Ocular Region Research Articles

Telehealth in a Pediatric Patient with Nevoid Basal Cell Carcinoma Syndrome

During COVID19, telemedicine was adapted by many practices to serve patients with a variety of health conditions including those affected by cancer. Here we report an 11-year-old patient who went to her dentist where a routine panorama x-ray showed multiple jaw keratocysts. Because jaw keratocysts can be identified with a hereditary predisposition to basal cell cancer and other tumors, she was referred for genetics. She was seen in 2021 where telehealth was the primary modality for visits. The hospital’s secure video platform was used to gather medical history and counsel the mother on genetic testing for nevoid basal cell carcinoma syndrome(NBCCS). While in the past genetic testing was often thousands of dollars, the genetic testing company offered a patient pay option of $250. Two days later, the patient presented to the cancer center to have her blood drawn and a fifteen-minute physical exam was performed which identified macrocephaly, and palmar pits. Of note the mother asked about numerous pinpoint lesions around the patient’s ocular region. Genetic testing was positive for a pathogenic variant in PTCH1 c.454_455del. The patient was referred to pediatric dermatology where over fifty basal cells were diagnosed and started treatment with imiquimod and efudex. She also was referred to cardiology and gynecology given reports of individuals with cardiac fibromas and gynecologic ovarian tumors. The patient is now 14 going into her freshman year of high school and is doing well. This case highlights how telehealth offers a holistic approach to patient care.

Bispectrum Analysis of Thermal Images for the Classification of Retinal Vascular Diseases

In the field of medicine, thermal imaging provides a non-invasive means to diagnose diseases by displaying temperature variations. Specifically, thermal images of the ocular region are proving effective in diagnosing retinal diseases like diabetic retinopathy (DR), diabetic macular edema (DME), age-related macular degeneration (AMD), and wet AMD. This study explores the use of bispectrum analysis on ocular thermal images. The bispectrum, derived from third-order statistics (cumulants), is estimated using parametric (ARMA) and non-parametric methods (direct and indirect). Various entropy measures are extracted as features from these bispectrum images. The effectiveness of these features is evaluated through experiments employing different machine learning algorithms: discriminant analysis (DA), K-nearest neighbour (KNN), decision tree (DT), and Naïve Bayes Classifier (NBC). The results indicate that the KNN classifier achieves the highest accuracy when using features extracted via the indirect method of bispectrum estimation. Meanwhile, the DT classifier performs exceptionally well with bispectrum features extracted through the direct method, outperforming other feature extraction approaches.

The Effect of Face Mask Wear on the Ocular Surface and Contact Lens Microbiome.

As face mask wear can result in the redirection of nasal and oral exhalation toward the ocular region, this study investigated the impact of face mask wear on the conjunctiva, eyelid margin, and contact lens (CL) surface microbiome. In this prospective, cross-over study, experienced CL wearers (N=20) were randomized to wear a face mask for 6 hr/day (minimum) for a week or no mask for a week. The conjunctiva, eyelid, and CLs were then sampled. After a 1-week washout period, participants were crossed over into the alternate treatment for 1 week and sampling was repeated. Sampling was bilateral and randomly assigned to be processed for culturing or 16S ribosomal(r) RNA gene sequencing. Culturing showed no effect of mask wear on the average number of bacterial colonies isolated on the conjunctiva, eyelid, or CL, but there was increased isolation of Staphylococcus capitis on CL samples with mask wear (P=0.040). Culture-independent sequencing found differences in the taxonomic complexity and bacterial composition between the three sites (P<0.001), but there was no effect of bacterial diversity within and between sites. Mask wear did not impact dry eye or CL discomfort, but increased ocular surface staining was reported (P=0.035). Mask wear did not substantially alter the microbiome of the conjunctiva, eyelid margin, or CL surfaces in uncompromised healthy eyes.

