Normal Arrangements Research Articles

Effects of Exogenous Regulation of PPARγ on Ovine Oocyte Maturation and Embryonic Development In Vitro.

Lactating oocytes consume a lot of energy during maturation, a large part of which comes from lipid metabolism. PPARγ is a key regulator of lipid metabolism. In this study, rosiglitazone (RSG), an activator of PPARγ, was added to a mature medium to investigate its effects on the levels of spindle and the chromosome arrangement, lipid deposition, reactive oxygen species (ROS), and glutathione (GSH) levels, oocyte secretion factors, apoptosis and lipid metabolism-related gene expression, and subsequent embryonic development during the maturation of sheep oocytes. The oocyte secretion factor affects gene expression related to apoptosis and lipid metabolism and subsequent embryonic development. The results showed that the proportion of spindle and normal chromosome arrangements increased in the 5 μM RSG treatment group, the lipid content increased after cell maturation, the ROS level decreased, and the GSH level increased. The expressions of oocyte secretion factor (GDF9 and BMP15), anti-apoptosis gene (BCL2), and lipid metabolism-related genes (ACAA1, CPT1A, PLIN2) were increased in the 5 μM treatment group. Finally, the development of blastocysts was examined. After the oocytes were treated with 5 μM RSG, the blastocyst rate and the gene expression of the totipotency gene (OCT4) were increased. It was concluded that increasing PPARγ activity during ovine oocyte maturation could promote lipid metabolism, reduce oxidative stress, and improve the ovine oocyte maturation rate and subsequent embryo development.

The Comparison between the Effect of Probiotics and Antibiotics against Enterotoxin A Produced by Staphylococcus aureus Microbial and Histopathological Study

Abstract Background: Staphylococcus aureus is a significant pathogen that causes nosocomial infections as well as community-acquired diseases; the spectrum of S. aureus infections ranges from pimples and furuncles to toxic shock syndrome and sepsis. Probiotics, which are defined as “live microorganisms that, when taken in suitable proportions, impart a health benefit on the host beyond basic nourishment,” have attracted increasing public and scientific interest in recent years; probiotics are crucial for preserving the integrity of the gut mucosal barrier and preventing the expansion of potentially harmful bacteria. Objectives: The aim of this study was to evaluate the efficiency of probiotics to protect against the Staphylococcal enterotoxin A (SEA) of S. aureus on different organs of rats comparing with the effect of antibiotics. Materials and Methods: Twenty-five isolates were obtained from a variety of clinical locations. The gene sea was detected by using specific primer, 20 rats were used in this study and randomly divided into 5 groups. A complete necropsy was performed for all the animals. Results: The results of the sea gene showed that 16 out of 25 isolates harbored this gene. And the photomicrograph of liver and intestine, after treatment by probiotics (bacteria and yeast), revealed normal hepatocytes and newly formed villi with mild thickness and intact a muscular layer, respectively. At the same time, after treatment with antibiotics, the results showed remarkable reversible changes of hepatic architecture, areas of hepatocytes with normal arrangements and reversible changes, and these were represented by a significant villi length and the areas of necrosis in a muscular layer in liver and intestine, respectively. Conclusion: The conclusion revealed, probiotics of both types (bacteria and yeast) showed curable effect in the organs under study that were altered by SEA and gave efficient effect as much as antibiotics, and also suggested the usage of probiotics instead of antibiotics for better health.

Relationship between emotional intelligence and non verbal behaviour in enhancing workplace relationship

The recent Covid 19 pandemic has disrupted the operations of many organisations around the world. Many employees had to change their work arrangements, by working at home. This was the work arrangement for about 1 and half years from 2020 until 2021. Towards the end of 2021 and beginning of 2022, many employees are happy to be able to resume their almost normal work arrangements. After working from remote places, the transition to return to normal would need some changes in habits and behaviour. The purpose of this paper is to examine the contribution of emotional intelligence and non verbal behaviour in enhancing the workplace relationship. A successful organisation has been chosen for this study. All of their executives took part in this analysis. The Genos emotional intelligence questionnaire has been used to collect the data from the respondents. From the analysis, it was found that both emotional intelligence and non verbal behaviour enhances the workplace relationship.

Prenatal diagnosis and clinical outcomes of isolated interruption of the inferior vena cava: an analysis of 12 cases

Objectives: This study aimed to comprehensively investigate the clinical manifestations and outcomes of prenatally diagnosed isolated interrupted inferior vena cava (IIVC) with azygos continuation to shed light on the significance of prenatal diagnosis.
 
