With the method of the background field expansion, we investigate the one-loop quantization of the Euclidean nonlocal f (R) model in the de-Sitter universe. We obtain the ghost-free condition (GFC) based on the transformation from the Jordan frame to the Einstein frame and the classical stability condition (CSC) satisfied \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${f}_{RR}^{\\left(0\\right)}-{\\phi }_{0}{F}_{RR}^{\\left(0\\right)}<0$$\\end{document}. We present the on-shell and off-shell one-loop effective action and quantum stability condition (QSC) by utilizing the generalized zeta-function. We find that under the fulfillment of GFC, CSC and QSC are inconsistent.
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