Normal Sexual Behavior Research Articles

Childhood Masturbation: A Case Report and Literature Review for Treatment

Background: Masturbation is normal sexual behavior. However, masturbation in childhood is rarely discussed in the research. Childhood masturbation or gratification disorder, is characterized by self-stimulation of genitalia in prepubescent children. However, childhood masturbation often stops if the child is distracted, and spontaneous recovery within two years in most cases Generally, no drug therapy is required for childhood masturbation unless it is very frequent or excessive and it affects the daily functionality of the child. Regarding the treatment of childhood masturbation, we highlight the fact that evidence-based therapy for childhood masturbation is lacking due to unclear standard guidelines on it. We need a path of therapy that can help doctors in the management of childhood masturbation. Case: Here we reported two cases of excessive childhood masturbation from a 3-year-old and a 10-month-old female patient who were brought by their mother to the outpatient clinic pediatric, Academic Hospital, Universitas Gadjah Mada, Indonesia, with a complaint of stretching by flexing the legs and rubbing on her genital part Risperidone as one of the drug therapies for this case and present a good outcome. Additionally, this article also provides literature reviews on childhood masturbation treatment that may guide clinicians in its evaluation and management. Conclusion: We conclude that behavioral treatment is the common strategy for childhood masturbation. The treatment, as well as behavioral and drug therapeutic strategies, should be considered to achieve an effective outcome.

Study on Sexual Behaviour Parameters of Marwari Stallions during Breeding Season

The ejaculation and mounting times of a stallion, as well as the amount of time it takes for the stallion to respond to an oestrus mare, are all elements that might affect the libido of the horse. In order to gain an understanding of how tropical horses adapt to potentially difficult climatic circumstances in terms of their sexual performance, it is necessary to study their reproductive behaviour. The present investigation was carried out on six healthy Marwari stallions (aged between 50 to 140 months) to evaluate and to analyse their sexual behaviour during the breeding season in the arid region. The study was carried out for a period of three weeks and sexual behaviour parameters were recorded at the time of semen collection. Parameters observed and analysed in the present study include erection time, reaction time, ejaculation time, number of mounts and number of thrusts. Erection time, reaction time and ejaculation time of stallions was 19.02±1.18 sec, 29.11±1.37 sec, 26.86±0.95 sec, respectively. The number of mounts and number of thrusts of stallions was 1.39±0.09 and 10.00±0.17 respectively. The above study describes the normal sexual behaviour parameters of Marwari stallions in the arid region and analysed that non-significant (P>0.05) difference exists among the horses for various sexual behaviour parameters.

Transient Receptor Potential channels (TRP) in GtoPdb v.2023.3

Transient Receptor Potential channels (TRP) in GtoPdb v.2023.3

Transient Receptor Potential channels (TRP) in GtoPdb v.2023.2

Transient Receptor Potential channels (TRP) in GtoPdb v.2023.2

Aerial release of Aedes aegypti male mosquitoes using an unmanned aerial vehicle: a novel control strategy

Objective. To development of a methodology for the chilling, handling, transport, and release of male Aedes aegypti mosquitoes, reared in insectary conditions to release in the field with unmanned vehicles to compete sexually with wild males in the field. Materials and methods. A population of Ae. aegypti from different areas in Tapachula, Chiapas, was used. Laboratory tests were conducted: Effect of temperature and cooling time on the knockdown, recovery of males, and copulatory success. Results. The chilling temperature of 3 ± 1ºC for 30 min, was used as a knockdown temperature before handling, packing, transportation, and aerial release. The males subjected to the entire process, including the semi-field aerial release test, showed normal sexual behavior activity, obtaining 100% of females inseminated. Conclusion. These results present the feasibility of applying a new control methodology using unmanned aerial vehicle (UAV) as support for the sterile insect release technique (SIT), use of Wolbachia or both, in male Ae. aegypti, for the design of strategies to control their populations.

