Introduction: Although there have been greater attempts to increase the rate of Hepatitis C screening in the ambulatory setting, several issues remain with regards to completion and documentation of screening by providers to ensure timely follow-up and subsequent treatment of patients. The goal of our study was to identify potential barriers that may affect completion of timely Hepatitis C screening. Methods: A retrospective review was conducted of all subjects in our Internal Medicine clinics with birth years from 1945-1965 that had visited their primary care provider (PCP) from August 2012-September 2017. Through use of SPSS software, appropriate documentation by the subject's PCP of Hepatitis C screening antibody results at any point over the five-year period was noted, and statistically significant differences in rates of documentation and screening were observed through use of univariate analysis. Results: A total of 380 subjects born from 1945-1965 had scheduled primary care visits during the designated time period. One hundred and twenty-six of these subjects had successfully completed Hepatitis C screening, and of these patients fifty-nine were female (59/126). Documentation of the results of Hepatitis C antibody screening was noted to assess the PCP's awareness of lack or presence of screening. Fifty-five percent of patients that received screening had documentation of their results by his or her PCP (69/126). Females were noted to be 15% less likely to have a Hepatitis C screening Ab compared to their male counterparts (OR: 0.80, 95% CI (0.522-1.229), p < 0.05). The population was divided into two age groups (52-64 years and 65-72 years of age) with the younger cohort 1.14 times more likely to have completed Hepatitis C screening (CI: 0.981-2.066, p < 0.035). Non-white patients were 53% less likely to have Hepatitis C screening completed (OR: 0.475, 95% CI: 0.304-0.742, p < 0.001), and there were no statistically significant differences noted among ethnic groups. Conclusion: Our results indicate that further study is required to assess for potential risk factors that may affect timely screening of patients for Hepatitis C. Lack of follow-up of subjects with their primary care providers and incomplete or absent documentation by providers may affect these rates. Potential interventions such as use of simpler health care maintenance note templates or reminders on electronic health record systems may be vital in improving future rates of screening.931 Figure 1 No Caption available.