Novel Protocol For Synthesis Research Articles

Novel Protocol for Synthesis of O,O-Dialkyl Monothiophospharic Acid Sodium Salt

Preparation of O,O -dialkyl monothiophospharic acid sodium salt (DMP-SNa) by addition of sulphur selectively on phosphorous using organic base to form a salt of O,O -dialkyl monothiophospharic acid trialkyl amine salt which is soluble in the non-polar organic solvent and treated with alkali to form O,O -dialkyl monothiophospharic acid sodium salt (DAP-SNa). Trialkylamine becomes free and remains in the nonpolar solvents can be recycled. This synthesis method is effluent free. DOI: http://dx.doi.org/10.17807/orbital.v13i5.1597

Transition-metal-free NaI-mediated reaction of aryl sulfonyl chloride with alkynes: Synthesis of (E)-β-iodovinyl sulfones

A novel protocol for synthesis of (E)-β-Iodovinyl sulfones via NaI-mediated of aryl sulfonyl chloride with alkynes is described, featuring transition-metal-free condition, commercial available substrates, convenient operation, as well as good functional group compatibility. A wide variety of substrate application and good functional group tolerance is provided by this approach, giving multiple (E)-β-Iodovinyl sulfones analogues with excellent yields (up to 98%, >4 g scale).

Novel protocol for synthesis of 1,4-diiminocurcumin stabilized silver nanoparticles and application as heterogenous recyclable catalyst and antibacterial agent

Curcumin [(1E, 6E)-1,7-bis(4-hydroxy-3-methoxy-phenyl)-1,6-heptadiene-3,5-dione] is a low molecular weight yellow-orange polyphenolic pigment extracted from the powdered rhizome of Curcuma longa. Curcumin has wide medicinal applications as an antioxidant, anti-inflammatory, cancer chemopreventive, and potentially chemotherapeutic agents as well as stabilizer/reducing agent in silver nanoparticles (AgNPs) synthesis. However, the low solubility of curcumin in aqueous solutions limits its applications and also, many of AgNP synthetic processes lack a greener synthetic route. In the present work, a Schiff base of curcumin is synthesized condensing curcumin and 1,4-diaminobutane in 2:1 ratio. The resulting product shows improvement in solubility in water and favours the synthesis of AgNPs in aqueous medium at room temperature, acting as a self-reducing/stabilizing agent. This proposed synthetic route is simple, feasible and green. The size and morphology of AgNPs are analyzed by TEM, SEM, EDS and XRD techniques. The recyclable AgNPs as a heterogeneous catalyst in the reduction of nitroaromatics to amino compounds is environmentally benign and can be re-used up to 5th cycle without considerable loss of its catalytic activity. Moreover, both Cur-1,4 and AgNPs show bactericidal properties against bacterial strains (Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa) which find medicinal importance in future. A greener approach has been proposed for the preparation of AgNPs stabilized on curcumin based Schiff base. The AgNPs finds applications as efficient, easily recyclable heterogenous catalyst in the reduction of nitroaromatics to environmentally benign aminoaromatics as well as an antibacterial agent.

Atomically dispersed Fe–Nx active sites within hierarchical mesoporous carbon as efficient electrocatalysts for the oxygen reduction reaction

A novel protocol for synthesis of high performance N-doped hierarchically porous graphitic carbon electrocatalysts with single Fe atoms by pyrolyzing a mesoporous Fe–polydopamine precursor without an extra template removal process.

Synthesis of immunotargeted magneto-plasmonic nanoclusters.

Magnetic and plasmonic properties combined in a single nanoparticle provide a synergy that is advantageous in a number of biomedical applications including contrast enhancement in novel magnetomotive imaging modalities, simultaneous capture and detection of circulating tumor cells (CTCs), and multimodal molecular imaging combined with photothermal therapy of cancer cells. These applications have stimulated significant interest in development of protocols for synthesis of magneto-plasmonic nanoparticles with optical absorbance in the near-infrared (NIR) region and a strong magnetic moment. Here, we present a novel protocol for synthesis of such hybrid nanoparticles that is based on an oil-in-water microemulsion method. The unique feature of the protocol described herein is synthesis of magneto-plasmonic nanoparticles of various sizes from primary blocks which also have magneto-plasmonic characteristics. This approach yields nanoparticles with a high density of magnetic and plasmonic functionalities which are uniformly distributed throughout the nanoparticle volume. The hybrid nanoparticles can be easily functionalized by attaching antibodies through the Fc moiety leaving the Fab portion that is responsible for antigen binding available for targeting.