Number Of Hospital Deaths Research Articles

Human placental mesenchymal stromal cell-derived small extracellular vesicles as a treatment for severe COVID-19: A double-blind randomized controlled clinical trial.

The current study aimed to investigate the effects of human placental mesenchymal stromal cell-derived small extracellular vesicles (hPMSC-sEVs) as a treatment for COVID-19. This double-blind, randomized, controlled clinical trial was conducted on two groups of patients with COVID-19-associated acute respiratory distress syndrome. After randomization, the control group received standard treatment and placebo, and the intervention arm received standard treatment plus hPMSC-sEVs. The number of hospital deaths was considered the primary outcome. After meeting the exclusion and inclusion criteria, 21 and 24 patients were allocated to intervention and control arms, respectively. Besides admission SpO2 levels, which were significantly lower in the intervention arm (p=0.008), all the baseline demo-biographic and laboratory variables were similar between the groups. It was shown that hPMSC-sEVs could significantly (p=0.015) decrease the mortality ratio in the intervention group (4/21 [19.04%]) compared to the controls (13/24 [54.16%]). The mean time to death in the intervention and control groups was 28.06 and 11.10 days, respectively (p <0.001). This study showed that hPMSC-sEVs are a possible treatment for critically ill patients with COVID-19.

Abstract TP243: The Association Between Frailty and Survival in Older Mexican Patients With Acute Ischemic Stroke

Introduction: Frailty, a prevalent geriatric syndrome, has been consistently linked to unfavorable outcomes. Prior investigations have demonstrated a notable correlation between frailty and survival rates among individuals experiencing acute stroke. To our knowledge, there are not studies in Mexican stroke patients. Objective: We investigated the association between pre-stroke frailty status and 30-day survival in older Mexican patients with acute ischemic stroke. Methods: This prospective study included Mexican patients older than 60 years old hospitalized with acute ischemic stroke who were ineligible for reperfusion therapy between May and July 2023. Pre-stroke frailty status was assessed using the FRAIL score. The sample size was determined to be 190 individuals (α 0.1, β 0.2, p0 0.16, p1 0.05, and r1). Descriptive statistics and Kaplan-Meier survival analyses were performed. This research was authorized by our institution’s board, and informed consent was obtained. Results: A total of 133 patients were included, of whom 97 (72.9%) were frail. Frail group was older (77 vs. 72 years, p =.002), had more females (50 vs. 11, p = 0.031), had a higher NIHSS score (13 vs. 10, p = 0.01), had more history of previous strokes (50 vs. 5, p = 0.001), and had a longer hospital stay (8 vs. 5 days, p = 0.026) compared with the non-frail group. In 30 days, 45 deaths were recorded, of which 41 occurred in the frail group. The number of hospital deaths among frail patients was higher (31 vs. 1, p = 0.001). In the survival analysis, frailty was associated with decreased 30-day survival and, frailty increased the risk of death 12 times after 15 days of stroke (p = 0.021); other variables were not associated with survival in the frailty subgroup analysis. Conclusion: Pre-stroke frailty status is associated with decreased 30-day survival in older Mexican patients with acute ischemic stroke.

A social profile of deaths related to sickle cell disease in India: a case for an ethical policy response.

India accounts for 14.5 percent of the global SCD newborns, roughly over 42,000 a year, second to sub-Saharan Africa. Despite the availability of cheap diagnostic and treatment options, SCD remains a largely neglected disease within healthcare policy and practice. Epidemiological modeling based on small, often dated, regional studies (largely from sub-Saharan Africa) estimate that between 50 and 90 percent of affected children will/die before the age of 5 years. This premise, coupled with targets of reducing under 5 mortality (SDG 4), privileges public health interventions for screening and prevention of new births, undermining investments in long-term health and social care. This paper presents a retrospective, descriptive analysis of the socio-demographic profile of 447 patients diagnosed with sickle cell or sickle-beta thalassemia, who died following admission at a tertiary care entre in India. We used anonymized hospital records of 3,778 sickle cell patients, admitted in pediatric and adult/medical wards between January 2016 and February 2021. A majority of hospital deaths occurred in the second and third decades of life, following a hospital admission for a week. The overall mortality during 2016-2019 was 14% with little gender difference over time. Contrary to our expectations, the number of hospital deaths did not increase during the first year of the COVID-19 pandemic, between 2020 and 2021. The conclusion highlights the importance of longitudinal, socio-demo-graphic data on deaths as providing important insights for identifying ethical policy interventions focused on improving SCD outcomes over time, reducing inequities in access to care, and preventing what might be considered "excess" deaths.

