Official Guidance Research Articles

Screening for congenital Chagas disease in a non-endemic area: a cost-effectiveness analysis

Abstract Background Due to climate changes, immigration, and globalization, Chagas Disease (CD) also afflicts nations without vector transmission. In Europe, congenital CD (cCD) is a significant public health issue, perpetuating the disease: it is crucial to perform CD screening in pregnant women at risk, as the treatment of infants is effective in eradicating the infection. Only a few European regions have a definite algorithm for diagnosing cCD, but no official guidance has been published at the national or European level. To support policymakers, this study aims to outline a cost-effectiveness analysis of CD screening in non-endemic areas, such as Italy, in pregnant women born or arriving from endemic countries and in their newborns. Methods To measure the economic impact of cCD screening, a decision tree model will be used to compare the test option (screening, diagnosis, treatment, follow-up) with no test option (no screening, progression of disease). Model parameters will be taken from relevant scientific literature. The primary outcome will be the Incremental Cost-Effectiveness Ratio (ICER) between the two options. Sensitivity analyses will be conducted to determine how changes in prevalence, transmission rate, screening adherence, and treatment adherence may affect the ICER. Results We expect the ‘test’ option to be cost-effective even with significant reductions in prevalence, transmission rate, adherence to screening or treatment. Threshold levels of these variables will allow to critically extend the results to areas with reduced immigration, patchy distribution of migrants at risk, health logistical limitations, and limited access to care for immigrants. Conclusions Our findings can help policymakers implement official screening programs and diagnostic algorithms for cCD in Italy and other non-endemic countries. This contributes to SDG 3 by combating the spread and burden of neglected tropical diseases and contributing to maternal, child, and migrant health. Key messages • Screening for congenital Chagas Disease in a non-endemic area may be cost-effective and cost-saving. • Study findings could provide useful information for health policymakers to combat Chagas Disease in Europe.

Minority ethnic older adults’ perception and behaviour towards COVID-19 public health campaigns in the UK

In the UK, minority ethnic groups were reported to face the greatest risk from COVID-19. Yet, little is known about their perception and behaviour towards COVID-19 campaigns. This study used 35 semi-structured, in-depth interviews with minority ethnic adults aged 60 or over in England and Wales to explore their motivations for complying with or disregarding official guidance and their evaluations of various campaign content and channels used early in the pandemic. Using Template Analysis, key themes in the interviewees’ discourse were identified, which were subsequently analysed using the Theory of Planned Behaviour (TPB). This study found that the predominant motivations for non-compliant behaviour included fatigue from information overload, government- and socially-induced distrust, as well as self-reported personality traits. In contrast, compliant individuals emphasised community-based obligations and their trust in official communications. Although participants recognised the pandemic as a challenging time, they were generally unsatisfied with the credibility, consistency, and accessibility of public health messaging. This investigation contributes to health communications studies by adopting a qualitative approach and providing insights into an under-researched demographic.

UK Trainee Experience with WALANT - An Audit of 102 Cases.

Background: WALANT has gained much popularity in recent years, especially with COVID-19. However, a recent survey of the American Society for Surgery of the Hand membership (i.e. attendings/consultants) showed that only 17% were exposed to WALANT during residency or fellowship training. There is much interest in WALANT from trainees, but interpretation of the type and volume to be administered is highly varied. Methods: The aims of this study were (1) to survey a group of plastic surgery trainees in the UK about their knowledge of WALANT formulas, and (2) to compare trainee logbook records of WALANT procedures (if available) with published data from the UK. Results: All trainees were familiar with the 'standard' WALANT formula (1% lidocaine, 1:100,000 adrenaline ± 8.4% NaHCO3) described by Lalonde. However, because of local formularies, rather than 1:100,000 adrenaline, all used 1:200,000 adrenaline as it comes premixed in the UK. Other formulas used by UK trainees included 0.5% bupivacaine + 1:200,000 adrenaline, and mixing 1% lidocaine + 1:200,000 adrenaline with 1% lidocaine 1:1. In comparing available trainee WALANT records with published UK data, the average volume of WALANT used was 6.6 mls in the current study versus 12.9 mls for similar procedures (wound debridement and skin closure ± local flap, digital nerve repair, fingertip reconstruction, thenar injuries, phalangeal fracture and single digit extensor repair); specifically, for single digit flexor tendon repairs, this was 10 mls versus 16.3 mls. Conclusions: While the British Society for Surgery of the Hand (BSSH) have developed official guidance for the use of WALANT in the UK, it appears there remains much variation in interpretation and hence, application. Comparison of trainee logbook records of common hand surgery procedures suggests that most can be done with much less WALANT administered than previously reported, with safe and reproducible results. Level of Evidence: Level IV (Therapeutic).

