Officinalis Research Articles

Anti-epileptic Activity of Rosmarinus offi cinalis Extracts with Male Rats Experiment

Rosmarinus offi cialis L., Lamiaceae, has been used to treat a range of illnesses in Iraq for decades and is regarded as a desirable species due to its medicinal properties and antioxidant properties. Aim of study: The main aim of this study was to study more about how the R. offi cialis L plant may help to reduce the negative eff ects of epilepsy. Materials and methods: To estimate the alteration of antioxidant enzymes and lipid peroxidation. Fifty male rats were split into fi ve groups: control (no additions), FeCl3 group, and the rest of the groups were fed R. offi cialis L. components (fl avonoid, glycoside, and alkaloids). Results: β-asecretase, Na and K levels raised in FeCl3 and other R. offi cialis compounds groups while. In contrast to the FeCl3 group and FeCl3 groups containing R. offi cialis L. plant components reduced fucose, vit-C, and Zn levels. In compared to the control group, the activity of oxidant enzymes and lipid peroxidation resulted in a signifi cant amount of glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) in the FeCl3 group; however, R. offi cialis components increased the levels of MDA and SOD, whilst reducing GSH, and CAT. Conclusion: R. offi cinalis extraction components have an eff ects on -asecretase, fucose, and vit-C in male rats, in addition to antioxidant activity and may increase or decrease lipid peroxidation while also improving antioxidative enzymes significantly. The active components of the R. offi cinalis L. plant might be used as one of the next generation of anti-epileptic medications.

Evaluation of anti-helmintic activity of Zingiber officinale roscoe extract on Fasciola hepatica miracidia In vitro

Aims: The control of fascioliasis has depended on the utilization of a predetermined number of anthelmintic drugs. Nonetheless, the resistance of antifasciolid is presently boundless, and there is a need for potential drug properties of medicinal plants as new medications against Fasciola spp. to interrupt the parasite transmission. Materials and Methods: This investigation is meant to assess the potential anti-fasciolicide impacts of Zingiber officinale roscoe hydroalcoholic extract against the Fasciola miracidia. The eggs of Fasciola hepatica were gathered from the livers contaminated goats and sheep and washed 20 times with chlorine-free water, and afterward incubated at different pH, temperature, and light density for embryonic development. Concentrated miracidia of Fasciola spp. were incubated at different concentrations (2, 5, and 10 μg/mL) of hydroalcoholic extract of Z. officinale at different time intervals. The data were analyzed using the ANOVA statistical test. Results: The extract at different concentrations showed antifasciolid effects in comparison to triclabendazole. This braking action was dose-proportional and further related firmly to the disclosure time ( P

Evaluation of wound healing and anti-inflammatory activities of a herbal ointment consisting of Althaea officinalis, Lavandula angustifolia, and Rosa x damascena in animal excision wound model

Evaluation of wound healing and anti-inflammatory activities of a herbal ointment consisting of Althaea officinalis, Lavandula angustifolia, and Rosa x damascena in animal excision wound model

Suplementação aguda de substrato de gengibre não aumenta o metabolismo em repouso e durante o exercício

This study evaluated the acute effect of ginger (Zingiber officinale) supplementation (3.0 g) on metabolism. For this, 12-male physically active college were measured (22.8±3.3 yrs.; 79.4±12.5 kg; 1.8±0.1 m; 25.4±3.0 kg/m2; 16.9±3.1 %BF). Three-hours after supplementation (ginger or placebo) (Baseline – lasting 30-min) the resting metabolic rate (RMR), oxygen uptake (VO2), carbon dioxide production (VCO2), respiratory quotient (RQ) protein (PRO), carbohydrate (CHO), and fat oxidation were measured. All participants then performed 30-min of aerobic exercise (75-85 % of reserve heart rate – RHR). Finally, the same post-exercise variables for 60-min were measured. For the measures performed at rest and after exercise were observed effect of the moment of measurement, where the measures obtained at post-exercise 1 exercise (0-30 min) were significative higher (p≤0.001 for RMR; VO2; VCO2; PRO and CHO; p=0.001 for RQ; p=0.03 for FAT) in comparison to rest and post-exercise 2 (30-60 min) moments. Similar results were observed at the exercise for VO2 (31.5±3.1 vs. 31.9±3.7 mL/kg/min; p=0.78) and ventilatory equivalents for oxygen (VE/VO2: 24.1±2.5 vs. 24.4±3.3; p=0.75) where no differences were observed between conditions. In conclusion, for the applied protocol, acute ginger extract supplementation produced no metabolic ergogenic effect.

