Non-insertional Achilles Tendinopathy Research Articles

Efficacy of shock wave therapy and ultrasound therapy in non-insertional Achilles tendinopathy: a randomised clinical trial

ObjectivePhysiotherapists and physicians continue to seek effective conservative treatments for Achilles tendinopathy. This study aimed to subjectively and objectively determine the therapeutic efficacy of radial shock wave therapy (RSWT) and ultrasound therapy in non-insertional Achilles tendinopathy.Materials and methodsThirty-nine patients with non-insertional Achilles tendinopathy were randomly assigned to three experimental groups, i.e., RSWT (group A), ultrasound therapy (group B), and placebo ultrasound (group C) groups. Before the intervention and at weeks 1 and 6 after the treatment, the patients were assessed using the Victorian Institute of Sport Assessment–Achilles (VISA-A) questionnaire and posturographic measurements of step initiation performed on the force platforms under two different conditions (non-perturbed transit and perturbed transit).ResultsSix weeks after therapy, all groups exhibited significantly increased VISA-A scores against the measurement at week 1 after therapy. The post-therapy percentage changes in VISA-A scores were significantly greater in group A compared to group B. The three-way ANOVA demonstrated that treatment type affected sway range in the frontal plane and mean velocity of the centre of foot pressure displacements in the sagittal and frontal planes during quiet standing before step initiation. The Bonferroni post-hoc test showed that the means of all those variables were significantly smaller for group A than for group B patients. The three-way ANOVA revealed an effect of the platform arrangement on transit time and double-support period. The Bonferroni post-hoc test revealed statistically longer transit time for the perturbed vs. non-perturbed trials; a reverse relationship was observed for the double-support period.ConclusionThe VISA-A showed that RSWT was significantly more effective than sonotherapy for alleviation of pain intensity as well as function and activity improvement in patients with non-insertional Achilles tendinopathy. Therefore, RSWT therapy can be used in clinical practice by physiotherapists to alleviate the symptoms of non-insertional Achilles tendinopathy. Objective data registered by force platforms during quiet standing before and after step initiation did not prove useful for monitoring the progress of treatment applied to patients with non-insertional Achilles tendinopathy between consecutive therapy interventions.Clinical trial registration:https://anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12617000860369, identifier (ACTRN12617000860369).

Autologous bone marrow derived mesenchymal stem cells are safe for the treatment of Achilles tendinopathy

Achilles tendinopathy is a disabling condition that affects more than 50% of runners. Pre-clinical studies in a large animal model of naturally-occurring tendinopathy similar to human Achilles tendinopathy has shown benefits of autologous bone marrow-derived mesenchymal stem cell (MSC) implantation. However, MSCs are advanced therapies medicinal products (ATMPs), with strict regulatory requirements. Guided by the regulator we carried out a first in man study to assess the safety and efficacy of autologous MSC injection in human patients with non-insertional Achilles tendinopathy. Ten patients, mean age 47 with mid-portion Achilles tendon pain and swelling for more than 6 months, underwent autologous cultured cell injections (median 12.2 × 106, range 5–19 × 106 cells) into their Achilles tendon. At 24 weeks follow-up, no serious adverse reactions or important medical events were observed. MOXFQ, EQ-5D-5L, and VISA-A scores improved clinically at 12 and 24 weeks. VAS pain improved increasingly at 6, 12 and 24 weeks. MOXFQ Pain and VISA-A Scores improved > 12 points from baseline to 24 weeks in 8 patients. Maximum anteroposterior tendon thickness as measured by greyscale US decreased by mean 0.8 mm at 24 weeks. This phase IIa study demonstrated the safety of autologous MSC injection for non-insertional Achilles tendinopathy and provides proof-of-concept of the technique in patients, all of whom had previously failed conservative treatments for chronic disease and leads the way for a larger randomised controlled trial.

Needle‑based gastrocnemius lengthening: a novel ultrasound‑guided noninvasive technique: part II—clinical results

