Nonpigmented Mass Research Articles

Intraocular schwannoma: case series of 28 patients and literature review.

Intraocular schwannoma is a rare tumour, which is often misdiagnosed. We presented the demographics and clinical characteristics of patients with intraocular schwannoma. Retrospective case series were collected between May 2005 and July 2021 in Beijing Tongren Hospital. A total of 28 patients were diagnosed with intraocular schwannoma on histopathological examination of surgical specimen. The median age was 39 years (range: 12-64). Fourteen patients were female and 14 were male. Among the all subjects, 21/28 patients (75.0%) presented as visual loss, and 3/28 patients (10.7%) had visual field loss. Intraocular schwannoma presented as nonpigmented mass in the ciliary body in 12/28 cases (42.9%), in the choroid in 9/28 cases (32.1%), and in ciliochoroid in 7/28 cases (25.0%). Intraocular schwannoma was often clinically misdiagnosed as uveal melanoma, which occurred in 16/28 patients (57.1%). Tumour excision with pars plana vitrectomy was performed for all included patients. Endoresection with lens removal was performed for tumours in the choroid, while transscleral resection was performed for tumours located in ciliary body or ciliochoroid. Increased light transmission was detected in 12/28 cases (42.9%). In the consecutive follow-up (median: 73 months, range: 7-193 months), no cases of recurrence or metastatic disease were detected. Intraocular schwannoma is a rare benign tumour. It usually presents as nonpigmented mass, which can easily be misdiagnosed as nonpigmented uveal melanoma.

A rare case of primary lymphoma of the ciliary body – A case report

A 73-year-old lady presented with complicated cataract, white tumor hypopyon, and an elevated, nonpigmented mass at the root of iris. Magnetic resonance imaging (MRI) revealed ciliary body involvement suspicious of atypical melanoma. Patient underwent enucleation. Histopathology with immunohistochemistry (IHC) markers clinched the diagnosis of diffuse large B-cell lymphoma (DLBCL) of ciliary body, with positive lymphoma markers CD20, CD3, BCL2, and PAX5 and negative melanoma markers HMB45 and S100. Primary lymphoma of ciliary body, especially the DLBCL type, is rare. Our report shows that primary lymphoma of ciliary body may be considered as a differential in cases with atypical features. Histopathology and immunohistochemistry are valuable tools in diagnosing challenging cases.

Primary malignant melanoma at base of the tongue

Primary malignant melanoma is rarely seen in the oral cavity, especially in the tongue. However, the base of the tongue is an extremely rare location for primary malignant melanoma. A 68-year-old male attended the otorhinolaryngology clinic with complaint of foreign-body sensation in the throat for 1 year. Intraoral examination showed a painless and black-colored mass on the right side of the base of the tongue. Histopathology report showed the diagnosis of a malignant melanoma. He underwent composite resection of the tumor and right-sided functional neck dissection. Early diagnosis should be made by proper examination of the oral cavity and oropharynx and early biopsy of the pigmented and nonpigmented mass. Early detection and treatment is required for better prognosis of the malignant melanoma at the base of tongue.

Suspected Iatrogenic Seeding of Oral Melanoma Secondary to Endotracheal Intubation in a Dog

A 10 yr old castrated male pug was presented with a 3 day history of intermittent dyspnea, cough, inappetence, and inability to breathe while sleeping. He had previously received hypofractionated radiation therapy for an amelanotic oral malignant melanoma (OMM) 7 mo prior to presentation. At presentation, the dog was gasping and dyspneic. Oral examination identified the OMM on the right hard palate. Thoracic radiographs revealed an angular soft-tissue opacity within the trachea just distal to the thoracic inlet. No evidence of pulmonary metastatic disease was seen. Tracheoscopy identified a pedunculated, nonpigmented mass within the lumen of the distal trachea near the carina. Treatment options were presented to the owners and included tracheal stenting or tracheal resection and anastomosis. Because of the poor prognosis, the owners elected humane euthanasia. Postmortem examination confirmed the presence of melanoma in the distal trachea; no other sites of OMM metastasis were identified. The cause of OMM development in the distal trachea in this case is suspected to have resulted from mechanical tumor cell seeding during endotracheal tube placement for general anesthesia 7 mo prior to presentation. Despite the reported rarity of mechanical tumor seeding, this potential complication warrants consideration in dogs with OMM.

Ocular Non-pigmented Ciliary Adenomatous Neoplasm:Report of a Rare Case and Review of the Clinicopathologic Classification

Ocular Non-pigmented Ciliary Adenomatous Neoplasm:Report of a Rare Case and Review of the Clinicopathologic Classification A 27-year-old man presented with a phthisical left eye. Physical and radiologic examinations revealed an intraocular non-pigmented mass that occupied the anterior chamber. The patient underwent an uneventful left eye enucleation. Histopathologic examination revealed a non-pigmented adenomatous ciliary epithelial neoplasm. Three years after surgery, the patient is alive and well. Here, we discuss the histopathologic features in the context of the clinical behavior of ocular non-pigmented ciliary adenomatous neoplasms.

Presumed metastasis of choroidal melanoma to the contralateral choroid.

To report a case of choroidal melanoma metastasizing to contralateral choroid along with systemic metastasis. This is a retrospective study of a case of a 52-year-old man who was found to have a choroidal lesion in the left eye temporal to fovea. The ultrasound and angiographic findings were suggestive of choroidal melanoma, which prompted enucleation of the eye. After approximately 74 months, the patient noticed decreased vision in the contralateral (right) eye. Examination revealed a nonpigmented mass lesion approximately two disk diameters in size superotemporal to fovea, and the patient was found to have multiple secondary tumors in the abdomen and liver. The development of choroidal metastases from a contralateral choroidal melanoma is of ophthalmic interest and seems to be unique.

Malignant Melanoma of the Subcutaneous Tissues in an Umbrella Cockatoo (Cacatua alba)

A 24-year-old female umbrella cockatoo (Cacatua alba) was examined because of a subcutaneous swelling of the left shoulder. Radiographs of the left wing revealed boney proliferation of the left proximal humerus. At surgery, an unencapsulated infiltrative nonpigmented mass within the subcutaneous tissue and skeletal muscle was identified overlying the left humerus. The mass was surgically excised and submitted for histologic examination; however, the cockatoo died after excision. Histologically, the mass was composed of nests and sheets of pleomorphic neoplastic cells with a high mitotic index and extensive necrosis. Rare neoplastic cells contained fine brown cytoplasmic granules that stained black with Fontana-Masson, confirming the presence of melanin pigment. The histomorphologic diagnosis was consistent with an anaplastic malignant melanoma of subcutaneous tissues.

Conjunctival Melanoma 3 Years After Radiation and Chemotherapy for Retinoblastoma

An 8-month-old infant with advanced bilateral retinoblastoma was managed with enucleation of the right eye and chemotherapy and radiotherapy of the left eye. Three years after treatment, an ill-defined, nonpigmented mass was noted in the anophthalmic right socket. Excisional biopsy revealed an amelanotic melanoma of the conjunctiva with superficial orbital invasion. There has been no tumor recurrence during 20 months of follow-up.