Objectives of the Study: 1. To evaluate the level of depression in elderly individuals before undergoing pet therapy. 2. To assess the effectiveness of pet therapy in reducing depression among elderly individuals post-intervention. 3. To examine the association between depression levels and selected demographic variables among elderly residents in selected old age homes in Bangalore. Methods: This quasi-experimental study utilized a non-equivalent control group design with 60 depressed patients (30 in each group) selected via convenient sampling. Data collection involved a structured questionnaire for socio-demographic details and Beck’s Depression Inventory to measure depression levels. Pet therapy was administered exclusively to the experimental group for 14 days after the pre-test, followed by a post-test using the same scale for both groups. Analysis included descriptive and inferential statistics. Results: Pre-test results showed the experimental group had 40% severe and 6.7% extreme depression, while the control group had 40% moderate and 10% extreme depression. Post-test results indicated no extreme depression in the experimental group, with 40% showing moderate depression. In contrast, the control group had 36.7% moderate and 10% extreme depression. The experimental group showed a significant reduction in depression levels from pre-test to post-test (t=16.53*, p &lt; 0.05). Additionally, post-test scores differed significantly between the experimental and control groups (t=2.04*, p &lt; 0.05), confirming hypothesis H1. Conclusion: Pet therapy integration into nursing practice for elderly patients with depression emphasizes its efficacy in reducing depression levels, highlighting its importance in clinical settings.

Associations between depressive symptoms, glial fibrillary acid protein, and cognitive decline in a population‐based study

AbstractBackgroundDepressive symptoms are a known risk factor for dementia, and higher concentrations of glial fibrillary acid protein (GFAP) is associated with a faster rate of cognitive decline. However, it is unknown whether the two risk factors increase the risk of cognitive decline additively.MethodThis investigation is based on 1,169 participants from the Chicago Health and Aging Project (CHAP), a population‐based cohort study, who completed at least two cognitive performance assessments with baseline serum GFAP measurement. Depressive symptoms were determined utilizing a modified version of the Center for Epidemiologic Studies‐Depression Scale. A composite global cognitive function score was calculated using cognitive performance testing. Linear mixed effects regression models were conducted to examine the association of depressive symptoms and GFAP concentrations on baseline global cognitive function and the annual rate of cognitive decline. Regression models also adjusted for age, race, sex, education, chronic medical conditions, and their interactions with time.ResultOur study sample consisted of 60% African American participants and 63% female participants and had an average age of 77 (SD = 6.0) years. In our sample, 21% had few depressive symptoms (0‐2), and the remaining 79% had more depressive symptoms (3‐10). We found a statistically significant interaction between depressive symptoms and GFAP (β = ‐111 (SE = .039), p = .005) on global cognitive function. Stratified analysis showed that the associations between the log of GFAP and global cognitive function were statistically significant for participants with few (0‐2) depressive symptoms (β = ‐.223 (SE = .087), p = .010) and more (3‐10) depressive symptoms (β = ‐.781 (SE = .198), p = .000). Statistically significant associations were also observed between the log of GFAP and global cognitive decline for participants with few (β = ‐.069 (SE = .017), p = .000) and more (β = ‐.100 (SE = .040), p = .012) depressive symptoms.ConclusionOur findings show additive effects of depressive symptoms in the association between the log of GFAP with baseline global cognitive function and rate of cognitive decline. Prevention and treatment of depression in old age can significantly impact the risk of progressive cognitive decline, especially among individuals with higher concentrations of GFAP.

