Number Of Pregnancies In Women Research Articles

The invisible problem of early adolescent pregnancy in the Dominican Republic: a descriptive analysis

Study objectivesThe aim of this article is to describe the problem of pregnancy in girls under 15 years of age in the Dominican Republic in the period 2000–2021, to develop a specific indicator for this age group and describing the related factors. MethodsThis is an exploratory ecological study, based on secondary data sources, such as birth records from the National Statistics Office (NSO) and the Ministry of Public Health (MPH). We calculated the rates of fertility and pregnancy in early adolescence, as well as analyzed their main determining factors and consequences. ResultsFertility Rate in Early Adolescence (FREA) decreases from 6.27 to 1.04 per thousand in the period 2001–2021. The average FREA for 2015–2021 was 1.78. The average Estimated Rate of Pregnancy in Early Adolescence (ERPEA) for the same period was 3.39. Disability-Adjusted Life Years (DALYs) were 11,620 years. Years of Life Lost (YLL) were 9,665.9 years. The prevalence of Low Birth Weight (LBW) in the under 15-year-old age group was 14.2 %. ConclusionsPregnancy in childhood implies risks for both the mother and the child, including low birth weight. The official fertility rate is substantially underreported (2.84 vs. 1.79).The fertility rate indicator traditionally used does not accurately measure the number of pregnancies in women, particularly in specific age groups or populations where pregnancies may be interrupted by various factors. Therefore, the use of ERPEA is recommended.We emphasize the need for implementing the proposed indicator for the target group, as well as monitoring Sustainable Development Goal indicator 3.7.2.

Use of leflunomide among girls and women of childbearing age and occurrence of leflunomide-exposed pregnancies in Germany

Leflunomide is contraindicated during pregnancy and treatment cessation is recommended two years before pregnancy. We aimed to describe leflunomide use in women of childbearing age in Germany, the occurrence of pregnancies in women using leflunomide and malformations among children possibly exposed in utero. Using the GePaRD database (claims data, ∼20% of the German population), we determined annual age-standardized prevalences of leflunomide use between 2004 and 2019 among females aged 13–49 years. Further, we estimated the number of exposed pregnancies by assessing whether the exposure window assigned to the last dispensation before pregnancy (days covered by the dispensation plus two years) overlapped the onset of pregnancy or whether there was a dispensation in the first eight weeks of pregnancy. For exposed live births, a mother-baby linkage was performed and the presence of congenital malformation was assessed. The age-standardized prevalence of leflunomide use ranged between 0.34 and 0.46 per 1000 females during the study period. About one third of the users were ≤40 years. We identified 205 leflunomide-exposed pregnancies ending during the study period. 71% of these pregnancies ended in a live birth (26% preterm) and 10% in an induced abortion. In 86% of the live births (n=125) the mother-baby linkage was successful. Among these 125 children, 13 children (10%) had congenital malformations. In conclusion, we observed a considerable number of pregnancies in women using leflunomide in the two years before or during early pregnancy. This highlights the importance of monitoring the implementation of existing risk minimization measures for leflunomide in Germany.

The Impact of Sustainable Exercise and the Number of Pregnancies on Self-Efficacy, Self-Esteem, and Assertiveness Levels in Pregnant Women