Chinese Pioneering Educators’ Understandings and Practices of STEM Education

The Chinese education system issued a series of policies to encourage educators to explore science, technology, engineering, and mathematics (STEM) education and selected a number of schools and educators as pioneers of STEM education. Through the education policy implementation framework, this qualitative study explores eight pioneering educators’ interpretations of STEM education, their knowledge of STEM education policies, and how they transform their understanding into practice. The results show that the pioneering educators hold a similar understanding of the definition of STEM education and how STEM education should be conducted. However, they adopted diverse STEM practices due to their different academic backgrounds, administration roles, school environment, available resources, and personal abilities and interests. They displayed tension and confusion over their own STEM practices and requested official guidance. The tension may have emerged from the conflicts between the top-down policy operation system and the place-based, bottom-up nature of STEM education. Further, STEM policies played a positive role in increasing educators’ openness and confidence in trying new STEM education strategies; however, they could not influence how educators performed their STEM practices. The educators proposed four kinds of policies to support STEM practices. This study highlights the importance of including teachers’ ownership and agency while drafting STEM education policies and proposing practices. The implications for better STEM education policy design and implementation are discussed.

RESHAPING CURRICULUM OF INDONESIAN MARITIME EDUCATION AND TRAINING

Maritime education and training are pivotal for the development and operation of autonomous ships and green port era, encompassing areas such as safety, economic advantages, legal frameworks, cybersecurity, and operational efficiency. The author aims to develop robust and resilience curriculum for future generation which is a combination of well developed STCW (Standard of Training & Certification of Watchkeeping) and Indonesia Educational Standards through literature review and applying a well-designed guidance from the Indonesian Ministry of Education. The research contribution lies in the development of an integrated curriculum that aligns international maritime standards with national educational requirements, using a systematic approach informed by literature and official educational guidance. The data then compared with some MET's curriculum and the results are proven to be aligned with every limitation set up by International Standards and Indonesian National Education Standards.

151 Use of a clay and algae-based decontaminant on sows naturally exposed to mycotoxins in gestation and lactation

Abstract Mycotoxin contamination in pig feed is a recurring problem leading to chronic exposure of the animals, even when mycotoxin levels are below official guidance (FDA, EFSA). Deoxynivalenol (DON) and its derivates are among the main mycotoxins impacting pig production in the United States. This study evaluated the effect of a clay- and algae-based mycotoxin decontaminant on the reproductive performance of sows (n = 207) exposed to chronic natural mycotoxin contamination from 35 d of gestation to weaning. The level of mycotoxins in the feed was measured using LC-MS/MS. A mean contamination of 956 ppb DON, 125 ppb 15-o-acteyl-DON, 338 ppb fumonisins B1 + B2 and 62 ppb zearalenone was reported. Despite a comparable starting body weight (BW) between the control (without decontaminant) and test (with decontaminant) groups at allotment (P = 0.67), sows in the test group had a greater BW than the control sows at entry in farrowing (P < 0.01), and a body condition score of 0.12 points greater (P = 0.04). More live-born piglets were observed in supplemented sows than in control sows (+4%; P < 0.01), as well as a smaller proportion of mummified and stillborn piglets (-39%; P < 0.05 and -34%, P < 0.01, respectively). In contrast, the BW and growth of piglets before weaning did not differ between groups (P > 0.10). These results indicate that the tested decontaminant can improve the body condition and farrowing performance of mycotoxin-exposed sows at levels below current recommendations.

