Occurrence Of Pharmaceutical Residues Research Articles

Occurrence of pharmaceutical residues in drinking water: a systematic review.

The aim of the present paper was to give a complete picture on the drinking water contamination by pharmaceutical residues all over the world. For this purpose, a systematic review was carried out for identifying all available research reporting original data resulting by sampling campaign and analysis of "real" drinking water samples to detect pharmaceutical residues. The investigated databases were PubMed, Scopus, and Web of Science. A total of 124 studies were included; among these, 33 did not find target analytes (all below the limit of detection), while the remaining 91 studies reported the presence for one or more compounds, in concentrations ranging from a few units to a few tens of nanograms. The majority of the studies were performed in Europe and the most represented categories were nonsteroidal anti-inflammatory drugs and analgesics. The most common analytical approach used is the preparation and analysis of the samples by solid-phase extraction and chromatography coupled to mass spectrometry. The main implications resulting from our review are the need for (a) further studies aimed to allow more accurate environmental, wildlife, and human health risk assessments and (b) developing integrated policies promoting less environmentally persistent drugs, the reduction of pharmaceuticals in livestock breeding, and the update of wastewater and drinking water treatment plants for a better removal of drugs and their metabolites.

Occurrence of Pharmaceutical Residues and Antibiotic-Resistant Bacteria in Water and Sediments from Major Reservoirs (Owabi and Barekese Dams) in Ghana

The presence of pharmaceuticals in the environment is undesirable since their biological activity may impair ecosystem health of reservoirs that receive inflows from other water sources. This work determined the concentrations of analgesics and antibiotics, and the occurrence of antimicrobial resistance among microbes in water and sediment samples from Owabi and Barekese reservoirs—two main sources of pipe-borne water in the Kumasi metropolis in Ghana. The study also assessed the knowledge, attitude, and practice of inhabitants near these reservoirs regarding the disposal of unused and expired medicines. Out of nine targeted pharmaceuticals, four were detected in at least one sample. Five analytes (caffeine, ciprofloxacin, doxycycline, ibuprofen, and metronidazole) were below detection limit for all samples. The levels of pharmaceuticals were low, as expected, ranging from 0.06 to 36.51 μg/L in the water samples and 3.34–4.80 μg/kg in sediments. The highest detected concentration of any pharmaceutical in water was for diclofenac (107.87 μg/L), followed by metronidazole (22.23 μg/L), amoxicillin (1.86 μg/L), chloramphenicol (0.85 μg/L), and paracetamol (0.16 μg/L). Chloramphenicol recorded the highest concentration (10.22 μg/kg) in the sediments. Five bacteria isolates (Enterobacter, Clostridium, Pseudomonas, Acinetobacter, and Klebsiella) from the samples were resistant to all the antibiotics tested. Isolates of Corynebacterium and Listeria showed susceptibility to only doxycycline. Isolates of Bacillus were susceptible to only two antibiotics (erythromycin and doxycycline). All the 100 respondents interviewed admitted that they dispose of medications once they do not need them. Of those who disposed of unwanted medicines, 79% did so inappropriately. Disposal in household trash (67%) was the most common method used. Majority of respondents felt the need for a facility or program to collect unused medicines (77%), hence their willingness to pay to reduce pollution by pharmaceuticals in the environment. It is quite clear from the ecotoxicological risk assessment that a single pharmaceutical at very low level as those in this study and other works is likely to pose many ecological risks upon long-term exposure and therefore cannot be ignored.

Effect of seasonal variation on the occurrences of high-risk pharmaceutical in drain-laden surface water: A risk analysis of Yamuna River