This study examined the variations in self-efficacy, self-esteem, and assertiveness levels among pregnant women engaging in sustainable exercise compared to those performing no physical activity. The study also explored the connection between these changes and the number of pregnancies. The sample included 220 pregnant women engaging in sustainable exercise and 210 pregnant women performing no physical activity. Sustainable exercisers were chosen from those engaged in physical activity for at least 30 min, twice a week. The participants were in the fourth to seventh month of their pregnancy. A simple random sampling technique was used to choose participants and a total of 430 pregnant women volunteered to participate in the study. The mean age of the participants was 31.45 ± 12.11 years. Data collection tools were the Self-Efficacy Scale (SES), the Coopersmith Self-Esteem Inventory (CSEI), and the Rathus Assertiveness Schedule (RAS). In data analysis, the impact of independent variables on self-efficacy, self-esteem, and assertiveness was evaluated by one-way ANOVA in groups of more than two, t-test in paired groups, the relationship between some independent variables and scales was evaluated by correlation, and descriptive features were shown as percentages. In cases where variance analyses were significant at 0.05 (p < 0.05), Tukey’s test was used as a post hoc test. The study’s results indicated a significant disparity between the mean self-efficacy and self-esteem scores of women engaged in sustainable exercise compared to those who were not. However, there was no significant difference between the two groups in terms of assertiveness levels. The mean scores of self-efficacy, self-esteem, and assertiveness differed significantly in respect to the number of pregnancies in exercising women. However, there were no significant differences in mean scores of self-efficacy, self-esteem, and assertiveness scores in terms of the number of pregnancies in women who did not exercise.

Nelson syndrome and perinatal challenges: A case report and systematic review of the literature.

Nelson syndrome is a rare and potentially life-threatening complication of treatment with total bilateral adrenalectomy for women with Cushing disease. A successful term pregnancy following fertility treatment in a patient with Nelson syndrome is presented. Our study provides guidance in the prenatal and intrapartum management of this condition. A case report and a systematic review of 14 papers describing 50 pregnancies are presented. An electronic database search included Medline (1946 to September 2022), Embase (1980 to September 2022), Cochrane Library, and UKOSS. A small number of pregnancies in women with Nelson syndrome are reported in literature, but there are no guidelines. Some authors detail the prenatal care provided to their patients. Four studies report prenatal monitoring with visual field checks and two report monitoring with X-rays. Five studies report the use of parenteral hydrocortisone at the time of delivery. Where described, women delivered appropriately grown newborns at term, with timing and mode of delivery dictated by obstetric indications. Preconception counseling and optimization of maternal health status improve pregnancy outcomes in women with Nelson syndrome. Multidisciplinary review in a combined obstetric-endocrine prenatal clinic is ideal. Awareness about potential complications during pregnancy and the postnatal period is crucial in providing optimal care to the mother and baby.

The key role of hepatology providers in optimizing reproductive care in patients with liver disease: A call to action.

The key role of hepatology providers in optimizing reproductive care in patients with liver disease: A call to action.

Inform Interferon Beta Exposure in the 2nd and 3rd Trimester of Pregnancy: A Register-Based Drug Utilisation Study in Finland and Sweden

Background: Previous studies showed no increased risk of interferon beta use before or early in pregnancy among women with multiple sclerosis (MS). However, knowledge about the utilisation and safety of interferon beta in later-stage pregnancy remains limited. This study aims to determine (1) the number of pregnancies in women with MS exposed to interferon beta in later-stage pregnancy (i.e. the second and third trimesters) in Finland and Sweden; (2) whether the number of pregnancies available in Finland and Sweden is adequate for a cohort study to assess the outcomes of interferon beta exposure in later-stage pregnancy.

Economic Effect of Covid-19 Pandemic on the Access of Birth Control Service in Health Facilities in Women of Childbearing Aged 15-49 Years

This paper describes the effect of the economic effects of the Covid-19 pandemic on access to birth control services in health facilities for women of childbearing age (WUS) 15-49 in West Java. This type of research is a quantitative description using Bivariate, Multivariate and dichotomic / binary logistic regression analysis. The results of this study indicate that there is no significant effect simultaneously between the effects of pandemic-19 on the use of modern contraceptives and an increase in the number of pregnancies in women of reproductive age (wus) 15-49 years in West Java because the p-value is 0.233 or more. The magnitude of the alpha used is 5% (0.05).) While each variable does not have a significant partial effect on Y in the X model. The sig values ​​are more than 0.05 (alpha) used. This means that the economic effect of the COVID-19 pandemic does not have a significant partial effect on access to family planning services in health facilities for women of childbearing age 15-49 years in West Java. The dependent variable is 33.1% and there are 100% -39% = 66.9 % other factors outside the model that explain the dependent variable in this study

Striae gravidarum and the Seynsche constitution (Zentr. F. Gyn., 1926, no. 27)

Having traced in 250 women the relationship between the tendency to form pregnancy scars and the woman's constitution, Seynsche (Zentr. F. Gyn., 1926, no. 27) found that there is a certain relationship between them, namely, in women with a clearly expressed female type, this tendency expressed much more sharply than in male-type women. The number of pregnancies in women does not have a significant effect on scar formation; a secondary role in this process is played by the age when a woman has her first birth.