 Methods: A longitudinal study involved 12 fetuses prenatally diagnosed with IIVC and azygos continuation. Detailed fetal anomaly scans and echocardiography were performed, and pediatric cardiologists confirmed postnatal diagnoses. Genetic testing and extensive follow-ups were also performed.
 
 Results: The study confirmed the high diagnostic accuracy of prenatal identification, with 100% postnatal confirmation. Most patients exhibited favorable outcomes, emphasizing the importance of prenatal diagnosis. Genetic testing revealed normal chromosomal arrangements in all tested cases.
 
 Conclusion: Our study underscores the vital role of prenatal diagnosis in managing isolated IIVC cases and highlights their generally favorable prognosis. This study contributes to understanding this rare vascular anomaly and its implications for clinical practice.

Evaluation of building arrangement on natural ventilation potential in ideal building arrays

ABSTRACT Nowadays, the process of urbanization is accelerating, and the density of buildings is increasing rapidly. Natural ventlation is an energy-saving way of building ventilation and to solve the issue of building overheating. The buildings are all considered as cubes and their arrays are evenly distributed. The results from nearly 100 cases show density is the main factor in uniform arrays and not much difference between the staggered and normal arrangements if consider a year. The method can reflect the ventilation capacity of the buildings, which is somewhat inverse to the air age but different meaning. It can be used to guide the layout and planning in early design stage.

Changes in cellular Ca2+ and Na+ regulation during the progression towards heart failure.

In adapting to disease and loss of tissue, the heart shows great phenotypic plasticity that involves changes to its structure, composition and electrophysiology. Together with parallel whole body cardiovascular adaptations, the initial decline in cardiac function resulting from the insult is compensated. However, in the long term, the heart muscle begins to fail and patients with this condition have a very poor prognosis, with many dying from disturbances of rhythm. The surviving myocytes of these hearts gain Na+ , which is positively inotropic because of alterations to Ca2+ fluxes mediated by the Na+ /Ca2+ exchange, but compromises Ca2+ -dependent energy metabolism in mitochondria. Uptake of Ca2+ into the sarcoplasmic reticulum (SR) is reduced because of diminished function of SR Ca2+ ATPases. The result of increased Ca2+ influx and reduced SR Ca2+ uptake is an increase in the diastolic cytosolic Ca2+ concentration, which promotes spontaneous SR Ca2+ release and induces delayed afterdepolarisations. Action potential duration prolongs because of increased late Na+ current and changes in expression and function of other ion channels and transporters increasing the probability of the formation of early afterdepolarisations. There is a reduction in T-tubule density and so the normal spatial arrangements required for efficient excitation-contraction coupling are compromised and lead to temporal delays in Ca2+ release from the SR. Therefore, the structural and electrophysiological responses that occur to provide compensation do so at the expense of (1) increasing the likelihood of arrhythmogenesis; (2) activating hypertrophic, apoptotic and Ca2+ signalling pathways; and (3) decreasing the efficiency of SR Ca2+ release.

Investigating Comproportionation in Multielectron Transfers via UV-Visible Spectroelectrochemistry: The Electroreduction of Anthraquinone-2-sulfonate in Aqueous Media.

UV-vis spectroelectrochemistry is assessed as a tool for the diagnosis and quantitative in situ investigation of the incidence of comproportionation in multielectron transfer processes. Thus, the sensitivity of the limiting current chronoabsorptometric signals related to the different redox states to the comproportionation kinetics is studied theoretically for different working modes (normal and parallel light beam arrangements) and mass transport regimes (from semi-infinite to thin layer diffusion). The theoretical results are applied to the spectroelectrochemical study of the two-electron reduction of the anthraquinone-2-sulfonate in alkaline aqueous solution, tuning the thermodynamic favorability of the comproportionation reaction through the electrolyte cation. The quantitative analysis of the experimental results reveals the occurrence of comproportionation in the three media examined, showing different kinetics depending on the cationic species in solution.