152 Reducing the bioavailability of a mix of mycotoxins in broiler chickens with a clay- and algae-based decontaminant

Abstract Poultry feed is often contaminated with several mycotoxins that can impair animal health and performance, even at levels below the official guidance. The incorporation of mycotoxin decontaminants in the feed can limit these adverse effects. It is necessary to test the efficacy of these supplementations in vivo, but this requires specific experimental setups. The objective of this study was to test, in a validated toxicokinetic model, the ability of an algae-clay-based decontaminant to reduce the exposure of broilers to mycotoxin polycontamination (aflatoxin B1 – AFB1, ochratoxin A – OTA and deoxynivalenol, DON). The study included 16 male broiler chickens (Ross 308) of approximately 1.6 kg body weight (BW). After an acclimatization period of 1 wk, the broiler chickens were fasted for 12 h and then administered a single oral bolus with either the mycotoxins (n = 8) or the mycotoxins in combination with the decontaminant (n = 8; 2.0 mg AFB1/kg BW, 0.5 mg DON/kg BW, 0.25 mg OTA/kg BW, 2.5 g decontaminant/kg feed), administered in a parallel study design. Blood samples of the 16 broiler chickens were taken at different time points between 0 h (before administration) and 24 h (post administration; p.a.). The analysis of deoxynivalenol-3-sulphate (DON-3S, DON main metabolite), OTA and AFB1 in plasma was performed using UHPLC-MS/MS. The following parameters were calculated: area under the curve from time zero to the last point above the LOQ (AUC0→t), maximal plasma concentration (Cmax) and time at maximal plasma concentration (Tmax). Results showed that, using the oral bolus model, the mycotoxin decontaminant significantly altered the AUC0- >12h of DON-3S in broiler chicken (P = 0.012). The relative oral bioavailability [(average AUC0- >t mycotoxin + decontaminant/ average AUC0- >t mycotoxin) * 100] of DON-3S when administered with the decontaminant was 60.1%. For OTA, the decontaminant decreased the absorption of OTA as indicated by a significantly decreased AUC0- >24h (P < 0.001). Consequently, the relative oral bioavailability of OTA when administered with the decontaminant was lowered as well, namely 55.7%. For AFB1, the decontaminant affected the absorption of AFB1 with a significantly decreased AUC0- >8h (P < 0.001), Cmax (P < 0.001) and a significantly delayed Tmax (P = 0.025). Consequently, the relative oral bioavailability of AFB1 when administered with the decontaminant was 35.9%. Therefore, it can be concluded that the tested algae-clay based mycotoxin decontaminant reduces the oral absorption of multiple mycotoxins orally administered to broiler chickens in a single oral bolus model. These results are consistent with results obtained with DON in different experimental models (in vitro dynamics and in vivo performance) and confirm the efficacy of the decontaminant tested to control this mycotoxin in poultry production.

Assessing the influence of preconception diet on female fertility: a systematic scoping review of observational studies