Ophthalmic Manifestations of Leukemia and Their Management

Patients with leukemia often have ophthalmic manifestations. These occur either from direct infiltrations of neoplastic cells or from indirect or secondary causes. Nearly all ocular structures can be affected by leukemia. Sometimes, ophthalmic involvement can be the first sign of disease relapse. This review article aims to highlight different ocular manifestations of leukemia along with treatment. It involves studying the available material in textbooks, printed and online journals. As there is high prevalence of ocular findings in leukemia, it can be a standard practice that all leukemic patients should have screening by ocular examination. Awareness of the clinical spectrum of leukemic infiltration of ocular region is essential for rapid diagnosis, prompt initiation of treatment and better outcome. If prompt diagnosis and treatment can be done, worsening of vision may be minimized or prevented. Mugda Med Coll J. 2024; 7(1): 36-41

Preferences for the ocular region aesthetics and elective double eyelid surgery in Chinese: A nationwide discrete choice experiment

ObjectiveThis study aimed to investigate preferences for elective double eyelid surgery and explore the psycho-social underpinnings influencing ocular aesthetics and attitudes towards aesthetic surgery. MethodThis nationwide online experiment was conducted throughout four tiers of cities in China using quota sampling, which included self-administered Likert scales for general self-efficacy and modified body image, and a set of discrete choice experiments (DCE) that measured the relative value and odds ratio of elective double eyelid surgery surgical options and marginal willingness to pay for procedure attributes. ResultsA total of 554 respondents were included in the final analysis (41.9% males, 57.9% females). Totally 47.1% of the respondents perceive double eyelid surgery as acceptable, with surgeon proficiency being the most important attribute (25.88%) followed by healthcare facilities (17.90%), maintenance time of double eyelid (18.62%), and others. Respondents held a Juste-milieu and moderate mind for ocular aesthetics. Those who accepted the surgery had higher ratings on all items of the modified body-image measures than their counterparts, with the sum of the 5-point Likert values being 27.5 (SD 11.2) versus 21.2 (SD 10.0) (P<0.001 for all), whereas there are no differences in the general self-efficacy scale. ConclusionChinese respondents prioritized improving their physical appearance and preferred undergoing aesthetic double eyelid surgery with a skilled surgeon at a higher-tier hospital. Understanding patients' stated preferences, training new surgeons, and improving Chinese medical system facilities are vital and urgent to better balance patient expectations and improve aesthetic surgical satisfaction.

Internal disorder in the temporomandibular joint in young patient : Conservative Treatment vs Surgical Treatment Part 1.

Abstract: The patient presents with algia in the left mandible and in the ocular region, specifically at the base of the orbit. Initially, after clinical examination, the suspicion was migraine associated with bruxism with internal joint disorder. After imaging exams by tomography and magnetic resonance imaging with T1, T2, and DP contrast, it was observed that in the left temporomandibular joint, there is disc displacement without reduction, and in the right temporomandibular joint, the disc shows partial recovery. After one year of using an interocclusal device, the patient shows improvement in pain symptoms; however, the disc has only slightly improved in recovery, suggesting the possibility of future open surgery for disc repositioning through discopexy.

Video Enhancement to Reduce Reflection and Darkness Caused by the Sunglasses using Fusion Algorithm

The enhancement of video of a person wearing sunglasses to reduce the reflection and darkness is a very challenging task in computer vision applications such as video surveillance. The existence of reflections and darkness caused by sunglasses results in intrusive images. The absence of a clear eye diminishes the visible quality of the complete face image. The eyes under sunglasses are not identified clearly if the reflection and darkness exist in the sunglasses. This paper demonstrates the reduction of adverse artifacts such as reflection and darkness in the eye region caused by sunglasses. The system is carried out with the fusion algorithm which consists of three modules: eyeglass tracking on face images, reduction of reflection, and reduction of darkness through the image enhancement method. The image enhancement method includes a color balance algorithm and a histogram stretching algorithm. Firstly, an automatic glasses presence detection model, based on a Robust Local Binary Pattern identifies the imaging process of the ocular region covered by the sunglasses. Secondly, a non-convex optimization scheme, guided by landmarks on the glasses, effectively reduces reflections through several iterations. The image enhancement method incorporating Color Balance, and Histogram Stretching is used to identify eye regions within sunglasses. The resulting regenerated eye regions within sunglasses exhibit increased brightness, subtle darkness, and minimized reflection. The objective evaluation metrics such as peak signal-to-noise ratio, structural similarity index measure, and logarithmic mean square error are used to measure the strength of the proposed system. Qualitative evaluations are conducted to demonstrate the good quality of eyeglass face images with reduced reflection and darkness.