Paraphilias: an update on nosology and diagnostic challenges

ABSTRACT Ever since the inception of paraphilias in the psychiatric nosological system, it has been in several controversies ranging from determining normal sexual behaviour from abnormal, role of culture, diagnosing paraphilia as deviant sexual behaviour and various medico-legal issues related to sexual offenders and predators. Over the years, several landmark changes have been made in the subsection of paraphilias in both DSM and ICD nosological system. The evolutionary journey of paraphilias to paraphilic disorder is remarkable, yet there are various unresolved issues related to its nosological status and diagnosis. To review some fundamental concepts of paraphilias related to its evolution in nosological systems and discuss its various diagnostic and medico-legal/forensic issues. A comprehensive literature search was conducted on paraphilias in PubMed and Google Scholar and through the cross-references of relevant articles till June 2022. Keywords included ‘paraphilias,’ ‘nosology,’ ‘critique’ ‘issues’ and ‘diagnosis’ in various combinations. Only original articles (abstract and full text), review articles, viewpoint articles and recommendations published in English, till June 2022, were reviewed and checked thoroughly. Articles published in non-English languages were excluded. 34 articles related to the topic were found, including those relevant to paraphilias’ nosology and diagnostic issues. We discuss in detail the nosological journey of paraphilias and various controversies related to it. Additionally, we discuss the various diagnostic and forensic issues. From our review, we conclude that the most valid indicators of true paraphilic disorders i.e. exclusiveness, fixation and compulsiveness, which are the most complex entities to establish in a forensic context, are not adequately addressed even by the new criteria of DSM-5 and ICD-11 of paraphilic disorders. Hence, even after so many modifications, paraphilic disorders still present challenges to our conceptualization of mental disorders.

24 Effects of Oral Supplementation of Cannabidiol on Young Stallion Behavior

Abstract Cannabidiol (CBD) has become a popular product in the recent months due to change in legislation with the passing of the Agricultural Improvement Act in 2018. Cannabidiol comes from the plant Cannabis sativa L. and binds to cannabinoid receptors throughout the endocannabinoid system. These receptors are located throughout the body and are prominent in the brain and reproduction tract. Although the effects of CBD on physiology have been researched, little data on the behavioral effects exist, even less so in horses. Calming supplements that may negate aggressive stallion behavior are not suitable due to potential soporific effects that can affect libido. In addition to the effectiveness of CBD to modify behavior in horses, it is also unclear if CBD influences stallion libido. The objective of this study was to evaluate sexual behavior in stallions given a daily CBD supplement for 70 days. Two-year old stallions (n = 8) were assigned to either a Control (CON; n = 3) or Cannabidiol (CBD; n = 4) treatment groups. Cannabidiol was administered at a rate of 0.6 mg/kg BW daily, and equal volume of olive oil was given as a placebo to CON. Horses were weighed every Monday at which time dosages were recalculated to adjust for body weight changes. Behavior data collection occurred twice per week during semen collections. Video data were recorded by placing two cameras, one placed in view of the tease area, and one placed in view of the mount, for behavior data backup. Behavioral data was tallied by handlers calmly calling each behavior as it occurred during collection. The behaviors collected included Flehman’s response, bites, strikes, mounts, high pitch vocalizations, and low pitch vocalizations. Data were analyzed using a Chi Square Test within R Statistical Program (R Core Team). Results were considered significant at P < 0.05. Throughout the duration of the study, all stallions exhibited normal sexual behavior, regardless of treatment. Results showed that total low and high pitch vocalizations, bites, and Flehman’s were affected by treatment (P < 0.01). Cannabidiol-treated stallions had more low pitches (60), compared to CON (58). Cannabidiol-treated stallions had fewer bites (145) compared to the CON (146). Cannibidiol stallions displayed Flehman’s more frequently (270) than CON (236). Flehman’s response and bites were lower for stallions on cannabidiol in Week 1 but increased by Week 10 (P < 0.01), while only Flehman’s response increased in the CON group over time (P < 0.01). These findings indicate that CBD may influence breeding behavior in young stallions specifically when supplemented over time. Further research should focus on the impact of CBD on breeding behaviors in mature stallions and the longevity of the behavioral response to CBD.

