The use of diesel engines for the transportation sector is ubiquitous and covers a broad continuum, like buses, trucks, agriculture, construction equipment, generators, and industrial applications. However, because of their increased use of off-road engines, they contribute more emissions in various sectors than on-road. As a result, worldwide, regardless of ongoing emission control efforts, these off-road, stationary engines also continue to be a substantial source of air pollutant emissions in the United States, European Union and Asian markets. Accordingly, while improving emissions performance, the selection of after-treatment system materials and the use of compatible after-treatment specification selections are also critical. This is only possible by effectively combining clean diesel technologies such as Fuel Injection Equipment (FIE), Turbocharger with Intercooler (TCIC), Cooled Exhaust Gas Recirculation (C-EGR), and after-treatment systems like Diesel Oxidation Catalyst (DOC), Selective Catalytic Reduction (SCR), and Diesel Particulate Filter (DPF). Overall, in this study, the influence of after-treatment system configurations and their effect on emission reduction performance are studied for three different DOC specifications based on emission testing for catalyst and size optimization. With the selected DOC catalyst specification, suitable combinations of DPF and SCR specifications are optimized further using GT-SUIT software simulation. This study was carried out during the conversion of a 15 kW NA engine to a 27 kW TCIC engine to meet diesel engine emission norms.