FC34: Cognitive reserve and depressive burden in older adults: variation according to reserve measurement

Objective:Individual differences in the timing of dementia have been attributed to cognitive reserve (CR), thought to reflect lifelong engagement in stimulating experiences, which provide resilience against brain pathology. In older adults, dementia and depression are closely related, and some studies have linked CR with depression risk in old age. It is unclear if different ways of operationalizing CR exhibit similar association with old-age depression. We examined the association of two measures of CR with depressive burden in older adults: activity-based CR, capturing engagement in stimulating activities using proxy variables, and residual-based CR, indicating residual variance in cognition, not explained by the brain status.Methods:We used data on 354 adults aged 60+ from the Swedish National Study on Aging and Care in Kungsholmen, followed for 15 years. Residual-based reserve was computed from a regression predicting episodic memory with a brain-integrity index incorporating six structural neuroimaging markers (white- matter hyperintensities volume, whole-brain gray matter volume, hippocampal volume, lateral ventricular volume, lacunes, and perivascular spaces), age, and sex. Activity-based reserve incorporated education, work complexity, social network, and leisure activities. Depressive burden was captured over the follow- up with the Montgomery-Åsberg Depression Rating Scale and time until clinically relevant level of symptoms (&gt;6) was modelled using Cox proportional hazard models.Results:Preliminary results indicate that, upon minimal adjustment (age, sex, brain integrity status), top tertiles (ref: bottom tertile) of both activity-based (HR: 0.77; 95% CI: 0.61-0.98) and residual-based CR (HR: 0.62; 95% CI: 0.44-0.98) were associated with a lower risk of depressive burden onset over 15 years. Upon further adjustment for anthropometrics, health behaviors, and chronic disease burden, the association of activity-based CR was attenuated, whereas residual-based CR preserved its effect on depressive burden (HR [fully adjusted model]: 0.59; 95% CI: 0.40-0.88). Next steps include evaluating the ability of reserve measures to attenuate the association of brain integrity with depressive burden using interaction analysis.Conclusion:Preliminary findings suggest that CR may be linked with depression development in older adults, although the association may vary depending on measurement of reserve. Association of activity- based reserve may be attributed to somatic disease pathways.

Predicting depression in old age: Combining life course data with machine learning

With ageing populations, understanding life course factors that raise the risk of depression in old age may help anticipate needs and reduce healthcare costs in the long run. We estimate the risk of depression in old age by combining adult life course trajectories and childhood conditions in supervised machine learning algorithms. Using data from the Survey of Health, Ageing and Retirement in Europe (SHARE), we implement and compare the performance of six alternative machine learning algorithms. We analyse the performance of the algorithms using different life-course data configurations. While we obtain similar predictive abilities between algorithms, we achieve the highest predictive performance when employing semi-structured representations of life courses using sequence data. We use the Shapley Additive Explanations method to extract the most decisive predictive patterns. Age, health, childhood conditions, and low education predict most depression risk later in life, but we identify new predictive patterns in indicators of life course instability and low utilization of dental care services.

Association of physical activity and stress reactivity with depression in elderly hypertensive population: A cross-sectional study from Eastern India.

Depressive disorder poses an increased risk for sudden cardiac death in elderly population with existing comorbidities. Also, few international studies suggest the association of decreased stress reactivity with symptoms of depression in old age. Our cross-sectional study has attempted to explore the relationship of daily exercise and stress reactivity with depression in elderly individuals with hypertension. Depression was assessed using Hamilton depression rating scale or HAM-D. The physical activity was assessed using the global physical activity questionnaire (GPAQ), developed by WHO. Stress reactivity is calculated from various cardiovascular parameters. The relationship of physical activity and stress reactivity scores on depression was explored using regression analysis. The prevalence rate of depressive symptoms in elderly hypertension population was around 40.2%. Significantly lower reactivity scores (P = 0.032) to deep breathing were evident in elderly hypertension population. After proper adjustment of the confounding factors, regression analysis depicted that decreased physical activity (Odds ratio = 4.48; 95% Confidence interval = 2.32-7.69) resulted in heavy risk of developing depressive symptoms besides old age and low educational status. Our findings suggest that low physical activity leads to the development of depressive symptoms and decreased stress reactivity among elderly hypertensive patients.

