North-Eastern Romania Research Articles

Evolution of the Correlation Between Body Mass Index (BMI) and Agility of Primary School Students in North-Eastern Romania

Interacting with children's cognitive processes and mental health status, body mass index (BMI) could be analyzed in relation to motor performance. This study aims to analyse the relationship between BMI and agility of primary school students in the northeast of Romania. Hypothesis testing was done by analyzing data obtained from 3250 pupils (1605 girls and 1645 boys) aged 6 to 11 years old from the North-East of Romania. BMI was calculated based on height and weight, as well as agility through the 505 change of direction speed test. The sample was divided according to gender and age, and the differences and correlations were analysed. We assumed that our sample has a significant correlation of BMI with agility and that its strength increases with age, based on neural maturation. Children's results showed gender- and age-determined differences in anthropometric as well as motor skills. The development of Romanian girls and boys differs punctually at this stage, with the two genders having close BMI values at age 11. The time to complete the 505 test is close at age 6, with boys performing better by age 11. The correlation between BMI and agility has weak strength in the 6-11 years age group of Romanian students. It is significant in girls at 9 (r = 0.20) and 10 years (r = 0.15), and in boys from 7 (r = 0.20) to 10 years (r = 0.22). The data partially confirm our hypothesis, with the correlation existing in the 7-10 years age range, its strength having a fluctuating evolution. At 11 years the link between BMI and agility ceases to exist.

Physical Activity and Cognitive Impairment in a Group of Adults with Down Syndrome from North-Eastern Romania

Background: Down syndrome (DS) is the most prevalent chromosomal condition, with the average life expectancy significantly rising from 25 years in 1983 to 60 years in 2020. People with DS generally can participate in most physical activities that individuals without the disability can, despite some physical limitations. However, the varying degrees of cognitive deficits can present challenges when it comes to performing physical activities. Methods: We conducted a prospective, cross-sectional study in the Cardiovascular Rehabilitation Clinic from the Clinical Rehabilitation Hospital from Iași, Romania, between July 2022 and February 2024 that included 28 patients diagnosed with DS. We collected data regarding age and comorbidities and performed several tests (MMSE, timed-up-and-go test, and handgrip strength). Results: The group consisted of 11 (39%) females and 17 (61%) males with a mean age of 28.07 ± 9.51 years. The weight profile of the study group differed according to the degree of physical activity: 62.50% of those with moderate physical activity were moderately overweight, while 75% of those with minimal activity were overweight or obese. The muscle strength and MMSE score was higher in the group of patients who performed moderate physical activity. Regarding comorbidities, there was a statistically significant difference in the percentage of patients with hearing loss among those with minimal physical activity. Conclusions: Our results provide an update on the very limited data available. The study indicates that people with DS are generally less physically active and face unique health challenges (hearing loss, intellectual disabilities, and osteoarticular pathologies).

Women’s anxiety and perceptions of Pap tests in North-eastern Romania

Women’s anxiety and perceptions of Pap tests in North-eastern Romania

Urinary neutrophil gelatinase-associated Lipocalin in children with recurrent urinary tract infections in North-eastern Romania

Urinary neutrophil gelatinase-associated Lipocalin in children with recurrent urinary tract infections in North-eastern Romania

Nutritional health in adults with down syndrome living in urban North-eastern Romania

Nutritional health in adults with down syndrome living in urban North-eastern Romania

Demographic Profile and Clinical Characteristics of Adults with Down Syndrome in North-Eastern Romania.

(1) Background: Down syndrome is characterized by physical abnormalities, intellectual disability (ID), and specific patterns of other health issues. Additionally, individuals with DS are known to experience premature aging and early onset of certain age-related medical conditions. These conditions are linked to higher incident disability and reduced survival rates compared to the general population. (2) Methods: Between July 2022 and February 2024, we conducted a prospective, observational study in the Cardiovascular Rehabilitation Clinic at Iasi Clinical Rehabilitation Hospital. The study included 28 patients diagnosed with Down Syndrome and a control group. Interdisciplinary interventions were tailored to address the needs of a complex patient, incorporating cardiological, endocrinological, genetical, biological and developmental support. Data on physical health, cognitive development, and psychosocial well-being were collected. (3) Results: Our DS group consisted of 11 (39%) females and 17 (61%) males. Their age ranged from 20 to 55 years with a mean of 28.07 ± 9.51. All patients were unmarried, living in urban areas, without a partner but with family support. In the study sample, 96.4% of participants had three or more comorbidities. (4) Conclusions: The high prevalence of multimorbidity, combined with little medication, contributes to a high level of clinical complexity, which appears to be similar to the one of the older non-trisomic population. As individuals with Down syndrome transition into adulthood, they may require a more comprehensive and holistic approach to their healthcare.