BackgroundIsolated gastrocnemius contracture has been associated with more than 30 lower limb disorders, including plantar heel pain/plantar fasciitis, Achilles tendinosis, equinus foot, adult flatfoot, and metatarsalgia. Although many techniques are available for gastrocnemius recession, potential anesthetic, cosmetic, and wound-related complications can lead to patient dissatisfaction. Open and endoscopic recession techniques usually require epidural or general anesthesia, exsanguination of the lower extremities and stitches and can damage the sural nerve, which is not under the complete control of the surgeon at all stages of the procedure. The purpose of this study is to evaluate the clinical results of a surgical technique for gastrocnemius lengthening with a needle, as previously described in cadaver specimens.Methods and resultsWe performed a prospective study of ultrasound-guided gastrocnemius tendon lengthening in level II using a needle in 24 cases (19 patients) of gastrocnemius contracture. The study population comprised 12 males and 7 females. Mean age was 41 years (18–64). All but 5 recessions were bilateral and occurred simultaneously. The indication for the procedure was gastrocnemius contracture; although the patients also presented other conditions such as non-insertional Achilles tendinopathy in 6 patients (2 were bilateral), insertional Achilles calcifying enthesitis in 4 (1 was bilateral), metatarsalgia in 4, flexible flat foot in 1 and plantar fasciitis in 5 (2 were bilateral). The inclusion criteria were the failure of a previous conservative protocol, that the Silfverskiöld test was positive, and that the pathology suffered by the patient was within the indications for surgical lengthening of the patients and were described in the scientific literature. The exclusion criteria were that the inclusion criteria were not met, and patients with surgical risk ASA 3 or more and children. In these patients, although possible, it is preferable to perform the procedure in the operating room with monitoring, as well as in children since they could be agitated during the procedure at the office. We used the beveled tip of an Abbocath needle as a surgical scalpel. All patients underwent recession of the gastrocnemius tendon, as in an incomplete Strayer release. We evaluated pre- and postoperative dorsiflexion, outcomes, and procedural pain (based on a visual analog scale and the American Orthopedic Foot and Ankle Society scores), as well as potential complications. No damage was done to the sural bundle.ResultsAnkle dorsiflexion increased on average by 17.89°. The average postoperative visual analog score for pain before surgery was 5.78, 5.53 in the first week, 1.89 at 1 month, and 0.26 at 3 months, decreasing to 0.11 at 9 months. The mean postoperative American Orthopedic Foot and Ankle Society Ankle-Hindfoot score the average was 50.52 before surgery, 43.42 at 1 week, 72.37 at 1 month, 87.37 at 3 months, and 90.79 at 9 months.ConclusionUltrasound-guided needle lengthening of the gastrocnemius tendon is a novel, safe, and effective technique that enables the surgeon to check all the structures clearly, thus minimizing the risk of neurovascular damage. The results are encouraging, and the advantages of this approach include absence of a wound and no need for stitches. Recovery is fast and relatively painless. A specific advantage of ultrasound-guided needle lengthening of the gastrocnemius tendon is the fact that it can be performed in a specialist's office, with a very basic instrument set and local anesthesia, thus reducing expenses.

Medial arch instability/internal foot overload association with non-insertional Achilles tendinopathy and the ‘Zone of Conflict Theory’

BackgroundNon insertional Achilles tendinopathy [AT] is a degenerative condition that is prevalent in runners. 30% have no preceding history and many runners do not develop AT. Overuse, pronation, and compromised blood supply are hypothesised as causal. The exact precipitant is still unknown. The link between medial arch instability and AT has not been made. The purpose of this study was to investigate the association between spring ligament (SL) laxity and first ray (FRI) instability, and the presence of (AT). MethodsEthical approval was obtained. Patients were identified from hospital databases for unilateral AT, allowing the opposite unaffected foot to be used as an internal control. SL laxity was measured using the lateral translation score and FRI was measured using a modified digital Klauemeter. Ultrasound was used to assess the tendoachilles [TA] in affected vs unaffected legs. Results17 patients were recruited with a mean age of 55.6 and mean body mass index (BMI) of 33.3. The average symptom duration was 3.62 years. There were 12 left feet and 5 right feet. There was no statistical difference in dorsiflexion angles for the TA or the gastrocnemius. All Beighton scores < 5. Lateral translation scores, FRI scores and TA thickness was significantly greater in AT feet [p < 0.05]. More affected feet had Tibialis posterior tendon pain (TP) [p < 0.05]. ConclusionsFeet with AT exhibit higher lateral translation scores and greater FRI compared to healthy feet, and combined with previous literature evidence, suggests alteration of the subtalar axis alters force moments that may lead to an intrinsic overload of the TA, when the foot enters a "zone of conflict". Medial arch instability, in particular SL laxity and FRI, may contribute to the development of non-insertional AT and treatment of this with early arch support may prevent progressive degeneration.

