Purpose This study aims to assess the knowledge of Amhara Sayint district community in Northeastern Ethiopia towards the health impacts of climate change. Design/methodology/approach A community-based cross-sectional study was conducted from 20 July to 5 September 2022, involving 605 randomly selected households in Amhara Sayint district, Northeastern Ethiopia. Data were collected through face-to-face interviews using a pilot-tested and content-validated questionnaire administered via Kobo Collect survey tool. The data were then exported to STATA for management and analysis. A proportional odds approach of ordinal logistic regression model was fitted with a 95% confidence level to identify factors associated with the community’s knowledge towards the health impacts of climate change. Findings Of the total respondents, 3.47% (95% confidence interval [CI]: 2.1, 5.3) and 42.98% (95% CI: 38.9, 47) had inadequate and medium levels of knowledge towards the health impacts of climate change, respectively. Proportional odds model analysis result indicated that gender (female) (adjusted odds ratio [AOR] = 1.49; 95% CI: 1.053, 2.13), wealth status (poorest) (AOR = 1.97; 95% CI: 1.01, 3.83), educational status (unable to read and write) (AOR = 4.13; 95% CI: 1.25, 13.68) and participation status in environmental protection activities (not) (AOR = 1.78; 95% CI: 1.17, 2.71) were factors that significantly associated with inadequate and medium levels of knowledge towards the health impacts of climate change. Research limitations/implications The result of this research is not supported by qualitative methods. Practical implications Residents of the study area know the climate is changing; however, they lack adequate knowledge towards the health impacts of climate change. Social implications Significant number of people have inadequate level of knowledge about health impacts of climate change so relevant health education is needed. Originality/value This research is original in its focus on assessing public knowledge about the health impacts of climate change in the Amhara Sayint district, northeastern Ethiopia, a perspective often overlooked in existing studies. Its findings are crucial for guiding future research and developing targeted public health strategies and educational initiatives.