Summer Discrepancies between 2 m Air Temperature and Landsat LST in Suceava City, Northeastern Romania

Summer Discrepancies between 2 m Air Temperature and Landsat LST in Suceava City, Northeastern Romania

First insights into the new particle formation and growth at a north-eastern Romanian urban site, Iasi. Potential health risks from ultrafine particles

New particle formation (NPF) process brings significant contribution to the global atmospheric particle number concentrations. Evidence on the formation and growth of NPF is reported for the first time at a Romanian urban site, i.e., Iasi, north-eastern Romania. Size-dependent aerosol number concentrations were obtained during two short-term campaigns undertaken in 2017 by using a scanning mobility particle sizer. The existence of two categories of events can be highlighted by investigating the net maximum increase in the nucleation mode particle number concentration and the maximum size of the geometric median diameter of new particles. The variability of meteorological parameters showed that the solar radiation peak was usually associated with NPF events, while relative humidity was anti-correlated with those events. Calculated nucleation rate values for events in May, median of 4.5 cm−3 s−1, was lower than the corresponding median values of 8.6 cm−3 s−1 for December. The particle growth rates showed a similar trend with a median of 4.0 nm h−1 and 7.7 nm h−1, in May and December, respectively. The obtained results suggest that regional emission sources might bring some contributions on the particle nucleation and growth processes, particularly over the cold season. Regarding the deposition of particles in the respiratory system, it appears that ultrafine particles are among the most significant contributors to the alveolar deposits. Moreover, evidences were obtained that the impact on the particle deposition at the alveolar region is not mandatory in direct relation to the intensity of the NPF event, the pollution burden of the particles most probably playing an important role.

Long-Term Evolution of the Climatic Factors and Its Influence on Grape Quality in Northeastern Romania

Long-Term Evolution of the Climatic Factors and Its Influence on Grape Quality in Northeastern Romania

Antibiotic use among patients with acute exacerbation of COPD in Pulmonary Diseases University Clinical Hospital from North-Eastern Romania

Antibiotic use among patients with acute exacerbation of COPD in Pulmonary Diseases University Clinical Hospital from North-Eastern Romania

Exploring myocardial bridges characteristics in North-Eastern Romania. a retrospective analysis

Exploring myocardial bridges characteristics in North-Eastern Romania. a retrospective analysis

UAV and field survey investigation of a landslide triggered debris flow and dam formation in Eastern Carpathians

In the May–August period of 2010, major heavy rains impacted the Eastern Carpathians (Northeastern Romania), leading to flash floods and triggering numerous landslides. The extreme weather conditions caused damage to the road network, extensive forest destruction, and lead to formation of impounded lakes. One of the hardest-hit areas was the mountain tributaries catchments of the Bistrița watershed. Particularly, the most significant landslide-triggered debris flow event occurred in the upper Iapa valley (Neamț County). The landslide process started near the top of the Drumul Chinezilor ridge in the Goșmanu-Geamăna Massif (Tarcău Mountains), at an elevation of 875 m a.s.l., and the flow-slide fan obstructed a 300-m section of the Iapa watercourse at 615 m a.s.l. This study compiles the climatic, anthropogenic, geological, and geomorphological evidence gathered during the field investigation in the October 2023 and utilizes Unmanned Aerial Vehicle (UAV) data collected to reconstruct the occurred debris flow-slide event. Additionally, it explores considerations regarding the reactivation of landslide processes, dam stability, and the future evolution of the impounded lake (Făgețel Lake: water surface area of 9,500 m2; maximum depth 10 m). Furthermore, the lessons learned and future actions required to prevent further mass movement associated with debris flow-slide processes in prone areas of the Eastern Carpathians are discussed.

Trends in Coronary Artery Anomalies Detection by Coronary Computed Tomography Angiography (CCTA): A Real-Life Comparative Study before and during the COVID-19 Pandemic.