Therapeutic effects following extracorporeal shock wave therapy for insertional and non-insertional Achilles tendinopathy

BackgroundThe treatment for Achilles tendinopathy varies widely, and there is no consensus regarding the optimal treatment for both non-insertional and insertional Achilles tendinopathy. The purpose of this study was to evaluate the clinical efficacy of extracorporeal shock wave therapy (ESWT) in the treatment of insertional and non-insertional Achilles tendinopathy (AT). MethodsSixty patients with AT were invited to participate in this study. Patients were allocated to one of two groups according to the site of the AT, including an insertional AT (IAT) group and a non-insertional AT (NIAT) group. ESWT was performed once a week for five weeks for both groups. The Victorian Institute of Sport Assessment-Achilles questionnaire (VISA-A) score and the visual analog scale (VAS) were used five times to evaluate the clinical outcomes, including before treatment, immediately after treatment, as well as one month, three months, and five years after treatment. ResultsAt three months after treatment, the IAT group exhibited a significantly higher VISA-A score (82 ± 6 vs. 76 ± 11; p = 0.01) and a significantly lower VAS score (1 ± 1 vs. 2 ± 1; p < 0.001) when compared with the NIAT group. At the five-year assessment, the IAT group (1 ± 1) had a significantly lower VAS score than the NIAT group (2 ± 1) (p = 0.02), while no significant difference for the VISA-A score was observed between the groups (84 ± 8 vs. 84 ± 10; p = 0.98). ConclusionsExtracorporeal shock wave treatment can improve the symptoms of both insertional and non-insertional AT. The IAT patients experienced better clinical outcomes compared with the NIAT patients.

Achilles tendon disorders: An overview of diagnosis and conservative treatment.

Achilles tendon-related pain affects up to 6% of the US population during their lifetime and is commonly encountered by primary care providers. An accurate diagnosis and early conservative management can improve patient quality of life and reduce unnecessary surgical consultations, saving healthcare dollars. Achilles tendon pathologies can be categorized into acute (pain lasting less than 6 weeks), chronic (pain lasting more than 6 weeks), and acute on chronic (worsening of pain with preexisting chronic Achilles tendon pathology). This article describes the diagnosis, conservative management, indications for imaging, and indications for surgical referral for acute and chronic Achilles tendon rupture, Achilles tendinitis, gastrocnemius strain, plantaris rupture, insertional Achilles tendinopathy, Haglund deformity, and noninsertional Achilles tendinopathy.

Use of Weight-Bearing Computed Tomography (WBCT) Imaging in the Assessment of the Achilles Tendinopathy: A Prospective Comparative and Controlled Study

Category: Hindfoot; Sports Introduction/Purpose: Insertional and non-insertional Achilles tendinopathy (AT) are prevalent diseases in the active, working-age population. Ultrasound (US) and magnetic resonance imaging (MRI) are frequently utilized in the assessment and grading of AT. Use of these imaging modalities are limited by operator interpretation/variability and costs, respectively. Also, these assessments are performed in the non-weight bearing positioning of the lower extremity, thus poorly evaluating the functional position of the loaded tendon. Validation of weight-bearing computed tomography (WBCT) for Achilles tendon imaging could provide a novel and functional means of quantifying tendon pathology. The study’s purposes were to: 1) Correlate Achilles tendon tissue structural findings when assessed by WBCT and US imaging, and 2) Compare WBCT Achilles tendon tissue changes between AT patients and controls. Methods: This was a prospective-comparative IRB-approved cohort study including 10 adults with AT (Age = 54.7 ± 10.3 years, BMI = 40.65 ± 10.07 kg/m2, 8F/2M), 10 age-matched controls (Age = 54.6 ± 11.33 years, BMI = 37.9 ± 9.55 kg/m2, 8F/2M), and 4 younger controls (Age = 32.25 ± 8.3 years, BMI = 24.32 ± 5.14 kg/m2, 2F/2M). WBCT scans (Curvebeam HiRise/PedCAT) and US imaging (Butterfly iQ+) of the Achilles tendon were collected. Tendons were manually segmented in WBCT images (3D Slicer software) and tendon thickness was measured at the maximum anterior-posterior (AP) diameter of the tendon (insertion and midportion regions). Radiodensity was quantified by the average Hounsfield Units (HU) of each tendon region and normalized to the radiodensity of each participant’s talus (segmented using Disior Bonelogic). US measures of the tendon thickness were similarly completed by independent observers who were blinded to the WBCT measurement. Intraclass correlation coefficient (ICC) assessed correlation between WBCT and US findings. Paired T-tests compared WBCT HU between patients and controls. P-values &lt; 0.05 were considered significant. Results: There was excellent correlation (ICC= 0.83-0.94, Table 1) between WBCT and US imaging regarding tendon thickness, with WBCT overestimating thickness by only 0.27-0.55mm (4-9% of total tendon thickness). These findings could be explained by decreased US tendon thickness measurements secondary to the tendon’s compression by the US probe. WBCT imaging demonstrated a higher radiodensity (HU) within the Achilles tendon (for both insertion and midportion regions) in AT patients when compared to controls (Table 2), with p-values of 0.009 and 0.001 for insertional and midportion regions, respectively. Findings are consistent with tendinopathic differentiation of the Achilles tendon substance in the AT patients. Color-coded maps demonstrating HU distributions across the Achilles tendon were created to facilitate interpretation of tissue characteristics (Fig. 1). Conclusion: In this prospective, comparative, and controlled study, we observed a high correlation between US and WBCT imaging in the assessment of Achilles tendon thickness in AT patients and controls. We also found that WBCT HU distribution in the Achilles tendon was significantly increased in the AT patients when compared to controls. Findings are likely explained by tendinopathic tissue changes in the diseased tendons, potentially related to the well-known chondroid metaplasia observed in Achilles tendinopathy pathological process. WBCT imaging and color-coded maps can represent a promising tool in the assessment of AT patients.

