Abstract BACKGROUND Inflammatory Bowel Disease (IBD) ranks as the 9th primary cause of mortality and the 10th main source of disability worldwide among individuals aged under 20. Grasping the worldwide implications for this age bracket is pivotal for shaping health care approaches and optimizing patient care. METHOD Leveraging the Global Burden of Disease instrument, we discerned the incidence, prevalence, mortality, and Disability Adjusted Life Years (DALYs) of IBD by age, gender, and year across 204 nations and territories spanning 1990-2019. The DisMod-MR 2.1 tool shed light on non-fatal health metrics like incidence and prevalence, whereas the Cause of Death Ensemble Model (CODEm) framework illuminated fatal health outcomes. RESULTS From 1990 to 2019, the overall prevalence of IBD escalated from 74,975 (95%UI: 60,678-92,219) to 88,828 (72,606-108,301), marking an Annual Percentage Change (APC) of 18% (16-22). Incidence exhibited an APC surge of 23% (20-26). Conversely, deaths and DALYs plummeted by 56% and 53% respectively during the same period. Delving into global regions, Sub-Saharan Africa noted a 6% death upswing, trailed by the African Union at 65% and Low SDI nations at 1%. Southeast Asia, East Asia, and Oceania recorded the steepest APC in age-standardized incidence rates at 67%, followed by High-SDI regions at 35%, OECD nations at 31%, and affluent countries at 30%. The 15-19 age bracket registered the most pronounced incidence rise by 24%. Males witnessed a steeper APC in incidence (24% vs. females at 21%) and prevalence (21% vs. females at 16%) from 1990-2019. CONCLUSION In 2019, IBD was responsible for 1.61% of all mortality linked to digestive diseases and contributed to 1.50% of the total digestive disease-induced disabilities. For pediatric clinicians, these findings underline the necessity for early intervention, tailored care strategies, and rigorous research into pediatric IBD. From a policy-making perspective, there is an urgent demand for resource allocation, enhanced public health campaigns, and international collaboration to mitigate the growing threat of IBD among the youth. Source: Global Burden of Disease 2019, IHME
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