The USE OF INDICATORS OF PLANT PHOTOSYNTHETIC AND ENZYMATICE ACTIVITY IN BIOINDICATION STUDIES

In the context of increasing anthropogenic impact on the environment, the study of the mechanisms of plant adaptation is an actual problem. To diagnose ecological troubles, it is advisable to study the indicators characterizing metabolic processes in autotrophic plants. The change in the parameters of the photosynthetic apparatus and antioxidant system in silver birch (Betula pendula), European spruce (Picea abies) and dandelion (Taraxacum officinale L.), depending on the intensity of anthropogenic load, was studied. The pigment composition of plants and the activity of antioxidant enzymes can be used as markers of the anthropogenic pollution level of a territory.

POTASSIUM FERTILIZER AND YOUNG SHOOT REMOVAL OF LARGE WHITE GINGER PLANT IMPROVE RHIZOME SEEDS STORABILITY

The application of the appropriate potassium dosage is expected to produce high quality of rhizome seeds, hence improving its storability.Growing shoots are a strong sink. Thus, shoot removal aims to divert the photosynthate partition of shoots to the rhizome to improve rhizome development. The purpose of the research was to evaluate K dosage and young shoot removal:s effect to improve the production and quality of rhizome seeds of large white ginger. The experiment was arranged in the glasshouse in a split-plot design with four replications. The main plot was shoot removal treatments: 1) un removal, and 2) young shoots removal at six months after planting(MAP). The subplots were five doses of K; 0, 150 kg/ha, 300kg/ha, 450kg/ha, 600 kg/ha equivalent to 0, 3.75, 7.5, 11.25 and 15 g/plant respectively. The potassium fertilization was two times at 1 and 3 MAP, half dosage for each application. There was no interaction between young shoot removal and potassium dosage on the rhizome’s yield, physical, and biochemical quality. However, potassium dosage affected seed viability significantly. Potassium dosage presented a quadratic response with 7.5 g K/plant gave the best seed viability, whereas the optimum dosage for plant height was at 6.7 g K/plant. Shoot removal at 6 MAP produced seeds with enhanced storability, up to 9 months. Furthermore, it also improved seed viability as indicated by better seed growth than unremoval shoot treatment. Keywords: optimum dosage, seed quality, yield, Zingiber officinal. Abstrak PEMUPUKAN KALIUM DAN PEMBUANGAN TUNAS MUDA TANAMAN JAHE MENINGKATKAN DAYA SIMPAN BENIH JAHE PUTIH BESAR Pemberian pupuk K yang tepat diharapkan dapat menghasilkan benih rimpang yang bermutu tinggi karena dapat disimpan dalam jangka waktu yang panjang. Tunas yang sedang berkembang merupakan sink yang kuat. Pembuangan tunas bertujuan untuk dapat mengalihkan partisi fotosintat dari tunas ke rimpang. Percobaan ini bertujuan untuk mendapatkan dosis pupuk K dan mengetahui pengaruh pembuangan tunas muda terhadap produksi benih dan mutu rimpang jahe putih besar (JPB) sehingga memiliki daya simpan lama. Percobaan disusun dengan rancangan petak terbagi dengan empat ulangan. Petak utama adalah pembuangan tunas yaitu: 1)tanpa pembuangan tunas, dan 2)tunas muda dibuang pada 6 bulan setelah tanam (BST). Anak petak adalah lima dosis pupuk K yang diberikan pada 30 dan 90 BST yaitu: 1) tanpa K, 2) 150 kg/ha, 300 kg/ha, 450kg/ha, 600 kg/ha. Dosis pupuk tersebut setara dengan penambahan 0; 3,75; 7,5; 11,25 dan 15 g per tanaman masing-masing 1/2 dosis pada setiap pemberian. Hasil percobaan menunjukkan bahwa faktor tunggal pembuangan tunas muda pada umur 6 bulan setelah tanam (BST) dan pupuk K tidak berpengaruh terhadap produksi dan mutu fisik serta biokimia rimpang. Dosis pupuk K memengaruhi viabilitas benih yang dihasilkan. Viabilitas benih terbaik didapatkan pada penambahan pupuk K dosis 7,5 g/tanaman dengan respon kuadratik dan konsentrasi optimum untuk tinggi tanaman adalah 6,7 g/tanaman. Pembuangan tunas muda tanaman induk pada 6 BST menghasilkan benih yang dapat disimpan dalam jangka waktu 9 bulan serta viabilitas benih dengan pertumbuhan bibit yang lebih baik dibandingkan tanaman tanpa pembuangan tunas. Kata kunci: dosis optimum, mutu benih, produksi, Zingiber officinal.