Favorable Outcomes Following Extra-Corporeal Shockwave Therapy for Chronic Non-Insertional Achilles Tendinopathy Compared to Chronic Insertional Achilles Tendinopathy: A Retrospective Review

Category: Ankle; Basic Sciences/Biologics Introduction/Purpose: Extracorporeal shockwave therapy (ESWT) is a non-invasive treatment modality that is utilized in the treatment of chronic Achilles tendinopathy (AT). The purpose of this study was to retrospectively assess outcomes following ESWT for both NAT and IAT at greater than 1-year follow-up, and to identify potential predictors of outcomes. Methods: Chart review was conducted to identify patients who underwent ESWT for AT with a minimum of 1-year follow-up. Data collected and assessed included: patient demographics, pathological characteristics, treatment characteristics, Victorian Institute of Sports Assessment-Achilles (VISA-A) and visual analog scale (VAS) scores and failures. Linear regression was performed to identify potential predictors of outcomes. Survival analysis was conducted using Kaplan Meier curves. Fifty-two cases of IAT and 34 cases of NAT were included. The mean follow-up in the NAT cohort was 22.3±10.2 months and the mean follow-up time in the IAT cohort was 26.8±15.8 months. Results: Improvements in VISA-A and VAS scores were observed in the NAT cohort at 6 months follow-up and at final follow-up (p &lt; 0.01). Improvements in VISA-A scores and VAS scores were recorded in the IAT cohort at 6 months follow-up which subsequently deteriorated at final follow-up. In the NAT cohort, the failure rate at 6 months follow-up was 11.8% which increased to 29.4% at final follow-up. In the IAT cohort, the failure rate at 6 months follow-up was 32.7% which increased to 59.6% at final follow-up. Predictors of poor outcomes in the NAT cohort included pre-ESWT subjective clinical score, male, presence of cardiovascular risk factor, and increasing MRI severity. Predictors of poor outcomes in the IAT cohort included pre-ESWT subjective clinical score and increasing MRI severity. Conclusion: This study found that superior subjective clinical outcomes together with a lower failure rate maintained over 1 year in the NAT cohort compared to the IAT cohort. This may implicate ESWT as a temporising treatment in IAT and a longer term solution in patients with NAT.

Paper 68: Outcomes following Extracorporeal Shockwave Therapy for chronic Achilles tendinopathy at short to mid-term follow-up

Objectives: The purpose of this retrospective clinical study was to evaluate outcomes following extracorporeal shockwave therapy (ESWT) for the treatment of Achilles tendinopathy. Subgroup analysis was conducted to identify predictors of poor outcomes. Methods: This retrospective cohort study included existing clinical data from 74 patients from a single academic institution. Patients greater than 16 years of old who underwent ESWT for Achilles tendinopathy in the office setting between 3/3/2017 to 8/2/2022 were included. Data collected included: patient demographics, co-morbidities, treatment characteristics, Victorian institute of sports assessment – Achilles (VISA-A) scoring tool, visual analog scale (VAS), magnetic resonance imaging data, return to play (RTP) data and failures were recorded. Failure was defined as no improvement in VISA-A nor VAS scores or surgical intervention. For these data, mean and standard deviation were calculated, and paired samples T-tests and Welch’s T-tests were performed on clinical outcome scores. Results: In total, 74 patients (91 heels) with a mean age of 54.1 ± 14.0 years and BMI of 27.3 ± 4.5 kg/m2 underwent ESWT for Achilles tendinopathy at a mean follow-up of 25.7 ± 15.0 months. Eighteen patients were in the non-insertional Achilles tendinopathy (NAT) cohort and 56 patients were in the insertional Achilles tendinopathy (IAT) cohort. Both NAT and IAT cohorts had a similar improvement in VISA-A score (p=0.365) and VAS scores (p=0.65). A shorter return to play time was found in the NAT cohort (1.1 ± 0.9 months) compared to the IAT cohort (2.6 ± 5.7 months) but this was not statistically significant (p=0.34). There was a higher failure rate in the the IAT cohort (50.0%) than the NAT cohort (38.9%). Patients who received platelet-rich plasma (PRP) had a higher failure rate (61.2%) than those who did not receive PRP (39.6%). In the NAT cohort, the failure rate in females was 0.0%. In the IAT cohort, the failure rate in females was 61.9%. Linear regression analysis found that elevated BMI and MRI severity were associated with worse post-ESWT outcomes. Conclusions: This retrospective study demonstrated a high failure rate at short-term follow-up in patients who underwent ESWT for Achilles tendinopathy. Higher failure rates were found in patients with IAT and those who received intratendinous PRP. Predictors of poor outcomes included elevated BMI and MRI severity. Further studies with larger patient cohorts and a longer follow-up are necessary to determine the role of ESWT in the treatment of Achilles tendinopathy.

