Background: Sawmilling exposed workers to diverse occupational mishaps and subsequent health complications. Investigating workplace risk and health status can help mitigate morbidness and death among this group. Objectives: This study aimed to evaluate the occupational hazards and health status of sawmill workers in Akure, Nigeria. Methods: This cross-sectional descriptive survey was conducted on 304 sawmill workers in Akure metropolis selected via multi-stage sampling methodology. Data were collected using a pre-tested, standardized questionnaire. In addition, the body mass index (BMI), blood pressure (mmHg), and respiratory function parameters (spirometry) were measured. Descriptive and inferential statistics (chi-square) were used to evaluate and summarize the data, with a significance level of P < 0.05. Results: The respondents' average age was 42.0 ± 2.8 years. The common reported workplace hazards included noise 273 (89.8%), manual lifting of objects 221 (72.7%), heat 192 (63.2%), and wood dust 192 (63.2%), while common reported injuries were bruises 292 (96.1%), hearing impairment 281 (92.4%), electric shock 250 (82.2%), and fainting attack 232 (76.3%). The common prevalent ailments suffered by respondents in the last month were cough 158 (52.0%), phlegm production 149 (49.0%), chest pain 63 (20.7%), skin problems 100 (32.9%), and eyes irritation 111 (36.5%). The anthropometric measurement showed that most 272 (89.5%) sawmill workers are overweight and obese. Spirometry measurements revealed that one-third of the respondents had a forced expiratory ratio (FER) measurement below 70.00% and an abnormal respiratory rate. The bivariate analysis showed a significant correlation between the respondents' self-reported prior workplace injury, knowledge of workplace dangers, and sociodemographic characteristics (job category and educational level). Conclusions: The results showed that the respondents suffered from impaired respiratory function related to workplace hazard exposure and the non-usage of protective devices during operational activities. In addition, the majority are at risk of developing diverse cardiovascular and respiratory diseases due to workplace exposures.