The article discusses the importance of implementing innovations at road transport enterprises in the context of achieving the region's sustainable development goals. The author emphasizes that road transport enterprises are significant sources of harmful emissions and environmental pollution, so using innovative technologies, such as electric vehicles, hybrid cars, and alternative fuels, is an important tool for reducing the negative environmental impact. In particular, these technologies help to reduce greenhouse gas emissions and other harmful substances, which is in line with Sustainable Development Goals 7 (access to modern energy), 13 (combating climate change), and 15 (protecting terrestrial ecosystems). In addition, innovations in transport technologies, such as automated driving systems, help to improve road safety and reduce the number of road accidents, which is in line with Goal 3 (good health and well-being). The creation of new jobs and infrastructure development through the construction of electric charging stations and the introduction of intelligent transport systems (smart cities) are also linked to Sustainable Development Goals 9 (sustainable infrastructure) and 11 (sustainable urban development). The author analyses the performance indicators of innovations at motor transport enterprises, taking into account economic, social, and environmental aspects. Particular emphasis is placed on the adaptation of these indicators to the current realities of Ukraine. Using game theory, the article develops a model for the selection of optimal strategies for motor transport enterprises and the region. This model allows us to find the Nash equilibrium - a situation where both parties achieve the optimal result. Enterprises that implement innovations not only improve their own performance indicators, but also contribute to the achievement of sustainable development goals of the region. The article also presents two sets of strategies: for the development of logistics activities of a motor transport enterprise and the sustainable development of the region. Both approaches aim to comprehensively improve the region's environmental, economic, and social situation. The conclusions emphasize the importance of implementing innovation development assessment systems as a tool for making strategic decisions and improving the efficiency of logistics operations.