Online measurement of mean residence time of supercritical-pressure fluid with/without chemical reaction in pipe flow: A particle image statistics method considering optical distortion and radial uneven distribution of tracer particles

This paper proposed a nonintrusive, in-situ experimental method for visualizing and measuring the mean residence time (MRT) of supercritical-pressure pipe flow with/without chemical reactions based on the high-frequency sampling of laser-induced particle images. Normal and oblique optical arrangements (NOA & OOA) for the incident laser were applied to induce particle scattering in the JP-10 pipe flow, using SiO2 microsphere as tracers. Optical distortion caused by drastic change in fluid properties was analyzed. The relative deviation of the proposed particle image statistics (PIS) method was within ±4% with NOA after considering optical distortion and uneven radial distribution of particles. Although the same level of accuracy was achieved with OOA without the need for correction, the noise in images became significant when the fuel approached pseudo-critical temperature. When there was no influence from pyrolysis, the MRT simulated using 1D subroutine agreed well with measured data. However, the relative deviation increased after pyrolysis.

P‐13.3: A Novel Sub Pixel Arrangement based on OLED

Several normal sub pixel arrangements were introduced in this paper, including RGB Stripe and PenTile RGBG. The paper compared the advantage and disadvantage of each arrangement. The pixel of PenTile RGBG includes only two color channels, which causing the color leakage and image distortion. To solve this problem, two novel arrangements after light interleaved and light overlapped based on lens refraction were proposed. The results of image test and contrast experiment showed that the improved sub pixel arrangement can weaken color artifacts effectively.

Working in a pandemic and post-pandemic period – Cultural intelligence is the key

Working environment has been transformed by this pandemic into flexible work arrangements with a swift acclimatization of technology. The post-pandemic working arrangements are expected to be increasingly driven by technology as business models will also evolve to adopt these changes. Virtual working arrangements bring several challenges like reduced trust, disrupted communication, limited collaboration, lack of role clarity and lowered team performance. The research suggests that the future of work is going to be more dynamic and virtual. The normal physical work arrangements that were in place before the pandemic will evolve to include multiple models. Therefore, the challenges and problems associated with virtual working needs to be addressed along with the increasing adoption. Cultural intelligence helps in fostering ‘trust and understanding’ even among virtual teams. The study surveyed people working virtually during this pandemic and analysed, if cultural intelligence and its dimensions i.e. cognitive, metacognitive, motivational and behavioural have effect on the challenges faced by the virtual teams. It is observed that the behavioural cultural intelligence predicts virtual team effectiveness and address the challenges faced by virtual teams.

Assessment of point and line contact stiffness formulations leading to the initiation of hammering type brake squeal

This article proposes a refined nonlinear mathematical model to conceptually investigate the brake pad kinematics and dynamics in order to reveal certain important aspects that have been ignored in prior studies. In particular, the proposed model is formulated as a three degree-of-freedom mass positioned on a rigid frictional surface moving at constant velocity. The mass is assumed to make planar motion in vertical plane, two translations and one rotation. The interfacial contact is first examined by a point contact model with linear translational springs at edges and then the line contact is defined over the entire interface. Furthermore, kinematic and clearance nonlinearities are included. The nonlinear governing equations with point contacts at edges are numerically solved at certain angular arrangements of normal force vectors. Then, the line contact interface is solved again for the same normal force vector arrangements. Comparison reveals that the line contact approach provides more meaningful results. Finally, a linearized system model and the existence of quasi-static sliding motion are examined over a range of the normal force vector arrangements. Overall, inclusion of the rotational degree of freedom in the source model is crucial and the importance of pad-disc separation is clearly explained by the proposed formulation. This leads to a better understanding of the hammering type brake squeal source mechanisms while overcoming the limitation of prior minimal order models

Influence of the inversion factor on Madelung constants in spinel systems

The influence of the inversion factor on the Madelung constants of the partially inversed spinel systems Mg-Zn-(FeTM)O4 where (TM = Ni and Cr) have been investigated. These results showed that both the ordering parameter, Q and the inversion factor, λ depend on the oxygen positional parameter, u in these spinels. An inverse relation between lattice constants and the inversion factor is well defined in these spinels. From the cation distributions the sample with λ = 2/3, Q = 1 and maximum configurational entropy Sc(≈15.876 J/mol,K) should represents the sample with the complete randomness of the cation distributions in these spinels and can be written as ((MgZn)1/3Fe2/3)[(MgZn)2/3Fe1/3TM3/3]O4. The total Madelung constants Mtot increase as the inversion factor decreases in these spinels. The presence of the Zn2+ (Mg2+) cations enhances the normal (inverse) spin phase arrangements; this might be caused by the strong tendency of the Zn2+ (Mg2+) cations to reside at the tetrahedral (octahedral) sites. The Zn- (Mg-) spinels are largely having the normal (inverse) type structure. Values of the ordering, inversion and randomness parameters moves towards the spinel structure normality as the Zn content (x) increases in the sample. Values of the calculated total Madelung constants, Mtot increase as uavg increases. An inverse relation between the lattice constants and the inversion factor, λ is well defined in these spinels.