A preliminary investigation into the impact of shock wave therapy and sonotherapy on postural control of stepping tasks in patients with Achilles tendinopathy.

The outcomes of physical therapy are commonly assessed with subjective scales and questionnaires. Hence, a continuous search to identify diagnostic tests that would facilitate objective assessment of symptom reduction in those patients with Achilles tendinopathy who undergo mechanotherapy. The main aim of this study was to evaluate and compare the effectiveness of shock wave and ultrasound treatments, using objective posturographic assessment during step-up and step-down initiation. The patients with non-insertional Achilles tendinopathy and pain lasting for more than 3 months were randomly assigned to one of the experimental groups, i.e., radial shock wave therapy (RSWT), ultrasound therapy, or placebo ultrasound. All groups also received deep friction massage as the primary therapy. The transitional locomotor task was performed with the affected and unaffected limb in random order, on two force platforms under two conditions (step-up and step-down). The recording of center of foot pressure displacements was divided into three phases: quiet standing before step-up/step-down, transit, and quiet standing until measurement completion. Pre-intervention measurements were performed and then short-term follow-ups at weeks 1 and 6 post-therapy. The three-way repeated measures ANOVA showed few statistically significant two-factor interactions between therapy type, time point of measurement and the type of the locomotor task. Significant increases in postural sway were observed in the entire study population throughout the follow-up period. Three-way ANOVAs revealed a group effect (shock wave vs. ultrasound) on almost all variables of the quiet standing phase prior to step-up/step-down initiation. Overall, postural stability before the step-up and step-down tasks appeared to be more efficient in patients who had undergone RSWT compared to the ultrasound group. Objective posturographic assessment during step-up and step-down initiation did not demonstrate therapeutic superiority of any of the three therapeutic interventions used in patients with non-insertional Achilles tendinopathy.Clinical Trial Registration: The trial was prospectively registered in the Australian and New Zealand Clinical Trials Registry (no. ACTRN12617000860369; registration date: 9.06.2017).

Epidemiological Analysis of Foot and Ankle Injuries in Athletes: Experience of a Single Specialized Center

Category: Sports; Ankle Introduction/Purpose: The number of professional and amateur athletes has increased, consequently leading to an increase in the incidence of sports injuries. Understanding the epidemiological profile of foot and ankle's injuries in athletes is relevant for the prevention and treatment its occurrence. As far as we know, there is a lack of studies that report the epidemiological profile of athletes with foot and ankle disorders considering different sports. The aim of this study is to describe the epidemiology of foot and ankle injuries in athletes treated at an outpatient clinic specializing in injuries resulting from sports practice. The primary hypothesis is that ankle instability is the most frequent injury in athletes in the foot and ankle specialty outpatient clinic. Methods: Observational, retrospective, descriptive and comparative level IV of evidence study. The sample consisted of patients treated at an outpatient clinic specializing in foot and ankle injuries in sport, between January 1, 2015 and December 31, 2020. Three certified orthopedic physicians reviewed the charts and documented patient demographics, sport, diagnosis and lesion laterality. Age was analyzed according to age groups. The inclusion criteria were patients practicing amateurs or sports professionals of all age groups. We only count the first visits and the main modality and diagnosis of the patient. Exclusion criteria were insufficient data documented in chart, injuries that did not occur secondary to sports practice, and patients with conditions unrelated to the ankle and foot. Statistical analyzes were performed using software: SPSS V20, Minitab 16 and Excel Office 2010. We performed a multivariate logistic regression analysis to verify the association of gender, age and laterality with the main injuries documented. Results: A total of 763 patients (387 men and 376 women) met the inclusion criteria. The mean age was 35 years (SD= +-14.1; min=8.9; max=77). The most prevalent age group was young adults with 51.7% and the least prevalent was children with 1.4%. The most prevalent diseases were chronic lateral ankle instability (n=134, 17.6%), acute lateral ankle sprain (n=120, 15.7%) and plantar fasciitis (n=69, 9%). The multivariable analysis by logistic regression identified as a risk factor for lateral ankle instability the age group of young adults and females. In acute lateral ankle sprain, age was identified as a risk factor with statistical significance. In overuse injuries, only the female gender was evidenced as a risk factor. In non-insertional Achilles tendinopathy, bilaterality was associated as a risk factor with disease while in insertional Achilles tendinopathy, only the male gender was identified as a risk factor, as well as in Achilles tendon rupture. Conclusion: The literature specifically describing foot and ankle injuries during sport is limited, despite being highly prevalent injuries. Our work correlated several factors such as age, gender and laterality with specific sports through multivariate analysis, adding epidemiological data to the literature that help in the prevention and treatment of foot and ankle injuries in sports.

