A multi-level matching transformation and optimization design method for complex sections of thin-walled structures in steel/aluminum vehicle body skeleton was proposed. The problems of lengthy body performance numerical analysis and low optimization efficiency were solved by the rapid collaborative optimization of simplified cross-sections and performance of the body skeleton. A complex cross-sections shape library of thin-walled structures in steel/aluminum body skeleton and formulas for solving section mechanical properties were established, which overcame the difficulty of translating simplified cross-sections of thin-walled structures in steel/aluminum body skeleton to actual complex sections. A precise optimization method for complex cross-sections of thin-walled structure controlled by proportional vectors was established, which solved the defect that it was difficult to precisely control the arbitrary change of complex cross-section shape, and provided a new way for lightweight optimization design of complex cross-sections. The proposed method achieved the rapid collaborative design of steel/aluminum body thin-walled structure with complex cross-sections and body skeleton performance through multi-level progressive cross-section matching transformation and optimization. A body skeleton model with actual complex cross-sections was established, and compared with the initial simplified structure, the weight reduction ratio of the body skeleton was up to 6.9 %, and the performance indicators of the body skeleton fully met the design requirements, which verified the effectiveness of the proposed method.