136 The effects of cannabidiol on libido and heart rate in stallions

Changes in the Agriculture Improvement Act of 2018 increased popularity of Cannabidiol (CBD) as a supplement. Exogenous CBD, derived from Cannabis Sativa L., binds to cannabinoid receptors in the endocannabinoid system. These receptors are located throughout the body, CB1 being prominent in the central nervous system and CB2 in the immune system. Physiological effects of CBD have been well researched but the effects on libido have not. Lack of libido or sexual drive can be detrimental to stallion breeding productivity. The use of CBD as a calming supplement in animals is increasing due to marketing strategies. The study objective was to evaluate libido and heart rate (HR) in stallions given a daily oral CBD supplement for 90d. Two-year old stallions (n = 7) were assigned to either Control (CON; n = 3) or Cannabidiol (CBD; n = 4) treatment groups. CBD was administered at 0.6mg/kg of BW/d, while CON was administered an equal volume of olive oil, as a placebo of similar nature. Treatments were top-dressed over morning feed. Horses were weighed every Monday with dosages recalculated accordingly. Data collections occurred 2x/wk during semen collections with an artificial vagina. Behaviors were previously defined, calmly called out and logged as they occurred. Observations included time spent licking a tease mare, time to erection, time to first mount, and time to ejaculation. A Polar® heart rate monitoring system linked to the KER® ClockItapp was usedto measure HR. Variations of HR included resting HR, teasing HR, mounting HR, step-off HR, and walk-off HR. Data was analyzed using a repeated measures ANOVA within R Statistical Program®(R Core Team, 2022). Results were considered significant at P ≤ 0.05. Throughout the duration all stallions exhibited normal sexual behavior, regardless of treatment. A treatment affect was not seen for licking time between CBD and CON (11.92s ± 3.76 and 0.32s ± 0.20 respectively). There was no difference between CBD and CON for time to erection (27.64s ± 6.84 and 22.9s ± 4.76 respectively). Time to first mount CBD stallions averaged 330.6s ± 23.04, CON stallions averaged 359.5s ± 25.51, with no effect of treatment. Time to ejaculation in CBD stallions was 356s ± 23.78 and 374s ± 24.84 in CON stallions. There were no differences in behaviors over time. There was a time x day effect for walk-off HR(P = 0.04), though this was significant in both groups. No other differences in HR occurred. Long-term use of CBD for young stallions was seen to not affect libido. However, supplementation may lower HR over time. The immediate and lasting response to CBD use in mature stallions and older aggressive stallions is needed to understand the effects of using these products.

Transient Receptor Potential channels (TRP) in GtoPdb v.2023.1

Transient Receptor Potential channels (TRP) in GtoPdb v.2023.1

Female sexual behavior is disrupted in a preclinical mouse model of PCOS via an attenuated hypothalamic nitric oxide pathway

Women with polycystic ovary syndrome (PCOS) frequently experience decreased sexual arousal, desire, and sexual satisfaction. While the hypothalamus is known to regulate sexual behavior, the specific neuronal pathways affected in patients with PCOS are not known. To dissect the underlying neural circuitry, we capitalized on a robust preclinical animal model that reliably recapitulates all cardinal PCOS features. We discovered that female mice prenatally treated with anti-Müllerian hormone (PAMH) display impaired sexual behavior and sexual partner preference over the reproductive age. Blunted female sexual behavior was associated with increased sexual rejection and independent of sex steroid hormone status. Structurally, sexual dysfunction was associated with a substantial loss of neuronal nitric oxide synthase (nNOS)-expressing neurons in the ventromedial nucleus of the hypothalamus (VMH) and other areas of hypothalamic nuclei involved in social behaviors. Using invivo chemogenetic manipulation, we show that nNOSVMH neurons are required for the display of normal sexual behavior in female mice and that pharmacological replenishment of nitric oxide restores normal sexual performance in PAMH mice. Our data provide a framework to investigate facets of hypothalamic nNOS neuron biology with implications for sexual disturbances in PCOS.