Partial Postero-Medial Superficial Release of the Proximal Crural Fascia in Patients with Positive Silfverskiold's Test: Case Series of Clinical Outcomes and Novel Technique

Category: Ankle; Hindfoot; Lesser Toes; Midfoot/Forefoot Introduction/Purpose: Ankle limitation to dorsiflexion in an extended knee is observed during the second rocker of gait in patients with positive Silfverskiold test confirming an isolated gastrocnemius contracture (IGC). Tendons and muscles share intrinsic contractility and relaxation properties which can be modified during physiotherapy in comparison to the fascia which lacks it. The present study describes a case series of patients with positive Silfverskiold associated with various foot pathologies who underwent a selective fasciotomy of the postero-medial superficial portion of the crural fascia. The purpose of this study is to describe the surgical technique and clinical outcomes of this procedure. We hypothesize that this procedure can reach satisfactory clinical outcomes with the advantage of being a less invasive procedure. Methods: 26 patients treated with partial postero-medial superficial release (PMSR) of the crural fascia from January to October 2021 for IGC with associated chronic foot pain were included. Inclusion criteria considered patients with diagnosis of foot pain with IGC and positive Silfverskiold test. A transverse incision was made 2 cm distal to the flexion crease starting at the intermuscular line of the gastrocnemius muscle, 4 cm medially (Figure 1). Subcutaneous dissection was performed identifying the neurovascular bundle. A horizontal incision was performed to the superficial posterior fascia of the medial gastrocnemius head. The medial gastrocnemius muscle was not sectioned. Patients completed the FADI score previous to surgery and at final follow- up. Data was analyzed using SPSS 20. Paired samples T-tests were performed to identify significance of the difference in pain and function preoperatively and postoperatively with statistical significance set at p&lt;0.05. Descriptive statistics were used for demographic variables. Results: 18 patients underwent partial PMSR of the crural fascia while 8 patients had additional procedures. Mean age of the included patients was 40.6 +/-18.5 years. Specifically, this included 4 feet with a diagnosis of metatarsalgia, 3 feet with metatarsalgia and plantar fasciitis, 6 feet with metatarsalgia, plantar fasciitis and cavus foot, 5 feet with plantar fasciitis, 3 feet with plantar fasciitis and insertional achilles tendinopathy, 4 patients with non-insertional achilles tendinopathy and 1 foot with flexor hallucis longus tendinopathy.The average ankle dorsiflexion increased significantly (p&lt;0.0001) from -1.15 +/-2.15 degrees preoperatively to 10.65+/-2.02 degrees post-operatively. The average FADI score significantly increased (p&lt;0.0001) from 47.54 +/-12.26 preoperatively to 80.46 +/-14.04 post-operatively. The average follow-up was 9.38 +/-3.76 weeks. All patients had a negative Silfverskiold test at final follow-up. Conclusion: Partial postero-medial superficial release (PMSR) of the crural fascia was found to be an effective outpatient procedure when used to relieve foot pain in those patients with an isolated gastrocnemius contracture. Patients who have failed conservative treatment can expect notable improvement with satisfactory FADI scores after the procedure. Future prospective studies should involve a larger number of patients with no additional procedures to be compared with gastrocnemius muscle release procedure for isolated gastrocnemius contracture with associated foot pain.

Research protocol to evaluate the effectiveness of shockwave therapy, photobiomodulation and physical therapy in the management of non-insertional Achilles tendinopathy in runners: a randomised control trial with elective cross-over design

BackgroundAchilles tendinopathy (AT) is a common overuse injury in runners. While the mainstay of treatment for AT is tendon loading exercises (physical therapy and exercise programme (EXER)), some patients have...