Hospitalisations and in-hospital deaths following moderate to severe traumatic brain injury in Australia, 2015-20: a registry data analysis for the Australian Traumatic Brain Injury National Data (ATBIND) project.

To describe the frequency of hospitalisation and in-hospital death following moderate to severe traumatic brain injury (TBI) in Australia, both overall and by patient demographic characteristics and the nature and severity of the injury. Cross-sectional study; analysis of Australia New Zealand Trauma Registry data. People with moderate to severe TBI (Abbreviated Injury Score [head] greater than 2) who were admitted to or died in one of the twenty-three major Australian trauma services that contributed data to the ATR throughout the study period, 1 July 2015 - 30 June 2020. Primary outcome: number of hospitalisations with moderate to severe TBI; secondary outcome: number of deaths in hospital following moderate to severe TBI. During 2015-20, 16 350 people were hospitalised with moderate to severe TBI (mean, 3270 per year), of whom 2437 died in hospital (14.9%; mean, 487 per year). The mean age at admission was 50.5 years (standard deviation [SD], 26.1 years), and 11 644 patients were male (71.2%); the mean age of people who died in hospital was 60.4 years (SD, 25.2 years), and 1686 deaths were of male patients (69.2%). The overall number of hospitalisations did not change during 2015-20 (per year: incidence rate ratio [IRR], 1.00; 95% confidence interval [CI], 0.99-1.02) and death (IRR, 1.00; 95% CI, 0.97-1.03). Injury prevention and trauma care interventions for people with moderate to severe TBI in Australia reduced neither the incidence of the condition nor the associated in-hospital mortality during 2015-20. More effective care strategies are required to reduce the burden of TBI, particularly among younger men.

Three waves of COVID-19 in a Norwegian local hospital.

The objective of this article is to summarise the course of illness and treatment for patients with COVID-19 admitted to Bærum Hospital since the start of the pandemic. We present data from a prospective observational study with the aim of systematising knowledge about patients admitted because of COVID-19. All patients admitted to Bærum Hospital up to and including 28June 2021 were included. The results are presented for three waves of admissions: 9March-23June 2020, 21September 2020-28February 2021 and 1March-28June 2021. A total of 300 patients, divided into 77, 101 and 122 in the three waves respectively, were admitted because of COVID-19. The number of hospital deaths during the three waves was 14 (18%), 11 (11%) and 5 (4%) respectively. The average age of the patients was 67.6 years in the first wave and 53.3 years in the third wave. Altogether 204 patients (68%) received medical oxygen or ventilation support, and 31 of these (10% of all the patients) received invasive ventilation support. Non-invasive ventilation support was used as the highest level of treatment in 4 (8%), 9 (13%) and 17 (20%) patients with respiratory failure in the three waves respectively. In the second and third wave, 125 out of 152 patients with respiratory failure (82%) were treated with dexamethasone. Differences in patient characteristics and changes to treatment methods, such as the use of dexamethasone and non-invasive ventilation support, may have contributed to the apparent fall in mortality from the first to the third wave. Conditions that are not registered in the study, such as vaccination status, may also have impacted on mortality.

Assessment of Medical and Social Effectiveness of Innovative High-tech Cardiac Surgery Care for Patients with Acute Myocardial Infarction

The present research aims at comprehensive analysis to determine the effectiveness of cardiac surgery in patients in the acute period of myocardial infarction in comparison with patients who received drug treatment. A comparative assessment of the level of hospital mortality was carried out in the groups of patients of senior working age, elderly and old age, dividing them into patients who received cardiac surgery (main group) and drug treatment (comparison group). Among the patients of working age, 284 were assigned to the main group and 272 to the comparison group; among the patients of elderly age, 104 were assigned to the main group and 363 to the comparison group; and among the patients of old age, there were 9 patients in the main group and 235 patients in the comparison group. For reliable difference between the compared indicators, the authors determined the relative risk of socio-hygienic factors in terms of mortality rate and the significant limit of mortality formation, taking into account that the factor the relative risk of which is more than one is significant. The significant difference in mortality in hospital between patients who received high-tech medical services (HTMS) and the group of patients who did not undergo such high-tech heart surgery was found only in the elderly patients (65-74 years old), p = 0.002 (chi-square). The number of deaths in hospital from myocardial infarction in the main group increases with age. Mathematical modeling showed that the level of hospital mortality is also influenced by the provision of the hospital with qualified cardiologists, specialized bed and special medical equipment.