Zinc Oxide Nanoparticles attenuate Cadmium Chloride induced tongue toxicity in adult male albino rats (Histological and Biochemical study)

Introduction: Cadmium is a toxic heavy metal naturally present in plant food and unavoidable pollutant for many dental procedures. This metal shares in toxic peroxidation and destruction of macromolecules in different tissues, besides inhibition of DNA repair enzymes. The tongue is one of the vital organs that could be affected by chronic cadmium toxicity, especially the filiform papillae and tongue skeletal muscles due to their high metabolic activity. Aim of work: to study the possible role of Zinc oxide nanoparticles (ZnO NPs) in attenuation of the structural, ultra-structural and biochemical changes in rats' tongues induced by Cadmium chloride. Materials and Methods: sixty adult male Albino rats were divided equally -according to the utilized substance- into three groups; control, Cadmium chloride (CdCl) and (CdCl+ ZnO NPs) groups; every group received the allocated materials for 4 weeks. Samples were processed for light, electron microscopic examinations and biochemical analysis (malondialdehyde; reduced glutathione; catalase; superoxide dismutase; glutathione peroxidase). Results: Cadmium produced various apparent histopathological and biochemical alterations in tongue tissues in the form of filiform papillae with blunted ends, and thick keratin plaques. Epithelial cell layers appeared with vacuolated cytoplasm and dark nuclei. Degenerated muscle fibrils with wide spaces between them and many collagen fibers. Significant decrease of tongue reduced GSH, SOD, GPx and Cat enzymes activity and significant increase in MDA level in Cadmium chloride group as compared to control group. ZnO NPs attenuated these changes and revealed pointed tipped filiform papillae, nearly normal cells and Parallel arrangements of myofibrils. The levels of reduced GSH, SOD, GPx, Cat and MDA were insignificant compared to control group. Conclusion: Zinc oxide nanoparticles (ZnO NPs) attenuated the structural and biochemical changes in rats' tongues induced by Cadmium chloride.

Etiology of atrial fibrillation in patients with complex congenital heart disease — for a better treatment strategy

BackgroundThe demographics of patients with congenital heart disease (CHD) and atrial fibrillation (AF) differ significantly from the general population. The etiology and treatment strategy for AF in CHD patients have been investigated but are to date inconclusive. MethodsTo determine the etiology of AF in CHD and to seek a better treatment strategy, we retrospectively evaluated the atrial overload in 42 complex CHD cases with normal atrial arrangements and AF (age 25; range, 9–66 years) and the impact of a reduction in the atrial overload on the atrial rhythm. ResultsCardiac defect diagnoses varied, with 17% of the patients having a persistent left superior vena cava (PLSVC). In regard to the volume overload, the frequencies of an overload in the right atrium (RA), left atrium (LA), or both, were 50 %, 23%, and 10%, respectively (p = 0.015). Other sustained supraventricular tachycardias were observed in 29 patients (69%) before and after the onset of AF. Among these 29 patients, 26 had intra-atrial reentrant tachycardia. Fifteen patients (36%), 10 of whom had chronic AF, died during the follow-up including 3 with arrhythmias and 10 because of heart failure. Fourteen (33%) patients had no AF at the last follow-up due to medical interventions, 8 of which underwent solely an RA-sided catheter ablation and/or surgical RA overload reduction. ConclusionsAF in complex CHD with a normal atrial arrangement correlates with a higher RA-sided overload than an LA-sided and exhibits a high incidence of PLSVCs, high comorbidity of intra-atrial reentrant tachycardias, and high mortality rate. In a substantial number of patients, RA-sided interventions were effective in controlling AF. To effectively manage AF in complex CHD it is essential to understand each individual’s hemodynamics and consider hemodynamic interventions.