Analysis of the correlation between marker compounds contents and cultivation environment of Cornus officinalis

본 연구에서는 재배 환경에 따른 산수유나무의 지표성분인 loganin 및 morroniside을 함량 분석을 통한 상관관계 구명하고자 하였다. Loganin 및 morroniside 함량은 UPLC에 의해 동시 분석되었다. 토양 데이터의 Mg2+ 함량과 pH가 loganin 함량에 가장 큰 영향을 미치는 것으로 나타났으며 Mg2+, Na+ 함량, pH, 염도, silt 비율, 점토 비율이 morroniside 함량에 가장 큰 영향을 미치는 것으로 나타났다. 결론적으로 Mg2+ 함량, pH, 점토비율은 산수유 지표성분인 morroniside 및 loganin 함량에 높은 영향을 미치는 것으로 나타났다. 이러한 결과들은 산수유나무의 최적의 재배환경요건에 대한 기초자료로 이용될 수 있을 것으로 기대된다.

Avaliação do conhecimento e uso de plantas medicinais e fitoterápicos por dentistas do Seridó Potiguar/RN

O estudo teve como objetivo investigar o conhecimento, atitude e prática dos cirurgiões - dentistas, que atendem na região do Seridó no Rio Grande do Norte, sobre a fitoterapia na prática clínica. A pesquisa foi realizada por um estudo do tipo exploratório e descritivo a partir de um instrumento de coleta de dados do tipo questionário estruturado, com perguntas abertas e fechadas, disponibilizado na plataforma Google Forms e enviado por meio do endereço de e-mail profissional dos dentistas inscritos no CRO-RN que atuam na região. Os dados foram analisados a partir da análise bivariada e do teste Qui-quadrado. Apenas 17,7% dos dentistas entrevistados usam ou indicam plantas medicinais ou fitoterápicos, as espécie mais indicada pelos dentistas é a camomila (Matricaria chamomilla), para aliviar os sintomas da erupção dentária em bebês, tratamento de inflamação e ajuda no processo de cicatrização e o fitoterápico é a Valeriane (Valeriana officinalis L). 91,1% dos entrevistados nunca cursaram nenhuma disciplina sobre a temática em questão, 68,8% não tem conhecimento da Resolução Nº 082/2008-CFO. Conclui-se, assim, que os dentistas em questão fazem pouca indicação ou prescrição de plantas medicinais e fitoterápicos, e sendo possível que isso se dê pelo pouco conhecimento acerca da temática.

Uso da Salvia officinalis como agente fitoterápico no controle da Diabetes Mellitus

O presente estudo objetivou realizar uma revisão de literatura a respeito do uso da Salvia officinalis no tratamento da Diabetes Mellitus, tendo em vista a importância do controle glicêmico para a saúde sistêmica e bucal dos portadores dessa doença. A revisão de literatura foi elaborada utilizando as plataformas Google Scholar, PubMed e Scielo como fonte de pesquisa. A partir dos descritores: “Fitoterapia”, “Salvia officinalis” e “Diabetes”, foram selecionados 31 artigos publicados entre 2010 e 2020. A diabetes mellitus, destaca-se como um importante causa de morbidade e mortalidade em todo o mundo. Vários pesquisadores têm investigado os efeitos de Salvia officinalis contra a diabetes, e o seu uso tradicional como antidiabético pode ser justificado pelos metabólicos secundários que estão presentes nas preparações feitas dessa planta. Estudos indicam que S. officinalis pode melhorar o controle glicêmico e perfil lipídico, sendo útil no tratamento de pacientes diabéticos e hiperlipidêmicos. Além disso, não foi relatado nenhum efeito adverso. A Salvia officinalis vem se destacando por sua capacidade de ação hipoglicemiante, através da atividade dos seus diversos constituintes, mostrando-se capaz de reduzir a glicemia em jejum e pós-prandial em vários estudos, além da diminuição da hemoglobina glicosilada, colesterol total, triglicerídeos e LDL, seja isolada ou associada a outros compostos naturais.

