A nonlinear Schrödinger equation of fractional (N/s1,q)-Laplacian is considered with the Rabinowitz potential, critical Sobolev growth and Trudinger–Moser nonlinearity in RN−ΔN/s1s1u+−Δqs2u+V(ɛx)(uNs1−2u+uq−2u)=λfu+uqs2∗−2u.We establish the global existence of nonnegative ground-state solution for suitable parameter values primarily through variational analysis, fractional Trudinger–Moser inequality and mountain pass approach. It is a crucial ingredient to handle three aspects concerning the limiting setting s1p=N, the critical Sobolev growth and Trudinger–Moser nonlinearity.