Leucocoria como presentación inicial de un coloboma retiniano

Coloboma is a rare congenital defect (2.4-8.0/10 000 live births) of a sector of the eyeball. Iris disease manifests itself with anomalies in the shape of the iris (keyhole or oval pupil) and/or photophobia. An association may be observed with coloboma in other ocular regions and with complex malformation syndromes. We present the case of a 15-day-old newborn with a clinical diagnosis of unilateral leukocoria, which turned out to be an extensive coloboma of the optic nerve with retinal extension. The genetic study showed the presence of the morbid gene MAB21L2, described with heterozygous mutations related to microphthalmia and/or coloboma, with or without rhizomelic skeletal dysplasia.

OcularSeg: Accurate and Efficient Multi-Modal Ocular Segmentation in Non-Constrained Scenarios

Multi-modal ocular biometrics has recently garnered significant attention due to its potential in enhancing the security and reliability of biometric identification systems in non-constrained scenarios. However, accurately and efficiently segmenting multi-modal ocular traits (periocular, sclera, iris, and pupil) remains challenging due to noise interference or environmental changes, such as specular reflection, gaze deviation, blur, occlusions from eyelid/eyelash/glasses, and illumination/spectrum/sensor variations. To address these challenges, we propose OcularSeg, a densely connected encoder–decoder model incorporating eye shape prior. The model utilizes Efficientnetv2 as a lightweight backbone in the encoder for extracting multi-level visual features while minimizing network parameters. Moreover, we introduce the Expectation–Maximization attention (EMA) unit to progressively refine the model’s attention and roughly aggregate features from each ocular modality. In the decoder, we design a bottom-up dense subtraction module (DSM) to amplify information disparity between encoder layers, facilitating the acquisition of high-level semantic detailed features at varying scales, thereby enhancing the precision of detailed ocular region prediction. Additionally, boundary- and semantic-guided eye shape priors are integrated as auxiliary supervision during training to optimize the position, shape, and internal topological structure of segmentation results. Due to the scarcity of datasets with multi-modal ocular segmentation annotations, we manually annotated three challenging eye datasets captured in near-infrared and visible light scenarios. Experimental results on newly annotated and existing datasets demonstrate that our model achieves state-of-the-art performance in intra- and cross-dataset scenarios while maintaining efficient execution.

Chinese expert consensus on the diagnosis and management of ocular adnexal extranodal marginal zone mucosa-associated lymphoid tissue lymphoma (2023 edition)

Ocular adnexal extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (OAML) is a common malignant tumor that affects the ocular adnexal region. The incidence of OAML is increasing due to the aging population. The tumor invades the ocular adnexal region, which can result in abnormal ocular appearance and function, thereby reducing the quality of life. Currently, there is no standardized diagnosis and management guideline for OAML. To enhance the standardization of diagnosis and management in OAML, a collaborative effort was undertaken by esteemed organizations in China. The Cellular Immune Therapy Committee of China Association for Promotion of Health Science and Technology, the Ocular Tumor Committee of Chinese Medical Doctor Association for Ophthalmologist Branch, the Imaging Medicine Branch of Chinese International Exchange and Promotion Association for Medical and Healthcare, the Tumor and Microecology Professional Committee of China Anti-cancer Association, and the Lymphoma Immunotherapy Committee of Beijing Cancer Prevention Society jointly convened a panel of experts to develop the inaugural "Chinese Expert Consensus on the Diagnosis and Management of ocular adnexal extranodal marginal zone mucosa-associated lymphoid tissue lymphoma (2023 edition)"..

Feasibility of video-based real-time nystagmus tracking: a lightweight deep learning model approach using ocular object segmentation.

Eye movement tests remain significantly underutilized in emergency departments and primary healthcare units, despite their superior diagnostic sensitivity compared to neuroimaging modalities for the differential diagnosis of acute vertigo. This underutilization may be attributed to a potential lack of awareness regarding these tests and the absence of appropriate tools for detecting nystagmus. This study aimed to develop a nystagmus measurement algorithm using a lightweight deep-learning model that recognizes the ocular regions. The deep learning model was used to segment the eye regions, detect blinking, and determine the pupil center. The model was trained using images extracted from video clips of a clinical battery of eye movement tests and synthesized images reproducing real eye movement scenarios using virtual reality. Each eye image was annotated with segmentation masks of the sclera, iris, and pupil, with gaze vectors of the pupil center for eye tracking. We conducted a comprehensive evaluation of model performance and its execution speeds in comparison to various alternative models using metrics that are suitable for the tasks. The mean Intersection over Union values of the segmentation model ranged from 0.90 to 0.97 for different classes (sclera, iris, and pupil) across types of images (synthetic vs. real-world images). Additionally, the mean absolute error for eye tracking was 0.595 for real-world data and the F1 score for blink detection was ≥ 0.95, which indicates our model is performing at a very high level of accuracy. Execution speed was also the most rapid for ocular object segmentation under the same hardware condition as compared to alternative models. The prediction for horizontal and vertical nystagmus in real eye movement video revealed high accuracy with a strong correlation between the observed and predicted values (r = 0.9949 for horizontal and r = 0.9950 for vertical; both p < 0.05). The potential of our model, which can automatically segment ocular regions and track nystagmus in real time from eye movement videos, holds significant promise for emergency settings or remote intervention within the field of neurotology.

