This study utilized high-resolution numerical simulation data from the WRF model to conduct a thermodynamic diagnosis of the process by which Typhoon “Maysak” transformed and merged with the Northeast Cold Vortex. The results indicated that the continuous intrusion of cold vortex air and the relative cold advection formed by the typhoon’s movement led to the demise of the typhoon’s warm core structure. The low-level low-pressure convergence and upper-level high-pressure divergence structure disappeared. After the transformation and merging with the Northeast Cold Vortex, the cyclone became cold throughout the entire layer, with a cold center appearing at low levels. During the process of the typhoon’s transformation and merging with the Northeast Cold Vortex, cold air accumulated near the low levels of the cyclone, causing the pseudo-adiabatic potential temperature lines to tilt and resulting in the slanted development of vertical vorticity in the mid-levels of the cyclone. After the typhoon transformed and merged with the Northeast Cold Vortex, the positive vertical vorticity advection at the bottom of the upper-level cold vortex trough promoted the cyclone’s development directly from the mid-levels to the upper levels, while the jet stream at the bottom of the cold vortex trough facilitated the maintenance of the positive vertical vorticity advection. Concurrently, the thermodynamic shear vorticity parameter could describe the typical vertical structure characteristics of the dynamic and thermodynamic fields above the rain area during the typhoon transformation process. In terms of temporal evolution trends, there was a certain correspondence with the development and movement of the ground rain area, and the perturbation thermodynamic divergence parameter had a good indicative effect on the area of heavy rainfall.