Students’ understanding of normal sexual behavior definition through evaluation and group discussion

IntroductionThe assumption that “normal” or typical sexual behavior exists is important for research and practice (van Lankveld, 2013). The definition of normal sexual behavior is multifaceted, that is why its adequate understanding by students in the course of sexuality requires some effort.ObjectivesThe focus of the research was the students’ understanding of complicated normal sexual behavior.Methods24 students (20 women; aged from 20 to 37 with M=25.5 and SD=5.7) completed adapted and modified questionnaire (Kite, 1990) consisting 30 items concerning sexual behavior by deciding whether or not they consider each item as normal. Then the evaluations by each student on all items were generalized and discussed and summarized in this general form among all participants.ResultsOnly 2 items were considered by all students as a normal: concerning sex somewhere other than a bed and masturbation after marriage. Some items were evaluated as normal by the half of participants: fantasizing about a person other than one’s partner during sex; becoming aroused by peeping; dressing of the clothing of the other sex; having rape fantasies. Many items were characterized as normal by less or more than a half of the participants. Trying to answer the question of what elements of sexual behavior can be considered as normal, students aware the ambiguity of these assumptions and observe the variability in the opinions of other participants.ConclusionsEvaluation of different elements of sexual behavior and subsequent group discussion demonstrates for students some difficulties and uncertainty in defining normal sex behavior.DisclosureNo significant relationships.

Melanocortin-4 receptor agonism modulates sexual brain processing in women with low sexual desire

ABSTRACT Introduction Hypoactive sexual desire disorder (HSDD) is characterized by a persistent lack of sexual desire and sexual fantasies, causing marked interpersonal distress1. It is the most common global female sexual health problem, affecting up to 1 in 10 women2,3. Despite its significant social and economic burden4,5, the exact pathophysiology of this condition remains unknown. Furthermore, existing treatment options are limited by their efficacy and side effects6. Melanocortin-4 receptor (MC4R) agonists are a promising therapeutic avenue, although their exact mechanism of action within the CNS remains unknown. Investigating the neural pathways through which MC4Ra's exert their effect will deepen our knowledge of normal and abnormal sexual behaviour, and hence provide information which could contribute to the development of novel treatment strategies. Objective To determine the mechanism by which MC4R agonists mediate their effects on sexual behaviour in women with HSDD. Methods We performed a randomized, double-blind, placebo-controlled crossover study in 31 premenopausal women with HSDD. A combination of psychometric, functional neuroimaging and hormonal analyses was used to investigate the effect of MC4R agonism versus placebo on sexual brain processing. A standard fMRI block design task with short (20 second) erotic videos was used to examine brain activation. Additionally, a ‘naturalistic’ fMRI paradigm was used with long (ten minute) erotic videos to examine functional brain connectivity. Results MC4R agonism increased self-reported sexual desire for up to 24-hours following administration, when compared with placebo (P=0.007). The mechanism of action behind this effect may be explained by the changes in brain activation and connectivity, in response to visual erotic stimuli. In the short video task, MC4R agonism led to increased activation of the supplementary motor area and cerebellum, alongside deactivation of the secondary somatosensory cortex, when compared with placebo (Z=2.3, P<0.05). In the long video task, a reduction of functional connectivity between the amygdala and insula in response to erotic stimuli was prevented by MC4R agonism (F (1,30) = 5.553, P=0.025). Regarding hormonal analyses, MC4R agonism led to a small mean increase in LH of 1.1iU/L (F [1,58] = 13.38, P=0.0005) and FSH of 0.35iU/L (F [1,60] = 10.97, P=0.0016) during the study, with no effect on estradiol or progesterone levels. Conclusions This is the first study investigating the effect of MC4R agonism on sexual brain processing in women with HSDD. These results shed light on the neural substrates through which MC4R agonism increases sexual desire. The observed changes in brain activation may serve to ease self-consciousness, enhance sexual imagery and disinhibit the sexual response in women with HSDD. This is in line with the “top-down” neurofunctional model of HSDD whereby inspecting and monitoring one's sexual response interferes with desire7. This information is important for the ongoing development of therapies for HSDD, as well as MC4R agonist development more widely, such as in obesity medicine where there their use is being rapidly developed. Disclosure Work supported by industry: yes, by AMAG Pharmaceuticals Inc.