The Number of Pregnancies and Deliveries and Their Association with Selected Morphological and Hemodynamic Parameters of the Pelvic and Abdominal Venous System.

Background: Although pregnancy has been identified as one of the risk factors for venous disease, the mechanism of this interaction remains unclear. Possibly, pregnancy results in overstrain and vein dilatation, which exceed their durability and persist after pregnancy. The aim of this study was the assessment of the relationship between the number of pregnancies in women with venous disease and the selected parameters of their venous systems. Patients and methods: The retrospective assessment concerned 518 patients subjected to the diagnostics of the venous system in the lower limbs and the abdomen/pelvis using ultrasound scan and magnetic resonance or computed tomography. Results: We found that the occurrence of pelvic venous symptoms increases proportionally to the number of pregnancies and is correlated with ovarian and parauterine vein dilatation/incompetence (e.g., 13.5% of nulliparous women reported pelvic pain, and reflux in left ovarian veins was detected in 21.4% of the patients from that group, whereas in women after two pregnancies, pain and reflux concerned 22.8% and 90.6% of patients, respectively). In the nulliparous group, the development of venous disease resulted from the presence of anatomic abnormalities in abdominal/pelvic veins. Conclusions: Our report proved that the number of pregnancies is correlated with the incidence of pelvic vein insufficiency. Although not specifically addressed in this study, some correlation was found with saphenous disease as well. However, further studies are necessary to provide more evidence about the role of pelvic vein insufficiency in chronic venous disease of the lower limbs.

Cardiometabolic and Thrombotic Risk Profile in Women Undergoing Oocyte Donation for Assisted Reproduction.

Background: The last two decades have seen a growing number of pregnancies in women who needed the donation of oocytes. With oocyte donation pregnancies, studies on obstetric outcomes among these women revealed an increased incidence of pre-eclampsia and pregnancy-induced hypertension. Furthermore, several studies have found a higher incidence of low birth weight, preterm birth, and delivery by cesarean section in oocyte donation rather than in women subjected to assisted reproduction techniques (ART) with autologous oocytes. Numerous studies have also shown a deep connection between cardiovascular and thrombotic risk factors and adverse pregnancy outcomes. In this setting, to strictly assess the preconceptional risk for women who undergo egg donation to achieve pregnancy, the aim of our study is to draw a detailed assessment of the vascular risk profile of patients with gamete donation ART indications through the evaluation of comorbidities and cardiometabolic and thrombophilic markers Materials and Methods: Patients undergoing ART with oocyte or sperm donation or double donation of gametes underwent a careful clinical assessment through a detailed personal and family anamnesis and they were evaluated for cardiometabolic and thrombophilic profile. Clinical and demographic characteristics, comorbidities, and biohumoral parameters were collected. The study was approved by the Regional Ethical Committee(Em 2018-017 CINECA 10189). Results: We evaluated 525 women. Around 73.1% were >40 years and 35% of them were older than 45 years. There was a high prevalence of dyslipidemias (58.1%), smoking habit (24.6%), a body mass index >25 in 28.6% of patients, a high abdominal circumference in 58.1% of cases, a prevalence of acquired thrombophilia in about 7% and hereditary of 19.2%. Around 39.2% of patients had total cholesterol >200 mg/dL, 19.5% had high-density lipoprotein <48 mg/dL and 43.6% had low-density lipoprotein >115 mg/dL, and 6.9% had triglyceride values >150 mg/dL. Conclusions: A careful assessment of the preconceptional status of patients undergoing ART programs with oocyte donation can be highly recommended.