Preconception diet is a proposed modifiable risk factor for infertility(1). However, there is no official guidance for women in the preconception period as to which dietary approaches may improve fertility. A comprehensive synthesis of the relevant evidence is key to determine the potentially effective dietary patterns and components as well as evidence gaps, and to provide information for nutritional recommendations for couples planning a pregnancy. In this systematic scoping review, four electronic databases (Medline and EMBASE via Ovid processing, CAB Direct, and CINAHL via EBSCO) were searched for observational studies (prospective and retrospective cohort, cross-sectional, and case–control studies) from inception to 27 September 2021. Eligible studies included women of reproductive age during the preconception period, and evaluated exposures related to preconception diet and outcomes related to fertility. Results were synthesised using a descriptive approach. A total of 36 studies were eligible for inclusion (31 prospective, 3 cross-sectional, and 2 case–control studies) and were published between 2007 and 2022. Of the assessed dietary exposures, increased adherence to the Mediterranean diet displayed the strongest and most consistent association with improved clinical pregnancy rates. Reducing trans fatty acids (TFAs), saturated fatty acids, and discretionary food intake (fast food and sugar-sweetened beverages) were associated with improvements in live birth, clinical pregnancy rates, and related ART outcomes. The dietary components of seafood, dairy, and soy demonstrated inconsistent findings across the few included studies. Due to heterogeneity and the limited available literature on most exposures, there is insufficient evidence to support any specific dietary approach for improving fertility. However, following some of the dietary approaches outlined in this review (anti-inflammatory diets, reducing TFA, and discretionary food intake) are consistent with broad healthy eating guidelines, have little to no associated risk, and offer a plausible set of possible benefits. This warrants further exploration in randomised controlled trials.

Generalized overview infographic: a customizable library instructional material on the NIH Data Management and Sharing Policy.

The Generalized Overview of the NIH Data Management and Sharing Policy Effective 2023.01.15 (Generalized Overview) is an instructional material that provides a basic, clear, and linear understanding of the NIH policy and its requirements. While not developing or utilizing new technology, the Generalized Overview is innovative and notable for creatively using a freely available graphic design tool to translate government policy language into an accessible and understandable infographic that can disseminate important information about the NIH DMS Policy needed by researchers and by those who support them. Shared via a Creative Commons license, others may fully adapt the infographic or may simply add their own institutional contact information. The Generalized Overview can be used by any who find themselves responsible for publicizing and/or teaching the NIH Data Management and Sharing Policy at their respective libraries and institutions. It is intended for educational purposes only and should not be used as a substitute for official guidance from the NIH.

MPC-based framework incorporating pre-disaster and post-disaster actions and transportation network constraints for weather-resilient power distribution networks

Enhancing power system resilience to extreme weather requires an effective coordination of pre-disaster preventive response actions and post-disaster repair and restoration services. In this context, this article presents a two-stage framework to enhance resilience of power distribution networks to severe weather events. It considers operating and resource constraints in interdependent power and transportation networks based on official guidance from transport appraisal studies. It also incorporates sources of information available in a smart city context, such as energy measurements, traffic flows, and geographical information systems. In the first stage, a pre-disaster operational planning strategy is defined to prepare the grid for a high-risk outage scenario with the objective of minimizing the value of lost loads, formulated as a mixed-integer quadratic programming model. In the second stage, a post-disaster corrective strategy is implemented over a receding time horizon to compensate for deviations between the actions computed in the first stage and the actions required to minimize power outages, embedded into a model predictive control scheme. The effectiveness of the proposed framework is demonstrated on a real-world large-scale distribution network in the United Kingdom over a range of outage scenarios. Simulation results show that the proposed framework is capable of effectively minimizing first-stage operational costs and second-stage deviations between the projected and actual load demand supply. Numerical results obtained with the proposed framework indicate that the load energy unserved is at least twice smaller than with typical practices adopted by distribution network operators and computational times take two minutes or less. Therefore, it can be effectively used by distribution network operators to ensure an appropriate level of preparedness to power outages caused by extreme weather along with prompt restoration and repair services.

