Background: Noninvasive ventilation is indicated in patients with acute respiratory failure, especially in acute heart failure. The study aimed to evaluate the effectiveness of noninvasive ventilation in patients with acute heart failure. Methods: The descriptive study on 23 patients with acute heart failure and respiratory failure who were applied non-invasive ventilation at Cardiovascular Center, E Hospital. Results: The mean age of the patients was relatively high (74 years old), the rate of male accounted for 56.5%. The main causes were ischemic heart disease accounting for 82.6% and acute myocardial infarction accounting for 43.5%. Non-invasive ventilation improved the respiratory failure condition: gradually reducing respiratory rate, increasing SPO2, PaO2, and P/F ratio. In addition, it improved the hemodynamic status: increasing mean blood pressure, reducing heart rate and increasing tissue perfusion by reducing lactate level. The successful rate of noninvasive ventilation is 65.2% and the mortality rate is 21.7%. Conclusion: Non-invasive ventilation is a simple respiratory support, easy to apply in many facilities to help improve respiratory condition and hemodynamic status.