This study is a narrative review of the literature that addresses the topic of orofacial harmonization with the use of polydioxanone (PDO) threads. PDO threads have been used as an option to slow down the natural aging process, promoting facial rejuvenation. The non-surgical procedure is performed in the office and is minimally invasive. However, there are still contraindications, for example, in the case of autoimmune diseases, pregnancy, and use of anticoagulants. In these cases, complications such as hematoma and infection may occur; however, they are mostly easy to manage, since they are transient and disappear in a few days. Furthermore, it is essential to apply the technique correctly to avoid complications, such as thread migration. Although most studies point to positive results with the use of PDO, research is still needed to verify its long-term effectiveness, especially in older people and those with more facial sagging, since this technique is more suitable for patients with mild wrinkles and sagging. Based on this, the objective of this study was to conduct a narrative review of the literature on the effectiveness of using PDO threads in orofacial harmonization. To this end, searches for scientific articles were carried out on the PubMed and SciElo platforms in 2024, using the descriptors: “Orofacial harmonization”, “PDO threads”. Nine articles were selected and presented in order to contribute with theoretical basis on the benefits, indications, applicability, safety, in addition to highlighting the effectiveness of use.
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