This paper aims to investigate the response and fracture of EMT carbon steel round-hole tubes (EMT carbon steel RHTs) under cyclic bending loads. The study considers four different hole orientations (0°, 30°, 60°, and 90°) and five distinct hole diameters (2, 4, 6, 8, and 10 mm). The results reveal that hole orientation and diameter exert a minimal impact on the moment-curvature relationship, leading to the formation of stable loops. The ovalization-curvature graphs demonstrate a trend of asymmetry, serration, and growth with an increasing number of bending cycles. Additionally, larger hole orientations or smaller notch diameters result in reduced ovalization. Furthermore, the double logarithmic coordinates of the controlled curvature–number of cycles required to induce fracture reveal five parallel lines for different hole diameters when the hole orientation is fixed. Finally, in adopting the formulas for smooth tubes and for 6061-T6 aluminum alloy round-hole tubes (6061 aluminum alloy RHTs), this study adjusts the related material parameters. These modifications effectively describe the controlled curvature–number of cycles required to induce fracture for EMT carbon steel RHTs with different hole orientations and diameters under cyclic bending, demonstrating reasonable agreement with the experimental results.