Maternal Expressions (Serum Levels) of Alpha Tumour Necrosis Factor, Interleukin 10, Interleukin 6 and Interleukin 4 in Malaria Infected Pregnant Women Based on Parity in a Tertiary Hospital in Southeast, Nigeria

Malaria has been reported as a condition caused by infestation with Plasmodium parasite specie, which is a great public health problem globally, particularly in developing countries like Nigeria. This study was carried out in Federal Medical Centre Umuahia in Abia State, Nigeria. The study was done to determine the maternal serum levels of alpha tumour necrosis factor, interleukin 10, interleukin 6, and interleukin 4 in malaria-infected pregnant women based on parities in Southeast, Nigeria. A total of 150 subjects between the ages of 18-45 years were recruited for the study comprising 50 subjects each of 3 parities (groups A-C). A commercial ELISA Kit was used to measure all the cytokines. Neither statistically significant differences were found for TNF-α (p=0.636), IL-10 (p=0.892), IL-6 (p=0.306) and IL-4 (p=0.222) between prime parity and second parity nor for TNF-α (p=0.356), IL-10 (p=0.896), IL-6 (p=0.304) and IL-4 (p=0.298) between prime parity and multi-parity of malaria-infected pregnant women. TNF-α (p=0.255), IL-10 (p=0.524), IL-6 (p=0.616), and IL-4 (p=0.672) between second parity and on multi-parity respectively. The study showed no changes in the cytokines studied among the malaria-infected pregnant women based on parities. It shows that the number of pregnancies in women infected with malaria has no changes in the levels of the cytokines studied.

EVALUATION OF HORMONAL ASPECTS BY CERVICAL INSUFFICIENCY IN WOMEN WITH HISTORY OF INFERTILITY

Introduction. Today, the frequency of infertility is increasing worldwide. Infertility, associated with anovulation, is especially challenging for the medical correction especially. The leading aspect of this problem is hormonal disorders in the body of a woman. The aim of this study was to assess the level of estradiol and progesterone in the blood serum of pregnant women with cervical insufficiency and infertility associated with anovulation in the history. Materials and methods. The main group included 30 pregnant women with the II trimester of pregnancy, who had cervical insufficiency and infertility associated with anovulation in the past medical history. They got pregnant after assisted reproductive technologies. The control group included 30 pregnant women without cervical insufficiency and with physiological gestation. Estradiol and progesterone levels in blood serum were determined at 20-22 and 30-32 weeks of gestation. Results. The average age of the women in the basic group was statistically higher relative to the control one – 31.30±1.16 and 27.30±0.92 years, respectively (p=0.02). There was no difference in the number of pregnancies in women between both groups. In the main group, 73.33% of the persons were primagravida, 10.00 % of patients had two pregnancies, and 16.67 % - three pregnancies. 56.67 % of the women in the control group were primagravida, 26.67 % had two pregnancies, 16.66 % - three pregnancies. Although primaparas predominated in both groups, the number of such women was in 1.47 times higher in the main group (93.33 %) than in control (63.33 % of patients; χ2=6.28, p=0.01); 6.67 % and 26.67 % women had two labors respectively and 10.00 % of healthy patients - three labors. The concentration of estradiol at the 20-22 and 30-32 weeks of pregnancy in women of the main group almost corresponded to physiological parameters. However, the progesterone level in women with cervical insufficiency and a history of infertility was by 13.44 % lower than in healthy pregnant women at 20-22 weeks, and by 17.02% at 30-32 weeks (p=0.003). Conclusions. In pregnant women with cervical insufficiency and infertility associated with anovulation, the level of estradiol in the II and III trimesters of gestation mainly corresponds to the level of physiological pregnancy. However, they have the decrease in progesterone concentration in the III trimester of pregnancy relative to healthy pregnant women (p&lt;0.003).