Transient Receptor Potential channels (TRP) in GtoPdb v.2022.1

Transient Receptor Potential channels (TRP) in GtoPdb v.2022.1

A Case Report of Zoophilia in Aceh Where Lack of Education and Family Supervision can be a Trigger

BACKGROUND: Paraphilia or deviance is sexual stimulation or action that deviates from normal sexual behavior, but is necessary for some people to experience arousal and orgasm. People with paraphilia have unusual sexual interests, including inanimate objects, places, or individuals (children and corpses), and animals. Another paraphilic disorder involving a disapproving individual is characterized by a persistent and intense pattern of atypical sexual arousal manifested by sexual thoughts, fantasies, compulsions, or behavior in which the focus of the arousal pattern involves the other person being unwilling or unable to consent. However, it is not specifically described in any of the other so-called Paraphilic Disorder categories (e.g., arousal patterns involving corpses or animals). CASE REPORT: Here, we report a case of a male patient aged 37 years, unmarried status, his last education graduated from elementary school, the patient complained that he had frequent contact with cows, he had been experiencing it for 2 years, he felt lonely and had no close friends. As a child, he was often scolded and beaten by his father. He is also often teased by his friends. CONCLUSION: Zoophilia is another paraphilic disorder involving disapproving individuals characterized by a persistent and intense pattern of atypical sexual arousal manifested by sexual thoughts, fantasies, drives, or behaviors in which the focus of the arousal pattern involves the animal. This case is rarely reported because sufferers think their actions are not harmful, lack of parental attention and supervision may be one of the causes of this disorder.

Molecular Characterization of Two Known SRD5A2 Gene Variants in Mexican Patients With Disorder of Sexual Development.

Background: The 5α-reductase type 2 deficiency (5α-RD2) is a specific form of disorder of sexual development (DSD). Pathogenic variants in the SRD5A2 gene, which encodes this enzyme, are responsible for 46,XY DSD. Objective: The objective of the study was to investigate the genetic etiology of 46,XY DSD in two Mexican families with affected children. Materials and methods: The SRD5A2 gene of the parents and affected children was screened in both families via polymerase chain reaction amplification and DNA direct sequencing. The role of genetic variants in enzymatic activity was tested by site-directed mutagenesis. Results: Subject 1 presented two variants: p.Glu197Asp and p.Pro212Arg. Subject 2 was homozygous for the variant p.Glu197Asp. The two variants were reported in early studies. The directed mutagenesis study showed that the p.Glu197Asp and p.Pro212Arg variants lead to a total loss of enzymatic activity and, consequently, abnormal genitalia development in the patients. Conclusion: These results suggest that p.Glu197Asp and p.Pro212Arg are pathogenic variants that lead to the phenotypic expression of DSD. 5α-RD2 is of extreme importance not only because of its frequency (it is rare) but also because of its significance in understanding the mechanism of androgen action, the process of sexual differentiation, and the factors that influence normal sexual behavior.

Prevalence and Nature of Sexual Dysfunctions in OCD in a Tertiary Medical College

Normal sexual behavior brings pleasure to oneself and one's partner involves stimulation of the primary sex organs including coitus; it is devoid of inappropriate feelings of guilt or anxiety and is not compulsive. Sexual functioning is influenced by a number of factors, mental illness being one of them. Sexual dysfunction in patients with OCD has mostly been studied independently or in gender-specific studies. These studies have reported significant dysfunction in different areas of sexual functioning. The aim of this study is an attempt to assess & compare the presence, prevalence & types of sexual dysfunctions (SD) in OCD mostly coming from rural background in a Tertiary Government Hospital in West Bengal. Our study revealed Sexual dysfunction was in 53.33% of the subjects. Orgasmic dysfunction was the most frequent dysfunction 20.51% in females (N=8), followed by problems in desire15.38%. However since the data were collected from a specific population, the degree to which they represent the general population cannot be commented upon. Key word : OCD, Sexual Dysfunction