Chenopodium ambrosioides var. ambrosioides leaf extracts possess regenerative and ameliorative effects against mercury-induced hepatotoxicity and nephrotoxicity

Empirical literature reveals the use of Chenopodium ambrosioides var. ambrosioides leaf extract as antipyretic, antimicrobial, antioxidant, cancer chemoprotective, and antidiabetic agent in folklore medicine – with these pharmacological properties linked to its secondary metabolites. There are, however, no adequate information on the possible protective, regenerative, and ameliorative effects on toxicity induced by heavy metals. Hence, the investigations on mercury-induced nephrotoxicity and hepatotoxicity in this study. The leaf extract was profiled using gas chromatographic instrument coupled with mass spectrometer (GC–MS) and revealed 100 metabolites ranging from polyphenols, terpenes, terpenoids, and cardiac glycosides. The antioxidant assays revealed that C. ambrosioides leaf extracts possess antioxidant properties with hexane fraction exhibiting the highest scavenging activities for DPPH (IC50 = 0.02 mg/mL), FRAP (730.92 mg/AAE g), and metal ion chelating ability (IC50 = 3.18 mg/mL). Nephrotoxicity and hepatotoxicity biomarkers using total protein, albumin, total bilirubin, direct bilirubin, catalase, glutathione peroxidase (GPx), reduced glutathione (GSH), creatinine, uric acid, urea, ALT, and AST activities both in the kidney and liver homogenates of Wistar rats revealed significant regenerative improvement which differs significantly at p < 0.05 when compared with experimental rats with toxicant only. In the same vein, the histomorphological analysis showed remarkable hepatocellular regeneration presenting features of normal architectural arrangements of hepatic tissues while acute toxicological studies revealed that the LD50 of C. ambrosioides leaf material is well above 5000 mg/kg. The outcomes of this study showed that the leaf extract exhibited high hepatoprotective and nephroprotective activities as well as being implicated in the discovery of safe, cheaper, and effective therapeutic agents thereby highlighting its importance as a promising industrial crop.

Zinc oxide nanoparticles from Corydalis yanhusuo attenuated the mycoplasmal pneumonia in mice through inhibiting the MAPKs signaling pathway

BackgroundThe Mycoplasma pneumoniae (M.pneumoniae) was accounted to 3–10% of total pneumonia incidences. In recent decades, metallic nanoparticles were extensively examined as nano-antibiotics. ObjectiveIn this investigation, we intended to inspect the therapeutic potential of Zinc oxide nanoparticles (ZnONPs) from (Corydalis yanhusuo) C. yanhusuo against the mycoplasma infected pneumonia in mice. MethodologyThe ZnONPs were formulated via green route technique and characterized by UV–vis spectroscopy, transmission electron microscopy, Fourier transform infrared technique, and atomic force microscopy. The antimicrobial activity of formulated ZnONPs was tested by well diffusion method. The total protein, interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor alpha (TNF-α) and transforming growth factor (TGF) status in the BALF of M. pneumonia infected animals were investigated via kit method. The expressions of ERK1/2, JNK1/2, and NF-κB were examined through the Western blotting. The Histopathological analysis of lung tissues of experimental animals was done. ResultsThe UV–vis spectroscopy and TEM examinations were proved the existence of CY-ZnONPs. The formulated CY-ZnONPs were displayed the potential antimicrobial activity. The supplementation of CY-ZnONPs were noticeably diminished the total protein and IL-6, IL-8, and TNF-α levels in the BALF of pneumonia mice. The ERK1/2, JNK1/2, and NF-κB expressions were appreciably diminished in the CY-ZnONPs supplemented mice. It also reduced the inflammatory cells penetration, and exhibited normal tissue arrangements in the lung tissues of pneumonia mice. ConclusionThe findings of this investigation were proved that the synthesized CY-ZnONPs has the potential to ameliorate the M. pneumoniae infected pneumonia in investigational mice.