The Lutheran Experience in the Ottoman Middle East: Stephan Gerlach (1546–1612) and the History of Lutheran Accommodation

Abstract This article examines what it meant to be Lutheran in the early modern Middle East. Its point of departure is a letter in which Stephan Gerlach, a sixteenth-century Lutheran chaplain to the imperial ambassador in Istanbul, asked his superiors about the type of behaviour that befitted him as a Lutheran. Was he allowed to wear a Turkish turban to see mosques and learn about Islam? Was it permissible for him in exceptional circumstances to accept communion under both kinds from a Roman Catholic monk? Was he allowed to postpone the Sunday sermon to attend Greek Orthodox ceremonies? Reconstructing how sixteenth-century Lutherans who had business in the early modern Middle East tried to resolve such issues not only affords new insights into the Lutheran experience in the Ottoman Empire; it also raises a set of fundamental questions about late sixteenth-century Lutheranism itself. Did Lutherans in this period develop forms of religious accommodation similar to those of early modern Catholics? Did travel in the Eastern Mediterranean demand a more flexible and more fluid form of Lutheranism? Could one even adhere to Lutheranism’s core principles so far away from the place where the movement had first taken root? Through an examination of various Lutheran treatises and travelogues, I show that sixteenth-century Lutheranism did not develop an official policy of accommodation. Instead, Lutheran responses to questions about accommodation, (dis)simulation and conformity were often makeshift and idiosyncratic, because Lutheranism formulated little to no official guidance on the movement as a lived religion.

Performance of International Global Models and Official Tropical Cyclone Forecasts Over the Bien Dong Sea for the Period 2012–2019

This research validates tropical cyclone (TC) forecasts from the National Centre for Hydro‐Meteorological Forecasting of Vietnam, the Regional Specialized Meteorological Center (RSMC) Tokyo, and global models (the Japanese Meteorological Agency [JMA], global spectral model [GSM], the National Centers for Environmental Prediction [NCEP], Global Forecast System [GFS], and the European Centre for Medium‐Range Weather Forecasts [ECMWF] Integrated Forecasting System [IFS]) for 72 activated TCs over the Bien Dong Sea. The best quality track forecasts come from the IFS and then GFS and GSM, while the GFS provides a good intensity forecast compared to IFS and GSM. The official guidance and model track forecast tend to be slower and leftward compared to observations (negative biases of along and cross‐track errors). Regarding the ECMWF’s ensemble track forecast, the strike probability forecast is quite overforecast/overconfident, especially for a lead time of 72 h and at high probabilities.

Bridging the Gap: Communicating with Emergency Management Professionals in the Midst of Climate-Related Disasters

Abstract Objective The objective of this research is to assess how New York City Health + Hospitals emergency management professionals (EMPs) perceive climate change-related events, to a.) improve communication for increased receptivity and b.) identify gaps in perceived risks. Methods The study surveys EMPs from 13 geographically different healthcare facilities in NYC about their perceptions on climate change and its related emergency scenarios, preferred information sources on climate change, and the best modes of communication during climate-related extreme weather events. Results The results of this study support a.) the importance of official hospital-system guidance regarding climate risks b.) the use of a diverse array of terminology, including messaging that refrains from the phrase ‘climate change’ and instead refers to the ‘future’ c.) the incorporation of clear actionable deliverables and d.) the inclusion of expert voices into messaging. Overall, recent events and upcoming seasonal hazards appear to affect perception of risk more than objective measures. Knowledge of city and temporal factors that impact perceived risk can be mobilized to harness engagement. Conclusions The results of this study inform best practices for climate communications to EMPs, critical in preparing our health systems for future climate disasters.

Research on Community Marketing of Online Games under the SICAS Model --Taking the Genshin Impact as an Example

In recent years, the number of online game players has grown rapidly, the number of game brands has exploded, players have a wide range of choices, and the motivation to consume has become complicated from a single recreational pastime with strong social interaction. Unidirectional game brand promotion has already impressed consumers, and the community-based marketing model has been favoured by many game brands. It is necessary to explore more effective community marketing methods for game players for the development of game products. In view of this, this paper takes the typical representative of Genshin impact as an example and analyses the community marketing of Genshin impact based on the SICAS model applicable in the digital era. The author analyses the operation of the official and player-built communities of Genshin impact, and summarizes the advantageous features of its community marketing and the serious problems it faces. The study concludes that in the era of Internet social media, game communities need to satisfy the three characteristics of diversified content, rewarded discussion and strong interaction. The study also emphasises the official guidance rather than interference, so as to enhance the influence of community communication and the consumption desire of community users.