Impact of place of residence on place of death in Wales: an observational study

BackgroundPrevious research in England showed that deprivation level of a person’s place of residence affects the place of death and quality of care received at the end of life. People dying in their preferred place of death has also been shown to act as an indication for high quality of end of life care services and social equality. This study expands on current research to explore the effects of deprivation and place of residence on health related choices and place of death in Wales.MethodsWe used ten years combined mortality statistics from 2005 to 2014 and Welsh Index of Multiple Deprivation rankings for each lower super output area. After accounting for the population’s age, the number of deaths in Hospital, Hospice, Home, Care Home, Psychiatric Units, and Elsewhere were compared across deprivation quintiles.ResultsDistribution of place of death was found to be concentrated in three places – hospital (60%), home (21%) and care home (13%). Results from this study shows a high number of hospital deaths, especially for more deprived areas, despite being the least preferred place of death.ConclusionThis is the first Welsh study investigating place of death in relation to deprivation, which could be of major importance to academics, end of life care providers and policy makers interested in to reduce health care inequality in Wales.

Integrated care in practice

Introduction: System integration to achieve sustainable systemic change is not a new concept and something that has been around in International practice for a number of years. Experiential, comparative exploration of system models in Alzira, Boston and Washington DC (via an AQuA fellowship) highlight significant similarities with that of the Oldham economy, at the same time as identifying the stark difference in progress to develop and deploy sustainable system models in the UK. Oldham has taken learning from International best practice and used the intelligence and information to better shape the system in Oldham, aligned to the greater Manchester Devolution mandate. By deploying the same strategic approach as International models to the urgent care system in Oldham (via a multi agency alliance partnership) we are able to demonstrate sustained quality improvements for people and system flow via a number of innovative, transformational approaches that have sustained positive impact on a reduction in unplanned admissions in excess of the National expected average (3.5%). This achievement has received National recognition (NHS England) and also shortlist for two HSJ awards (integration and quality improvement). Description of practice change implemented: Oldham Urgent Care Alliance’s (a partnership of 8+ multi agency organisations) aim is to improve the urgent care system across the Oldham locality. It had a number of objectives: to reduce unplanned admissions to hospital by 3.5%, deliver a number of integration projects and take a performance management approach to the use of resilience funding. Via this approach a number of practice changes are evident, Development of a frail elderly unit which has reduced length of stay by 70-50% Development of a multi agency discharge to assess service, impacting upon admissions to residential and acute provision and improving quality of life Development of a multi agency Primary Care practice before the front doors of AE Pennine Acute Hospitals NHS Trust; Pennine Care NHS Foundation Trust; GotoDoc (a social enterprise providing an out of hours GP service) MIO Care, (a limited company owned by the council to provide homecare and re-ablement services), Voluntary Action Oldham; First Choice Homes; GP representation and Oldham CCG. Timeline: 12 months Highlights: (innovation, impact and outcomes) Sustained improvement in quality of care and life chances are evident as a result of deploying this systematic approach. A sustained reduction of 5.8% in unplanned hospital admissions achieved, despite an annual 6% increase in A&E attendances over the same period Total estimated system saving of £2.79m. Paediatric admissions Triage system introduced to assess conditions prior to admission. Almost 600 fewer paediatric admissions in 2015 compared with 2014 Alternative to transfer (minor injuries) A physiotherapy and occupational therapy service established enabling initial assessment of patients quickly to divert the patient from admission. Over 250 deflections from hospital achieved in 2015. Long term conditions Pro-active and self-management within the community. Almost 500 hospital deflections achieved in 2015, compared with the previous year. Early supported discharge for stroke rehabilitation 15 hospital deflections for stroke patients achieved in 2015. End of life care An overall reduction of the number of deaths in hospital per 1,000 population of 2% Intermediate care, A&E – therapy in-reach Over 250 additional hospital deflections in 2015. SPRINT (Senior persons resilience independence team) Reduced length of stay for over 85yrs by 70% Reduced length of stay for 65-85 yrs by 50% Comments on sustainability: Analysis of performance metrics continue to demonstrate sustained system impact despite growing demand. Review of quality impacts continue to yield positive impacts upon quality. Comments on transferability: The model can be replicated in any system/ care setting. Conclusions: The development of a systematic system leadership and governance approach via integrated working across a number of public, private and voluntary sector organisations has yielded a sustained impact upon quality and performance improvements within the urgent care system. The introduction of the Programme Management Office to co-ordinate and manage multiple projects across multiple partners was critical to the success of the transformation programme and the demonstration of sustained outcomes delivered. Discussions: This theory of change continues to be deployed within the Oldham urgent care economy and there are a number of other innovations that have been deployed as a result. This theory and concept has been driven forward by a sustained fastidious leadership approach across the system with interrogation of quality and performance data to evidence outcomes. Lessons learned: Sustained system leadership is critical to success Interagation of International systems has demonstrated the similarities between UK systems, which has been deployed further than theory and concept and implemented to make real and sustained system change Relationships across organisations are key to success Integrated working is a critical success factor Despite perverse financial incentives front line staff working in an integrated way can make real and sustained impact upon quality The deployment of quality improvement methodology enables and embeds rapid improvement