In the wake of the coronavirus disease 19 (COVID-19) pandemic, affecting healthcare systems globally, urgent research is needed to understand its potential repercussions on the diagnosis and management of cardiovascular disorders. This emphasises the importance of detecting coronary artery anomalies (CAAs), rare conditions that can range from benign to potentially life-threatening manifestations. We aimed to retrospectively assess the impact of the COVID-19 pandemic on the detection of various coronary anomalies using Coronary Computed Tomography Angiography (CCTA) within a regional tertiary cardiology unit in north-eastern Romania, focusing on perceived occurrence in the population under study, types, and related demographic and clinical factors. We analysed CCTA scans and investigated the trends in CAA detection among cardiology patients over a decade. We compared pre-COVID-19 and pandemic-era data to assess the impact of healthcare utilisation, patient behaviour, and diagnostic approaches on anomaly detection. Our analysis revealed a higher detection rate of CAAs during the pandemic (3.9% versus 2.2%), possibly highlighting differences in patient clinical profile and addressability changes presentation compared to the previous period. Origination and course anomalies, often linked to severe symptoms, were significantly higher pre-COVID-19 (64.1% versus 51.3%). Conversely, intrinsic CAAs, typically asymptomatic or manifesting later in life, notably increased during the pandemic (49.0% versus 61.4%; p = 0.020). Our study underscores a significant rise in CAA detection during the COVID-19 era, potentially linked to changes in cardiovascular and respiratory clinical patterns, with advanced imaging modalities like CCTA offering accuracy in identification.

"Primum, non nocere": The Epidemiology of Toxigenic Clostridioides difficile Strains in the Antibiotic Era-Insights from a Prospective Study at a Regional Infectious Diseases Hospital in Eastern Europe.

Clostridioides difficile infection (CDI), though identified nearly five decades ago, still remains a major challenge, being associated with significant mortality rates. The strains classified as hypervirulent, notably 027/NAP1/BI, have garnered substantial attention from researchers and clinicians due to their direct correlation with the severity of the disease. Our study aims to elucidate the significance of toxigenic Clostridioides difficile (CD) strains in the clinical and therapeutic aspects of managing patients diagnosed with CDI. We conducted a single-center prospective study, including patients with CDI from north-eastern Romania. We subsequently conducted molecular biology testing to ascertain the prevalence of the presumptive 027/NAP1/BI strain within aforementioned geographic region. The patients were systematically compared and assessed both clinically and biologically, employing standardized and comparative methodologies. The study enrolled fifty patients with CDI admitted between January 2020 and June 2020. Among the investigated patients, 43 (86%) exhibited infection with toxigenic CD strains positive for toxin B genes (tcdB), binary toxin genes (cdtA and cdtB), and deletion 117 in regulatory genes (tcdC), while the remaining 7 (14%) tested negative for binary toxin genes (cdtA and cdtB) and deletion 117 in tcdC. The presence of the presumptive 027/NAP1/BI strains was linked to a higher recurrence rate (35.56%, p = 0.025), cardiovascular comorbidities (65.1% vs. 14.2%, p = 0.016), and vancomycin treatment (55.8% vs. 14.3%, p = 0.049). The findings of our investigation revealed an elevated incidence of colitis attributed to presumptive 027/NAP1/BI. Despite the prevalence of the presumptive 027 strain and its associated heightened inflammation among the patients studied, no significant differences were observed regarding the clinical course or mortality outcomes.

Tillage and Straw Management Practices Influences Soil Nutrient Distribution: A Case Study from North-Eastern Romania

Tillage practices govern crop quality and quantity through soil nutrient availability and crop root systems. A deeper knowledge of the impact of conservation tillage on soil chemical characteristics (such as pH, soil organic carbon, macro and micronutrient storage and distribution) is required for both the promotion of agricultural sustainability and environmental preservation. This study assesses the changes in soil features and properties in the context of a long-field experiment with different tillage systems and straw management practices. Research findings revealed that compared with conventional tillage (CT) conservative tillage with partial straw retention (MT) and no-tillage with straw mulching (NT) substantially boosted the organic carbon (OC) (by 6–19%), total nitrogen (TN) (by 2–12%), and available potassium content (AK) (by 2–5%), in 0–30 cm soil depth. However, the stratification trend was observed for available macro and micronutrient content (Zn, Fe, Mn) in both conservative management practices. The concentration of Cu indicates a constant pattern through a 0–30 cm soil profile with a higher concentration under MT (1.41 mg kg−1) compared to NT (1.10 mg kg−1). In particular, the results failed to establish if conservation tillage can increase the total phosphorus (TP) and potassium content (TK), where only in surface 0–10 cm an increase was observed. This research also suggested that the X-ray fluorescence analysis (XRF) of total micronutrient content (Zn, Cu, Fe, Mn) is minimal or unpredictable with no substantial differences between the tillage systems and straw return management practices. These findings suggest that conservation tillage in north-eastern Romania might be optimal to maintain soil quality status and sustain high yields.