Threat Appraisal, Emotional Contagion, and Fear of COVID-19: Revision of the Extended Parallel Process Model

Fear of COVID-19 has been understandably widespread, given continual exposure to dire information from pandemic media coverage and interpersonal communications. The present study addresses a limitation of the extended parallel process model in predicting fear of COVID-19 by inclusion of the concept of emotional contagion. The main gap in the literature is filled by the study’s distinctive contribution that broadens and upgrades the extended parallel process model. The model is extended by its integration with the theory of emotional processing. The study is based on a national panel of adults ( N = 206). The methods include path modeling by SmartPLS. In addition, multigroup analyses examine overall model differences between gender classifications. Findings and conclusions can be used to minimize excessive fear, and at the same time to promote confidence in following official public guidance and protective regulations to cope with the pandemic.

Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Isavuconazonium Sulfate

A Biopharmaceutics Classification System (BCS)-based biowaiver monograph is presented for isavuconazonium sulfate. A BCS-based biowaiver is a regulatory option to substitute appropriate in vitro data for in vivo bioequivalence studies. Isavuconazonium sulfate is the prodrug of isavuconazole, a broad-spectrum azole antifungal indicated for invasive fungal infections. While the prodrug can be classified as a BCS Class III drug with high solubility but low permeability, the parent drug can be classified as a BCS Class II drug with low solubility but high permeability. Interestingly, the in vivo behavior of both is additive and leads isavuconazonium sulfate to act like a BCS class I drug substance after oral administration. In this work, experimental solubility and dissolution data were evaluated and compared with available literature data to investigate whether it is feasible to approve immediate release solid oral dosage forms containing isavuconazonium sulfate according to official guidance from the FDA, EMA and/or ICH. The risks associated with waiving a prodrug according to the BCS-based biowaiver guidelines are reviewed and discussed, noting that current regulations are quite restrictive on this point. Further, results show high solubility but instability of isavuconazonium sulfate in aqueous media. Although experiments on the dissolution of the capsule contents confirmed ‘very rapid’ dissolution of the active pharmaceutical ingredient (API) isavuconazonium sulfate, its release from the commercial marketed capsule formulation Cresemba is limited by the choice of capsule shell material, providing an additional impediment to approval of generic versions via the BCS-Biowaiver approach.

AI-powered decision-making in facilitating insurance claim dispute resolution

AbstractLeveraging Artificial Intelligence (AI) techniques to empower decision-making can promote social welfare by generating significant cost savings and promoting efficient utilization of public resources, besides revolutionizing commercial operations. This study investigates how AI can expedite dispute resolution in road traffic accident (RTA) insurance claims, benefiting all parties involved. Specifically, we devise and implement a disciplined AI-driven approach to derive the cost estimates and inform negotiation decision-making, compared to conventional practices that draw upon official guidance and lawyer experience. We build the investigation on 88 real-life RTA cases and detect an asymptotic relationship between the final judicial cost and the duration of the most severe injury, marked by a notable predicted $${R}^{2}$$ R 2 value of 0.527. Further, we illustrate how various AI-powered toolkits can facilitate information processing and outcome prediction: (1) how regular expression (RegEx) collates precise injury information for subsequent predictive analysis; (2) how alternative natural language processing (NLP) techniques construct predictions directly from narratives. Our proposed RegEx framework enables automated information extraction that accommodates diverse report formats; different NLP methods deliver comparable plausible performance. This research unleashes AI’s untapped potential for social good to reinvent legal-related decision-making processes, support litigation efforts, and aid in the optimization of legal resource consumption.