Molecular Mechanism and Targets of the Antimicrobial Activity of Metal Nanoparticles

The emergence of multi-resistant bacteria to drugs is recognized as a major cause of the increasing number of deaths in hospitals. Killing these bacteria require multiple expensive drugs that can have side effects. Metal nanoparticles may provide a new strategy to combat them. Due the antimicrobial and antiviral properties, nanoparticles (NPs) have outstanding biological properties that can be handled properly for desired applications. This review presents antibacterial and antiviral activity of metal NPs, including the molecular mechanisms by which NPs annihilate multidrug-resistant bacteria.

Knowledge and practices of nurses concerning intravenous potassium administration in a Turkish hospital

Objective: Based on this literature review, it is clear that intravenous potassium is a potentially toxic electrolyte, which has been responsible for a large number of deaths in hospitals. In Turkey, research on intravenous potassium administration is limited in the available literature. In addition, clinical observations made by the researchers suggests there is knowledge and practice deficiencies among nurses related to potassium administration. Thus, this study aimed to determine how wide the knowledge and practice deficiencies among nurses was concerning intravenous potassium administration in a Turkish Hospital. Design: This was a descriptive study. Setting: This study was conducted in a university hospital in Turkey. Subjects and Method: The sample of this study consisted of a total 105 nurses working in surgery clinics or surgical intensive care units of a university hospital, who volunteered to participate in the study.The questionnaire used in this study was developedby the researchers with the help of material obtained from the literature review. Questionnaires were distributed and collected to participants by researcher. In the calculation of knowledge and practice scores, every correct answer was assigned 1 point, while incorrect answers were assigned 0. Mean, percentage, ANOVA, the kruskal-wallis h test, the mann-whitney u test and pearson correlation were used for data analysis. Results: The mean knowledge score of nurses on intravenous potassium administration was found to be 9.48±3.21, while the mean practice score was 10.85±2.04. These results suggest that the nurses’ knowledge and practice scores were found to be relatively lower compared to 17 which is the highest scores of both knowledge and practice about intravenous potassium administration. It is also important to state that statistically significant and positive relationship was found (r: 0.595; p&lt; 0.05). The majority of the nurses (61.9%) did not know all the elements of a correct potassium order. The differences in nurses’ knowledge scores according to the type of hospital unit and training status on liquid electrolyte balance were found to be statistically significant (p&lt;0.05). Nurses with duration of employment of over 10 years were found to have higher knowledge scores than nurses with employment duration of below four years. This difference was found to be statistically significant (p&lt;0.05). Conclusion: In light of the findings of this study it is recommended that nursing curriculum and in-service training programs in Turkey should address intravenous potassium administration more extensively and that protocols related to intravenous potassium administration be developed and implemented.

Sociodemographic determinants of place of death in dementia: whole population cross-sectional analysis in England, 2001–10