A case of iridoschisis with partial lens dislocation in both eyes

BackgroundIridoschisis is a rare condition that primarily affects individuals aged 60–70 years. The predominant characteristics of iridoschisis involve the tissue splitting and separation of the iris stromal layers, often resulting in two distinct layers and the presence of floating fibers in the anterior chamber. This article reports the case of a 48-year-old male with iridoschisis with partial lens dislocation in both eyes.Case presentationTrauma is the leading factor in the development of iridoschisis. However, there is no documented case of ocular trauma in the patient’s medical history. Visible white atrophic fibers were observed bilaterally in the anterior iris stroma of both eyes of the individual, accompanied by a small quantity of iris tissue within the anterior chamber. In this instance, the magnitude of the iridoschisis corresponded with the degree of lens dislocation. We were apprised that the patient had regularly used a cervical massager for a prolonged period of time, positioning it upon the ocular region. Frequent stimulation of both eyes with excessive force resulted in the development of iridoschisis and the partial dislocation of the lens.During the initial surgical procedure, phacoemulsification (Phaco) was carried out on the left eye without the placement of an intraocular lens (IOL). Following a two-month interval, we proceeded with the IOL suspension. Subsequently, the right eye underwent Phaco, accompanied by the implantation of an IOL. After closely monitoring the patient’s progress for two months, it was evident that their vision had significantly improved, substantiating the success of the surgical interventions.ConclusionsThis finding posits that the recurrent friction applied to both eyes may induce iridoschisis and various ocular complications. In the event of ocular intricacies manifesting, expeditious medical intervention becomes imperative.

Advancing in vivo modelling and delivery systems for triplet repeat expansion‐mediated corneal endothelial dystrophy: Implications in Anti‐miR therapy

Aims/Purpose: Triplet repeat expansion‐mediated endothelial corneal dystrophy, including Fuchs endothelial corneal dystrophy (FECD), is characterized by abnormal expansions of trinucleotide repeats, resulting in corneal endothelium dysfunction [1,2]. This study aims to characterize a reliable in vivo model, that it lacks, and explore the therapeutic potential of anti‐miRs, which have shown efficacy in other disorders involving triplet repeat expansions [3,4,5]. Current invasive delivery methods for eye‐based treatments present challenges, so our focus is on optimizing non‐invasive delivery methods for anti‐miR‐based therapy.Methods: A transgenic mouse model with a significant CTG repeat expansion (&gt;1000), established in DM1, was investigated as an in vivo model for corneal endothelial dystrophy. The Fuchs‐like phenotype of the disease was characterized using immunohistochemistry and FISH techniques. Delivery methods were explored to enhance the targeting of corneal endothelial cells (CEC). Delivery efficacy and marker expression were assessed using fluorescence, RT‐qPCR, PCR, western blotting, and immunocytochemistry techniques. FECD cell cultures were established to evaluate the challenging FECD‐specific delivery systems.Results: A novel in vivo model has been characterized for studying corneal endothelial dystrophy caused by triplet repeat expansion, exhibiting similarities to the Fuchs‐like phenotype. Enhanced delivery methods have been identified to improve transfection efficiency in endothelial (HUVEC) and CEC. Successful establishment of FECD cell cultures has allowed the evaluation of these enhanced delivery systems.Conclusions: The first successful characterization of an in vivo model for triplet repeat expansion‐mediated corneal endothelial dystrophy has been achieved. This model shows potential for assessing the reversal of these phenotypes in the ocular region. Moreover, the successful delivery of new systems across CEC suggests the possibility of non‐invasive administration of anti‐miR directly into the eye. This breakthrough opens the door for future research on anti‐miRs in other diseases caused by triplet repeat expansion, such as FECD.ReferenceIn PMID: [1] 28886202, [2] 34130750, [3] 29946070, [4] 32805487, [5] 22764244.