Eco-friendly management of rice weevil, [(Sitophilus oryzae L.) Coleoptera; Curculionidae] in Rupandehi, Nepal

An experiment to manage rice weevil (Sitophilus oryzae L. Coleoptera, Curculionidae) in wheat (Triticum aestivum L. Gramineae) was carried out at Institute of Agriculture and Animal Science (IAAS), Paklihawa Campus, Nepal. The experiment was conducted under completely randomized design with seven treatments viz. neem (Azadirachta indica A. Juss) @ 15 g/kg, tobacco (Nicotiana tabacum L)@ 10g/kg, ginger (Zingiber officinale Roscoe) @20g/kg, garlic (Allium sativum L.)@20g/kg, sichuwan pepper(Xanthoxylum alatum Roxb.)@10g/kg, sweet flag (Acorus calamus L.) @5g/kg, and control and replicated three times. The highest weevil mortality of weevils was observed in the wheat treated with A. calamus (98.33%,), followed by N. tabacum (85.67%), A. sativum (73.34%), A. indica (70.67%), Z. alatum (70.34%)and Z. officinale (58.34%). Similarly, the lowest percent weight loss (3.32 %) and seed damage (4.0%) was observed in wheat treated with A. calamus. Moreover, germination (89%) was observed in seeds treated with A. calamus when tested after 90 days of treatment application. Based on weevil mortality and germination test in this experiment, it is found that sweet flag is the best treatment against rice weevil followed by tobacco and garlic respectively. Therefore, these botanicals could be one of the effective alternatives for the management of weevil especially to the farmers who do not use chemical insecticides in rural area of Nepal.

Cytotoxicity, anti-platelet aggregation assay and chemical components analysis of thirty-eight kinds of essential oils

Thirty-eight essential oils (EOs), including 4 products from Taiwan high-latitude trees, Chamaecyparis formosensis, Taiwania crypyomerioides, Cryptomeria japonica, and Chamaecyparis obtuse, as well as 34 commercial essential oils, were assayed on their cytotoxicity against 5 cancer cell lines and anti-platelet aggregation function.Two EOs from Juniperus virginiana and Santalum album showed significant cytotoxicity. Moreover, 2 EOs from Melissa officinalis and Piper nigrum exhibited moderate inhibitory effects on an anti-platelet aggregation assay. Some essential oils had been reported to contain cytotoxicity. However, the cytotoxicity of EOs from J. virginiana and S. album is revealed for the first time. To the best of our knowledge, this is the first report for anti-platelet aggregation effect of EOs.

Profil GC-MS Senyawa Metabolit Sekunder dari Jahe Merah (Zingiber officinale) dengan Metode Ekstraksi Etil Asetat, Etanol dan Destilasi

Red Ginger (Zingiber officinale) has a high economic value due to its use as a seasoning and also as traditional medicine. The test of phytochemical of vary Zingiber officinale rhizome showed that they have bioactive compounds. The bioactive compound was extracted using maceration techniques (using ethyl acetate and ethanol) and distillation. The aim of this study is to determine the profile of secondary metabolites compound and compare them from several technique of extraction. The results of GC-MS showed that the secondary metabolites compound from ethanol extract, ethyl acetate extract and distillation contains ar-curcumen, zingiberene,

Dendrobium officinale kimura et migo improved dry eye symptoms via promoting tear production in an experimental dry eye rat model

Objectives: To evaluate the ameliorative effect of Dendrobium officinale Kimura et Migo (DO) on a desiccated environment-induced experimental dry eye rat model and elucidate its underlying mechanisms. Materials and Methods: The Sprague-Dawley rats were kept in low-humidity environment and received constant airflow for 8 weeks to establish the experimental dry eye model. DO water extract (DOW, 372 mg/kg/day) was orally administered daily for 8 weeks. Schirmer's test was used to measure the tear fluid production at days 0, 14, 28, 42, and 56. At the end of experiment, lacrimal gland tissues and eyeballs were collected for hematoxylin and eosin staining, PAS staining, and immunohistochemical staining. Inflammatory cytokines in conjunctiva including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, and matrix metalloproteinase 9 were measured by real-time PCR. The aquaporin 5 (AQP5) expression in lacrimal gland was also determined using Western blot assay. Results: DOW treatment (DOWT) increased the tear production of rats significantly in the desiccated environment at day 42. Histological analysis revealed that DOW could reverse destruction of conjunctiva and increase goblet cell number and mucin expression in the experimental dry eye rats. In dry eye rats, desiccated environment and constant airflow induced TNF-α and IL-1β production in the conjunctiva, whereas DOWT reversed the upregulation of proinflammatory cytokines. Moreover, DOWT increased the expression of AQP5 at protein level in the lacrimal gland tissues in both desiccated and normal environmental conditions. Conclusion: The present study suggests that DO has therapeutic potential on dry eye symptoms through upregulating AQP5 expression, increasing tear production, inhibiting conjunctiva destruction and inflammation, as well as promoting mucin production.