BackgroundThe in-hospital death rate from dementia in England is among the highest in Europe. The personal, regional, and temporal factors influencing place of death in dementia are unknown. MethodsOffice for National Statistics mortality data were used for whole population cross-sectional analysis of deaths from dementia in England, 2001–10. Place of death (home, hospice, care home, hospital) was the outcome variable. Explanatory variables included demographic, social, and regional factors. Multivariable Poisson regression analysis was used to provide an independent relative risk of place of death for each of the variables studied. The change in place of death over time was studied using linear regression. Findings387 004 deaths were included. Most patients died in care homes (55·3%) or hospital (39·6%). Home deaths (4·8%) and hospice deaths (0·3%) were rare. Hospital deaths were less likely with increasing affluence (relative risk [RR] 0·83, 95% CI 0·81–0·85), and increasing provision of a care-home bed (0·61, 95% CI 0·58–0·63). Lack of social support (marital status) reduced home deaths (RRs 0·45–0·60). Hospice deaths were increased in areas with greater hospice bed provision (RR 4·23, 95% CI 2·14–8·35) and in patients whose underlying cause of death was cancer (19·0, 95% CI 16·2–22·3). Deaths in care homes were more common with increasing affluence (RR 1·28, 95% CI 1·24–1·32) and increased provision of a care-home bed (2·02, 95% CI 1·97–2·08). Time-trend analysis showed a recent decrease in hospital deaths and reciprocal increase in care-home deaths. InterpretationGovernments and policy makers recognise the urgent need for public health planning in dementia. Reducing the number of deaths in hospital, and increasing those at home, in dementia has both societal and economic benefits. Social support, deprivation, and service provision are key targets for policy. FundingNational Institute for Health Research.

Influence of house‐staff experience on teaching‐hospital mortality: The “July Phenomenon” revisited

The "July phenomenon" refers to a purported worsening of outcomes in teaching-hospital patients with the arrival of new, inexperienced house-staff. Previous quantitative studies of new house-staff and increased mortality have been limited primarily by a focused patient population and the use of limited data to adjust for severity of patient illness. We included all medicine, surgical, and obstetrical patients admitted to a teaching hospital in Ontario, Canada between April 15, 2004 and December 31, 2008. We calculated the ratio of observed to expected weekly number of deaths in hospital. The expected number of deaths was calculated using a validated, discriminative, and well-calibrated multivariate survival model. Collective house-staff experience was modeled from a minimum on July 1st to a maximum on June 30th using five distinct patterns. We studied 259,748 encounters that included 164,318 people. The mortality rate was 3.0%. The ratio of observed to expected number of weekly deaths was not associated with collective house-staff experience, irrespective of the pattern in which it was modeled. The lack of association between risk of death in hospital and house-staff experience did not vary by admission type (urgent vs elective) or specialty (medicine vs surgery). At our hospital, we found no association between the arrival of new house-staff and the adjusted risk of death in hospital. These data, along with the results of the vast majority of previous studies in this field, make the existence of the "July Phenomenon" for inpatient mortality extremely unlikely.

Hippocrates Affirmed? Limiting Residents' Work Hours Does No Harm to Patients

In this issue, the studies by Shetty and Bhattacharya and Horwitz and colleagues attempt to answer the following question: Did the resident work-hour rules violate the Hippocratic principle of doin...

Gender differences in prevalence and socioeconomic determinants of hypertension: findings from the WHO STEPs survey in a rural community of Vietnam

In Vietnam, hypertension was estimated to cause a large number of deaths in hospitals. However, population-based knowledge about the magnitude of hypertension in Vietnam and its relationship with socioeconomic status, especially in the rural communities, still remains scarce. This paper, taking advantage of a study on noncommunicable disease (NCD) risk factors in Bavi district, Vietnam, using the WHO STEPs approach, estimates the prevalence of hypertension in the setting and examines its association with some socioeconomic factors. A representative sample comprising 2000 adults aged 25-64 years were selected randomly and surveyed in 2002. The JNC VII criteria for hypertension were used. Socioeconomic status of the study subjects was estimated by assessing their education, occupation and economic conditions. Descriptive techniques and multivariate logistic regression were used. The prevalence of hypertension was 14.1%. Of hypertensives, only 17.4% were aware of their hypertensive status. Men were hypertensive more often than women and age was positively associated with hypertension. The association between hypertension and socioeconomic status was complex and differed between men and women. Among men, those with lower educational and occupational status but who were richer were more likely to be hypertensive. More women with lower occupational and economic status were hypertensive.

Injured moped riders who required admission to hospital in Sweden from 1987 to 1994.

