Abstract Ethylene glycol (EG) is a valuable commodity organic intermediate that is produced using the catalyzed gas-phase hydrogenation process of dimethyl oxalate (DMO) from syngas. The reactor process is challenging to control because of its nonlinearity and multivariable condition. Thus, this study proposes the application of Neural Wiener model predictive control (NWMPC) for DMO hydrogenation reactor control. The application of empirical-based MPC, such as NWMPC, is still new in DMO hydrogenation reactor control. In order to simulate the process, the DMO hydrogenation reactor is modeled using Aspen Plus and Aspen Dynamic software. The Neural Wiener (NW) model is developed based on state space and neural network modeling using a Linear-Nonlinear (L-N) identification approach. A validation test is also performed to verify the accuracy of the NW model. Based on the test, the model accuracy is acceptable with the coefficient of determination (R2) of 0.965 for EG output mole fraction (first output) and R2 of 0.936 for product temperature (second output). The NWMPC capability is evaluated with a PID controller to handle a setpoint change in EG output mole fraction and reject disturbance in the feed stream flow rate. The control performance results have demonstrated the superior ability of the NWMPC to handle such scenarios better than PID in terms of controller action speed and profile.
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