Evidence-based cognitive retraining in elderly depressives

Background: Aging is a normal biological process, and its dynamic changes are beyond the control of human beings. The role of depression, fear, and anxiety in old age is preoccupied with unhappy thoughts, and loneliness leads to early deterioration in their cognitive performance which makes it difficult to perform daily activities and hence affects their quality of life. Aim: The present study was done to assess the effectiveness of cognitive retraining in elderly depressives and its effect on their quality of life. Materials and Methods: The study was done on a sample of 20 depressive elderly patients with an age range above 60 years diagnosed with ICD-10 criteria. The study was pre- and post-intervention, and the sampling method was purposive. Firstly to screen handedness, Annet's hand preference battery was used, to assess the depression in elderly, the geriatric depression scale was done, and for attention and memory, Digit Span Test (WAIS-R) and Wechsler Memory Scale (WMS) were administered, respectively. WHO-QOL BREF was done to know the quality of life of the patient. After preassessment, cognitive retraining tasks were introduced to the patients. A total of 15 sessions were taken within three months of follow-up and after that to evaluate the efficacy of an outcome of the cognitive retraining, post-assessment was done. Results: Improvement was noticed in elderly depressive patients in the area of cognitive domain, i.e., attention, recognition, shifting, fixedness, recall, and planning which showed improvement in quality of life and daily activities. Conclusion: In the remediation of cognitive deficits, cognitive retraining plays a very important role, and it helps the elderly population to live their life healthily and hence enhance their coping skills.

2.P. Workshop: Mental health in old age

Abstract Mental health conditions affect people throughout the world, at all ages. Additionally, mental health conditions are associated with social health and with physical health. Applying a body - mind concept of health framework to mental health conditions can add to existing knowledge on mental health conditions in old age. We organized this workshop based on the understanding that mental health and mental health conditions differ according to individual and community factors. The data presented propose that mental health plays a critical role in old age, and as such, deserves greater attention to further understand how who might be at risk for mental health conditions in old age. More specifically, we focus attention on physical health, socio-economic and environmental factors that affecting mental health in old age. First, based on the Survey of Health, Ageing and Retirement in Europe (SHARE), the author examines a reciprocal relationship between functional disability and depression over time and further proposes the potential role of social participation in alleviating depression in old age. Second, mental health of older persons with migrant children will be analyzed across different European regions. Third, based on data from the SHARE study, retirement as a major life event with long term consequences on depression risk is identified. Fourth, the study examines how financial adversity in old age is associated with mental health among older adults who are living in a rural area in Germany. Finally, the associations between loneliness and mental health among Spanish older adults during the COVID-19 pandemic are presented. Based on the presentations, research gaps and promising areas of research, practice, and policy focused on promoting mental health in old age and across the lifespan will be discussed with participants. Key messages • Migration of children, functional disability and financial adversity are related to old age depression. • Loneliness in old age is associated with mental health conditions.

Clinical picture and differential diagnosis of depression in old age

Depression in old age is often underdiagnosed, although it is the leading mental health problem at this age. The significance of assessment and adequate treatment of depression among elderly patients cannot be overstated, since it significantly impairs the quality of life, increases morbidity and mortality in many of the chronic disease groups. In addition, it is a primary risk factor in completed suicide, which occurs up to three times more often among elderly than in other age groups. In our non-systematic (narrative) summary study, we briefly review the clinical picture and differential diagnosis of depression in elderly patients, as well as the main aspects of screening and treatment. The clinical characteristics and the pathology of the disease at this age raise a number of methodological questions that could be the subject of further empirical studies. Orv Hetil. 2023; 164(39): 1537-1543.