The effect of official intervention on reducing the use of potentially discriminatory language during the COVID-19 pandemic in China

This study used the Baidu Index to analyze searches using discriminatory language toward the source of the outbreak during the initial stages of the COVID-19 pandemic. The study found a strong correlation between official intervention and a reduction in searches using discriminatory language. Following the official naming of the virus bt the government, the general public understood that searches using discriminatory language should be avoided, and search behavior dramatically changed. Meanwhile, this study also found that official intervention also overcame the effects of local socioeconomic factors. Regions with higher levels of socioeconomic development and higher population density had a stronger discriminatory language in internet searches, while the opposite was the case for regions with lower CPI and unemployment rates. However, after the official intervention, these factors no longer had a significant effect. It is recommended that officials worldwide provide early official media guidance during infectious disease outbreaks to reduce the use of discriminatory language and ensure the delivery of transparent and effective information to the public.

Understanding your audience: The influence of social media user‐type on informational behaviors and hazard adjustments during Hurricane Dorian

AbstractIn 2019, Hurricane Dorian affected Atlantic Canada with widespread impacts across the region. In the days preceding landfall, there was a great deal of discussion about the storm and its potential impacts. This discussion also extended onto Twitter, which provided a platform for users to engage with storm‐related information. In this research, we disseminated a questionnaire to residents of Atlantic Canada from late September to late October through Qualtrics, an online survey provider. The questionnaire explored how Twitter influenced respondents' (n = 1218) self‐reported informational behaviors (i.e., searching, sharing, and processing) and behavioral responses before, during, and after the storm. The results demonstrate that users' informational needs and preferences were closely related to their online behaviors. For example, conduits (i.e., those who both searched for and shared information) were highly proactive users who disseminated information about evacuations, recommended protective actions, and other official guidance more so than others. Conduits were also the most likely to heed official guidance in terms of their own preparedness and response. Amplifiers (i.e., those who only share information) and consumers (i.e., those who only search for information) were also motivated to take action by information they saw online, albeit at lower rates than conduits. Lastly, the results demonstrate that users can be positively influenced by information they see online even if they do not actively engage with it. Taken together, the results of this study suggest that Twitter users may interact with storm‐related information in more nuanced and complex ways than previously understood.

Bipropellant Enabled Solid Oxide Fuel Cell Stack Power Supply: Energy Agility for Space Vehicles

Spacecraft often have instances where they are required to operate for long periods of time with significant power requirements and no access to solar power. While a battery system could be designed to meet these occasional, and possibly unexpected requirements, creating a power supply to meet these infrequent demands results in having a battery system that is excessively large, massive, and inefficient. A Solid Oxide Fuel Cell (SOFC) system capable of running on the same fuel and oxidizer as the onboard thruster of a bipropellant thruster equipped spacecraft can eliminate much of the added mass and volume needed to enable batteries to meet extreme power demands and create more operational flexibility on how the chemical energy in stowed bipropellants are used. If the spacecraft needs thrust, the bipropellant can be ignited to provide thrust. If the spacecraft needs electric power, the spacecraft can consume bipropellant to generate auxiliary power. In this work, the proven bipropellant pair ammonia (NH3) and nitrous oxide (N2O) are shown to be a viable fuel and oxidant for hydrogen (H2) consuming air breathing SOFCs, as spontaneous NH3 decomposition will generate H2 and spontaneous N2O decomposition will generate O2. A scale up to a 5-cell SOFC stack fed NH3 and N2O produced power up to ~89W. Higher power can be achieved by scaling up the number of cells in a stack to achieve required power demands. The results of this study demonstrate the potential and feasibility of integrating SOFCs with a bipropellant thruster to creating a dual functioning spacecraft system that can satisfy operational power requirements and on-orbit maneuverability.This material is based on research sponsored by Air Force Research Laboratory under agreement number FA9453-21-C-0060. The views expressed are those of the authors and do not reflect the official guidance or position of the United States Government, the Department of Defense or of the United States Air Force. Approved for public release; distribution is unlimited. Public Affairs release approval #AFRL20230023. Figure 1