Transient Receptor Potential channels (TRP) in GtoPdb v.2021.3

Transient Receptor Potential channels (TRP) in GtoPdb v.2021.3

Using sexual health and safety education to protect against child sexual abuse in residential care: The LINC model

AbstractChildren and young people living in residential care are vulnerable to sexual abuse, and there is scant evidence about what sexuality education could help address this vulnerability. This paper explores the impact of the Power to Kids: Respecting Sexual Safety programme, which involved capacity‐building workers to have ‘brave conversations’ with children and young people in residential care. The aim of the study was to capture the perceptions of workers about changes in their skill and confidence levels in relation to having brave conversations with children and young people and the impact of those conversations on children and young people. A mixed‐methods study was undertaken, involving multiple sets of interviews with 27 workers associated with four residential houses. The qualitative and quantitative data analysis showed that workers perceived the impact of the capacity building and brave conversations as strengthening protective factors available to children and young people vulnerable to sexual abuse. The research revealed the ‘LINC model’ as a viable approach to capacity‐building workers to educate children and young people in residential care about sexual health and safety. Workers perceived the enhancement of the following protective factors: stronger safe relationships, greater comfort disclosing abuse and improved knowledge of normal versus harmful sexual behaviour.

The effects of 28-day early-life exposure to triphenyl phosphate (TPhP) on odor preference and sexual behavior in female rats.

Many chemical substances are detectable in house dust, and they are consequently taken into our bodies via the mouth and nose. Triphenyl phosphate (TPhP), a flame retardant that has an estrogen‐like effect in vitro, is present in house dust at high concentrations. Estrogen exposure during development has significant influences on reproductive behavior in rodents, and its effects persist until maturity. In the present study, we investigated the effect of early life exposure to TPhP on the reproductive behavior of female rats. Oral treatment with TPhP (25 or 250 mg/kg), ethinyl estradiol (EE; 15 μg/kg) as a positive control, or sesame oil as a negative control, were given to female rats (from birth to 28 days of age). The 8‐week‐old rats were bilaterally ovariectomized. At 12–15 weeks of age, the rats were subjected to odor preference and sexual behavior tests. In the odor preference test, the oil group showed significantly higher preference for male odor than female odor, but the low‐dose TPhP treatment group lost the preference for male odor, indicating a possible outcome of early life TPhP exposure on sexual recognition. In the sexual behavior test, both the EE and TPhP treatment groups displayed significantly less proceptive behavior. These results suggest that early life exposure to TPhP disturbs the normal sexual behavior of female rats.

Diagnostic evaluation of subclinical endometritis in dromedary camels

The objective of the present study was to evaluate the efficacy of various diagnostic methods and to estimate the prevalence of bacterial pathogens associated with subclinical endometritis (SCE) in dromedary camels. During two consecutive breeding seasons, a total of 2122 infertile female dromedaries were assigned to this study and suspected cases of SCE were identified using the established criteria which included failure to conceive after three or more consecutive matings with a fertile male, a clinically healthy genital system, no observable vaginal discharge, and normal sexual behavior. Manual vaginal examination, Metricheck, bacteriological examination using endometrial swabbing, and hemogram assessments were conducted and there were comparisons of results to when there was cytological examination using the Cytobrush technique as the gold standard. The threshold value for positive cases of SCE was set at ≥ 5% polymorphnuclear cells in the cytological samples. Subclinical endometritis was diagnosed in 211 9.94 %) of the total infertility cases. Endometrial swabbing was a more sensitive and specific technique for diagnoses compared with the other methods. Bacillus sp., Staphylococcus sp., and Candida albicans were the most commonly isolated microorganisms. Hemogram testing and rectal and ultrasonographic examinations were not effective for the diagnosis of SCE. It was concluded that, compared with other diagnostic tests, bacteriological examination is more sensitive and specific for the detection of SCE in dromedaries.