Psychotherapy in the Time of COVID

Psychotherapy in the Time of COVID

Managing Euro Risk

Many people can now see that the EU project has lost touch with the normal arrangements that govern successful western economies. But less obvious is that the EU’s financial system and its legal underpinnings are weak. As this analysis shows, EU law sidesteps the Basel standards – the international rules which protect the financial system from systemic risk. But, whereas the UK has until now helped to manage the risk by applying its own controls to the business it regulates, after Brexit much will depend on whose laws govern trade. Managing Euro Risk explains how the problem has arisen. Legally, the Eurozone has circumvented the Basel rules. Eurozone states can raise funds on the debt markets, behaving as sovereign, but in fact are ‘sub sovereign’ ‒ and without the currency being backed by a single sovereign. The EU’s supra-national bodies, its central bank (the ECB) and investment bank (the EIB) operate under the same misassumptions. The problems have been exacerbated by an absence of transparent accounting practices. The upshot is that the Eurozone’s financial sector today is under-capitalised, under-collateralised and less liquid than it should be. The authors, Barnabas Reynolds, a UK and international financial services lawyer, David Blake, an academic economist and Robert Lyddon, a bank accounting and financial analyst, warn that the potential for systemic risk spreading to the UK or globally is grave, endangering businesses, savers and investors - a danger likely to become acute after Brexit. The authors explain how the risk can be managed and contagion contained. They propose that the EU should be obliged to apply the Basel and accounting standards properly, with Eurozone member states adopting joint-and-several liability for each other's debts. Above all, the UK should insist that future financial services trade with the bloc will be on an Enhanced Equivalence basis, with UK trade governed by UK law. If the EU refuses, the UK and US, the regulators of the global financial market, must take whatever steps are needed to prevent systemic risk.

‘Thinking like a nurse’. Changing the culture of nursing students′ clinical learning: Implementing collaborative learning in practice

This article reports a study evaluating the implementation of Collaborative Learning in Practice models at a university School of Nursing and Midwifery with practice partners across the South West of England. We conducted four focus group interviews with 40 students with experience of Collaborative Learning in Practice placements, and two focus groups with eight clinical practice staff with responsibility for implementing and supporting such models in their areas. Data were transcribed and analysed using the Framework Method. Key themes were ‘Real time’ Practice of Collaborative Learning Implementation, Collaborative Learning as Preparation for Registrant Practice, and the Student/Mentor Relationship. We conclude that Collaborative Learning in Practice utilising models of coaching and peer support, offers benefits to students who are exposed to the reality of nursing practice from the beginning of their placement experiences, enabling them greater responsibility and peer support than under normal mentoring arrangements. Furthermore, there are benefits to the registrants because the burdens of supervising students are spread more widely. This is timely given the review of Nursing and Midwifery Council standards for programmes and student support and the need to increase placement capacity as a response to global nursing shortages.

EGFR tyrosine kinase inhibition decreases cardiac remodeling and SERCA2a/NCX1 depletion in streptozotocin induced cardiomyopathy in C57/BL6 mice

AimEpidermal growth factor receptor (EGFR) related reactive oxygen species (ROS) generation results in myocardial damage. We aimed to investigate the role of gefitinib (EGFR-tyrosine kinase inhibitor) in diabetic cardiomyopathy (DbCM). MethodDbCM was induced by injecting streptozotocin (55 mg/kg for 5 consecutive days) to C57/BL6 mice intraperitoneally. Diabetic C57/BL6 mice (fasting blood glucose level ≥ 250 mg/dl) were allocated into four study groups and treated with two doses of gefitinib (30 mg/kg and 350 mg/kg per day) as well as ramipril (3 mg/kg/day) for four weeks. Key findingsWe observed a significant correlation between persistent hyperglycaemia with cardiac remodeling and alterations in myocardial architecture. Gefitinib significantly prevented lipid peroxidation (MDA), damage of antioxidant enzymes like superoxide dismutase (SOD), Catalase, glutathione (GSH) and thioredoxin reductase (TrxR). Gefitinib also prevented hypertrophy of myocardium evidenced by reduced heart weight to body weight ratio and TGF‑β related collagen deposition. Gefitinib maintained cardiac biomarkers like lactate dehydrogenase (LDH), Creatine Kinase‑MB, brain natriuretic peptide (BNP) and cardiac Troponin‑I (cTroponinI) indicating reduced myocardial damage. Decreased sarcoplasmic endoplasmic reticulum Ca2 + ATPase2a (SERCA2a) and sodium‑calcium exchanger-1 (NCX1) protein depletion after gefitinib administration indicated improved Ca2+ homeostasis during myocardial contractility. Histopathology and transmission electron microscopy clearly showed almost normal myofibrils and mitochondrial arrangements in gefitinib treated mice. SignificanceOur findings suggest that gefitinib protects myocardial damage in DbCM via balancing oxidant-antioxidant system, decreased collagen deposition as well as improved CKMB, BNP, cTroponinI and SERCA2a/NCX-1. Thereby, it indicated that gefitinib may be a potential therapeutic drug for treating DbCM.