Broad-Spectrum Cytotoxic Effect of Calendula officinalis L Against Breast Cancer Cells

Background: Calendula officinalis L used in Iraqi folklore medicine for several medical applications. This research evaluated the leaves extract as an anti-breast cancer agent in in-vitro cancer cell line systems and studies its active compounds. Crystal violet viability assay was used to determine the cytotoxicity of the leave methanolic extract of Calendula officinalis L against diverse breast cancer cell lines. Human breast cancer MCF7, AMJ13, MDAMB, and CAL51 cells were treated with different concentrations of extract for 72 hours. Morphological study for the exposed cell was done by examination under a phase-contrast inverted microscope. High-performance liquid chromatography (HPLC) analysis was performed to measure the concentrations of each component of phenols and flavonoids in the Calendula officinalis L extract. Results: It was found that methanolic extract of Calendula officinalis L inhibits the proliferation of all breast cancer cells significantly at the meantime; it does not affect normal embryonic cells. Additionally, it induced the cytopathic morphological changes in cancer cells. Furthermore, HPLC study revealed that Calendula officinalis L extract contained an important component of flavonoids. Conclusions: Calendula officinalis L leaves extract inhibited the proliferation of breast cancer cells especially MDAMB cells with no effect on normal cells. This work showed that Calendula officinalis L is a possible natural source as broad-spectrum anti-breast cancer drug.

Radioprotective efficacy of ginger (Zingiber officinale) extract against gamma-ray radiation-induced genotoxicity in rats

Radioprotective efficacy of ginger (Zingiber officinale) extract against gamma-ray radiation-induced genotoxicity in rats

Characterization and Antibacterial Activity of Phthalides from the Roots of the Medicinal Herb Levisticum officinale W.D.J. Koch.

A new phthalide, namely 7-methoxy-3-propylidenephthalide (1), along with two known compounds (2, 3) were isolated from the roots of the edible herb Levisticum officinale W.D.J. Koch, commonly known as lovage and well known in traditional medicine for its spasmolytic and diuretic effects. The structure of the new compound was established by HRMS and 1D & 2D NMR (1H 1H COSY, HMQC, and HMBC) spectroscopic analysis. All compounds are reported for the first time from L. officinale. Compounds 1-3 were tested against two Gram negative (Escherichia coli, Pseudomonas aeruginosa) and two Gram positive (Staphylococcus aureus and vancomycin-resistant Enterococcus [VRE] faecium) bacteria strains. Compound 3 was active against S. aureus, E. coli and vancomycin-resistant E. faecium with MIC values of 16, 64, and 128 μg/mL, respectively.

Healing Influence of Melilotus Officinalis Herbal Extract on Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice.

The present study was designed to primarily examine the therapeutic potential of the herbal extract of Melilotus Officinalis for the treatment of multiple sclerosis in the experimental autoimmune encephalomyelitis (EAE) model of the disease. The animal model was induced in C57BL/6 female mice, and then the herbal extract was intraperitoneally administered for a total of 21 days after the first day of post-immunization. The phenotypic signs, a gene expression profile of inflammatory cytokines, antioxidant state, and pathological hallmarks of the disease in the corpus callosum were evaluated. The prophylactic administration of Melilotus Officinalis attenuates the clinical signs of the disease. It significantly declined the gene expression of pro-inflammatory cytokines like IL-6, TNF-α, and IFN-γ. This herbal extract also surged the gene expression, as an anti-inflammatory cytokine. The gene expression of Glutathione peroxidase and Catalase (antioxidant enzymes) was meaningfully higher in the treatment group. Pathological evaluation of corpus callosum cross-sections by Luxol Fast Blue staining revealed preserved myelin sheath in the treated group compared to the EAE mice. The results of our assay confirmed that immunomodulatory and antioxidant features of the herbal extract of Melilotus Officinalis ameliorated the EAE severity. This study finding disclosed the therapeutic efficiency of this compound in MS treatment.