P0236COMPARISON OF THE CHARACTERISTICS AND SEVERITY OF RESTLESS LEG SYNDROME AND INSOMNIA IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND RENAL TRANSPLANT RECIPIENTS

Abstract Background and Aims Symptoms of restless legs syndrome (RLS) are common in patients with chronic kidney disease (CKD) and on dialysis, affecting up to 25% of patients when the international RLS diagnostic criteria are applied. RLS has been associated with disordered sleep, impaired quality of life, increased cardiovascular morbidity and mortality risk in patients with CKD. The aim of our study was to examine the relationship between RLS and the prevalence and severity of insomnia in non-dialysis CKD patients (CKD stage IV and V), in haemodialysis and PD patients, in renal transplant recipients (RTRs) as well as to identify the risk factors independently associated with RLS prevalence and severity in each group. Method 436 patients were included in the study (152 patients with CKD stage IV and V, 117 haemodialysis patients, 78 PD patients and 89 RTRs). RLS diagnosis was made according to IRLSSG diagnostic criteria. The questions of the IRLSSG Severity Scale were answered. Athens Insomnia Scale (AIS) was used for the diagnosis of insomnia. Statistical analysis was performed with appropriate parametric and non-parametric tests and regression analysis models. Results Applying the IRLSSG criteria for diagnosis, the prevalence of RLS was 17%, 25.9%, 26.5%, 32.1% and 16.9% in patients with CKD stage IV, CKD stage V, hemodialysis patients, PD patients and RTRs respectively. The mean severity of the syndrome was higher in PD patients (14.64), followed by haemodialysis patients (12), CKD stage V patients (11.9), KTRs (11.3) and patients with CKD stage IV patients (10.5). Prevalence of RLS did not significantly differ between groups. CKD patients displayed the lowest presence of insomnia, while PD patients showed the relatively highest presence of insomnia. The mean severity of insomnia differed between the pairs: RTRs vs PD patients, RTRs vs haemodialysis patients and PD patients vs patients with CKD stage IV and V (p &amp;lt;0.05). RLS in all groups correlated with the presence of peripheral neuropathy and female gender. By regression analysis models we found that among CKD patients, presence of RLS independently correlated with number of pregnancies in women, previous cerebrovascular disease, hypothyroidism requiring treatment and antidepressant drugs use, whereas RLS severity independently correlated with the presence of peripheral neuropathy. Regarding hemodialysis patients, presence of RLS independently correlated with body mass index (BMI), female gender, antidepressant drugs use and serum PTH levels. RLS severity in the same group independently correlated only with female gender. Regarding PD patients, RLS presence was independently associated with number of pregnancies in women and left ventricular ejection fraction. RLS severity in the same group was independently associated only with the presence of peripheral arterial disease. Among RTRs, RLS presence independently correlated with female gender and a lower GFR. We were the first to find that presence of RLS was associated with a higher bone mass density and lower levels of 25-OH vitamin D. Conclusion The prevalence and severity of RLS and insomnia worsen as kidney function deteriorates in CKD patients, being most burdensome among patients with stage V CKD, haemodialysis and PD patients. The severity of insomnia is especially increased in PD patients. Although the frequency of RLS decreases in KTRs, it still occurs at higher rates compared to the general population. Further studies are needed to investigate the relationship between RLS and associated risk factors in patients with CKD and following kidney transplantation.

Pregnancy in women with diabetic nephropathy.

The number of pregnancies in women with pregestational diabetes has been steadily increasing worldwide. These pregnancies are associated with an increased risk of a variety of complications, including miscarriages, congenital malformations, macrosomia, fetal growth restriction, preeclampsia, preterm delivery and stillbirth. In pregnant women with diabetic nephropathy it is important to evaluate both the effect of pregnancy on kidney function and the effect of kidney disease on pregnancy outcomes. Pregnant women with normal renal function and microalbuminuria have a low risk of loss of kidney function during pregnancy, while women with GFR < 60ml/min and/or proteinuria ≥ 3g/24h at the beginning of pregnancy are at risk of permanent kidney damage. The risk of fetal and maternal complications is associated with the severity of chronic kidney disease and glycemic control. Advances in prenatal care have improved fetal and maternal outcomes and preconception counseling has become key for a successful pregnancy in all women with diabetes and especially in those with diabetes and chronic kidney disease.