Fluocinolone Acetonide Loaded Chitosan Nanofiber Scaffolds for Treatment of Ocular Disorders: In Vitro Characterization, Ex-Vivo Corneal and Ex-Vivo Scleral Evaluation

Purpose Drugs administered in the ocular region need to overcome ocular barriers without permanently damaging the ocular tissues. Moreover, ocular disorders of the posterior segment are more difficult to treat due to invasive procedures required to reach the posterior segment. Hence, to treat posterior disorders of the eye an attempt was made to develop nanofiber (NF) scaffolds for effective management of chronic posterior uveitis. Nanofibers (NFs) were formulated using the electrospinning technique. Methods NF scaffolds were formulated using the electrospinning technique. The effect of different concentrations of chitosan on NF production was studied by considering different ratios of chitosan (CS) and polyvinyl alcohol (PVA). Physicochemical characterization of NFs was performed to evaluate developed NFs. Results The optimized NF scaffold had a diameter of 129 ± 3 nm. NF scaffolds were found to have a tensile strength of 0.2882 ± 0.078 N/m2, thickness of 0.16 ± 0.05 mm, and drug entrapment of 95 ± 2.0%. The bioadhesive strength of the NF was found to be 257.3 ± 0.04 g/cm2 indicating high bioadhesion of NFs to the ocular tissues. The in-vitro, ex-vivo corneal and ex-vivo scleral drug release after 12 h was found to be 78.4 ± 1.0%, 65.33 ± 0.2% and 78.41 ± 1.0%, respectively. Ex-vivo whole eye model experiment indicated a concentration of about 40 ± 1.75% of drug permeated from corneal layer to the vitreous humor after 12 h. The Hen’s egg test-chorioallantoic membrane study (HET-CAM) study and in-vitro cytotoxicity study on Statens Seruminstitut Rabbit Cornea (SIRC) cell lines indicated that the developed drug-loaded NF scaffolds were found to be non-toxic as compared to pure drug, thus suggesting cytocompatibility. Conclusion Results of HET-CAM, sterility and ex-vivo studies indicate that the developed formulation is non-toxic, sterile, and effective for the ocular delivery of fluocinolone acetonide to the posterior segment of eye.

Thermographic ranges of dromedary camels during physical exercise: applications for physical health/welfare monitoring and phenotypic selection.

Despite the relatively wide knowledge of camel biomechanics, research into the immediate functional response that accompanies the execution of physical exercise remains unapproached. Therefore, selective breeding programs lack an empirical basis to achieve genetic improvement of physical stress tolerance traits and monitor camel welfare in this regard. Given the fact that physical exercise increases net heat production, infrared thermography (IRT) was selected to study the temperature changes at the skin surface of the different body areas in clinically normal dromedary camels, mostly relegated to leisure activities. Specifically, a lower dispersion at the individual level of the surface temperature at the scapular cartilage region, shoulder joint, and pelvis region, as well as lower values for Tmax and Tmin at the region of the ocular region, pectoral muscles, semimembranosus-semitendinosus muscles, and hind fetlock after exercise, have to be considered as breeding criteria for candidate selection. Such thermophysiological responses can be used as indirect measures of tissue activity in response to exercise and hence are reliable indicators of animal tolerance to physical exercise-induced stress. Additionally, sex, castration, age, and iris pigmentation significantly impacted the thermo-physiological response to exercise in the study sample, which can be attributed to hormones, general vigor, and visual acuity-mediated effects. These specific factors' influence has to be considered for the evaluation of physical performance and the design of selection schemes for physical-related traits in dromedaries.

Homozygous Duplication in the CHRNE in a Family with Congenital Myasthenic Syndrome 4C: 18-Year Follow Up.