To find out the incidence, extent of injury, medical consequences, and mortality rate of moped riders involved in crashes in Sweden. Retrospective case study. The Swedish Hospital Discharge Register (SHDR). 4716 moped riders, a total of 5857 admissions to Swedish hospitals from 1987-94. Statistical analysis of the Register. Incidence of injured moped riders in Sweden, mortality rate, types of injuries, and medical consequences. From 1987 to 1994, Swedish hospitals admitted 4716 moped riders (5857 admissions) injured in crashes, which corresponds to a mean of 8.5 injured/100 000 population a year. Of these 3993 were male (85%) and 723 female (15%), with a median age of 16 years (range 3-93). Twenty-four percent of those admitted to hospital spent more than a week there. The annual number of injured moped riders did not change significantly during this period. The total number of deaths in hospital was 59 (1%). Among those who died in hospital, 32 (54%) had head injuries, 16 (27%) fractures, and 5 (9%) abdominal or thoracic injuries. The number of injured moped riders in Sweden is low. Fractures of the extremities were most common, followed by injuries to the head and brain. The usual victim was a teenager or young man. Of the patients treated in hospital few died, most of whom were elderly men.

Suburbia: a small obstetric hospital in Brisbane.

In a small suburban obstetric hospital, during the period from July 1, 1963 to December 31, 1970, 3760 private and intermediate patients were delivered by suburban general practitioners. The number of perinatal deaths in hospital were nine deaths per 1000 births, both live and still. During the same period, 4873 private and intermediate patients were delivered by suburban general practitioners in the private/intermediate section of a large centrally sited obstetric teaching hospital. The number of perinatal deaths in hospital were 18.9 per 1000 births, live and still. The reason for, and the implications of, these results are discussed.

Trends in hospital necropsy rates: Scotland 1961-74.

Examination of mortality statistic for Scottish hospitals showed that from 1961 to 1974 necropsy rates fell by almost 0-6% a year; by 1974, the rate over the whole country was 23% of hospital deaths. The fall resulted from a reduction in the number of necropsies and a coincident rise in the number of number of deaths in hospital. The necropsy rate fell with increasing age, was rather lower for women than men, and was lower for some diseases than others. There were considerable inaccuracies in the figures from which these trands were drawn, and these were in turn due to inaccurate recording of clinical and necropsy data. Examination of necropsy returns from the Scottish teaching hospital departments showed that, while a similar fall in necropsy rates was seen in some, there was no consistent pattern.

The contribution of intensive coronary care.

Coronary care units are expensive consumers of scarce resources, and it is unfortunate that there has been little attempt to evaluate their achievements: even simple data relating outcome to age, duration of stay, and severity are not available. Indirect evidence is presented from the Hospital In-patient Enquiry and the national mortality reports for England and Wales. Over the period in which intensive care facilities have become widespread the hospital admission rates have risen steeply but numbers of hospital deaths have been stable. A part of this decline in case fatality has probably resulted from therapeutic advance, but most is probably due to the admission of larger numbers of milder cases.

Hospital admission and absence from work attributed to asthma.

Study of a 10% sample of hospital admissions for asthma in England and Wales shows that in each age and sex group deaths have increased by at least a half between 1959 and 1964, while for males aged 15-44 years they have doubled. The number of deaths in hospital has risen in a similar way, and hence the hospital fatality rate has not changed over this period. Since study of certified absences from work has shown no comparable increase, it is suggested that the increase has occurred in the number of attacks of severe asthma requiring admission to hospital.

The Epidemiological Study of Malignant Neoplasms in Aichi Prefecture

From the analysis of the trend of mortality by malingnant neoplasms since 1900, and. from the survey of 14, 800 persons died by malignant neoplasms for 5 years, i. e., from. 1955, the following conclusions were abtained.1. The death rate by malignant neoplasms is steadily rising after the second world war, and this rise is crisp, when compared with general death rate. This trend is. more remakable in Aichi Prefecture than in all Japan.2. The mortality by malignant neoplasms of respiratory organs of males went up, remarkably, and the mortality by malignant neoplasms of uteri was declining.3. The regional accumulation of malignant neoplasms seems to by paralel with. that of stomachs. The high rate regions are observed amass in the alluviums of Kiso and Yahagi river basins, while in the Toyokawa river basin the low regions assembles.4. The curve of death rate of malignant neoplasms, showed in age-classes of males and that of females cross in the age-class. of 20-25 years, and 50-55 years.5. The frequent occurrence of deaths by malignant neoplasms of stomach was to be noted.6. Generally speaking, the life durations of the operateds from the beginning of the disease to death were longer the those of not-operated. Such elongation was not observed in the. cases of the operations of breasts.7. The number of deaths in hospitals were notable in the cases of young patients, . while it diminishes following the rise of ages of patients.8. Generally speaking, the life durations from the operation to death are very short.From the survey of 5, 991 patients of malignant neoplasm who visited the clinics and. hospitals in Aichi Prefecture, the following conclusions were abtained.