Thyroid nodule recurrence following lobo-isthmectomy: incidence, patient's characteristics, and risk factors.

This study was aimed at assessing the incidence and timing of thyroid nodules recurrence, defined as appearance of new benign or malignant nodules in contralateral lobe in patients with benign thyroid nodules or thyroid microcarcinoma treated with lobo-isthmectomy. Patient's characteristics and risk factors associated with this phenomenon were also investigated. A retrospective study was performed by evaluating 413 patients undergoing lobo-isthmectomy with a minimum follow-up of 1year. Clinical characteristics, surgical interventions and complications, histological diagnosis, and thyroid function at last follow-up were collected. Single or multiple thyroid nodule recurrence equally occurred in 80 patients (23%) with a median time to relapse of ~ 5years (range 0.3-34.5years) after lobo-isthmectomy. Recurrence was significantly associated with younger age (< 46 years) and number of pregnancies in women. Development of hypothyroidism was not rare either (~ 10%) and appeared in 3-19months; a preoperative TSH level > 2.43mIU/L was associated with the need of l-thyroxin replacement therapy after surgery. The most frequent surgical complication was transient hypoparathyroidism (4.6%), while the rate of permanent hypoparathyroidism significantly increased in patients submitted to completion thyroidectomy (5.3%). Thyroid nodules recurrence following lobo-isthmectomy is not a rare event and occurs within 5years after surgery, more frequently in younger patients with family history of nodular goiter and in women with multiple pregnancies. Pre-surgical TSH levels may predict the development of post-surgical hypothyroidism, possibly improving the management of patients addressed to surgery.

Complications and outcomes of pregnant women with adenomyosis in Japan

The frequency of adenomyosis in pregnancy has been increasing in recent years, along with the increase in the number of pregnancies in women of advanced age and the increase in pregnancies achieved by fertility treatments.Adenomyosis has been reported to be associated with poor pregnancy outcomes, including an increased risk of preterm delivery, preterm premature rupture of membranes, and fetal growth restriction.However, the potential impact of adenomyosis on the outcomes of pregnancy is still unclear, because few studies have addressed the associations between adenomyosis and pregnancy outcomes, and because the study populations of those studies were small. In addition, no data are available for analyzing the relationship between the type of adenomyosis (focal or diffuse) and the outcomes of pregnancy. To investigate the impact of adenomyosis on the complications and outcomes of pregnancy in Japan, a multicenter retrospective survey of pregnant patients with adenomyosis was carried out. A multicenter retrospective survey. We carried out a nationwide survey to evaluate the involvement of adenomyosis in pregnancy outcomes as an official project of the Japan Society of Obstetrics and Gynecology. A questionnaire was sent to 725 Japanese medical facilities and the retrospective analysis was based on the clinical records of each facility. The questionnaire inquired information related to adenomyosis, including the methods by which it was diagnosed, size (major axis), type (focal or diffuse), localization (anterior wall or posterior wall), pretreatment before pregnancy (medication, conservative operation, no pretreatment), and pregnancy complications. Data were obtained on the cases of 272 pregnant women with adenomyosis from 65 facilities. The complications of pregnancy included miscarriage before 12 weeks of pregnancy (14.8%), miscarriage after 12 weeks of pregnancy (9.9%), pre-term delivery (24.4%), fetal growth restriction (11.8%), pregnancy-induced hypertension (9.9%), intrauterine infection (7.3%), and cervical incompetency (5.3%). The rates of pregnancy complications in the three groups classified according to pretreatment for adenomyosis (no pretreatment, medication, surgery) did not differ to a statistically significant extent. The rates of miscarriage (>12 weeks) and cervical incompetency increased according to the size of the adenomyosis. The rates of pregnancy-induced hypertension and uterine infection in patients with diffuse-type adenomyosis were higher than that in patients with focal-type adenomyosis. Our results show that the increased size and diffuse type of adenomyosis are associated with adverse pregnancy outcome. We should be aware of the higher incidence of pregnancy-induced hypertension and uterine infection in patients with diffuse-type adenomyosis.

