An experimental campaign is conducted to investigate the pressure drop during the restart of a heavy oil-water core-annular flow (CAF) from a stratified configuration in a polyvinyl chloride (PVC) horizontal pipe. The evolution characteristic of restart pressure drop along time is explored, and the effects of various factors including oil holdup (0.26-0.76), oil viscosity (1.0553-3.02 Pa·s), standstill period (0.5 & 1.0 h) and water cleaning superficial velocity (0.25-1.01 m/s) on maximum restart pressure drop are emphatically investigated. The results demonstrate that the restart process can be divided into decay and steady two stages. The maximum restart pressure drop generally increases along with the increase of oil holdup, oil viscosity, standstill period and water cleaning superficial velocity. Moreover, of all the measured variables, oil holdup and water cleaning superficial velocity have a significant influence on maximum restart pressure drop. The results obtained can provide a theoretical reference and practical guidance for the development of appropriate restart schemes for on-site shutdown pipelines.