PurposeThis work uses entropy generation analysis to numerically analyze magnetohydrodynamics (MHD) unsteady flow, heat and mass transfer. The study considers changing viscosity, thermal radiation, viscous dissipation, mass suction, heat generation, and stratification processes in a hybrid nanofluid around a spinning sphere. A two-phase nanofluid flow model (Buongiorno model) is used to tackle the current challenge. Both the free stream velocity and the sphere's angular velocity changed over time. Design/methodology/approachThe case study's complicated partial differential equations are transformed into simpler ordinary differential equations utilizing similarity transformation. Implementing the fourth-order Runge-Kutta Fehlberg method with a shooting scheme in MATHEMATICA has allowed us to get numerical solutions for ordinary differential structures. FindingsThe many aspects of these regulated physical characteristics have been elucidated and thoroughly examined via the use of charts and tables. For increasing values of unsteadiness parameter, the velocity profiles in the x-direction grow while they decrease in the z-direction. On the other hand, the temperature profile exhibits a dual pattern, and the concentration profile decreases. As the chemical reaction parameter climbs from 0.25 to 1.0, the Sherwood number for the nanofluid rises by 6721.39% and for the hybrid nanofluid, 3818.9%. When Nr increases from 0.2 to 0.8, nanofluid Nusselt number climbs 22.5% and hybrid nanofluid's Nusselt number rises 21.9%. The Brinkmann number and nanoparticle volume percentage are strongly associated with entropy production. Entropy generation is dual for the temperature difference, magnetic, radiation, and changeable viscosity parameters. The findings are also compared to those from the existing literature and are in excellent agreement with them.