The annual b-value fluctuation patterns in Burmese subduction zone and Andaman–Sumatra subduction zone are evaluated from earthquake data (January 1990 to June 2016; Mw ³ 4.3) to identify seismic cycles with sequential dynamic phases as described in the ‘elastic failure model’ of Main et al. (1989). Two seismic cycles have been identified in Andaman–Sumatra subduction zone, one started in 1990 and ended on 2004 with occurrence of great Sumatra earthquake (Mw 9.0) and the other started in 2005 and continuing till date with the phase of crack coalescence and fluid diffusion (3A&B). Similarly, the subduction zone of Burma shows evidence of one incomplete seismic cycle within 1990–2016 and presently undergoing the crack coalescence and fluid diffusion (3A&B) phase. The analysis has prompted to subdivide the area into thirteen smaller seismic blocks (A to M) to analyse area specific seismic trend and vulnerability analysis employing Hurst Statistics. Hurst plots with the dynamic phases of ‘elastic failure model’ of earthquake generation is compared to assess the blocks with high seismic vulnerability. The analysis suggest that north Andaman zone (block G) and north Burma fold belt (block M) are seismically most vulnerable. Moreover, the seismic vulnerability of Tripura fold belt and Bangladesh plain (block K) is equally high.