Neuromuscular and structural tendon adaptations after 6 weeks of either concentric or eccentric exercise in individuals with non-insertional Achilles tendinopathy: protocol for a randomised controlled trial

IntroductionThere is limited evidence on the neural strategies employed by the central nervous system to control muscle force in the presence of non-insertional Achilles tendinopathy (NIAT). Additionally, the neuromuscular mechanisms...

Nearly half of patients with chronic tendinopathy may have a neuropathic pain component, with significant differences seen between different tendon sites: a prospective cohort of more than 300 patients

ObjectivesIdentifying the prevalence of neuropathic pain components in patients with chronic tendinopathy conditions using the Self-Administered Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) questionnaire.MethodsPatients with chronic tendinopathy and ‘tendon-like’...

The Statistical Fragility of Platelet-Rich Plasma as Treatment for Chronic Noninsertional Achilles Tendinopathy: A Systematic Review and Meta-analysis.

Background:Randomized controlled trial (RCT) outcomes reaching statistical significance, frequently determined by P <.05, are often used to guide decision making. Noted lack of reproducibility of some RCTs has brought special attention to the limitations of this approach. In this meta-analysis, we assessed the robustness of RCTs evaluating platelet-rich plasma (PRP) for the treatment of chronic noninsertional Achilles tendinopathy (AT) by using fragility indices.Methods:The present study was a systematic review and meta-analysis of RCTs comparing outcomes after PRP injection vs alternative treatment in patients with AT. Representative data sets were generated for each reported continuous outcome event using summary statistics. Fragility indices refer to the minimal number of patients whose status would have to change from a nonevent to an event to turn a statistically significant result into a nonsignificant result, or vice versa. The fragility index (FI) and continuous FI (CFI) were determined for dichotomous and continuous outcomes, respectively, by manipulating each data set until reversal of significance (a=0.05) was achieved. The corresponding fragility quotient (FQ) and continuous FQ (CFQ) were calculated by dividing FI/CFI by sample size.Results:Of 432 studies screened, 8 studies (52 outcome events) were included in this analysis. The 12 dichotomous outcomes had a median FI of 4.5 (FQ: 0.111), and the 40 continuous outcomes had a median CFI of 5 (CFQ: 0.154). All 52 outcome events included lost-to-follow-up data, and 12 (23.1%) indicated a greater number of patients lost to follow-up than the FI or CFI.Conclusion:Our findings suggest that RCTs evaluating PRP for AT therapy lack statistical robustness, because changing only a small number of events may alter outcome significance.Level of Evidence:Level II, therapeutic study.

Effects of deep heating modalities on the morphological and elastic properties of the non-insertional region of achilles tendon: a pilot study

Background Over the last 20 years, both diathermy and ultrasound have been popular choices for many clinicians in treating musculoskeletal disorders. However, there is a lack of clinical evidence of deep heating modalities to treat tendon pathology, There is no study to investigate the effects of such as physical modalities on morphological and elastic properties on the human tendons. Objective the objective of the present study was to compare the effects of diathermy and ultrasound therapies on cross sectional area, transversal height and hardness percentage of the non-insertional region of the Achilles tendon in able-bodied subjects. Methods healthy volunteers were divided in diathermy and ultrasound group received six 15-min treatment sessions. Before and after treatment a sonographic assessment was conducted by mean of ultrasonography and the following parameters were recorded: cross sectional area, transversal height and hardness percentage. Results thirty-two subjects were enrolled. Between-group comparisons showed a significant change on hardness percentage (p = 0.004) after treatment in diathermy therapy group. Within-group comparison showed a significant improvement in the hardness percentage for the diathermy (p = 0.001) and ultrasound (p = 0.046) after two weeks of treatment. Conclusion this pilot study demonstrated larger effects on morphological and elastic properties of the non-insertional region of the Achilles tendon after diathermy than ultrasound therapy in normal tendons. Diathermy may be a useful deep heat modality for treating non-insertional Achilles tendinopathy.