Congenital myasthenic syndromes (CMSs) are rare inherited diseases characterized by muscle weakness and fatigability on exertion resulting from defects in the neuromuscular junctions. Mutations in 32 genes have been reported as the underlying causes of CMS, with mutations in the cholinergic receptor nicotinic epsilon subunit (CHRNE) being the most common cause of the disease. Methodology and Materials: This study investigated a large consanguineous family with multiple individuals suffering from abnormal fatigue and muscle weakness in the ocular and limb regions. Moreover, the affected individuals were followed up for 18 years to observe the clinical course of the disease. High-quality exome sequencing followed by bidirectional Sanger sequencing revealed a homozygous duplication variant (NM_000080.4: c.1220-8_1227dup) in the splice acceptor site of exon 11 of the CHRNE gene. This variant is predicted to cause frameshift and premature termination (p.Cys410ProfsTer51). Both parents had heterozygous duplication variants with no clinical symptoms. The personalized treatment of the affected individuals resulted in a marked improvement in the clinical symptoms. More than 80% of the disease symptoms in the affected individuals subsided after the use of pyridostigmine and salbutamol (4 mg). This is the first report of long-term follow up of cases with homozygous insertion (c.1220-8_1227dup) in the CHRNE gene. Furthermore, this report expands the phenotypic symptoms associated with the CHRNE mutation.

Ion-Sensitive in situ gelling Solution containing Tobramycin for Management of Ocular Infections

Stimuli Sensitive Drug Delivery Systems have become a promising approach in the field of drug delivery and contributed by use of polymers which are able to deliver drug in response to change in surrounding environmentsuch change in temperature, pH, ionic strength, enzymes or biomolecules. Ocular drug delivery often encounters the problems of low instillation quantity of medicament and also poor residence of drug in the ocular region which decreases the efficiency of the treatment. An ineffective antibacterial treatment would lead to bigger problems like resistance. Hence the current study was undertaken to formulate Ion-sensitive in-situ ophthalmic gelling solution of Tobramycin using Sodium alginate as ion sensitive polymer. The batches were prepared by using 32 factorial designwhere sodium alginate and HPMC K4M were selected as independent variables. The evaluation of various dependent parameters like clarity, viscosity, mucoadhesion and in vitro release was done. The formulations were ensured to be sterileand isotonic. The in-situ gelation occurred when the formulation came in contact with tear fluid with good mucoadhesion and gel strength. The Tobramycin drug release study showed release over a period of more than two hours. In vivoeye irritation test was done on white rabbits.

BILATERAL SELF-ENUCLEATION IN THE FIRST PSYCHOSIS EPISODE IN A PERSON WITH DEPRIVED OF LIBERTY: CASE REPORT

Introduction – Self-mutilation is an uncommon manifestation of diverse mental disorders and is more frequent in the first psychotic episode. The ocular, genital, and limb regions are the main areas affected. Methods – Presented the case of a 25-year-old male deprived of liberty who committed bilateral self-enucleation using a razor blade secondary to a first psychosis episode. Results – Patient did the auto-mutilation associated with magical and religious delusions, but there was no clinical evidence to consider it an organic mental disorder. Discuss – Self-multilation during the first episode of psychosis is highly related to schizophrenia spectrum pathologies. Delusions, especially auditory delusions and substance abuse, should be a red flag of psychosis. Conclusion – Knowledge about the consequences of psychiatric pathologies has a relevant impact on morbidity and mortality, especially in vulnerable populations. The case demonstrated the necessity of prompt treatment and psychiatric intervention to avert personal and non-personal injuries. Keywords: self-enucleation, self-mutilation, psychosis, self-harm, case report.

Sebaceous Cell Carcinoma of the Ocular Region

Sebaceous Cell Carcinoma of the Ocular Region

Ocular Artifact Removal Method Based on the Wavelet and ICA Transform

The electroencephalogram is a promising tool used to unravel the mysteries of the brain. However, such signals are often disturbed by ocular artifacts caused by eye movements. In this study, Independent Component Analysis and Wavelet Transform based ocular artifact removal method, which does not need reference signals, is proposed to obtain signals free from ocular artifacts. With our proposed method, firstly, the ocular artifact regions in the time domain of the signal are detected. Then the signal is decomposed into its components by independent component analysis and independent components containing artifacts are detected. Wavelet transform is only applied to these components with artifact. Zeroing is applied to the parts of the wavelet coefficients obtained as a result of the wavelet transform corresponding to the ocular artifact regions in the time domain. Finally, the clean signal is obtained by inverse Wavelet transform and inverse Independent Component Analysis methods, respectively. The proposed algorithm is tested on a real data set. The results are given in comparison with the method in which the zeroing is applied to the classical independent components. According to the results, it is seen that most of the signal is not affected by the zeroing and the neural part of the EEG signals is successfully preserved.