The occurrence of pharmaceutical residues in the aquatic ecosystem is an emerging concern of environmentalists. This study primarily investigated the seasonal variation of high-priority pharmaceutical residues in the Yamuna River, accompanied by 22 drains discharge from different parts of Delhi. Five sampling sites were selected for analyzing high-priority pharmaceuticals along with physico-chemical and biological parameters for 3 season's viz. pre-monsoon (PrM), monsoon (DuM), and post-monsoon (PoM), respectively. The maximum occurrences were detected during the PoM, compared to the PrM and DuM seasons. The maximum concentration of BOD, COD, and Phosphate was detected at the last sampling station (SP-5). Similarly, all targeted pharmaceuticals concentration were maximum at the last sampling point i.e. Okhla barrage (SP-5, max: DIC = 556.1 ng/l, IBU = 223.4 ng/l, CAR = 183.1 ng/l, DIA = 457.8 ng/l, OFL = 1726.5 ng/l, FRU = 312.2 ng/l and SIM = 414.9 ng/l) except at Barapulla downstream (SP-4, max: ERY = 178.1 ng/l). The mean concentrations of Fecal coliform (FC) ranged from 1700 to 6500 CFU/100 ml. The maximum colonies were detected in PrM season (6500 CFU/100 ml) followed by PoM (5800 CFU/100 ml) and least in DuM (1700 CFU/100 ml). Risk quotient (RQ) analysis of high-priority pharmaceuticals indicated high ecotoxicological risks exposure (>1) from DIC, DIA, OFL, and SIM in all seasons at all the sampling sites. However, lower risk was predicted for IBU, CAR, ERY, and FRU, respectively. This risk assessment indicated an aquatic ecosystem potentially exposed to high risks from these pharmaceutical residues. Moreover, seasonal agricultural application, rainfall, and temperature could influence the levels and compositions of pharmaceutical residue in the aquatic ecosystem. Hence, attention is required particularly to this stream since it is only a local lifeline source for urban consumers for domestic water supply and farmers for cultivation.

Occurrence of pharmaceutical residues, personal care products, lifestyle chemicals, illicit drugs and metabolites in wastewater and receiving surface waters of Krakow agglomeration in South Poland

This is the first study of broad range of chemical classes CECs conducted in the upper Wisla river catchment including the biggest WWTPs in this region and surface waters. The list of compounds is extensive and the paper provides, for the first time, better understanding of environmental burden from PCPCs in Poland. Cumulative contribution of hypertension pharmaceuticals, nonsteroidal anti-inflammatory drugs (NSAIDs) and lifestyle chemicals was 89% and 95% in wastewater influent, and 75% in wastewater effluent at both WWTPs. Significant removal efficiencies, exceeding 90%, were found for parabens, UV filters, NSAIDs, steroid estrogens, plasticizers, antibacterials/antibiotics, stimulants and metabolites and lifestyle chemicals. The comparison of the average mass loads of CECs between the influent and effluent, has shown that 27% and 29% of all detected CECs were removed by less than 50%. An increase of concentrations of CECs in the effluent was observed for 18% and 20% of all detected CECs in Kujawy and Plaszow WWTPs, respectively. Negative mass balances of fexofenadine, venlafaxine, o-desmethyltramadol, ketamine and temazepam were noted within WWTPs, which are a result of dissolution of persistent contaminants accumulated in aggregates and/or back-transformation or de-conjugation of metabolites into parent compounds. 44 CECs were detected in surface waters located upstream and downstream of the WWTPs. The concentrations of compounds were largely dependent on the dilution factor of WWTP discharge. The risk quotation (RQ) values for compounds present in surface waters were calculated in relation to their potential for bioaccumulation. Among compounds with high potential for bioaccumulation, with log KOW ≥ 4.5, diclofenac, atorvastatin and triclosan were found to be of high risk. Many CECs with high, moderate or even low environmental impact have shown high potential for bioaccumulation and should be considered as priority at the same risk level. Moreover, possible synergistic action is still of concern.

Single-Molecule Sensing of DNA Intercalating Drugs in Water.

The occurrence of pharmaceutical residues in surface water is raising environmental concern. To accompany the evolution of measures for natural resources protection, sensing methods enabling sensitive and rapid water quality monitoring are needed. We recently managed the parallelization of the Tethered Particle Motion (TPM), a single molecule technique, sensitive to the conformational changes of DNA. Here, we investigate the capacity of high throughput TPM (htTPM) to detect drugs that intercalate into DNA. As a proof-of-concept we analyze the htTPM signal for two DNA intercalating dyes, namely, YOYO-1 and SYTOX orange. The efficient detection of intercalating drugs is then demonstrated with doxorubicin. We further evaluate the possibility to detect carbamazepine, an antiepileptic massively prescribed and persistent in water, which had been described to interact with DNA through intercalation. Our results corroborated by other techniques show that, in fact, carbamazepine is not a DNA intercalator. The comparison of the results obtained with different aqueous buffers and solutions allows us to identify optimal conditions for the monitoring of intercalation compounds by htTPM.