Zencefil (Zingiber officinale)’in Gökkuşağı Alabalıklarında (Oncorhynchus mykiss Walbaum) İmmunostimulant ve Büyüme Destekleyici Olarak Kullanımı

Bu çalışmada, temini kolay ve ucuz olan zencefil (Zingiber officinale) kökütozunun gökkuşağı alabalıklarında (Oncorhynchus mykiss) nonspesifik savunmamekanizmalarına etkisi araştırılmıştır. Araştırmada, önce zencefil katkılı yemlerlebalıkların beslenmesi, sonra zencefil katkılı yemlerle beslenmiş balıklardaenfeksiyon oluşturulması denemesi gerçekleştirilmiş olup deneme gruplarındabüyüme parametreleri ile nonspesifik immun sistem göstergesi olarak kanparametreleri incelenmiştir. Deneme yemlerinde zencefil kökü tozu oranı0,0 - 0,5 - 1,0 - 2,5 - 5,0 - 10,0 ve 20,0 g/kg olacak şekilde diyetler hazırlanmıştır.Denemede başlangıç ağırlıkları 108,7±17,0 g olan gökkuşağı alabalıklarıkullanılmıştır. Besleme denemesinde 7, 15, 25, 40 ve 60 gün besleme sonrası hergrupta biyometrik ölçümler ve kan parametreleri tespiti yapılmıştır. Enfeksiyondenemesinde 15 gün 0,5 - 1,0 - 2,5 - 5,0 - 10,0 ve 20,0 g/kg oranlarında denemeyemleriyle çalışma yürütülmüş ve Yersinia ruckeri enfeksiyonu oluşturulmuştur.Enfeksiyon denemeleri 35 gün sürmüştür. Sonuç olarak alabalıklarda zencefilkullanımının büyüme ve bağışıklık açısından olumlu etki gösterdiği ve alabalıkyetiştiricilerine 7 gün kullanım için 1,0 - 5,0 g/kg; 15 ve 25 gün kullanım için2,5 g/kg; 40 ve 60 gün kullanım için 0,5 - 2,5 g/kg oranında zencefil kullanımınıntavsiye edilebileceği belirlenmiştir.

Comparative effects of different concentrations of garlic (Allium sativum) and ginger (Zingiber Officinale) on growth performance, goblet cell histochemistry and gut microbiota of broilers

The present study investigates comparative effects of different concentrations of garlic (Allium sativum) and ginger (Zingiber Officinale) on growth performance and selected histo-microbial parameters of broilers. A total of 80 one day- old chicks were divided into five different groups with each group having 4 replicates in a trial of 42 days. The first group was kept as control whereas, the second, third, fourth and fifth groups were given garlic 0.25%, garlic 0.5%, ginger 0.25% and ginger 0.5% respectively. At the end of trial all birds were slaughtered for analysis. Results revealed that feed conversion ratio and live body weight were significantly (P < 0.05) improved by garlic 0.5% supplementation compared to other groups. Histo-microbiology revealed that lactic acid bacteria, yeast, acidic goblet cells, mixed goblet cells and total goblet cells increased significantly (P < 0.05) by the dietary supplementations under study. In was concluded that 0.5% garlic supplementation was a better alternate to antibiotic in broilers.

Desenvolvimento e controle de qualidade de um gel-creme antiacneico a base do óleo da Copaífera officinalis L. (copaíba)

Objetivo: Desenvolver um gel-creme antiacneico a base do óleo da Copaífera officinalis L. (copaíba) e realizar o controle de qualidade do mesmo. Métodos: Foi desenvolvida uma formulação, e incorporou-se o óleo da planta na mesma, verificou-se a compatibilidade entre ambos. Realizou-se os ensaios organolépticos (aspecto, cor e odor), físico-químicos (pH, densidade e espalhabilidade) e microbiológicos, nos tempos 0 e 30 dias após a produção, e também os testes de centrifugação e estresse de temperatura visando a previsão de possíveis instabilidades. Resultados: No teste de incorporação, a melhor concentração foi 3,5%, com ausência de alterações. O teste de centrifugação, não apresentou separação de fases e precipitações, assim como o de estresse térmico, onde o produto foi submetido à elevadas condições de temperatura. O gel-creme apresentou-se na cor levemente verde, aspecto gelificado, odor característico, pH, dentro dos padrões de segurança (5,0 – 5,5), densidade 0,97420g/cm³ - 0.99820g/cm³, boa espalhabilidade, esta aumentou à medida em que o peso foi adicionado. Embora a amostra tenha apresentado crescimento microbiano e fungicida, o número de Unidades Formadoras de Colônias encontra-se abaixo do limite máximo. Conclusão: Por conseguinte o gel-creme apresenta um elevado perfil cosmetológico, com ausência de instabilidades, adequado aos padrões de segurança e eficácia especificados.