Fertilizers’ Impact on Grassland in Northeastern Romania

In order to obtain more data concerning the influence of fertilizers (organic and mineral) on different forage plants in the northeastern Romanian grassland, the mass fractions of 14 essential, enzymatic, or toxic elements were determined by instrumental neutron activation analysis together with the amount of crude proteins, ash, fibers, as well as fat ether extract. The final results showed a significant variance in the content of analyzed elements on organic as well as on mineral fertilized experimental plots. At the same time, increased content of crude protein and fat ether extract was evident in fertilized grasses for all applied fertilizers, while other global indicators such as neutral and acid fibers of sulfuric lignin content decreased, suggesting significantly higher nutritional values for fertilized forage plants.

Essential and toxic elements analysis of wild boar tissues from north-eastern Romania and health risk implications

IntroductionThe level of essential minerals in meat is an important factor in human nutrition and health. Meat from responsibly managed wildlife is an alternative raw material with considerable nutritional benefits. Meat from hunted animals has essential and non-essential elements for the human body. It is important to carefully monitor the levels of heavy metals accumulated in the tissues of hunted animals in polluted areas to ensure food safety and environmental contamination. High levels of heavy metals in food and the environment can pose a danger to human health.MethodsThe study aims to investigate the levels of essential mineral elements and heavy metals in the muscle tissue and organs of wild boar harvested through the herd density control plan over the last decade in north-eastern Romania.Results and discussionThe statistical analysis indicates that the age of the animals had a significant impact on Fe, Cu, and Zn levels in Longissimus lumborum. In the kidney a highly significant difference in Fe content by sex, with males showing higher values than females. The sex was shown to significantly influence the Mg levels. However, there are concerns about the accumulation of heavy metals such as Lead (Pb) and Cadmium (Cd), which may hurt the health of game meat consumers in the study area. Cd level it shows significant differences according to both age and sex, with higher concentrations in adults and males. Statistical analysis shows a negative correlation between Fe and Zn concentrations in muscle samples, while a positive correlation was found between Fe and Mn in kidney samples. There was also a positive association between Zn and Cu in muscle samples, but a negative association in kidney samples. Principal component analysis shows significant variation in essential element and heavy metals data between muscle and kidney samples. The loading plot shows a direct correlation between Pb and Cu and between Pb and Cd. However, an opposite correlation also is observed between Cu and Mg, Cd and Mg, and Pb and Mg. HQ (Hazard Quotient) for children compared to adults indicates a potentially higher risk associated with meat consumption among children because children are more vulnerable than adults. We report for the first time, to the best authors’ knowledge, various levels of essential minerals and exceeded maximum admitted level of heavy metals in the muscle tissues and kidneys of Sus scrofa ferus from Romania intended for human consumption, moreover, our findings highlight the need for strict monitoring and implementation of appropriate corrective measures, given the significant percentages of muscle and kidney samples exceeding the allowable limits for two of the most common toxic metals in the environment.

Retrospective study of lumbar disc herniation in a hospital in North-Eastern Romania

Abstract: Lumbar disc herniation is a degenerative neurological disorder characterized by a notable rise in incidence and prevalence among the population in modern times. It is primarily caused by factors such as microtrauma, sedentary lifestyle, prolonged static postures, excessive time spent at the computer, and overexertion. Materials and methods: A study was conducted retrospectively from 2022 to 2023 on patients who were admitted with lumbar disc herniation, at the Neurosurgery Hospital "Prof. N. Oblu”, in Iași.The research focused on showcasing the aspects of disc issues/pathology in the North Eastern re-gion.Findings; The research included 1969 individuals with a majority noted among par-ticipants, from rural areas and females.The majority of patients fell into the adult age range of 41 60 years. Surgical procedures were performed on 71% of the patients while conservative treatment was administered to the remaining 29%.The distribution of ages shows that most individuals undergoing surgery or receiving conservative treatment fall, within the adult age range of 41 to 60 years. Surgery is performed on 71% of patients while conservative treatment is given in 29% of cases.All patients were advised to undergo follow up remedial therapy upon discharge. We faced challenges in evaluating the level of adherence which posed a limitation in our study.Conclusions: The study brings to the forefront the need for reparative therapy for patient’s socio-professional and family reinte-gration and improvement of quality of life.

Chronic hepatitis B infection in pediatric population: a retrospective study from a tertiary center in North-Eastern Romania

Chronic hepatitis B infection in pediatric population: a retrospective study from a tertiary center in North-Eastern Romania

Comorbidities of autoimmune bullous dermatoses in North-Eastern Romania

Comorbidities of autoimmune bullous dermatoses in North-Eastern Romania