The factors associated with quality of life and depression score in adults aged 65 and over

Introduction: In recent years, there has been an increase in the number of elderly population with the improvement of living conditions and the acquisition of healthy life behaviors in Türkiye. In this study, it was aimed to evaluate the quality of life of the elderly and the affecting factors. Methods: Our study is planned with a descriptive and cross-sectional design. Quality of life of the participants was assessed using the World Health Organization Quality of Life-Old module (WHOQOL-OLD), whereas depressive symptoms were evaluated using the Geriatric Depression Scale. Results: Their mean total score on the WHOQOL-OLD module was 56.64 ± 15.57. The total quality of life score was found to be significantly lower among females, elderly, illiterate and those who lacked a regular monthly income, who perceived their health status to be worse than that in the previous year, who considered themselves very old and who suffered from chronic diseases (p ˂ 0.001). The mean score of the participants on the Geriatric Depression Scale was 14.59±5.27, whereas the frequency of depression was 56.5%. There was a negative and significant relationship between depression and quality of life scores (p˂0.001, r=0.658). Conclusion: In our study, the indicators, dimensions, and measurement of quality of life and levels of depression in old age are presented. Additionally, factors influencing the perceptions of aging among the elderly and the individual perspective on aging, as well as their associations with depression, are discussed. Keywords: Elderly, Aging, Quality of life, Depression, Perception of aging, Geriatric Depression Scale

The prevalence of depression and its associated factors among the geriatric age group living in the rural area of Wardha District Maharashtra: A cross-sectional study

Background: In India, the percentage of adults over 60 years is rising. Depression is the most prevalent neuropsychiatric condition. People live longer, and households are smaller and crowded, creating stress. These issues influence the mental health of elderly persons and can cause depression. Depression poses a serious threat to public health, especially for senior citizens and inhibits cognitive function and decreases the quality of life. The objective of this study is to determine the prevalence of depression and evaluate its relationship with sociodemographic factors among older people. Methods: Cross-sectional community research will be conducted in the Wardha district. The whole sample of elderly age groups will be examined using a semi-structured survey to identify the sociodemographic features and related risk factors for depression. Using a pre-tested survey called the short version of the Geriatric depression scale (GDS-15), the prevalence of depression in the geriatric age groups of both sexes will be assessed. Conclusions: Older people (those 60 years and older) play important roles in families and the workplace as volunteers. This study will help formulate policies that will inculcate old people to get an insight into how much mental health implications impact everyone, be it adolescents, middle-aged people, or old people. Its significance in public health will pave the road to include mental health screening of old people in non-governmental bodies like NGOs and other organizations like old age homes. Furthermore, the government should pay more attention to old-age depression in the current mental health program so that the burden of the disease can be overcome.

Association of Neighborhood Deprivation and Depressive Symptoms With Epigenetic Age Acceleration: Evidence From the Canadian Longitudinal Study on Aging.

Neighborhood deprivation and depression have been linked to epigenetic age acceleration. The next-generation epigenetic clocks including the DNA methylation (DNAm) GrimAge, and PhenoAge have incorporated clinical biomarkers of physiological dysregulation by selecting cytosine-phosphate-guanine sites that are associated with risk factors for disease, and have shown improved accuracy in predicting morbidity and time-to-mortality compared to the first-generation clocks. The aim of this study is to examine the association between neighborhood deprivation and DNAm GrimAge and PhenoAge acceleration in adults, and assess interaction with depressive symptoms. The Canadian Longitudinal Study on Aging recruited 51 338 participants aged 45-85 years across provinces in Canada. This cross-sectional analysis is based on a subsample of 1 445 participants at baseline (2011-2015) for whom epigenetic data were available. Epigenetic age acceleration (years) was assessed using the DNAm GrimAge and PhenoAge, and measured as residuals from regression of the biological age on chronological age. A greater neighborhood material and/or social deprivation compared to lower deprivation (b = 0.66; 95% confidence interval [CI] = 0.21, 1.12) and depressive symptoms scores (b = 0.07; 95% CI = 0.01, 0.13) were associated with higher DNAm GrimAge acceleration. The regression estimates for these associations were higher but not statistically significant when epigenetic age acceleration was estimated using DNAm PhenoAge. There was no evidence of a statistical interaction between neighborhood deprivation and depressive symptoms. Depressive symptoms and neighborhood deprivation are independently associated with premature biological aging. Policies that improve neighborhood environments and address depression in older age may contribute to healthy aging among older adults living in predominantly urban areas.