Public awareness level and occurrence of pharmaceutical residues in drinking water with potential health risk: A study from Kajang (Malaysia)

Studies on the occurrence of pharmaceutical residues in drinking water were conducted especially in developed countries. However, limited studies reported the occurrence of pharmaceutical residues in developing countries. Thus, this study is conducted to fill the knowledge gap of pharmaceutical residue occurrences in developing countries, particularly in Malaysia, along with public awareness level and its potential human health risk. This study investigates public awareness level of drinking water quality and pharmaceutical handling, the occurrence of nine pharmaceutical residues (amoxicillin, caffeine, chloramphenicol, ciprofloxacin, dexamethasone, diclofenac, nitrofurazone, sulfamethoxazole, and triclosan) and potential human health risks in drinking water from Kajang (Malaysia) using commercially competitive enzyme-linked immunosorbent assay kits. In general, the public awareness level of Kajang population showed poor knowledge (82.02%), and less positive attitude (98.88%) with a good practice score (57.3%). Ciprofloxacin was detected at the highest concentration (0.667 ng/L) while amoxicillin was at the lowest concentration (0.001 ng/L) in drinking water from Kajang (Malaysia). Nevertheless, all the reported occurrences were lower than previous studies conducted elsewhere. There was no appreciable potential human health risk for all the pharmaceutical residues as the risk quotient (RQ) values were less than 1 (RQ < 1). The results of this study will provide authorities with quantitative knowledge and resources to improve drinking water risk management and regulation in Malaysia.

Pharmaceutical residues in water and sediment of Msunduzi River, KwaZulu-Natal, South Africa

The little data about pharmaceutical residue contamination in African water bodies motivated our study on the occurrence of pharmaceutical residues in the water and sediment of Msunduzi River in the KwaZulu-Natal province of South Africa; and in the Darvill wastewater treatment plant found in Msunduzi catchment. Samples collected along the River and wastewater treatment plant were extracted and analysed for pharmaceutical residues selected based on statistics of drug usage in South Africa i.e. antipyretics, antibiotics, caffeine, an antiepileptic and an antipsychotic drug were determined using HPLC–MS/MS.In all the matrices investigated, the antipyretic ibuprofen had the highest concentration of up to 117μgL−1, 84.60μgL−1 and 659ngg−1 in wastewater, surface water and sediment respectively. Antibiotics were detected in generally low concentrations of<10μgL−1 in surface water samples and up to 34.50μgL−1 in wastewater; moreover they were not completely removed during wastewater treatment. The percentage removal efficiency of the studied group was 6.55–98.00% for antipyretics, 73.33–98.90% for antibiotics, 48.80% for the anti-epileptic drug and 86.40% for Caffeine. Clozapine exhibited a negative removal.In surface water, Henley dam exhibited a high concentration of the pharmaceutical residues and the highest concentration of metronidazole in sediment (up to 1253.50ngg−1) detected. Metronidazole was only detected in sediment and bio-solids.

Occurrence and environmental implications of pharmaceuticals in Chinese municipal sewage sludge

The presence of pharmaceuticals in aquatic environment has become a topic of concern because of their potential adverse effects on human health and wildlife species. A total of 45 dewatered sewage sludge samples were collected throughout China and analyzed for 30 commonly consumed pharmaceutical residues. Ofloxacin was found to be the dominant contaminant with concentrations up to 24760μgkg−1, followed by oxytetracycline (5280μgkg−1), norfloxacin (5280μgkg−1) and ketoprofen (4458μgkg−1). The concentration of pharmaceutical residues varied greatly depending on the operation conditions of wastewater treatment plants and sampling locations. Poor agreement was found between the predicted (calculation based on the annual consumption and coefficient of sludge water partition) and detected concentrations of the pharmaceuticals indicating that the occurrence of pharmaceutical residues was affected by various factors such as loading rates, sewage properties and the chemical properties such as the contribution from polar groups. National wide fate and ecotoxicity study is required for the development of control strategies.

Occurrence of antibiotics as emerging contaminant substances in aquatic environment

The occurrence of pharmaceutical residues in the environment has become a subject of growing concern. Due to the constant input of the emerging contaminants in the surface water via wastewater which leads to the long-term adverse effects on the aquatic and terrestrial organisms, special attention is being paid to their presence in the aquatic environment. Most of the emerging substances, especially pharmaceuticals, could not be completely removed using the wastewater treatment. Pharmaceuticals are usually water soluble and poorly degradable. They can pass through all natural filtrations and then reach the groundwater and, finally, the drinking water. The trace levels of antibiotics could have a negative impact on the environment and public health because of their inherent bioactivity. This article is an overview of the presence of the antibiotic residual concentrations, methods and levels of detection and possible risks to both health and environment.