Clinical features and peripartum outcomes in pregnant women with cardiac disease: a nationwide retrospective cohort study in Japan.

Although the number of pregnancies in women with cardiac disease is increasing worldwide, there are few data concerning their clinical characteristics and peripartum outcomes. Using the Diagnosis Procedure Combination database between 2008 and 2014 in Japan, we retrospectively identified pregnant women who underwent high-risk delivery due to obstetric or non-obstetric comorbidities. We classified eligible women into those with pre-existing cardiac disease (cardiac disease group) and those with non-cardiac comorbidities (non-cardiac disease group) and compared their characteristics and peripartum outcomes. Of 94,364 women undergoing high-risk delivery at 556 hospitals, 857 (0.91%) had pre-existing cardiac disease (302, congenital heart disease; 190, arrhythmia; 176, valvular heart disease; 120, ischemic heart disease; 65, cardiomyopathy; 4, pericardial disease). Women in the cardiac disease group were more likely to be treated at university hospitals (51.1 versus 28.6%; p<0.001) and in intensive care units (33.5 versus 18.8%; p<0.001) than those in the non-cardiac disease group. The proportion of cesarean deliveries was 69.4% (emergency, 28.4%; elective, 41.1%) in the cardiac disease group and 73.4% (emergency, 38.4%; elective, 35.0%) in the non-cardiac disease group. Epidural analgesia during vaginal delivery was used significantly more frequently in the cardiac disease than non-cardiac disease group (15.6 versus 2.3%; p<0.001). Heart failure occurred more frequently in the cardiac disease than the non-cardiac disease group (10.2 versus 0.3%; p<0.001). In cardiac subgroup comparisons, heart failure occurred more frequently in women with congenital heart disease (12.3%), valvular heart disease (12.5%), or cardiomyopathy (12.3%) than in women with arrhythmia (6.3%) or ischemic heart disease (5.8%). Multivariable logistic regression analysis showed a significant positive association between pre-existing cardiac disease and risk of heart failure (adjusted odds ratio, 24.7; 95% confidence interval, 17.6-34.6; p<0.001). No woman in the cardiac disease group died, whereas 18 women (0.02%) in the non-cardiac disease group did (p=1.000). These findings suggest that pregnant women with pre-existing cardiac disease are at a higher risk of heart failure during the peripartum period than those with non-cardiac comorbidities.

Pregnancy and cystic fibrosis - an overview

Life expectancy and quality of life of cystic fibrosis (CF) patients have been steadily increasing for many decades, due to intensified therapy and research. Correspondingly, the number of pregnancies in women with CF rises. Often it is not possible for the patients to assess the consequences of pregnancy in terms of their disease and the impact of their disease on the growing child. A pre-existing poor lung function, low body mass index, CF-related diabetes, chronic microbial colonisation, and transplanted lungs are the main risk factors for complications during pregnancy in CF. Generally, the best outcome for mother and child can be reached under exact planning and meshed multidisciplinary care. The purpose of this summary is to give a practical review of the risks and options associated with pregnancy in CF patients.

A population-based observational study of diabetes during pregnancy in Victoria, Australia, 1999–2008

ObjectivesThis paper reports secular trends in diabetes in pregnancy in Victoria, Australia and examines the effect of including or excluding women with pre-existing diabetes on gestational diabetes (GDM) prevalence estimates.DesignPopulation-based...

SAT0533 Time Trends of Number of Pregnancies and Mean Birth Weight in Newborn of Patients with Specified Arthritis or Connective Tissue Disease

BackgroundImproving treatment options, pre-pregnancy councelling and interdisciplinary monitoring throughout pregnancy, make more rheumatic patients able to plan pregnancies.ObjectivesTo study time trends in number of pregnancies and mean birth weight in...