Biologic Adjuvants for Foot and Ankle Conditions

Orthobiologics are a family of treatments including molecules, cells, or tissues that aid in reparative musculoskeletal processes, employed in the setting of surgical or nonsurgical therapies to supplement bone, cartilage, and tissue regeneration. They are classified as bone grafts, growth factors, stem cell therapy, blood-based preparations, viscosupplementation, and scaffold-based therapy. The most common orthobiologic products used in foot and ankle include platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), bone morphogenic proteins, and platelet derived growth factor (PDGF). While extracorporeal shock wave therapy is not itself a biologic, it does stimulate a biologic response, and is included in this chapter. There is ample level I evidence supporting PRP use for osteochondral lesions of the talus, plantar fasciitis, chronic remitting non-insertional Achilles tendinopathy, and diabetic foot ulcers. PRP may also provide benefit in ankle osteoarthritis and fracture healing. recombinant human PDGF has been consistently proven in level I studies as a safe and effective alternative to autograft to augment ankle and hindfoot fusions, eliminating the morbidity associated with autograft harvesting. Bone marrow aspirate concentrate may be considered as an adjuvant treatment for bone healing, osteochondral lesions of the talus, and Achilles tendon repair. Extracorporeal shock wave therapy is a treatment option for patients with plantar fasciitis and Achilles tendinosis. Cell-based therapies may provide cells capable of osteoblastic differentiation and osteogenic potential, however, further investigation is warranted. In general, orthobiologics have rapidly expanding indications and are becoming increasingly accepted given their clinical benefits of improved pain and function, minimally invasive delivery, and positive safety profiles. To strengthen future evidence-based guidelines for biologic use in foot and ankle, higher evidence studies are required with improved standardization of concentration, treatment protocols, and outcome measures.

Outcomes of iliac crest bone marrow aspirate injection for the treatment of recalcitrant Achilles tendinopathy.

Achilles tendinopathy is a common cause of posterior ankle and heel pain in both active and sedentary patients. Though the majority of patients respond to first-line non-operative management including activity modification, immobilization, orthotics, and physical therapy with stretching and eccentric strengthening, there is no consensus for patients who fail these treatments. We evaluate the role of iliac crest bone marrow aspirate (BMA) injections as a treatment option for recalcitrant cases. A retrospective chart review was conducted of patients with refractory Achilles tendinopathy treated with iliac crest BMA concentrate injection. Symptoms were assessed using the numeric rating system (NRS) pain score at the pre-operative visit and at six, 12, 24, and 48weeks postoperatively. Post-operative complications were recorded. A total of 15 patients (15 feet) with recalcitrant Achilles tendinopathy (5 insertional, 8 non-insertional, 2 combined) treated with iliac crest BMA concentrate injections were included in the study. Average age was 53.2years (range, 25 to 64), average BMI was 27.1kg/m2 (range, 18.4 to 34.4), and average duration of symptoms prior to BMA injection was 2.3years (range, 1 to 7). Pre-operatively, average NRS was 6.26 (95% CI, 5.04 to 7.49), with significant improvement at sixweeks (mean, 4.26; 95% CI, 2.94 to 5.59; p = 0.04), tenweeks (mean, 4.13; 95% CI, 2.91 to 5.35; p = 0.012), 24weeks (mean, 3.40; 95% CI, 2.05 to 4.75; p = 0.03), and 48weeks (mean, 2.60; 95% CI, 1.14 to 4.06; p = 0.007) post-operatively. Overall, there was trending improvement over the 48-week follow-up period, with a mean improvement in NRS of - 3.22 (95% CI, - 1.06 to - 5.38; p = 0.007) at final follow-up. There was no discernable difference between insertional and non-insertional tendinopathy, and there were no incidences of post-operative complications. Iliac crest BMA appears to be a safe, effective, and potentially lasting treatment option for patients with intractable, insertional and non-insertional Achilles tendinopathy. Patients demonstrated and maintained statistically significant decrease in NRS pain score post-operatively with no complications at the donor or injection site.

Functional Gains Using Radial and Combined Shockwave Therapy in the Management of Achilles Tendinopathy

Achilles tendinopathy is a common condition and many patients have functional limitations after initial conservative treatment. Shockwave therapy has been shown to improve function within patients; however, comparative outcomes for different forms of shockwave are poorly described. In this retrospective cohort study, we describe findings from a quality improvement initiative evaluating safety and functional outcomes after treatment with radial shockwave therapy (n=58) or combined radial and focused shockwave therapy (n=29) for patients with Achilles tendinopathy refractory to exercise therapy. All patients were prescribed an eccentric exercise program. We hypothesized both groups would see improvements in function quantified using the Victorian Institute of Sports Assessment-Achilles with similar safety outcomes. Overall, the minimal clinically important difference (defined at 7 for insertional and 12 for noninsertional Achilles tendinopathy) was met in a greater proportion of patients treated with combined shockwave compared to radial shockwave (26 [89.7%] vs 37 [63.8%], p=.022). The change in Victorian Institute of Sports Assessment-Achilles from baseline to final treatment was not different between combined and radial-only groups (23.3 ± 12.6 vs 19.9 ± 18.7, p=.2). Within group differences from baseline to final follow-up measures (mean duration 17.9 ± 14.8 weeks) demonstrated overall functional improvement for both groups (both p < .0001). No serious adverse effects were observed. Our findings suggest combined radial and focused shockwave therapy may provide more predictable functional gains for treatment of Achilles tendinopathy compared to radial shockwave therapy.