Non-epidemic Period Research Articles

Impacts of the COVID-19 Pandemic on Health-Related Behaviours in Community Gardens in China: An Evaluation of a Natural Experiment

There is little robust quantitative evidence on how community gardens impact on physical activity and other health-related behaviours. This natural experiment study aimed to examine the effects of a community garden within a Chinese neighbourhood on health-related behaviours during the COVID-19 epidemic. The study design was a repeat cross-sectional pre–post study, assessing differences between the non-epidemic period and epidemic period. Camera-based systematic observations were conducted at two locations within a community garden. A total of 180 h of video recordings were collected and coded by two researchers during a “non-epidemic” period when there were no COVID-19 restrictions (120 h) and the “epidemic” when COVID-19 restrictions were implemented (60 h). Observations of these video recordings assessed the total number of users, physical activities (Sedentary, Walking, Vigorous), social interactions (Connect), and people taking notice of the environment (Take Notice), followed by a breakdown of observed gender and age group. Data were analysed using paired t-tests and Wilcoxon signed-rank tests, comparing outcomes during the epidemic period and non-epidemic period. Results showed a significant increase in total number of users during the epidemic, particularly in females, older adults and children. Sedentary and moderate physical activities were significantly higher during the epidemic period. The increase in the total number of users of the community garden during the 2022 epidemic outbreak in Suzhou shows the importance of community gardens as a primary space for outdoor activities. This robust natural experiment study demonstrated that the community garden contributed more to physical activity, such as walking, but less to interactions between people (connecting) or people–place interactions (taking notice of the environment). More natural experiment research on community gardens like this is needed to better understand how the health and well-being benefits of community gardens can be maximized.

Physical activity, weight management, and mental health during COVID-19 lockdown: A cross-sectional study of healthcare students in China.

There is growing evidence that the social blockade brought about by the COVID-19 pandemic has dramatically affected college students' physical activity; however, their weight management behaviors and mental health have not been fully explored, especially among healthcare students. This study aimed to assess physical activity, weight management behaviors, and mental health among healthcare students during the campus lockdown and to analyze the factors influencing physical activity. A cross-sectional survey of 1,216 healthcare students from March 24, 2022, to April 11, 2022. To collect information about students' physical activity, weight management behaviors, and mental health, they were asked to complete the Physical Activity Questionnaire-Short Form (IPAQ-SF), 11 issues related to weight management behavior, and the World Health Organization 5-Item Well-Being Index (WHO-5) questionnaire. Binary logistic regression was performed to determine the factors influencing physical activity. Almost half of the participants had low levels of physical activity (45%), the mean score for weight management behavior was 39.55±6.26, and 54.6% had low levels of well-being. Healthcare students without exercise habits during the non-epidemic period reported lower levels of physical activity (OR = 1.81; 95%CI = 1.41-2.34, P<0.001). Participants with poor weight management behavior were more likely than other participants to report lower levels of physical activity (OR = 0.92; 95%CI = 0.90-0.94, P < 0.001). Likewise, the odds of being physically inactive were higher among the happier participants (OR = 0.98; 95%CI = 0.96-0.99, P = 0.031). During the COVID-19 lockdown, most healthcare students in Gansu province lack physical exercise and have a low health level. Significant correlation factors for low physical activity levels were grade level, non-lockout exercise habits, weight management level, and well-being. These findings demonstrate the importance of developing targeted policies and programs encouraging physical activity among medical students.

2329. What Causes a Cluster to Grow? Factors Associated with a Nosocomial COVID-19 Cluster at a University Hospital in Central Tokyo

Abstract Background Coronavirus disease 2019 (COVID-19) remains a significant threat to hospital infection control. Despite the decrease in severity and mortality associated with changes in the variants of concern and increased vaccination, SARS-CoV-2 transmissibility remains high, and nosocomial clusters continue to be reported in various countries. Although COVID-19 may be detected in multiple patients and healthcare workers (HCWs) in a given ward within a few days, it is uncertain whether these cases will develop into a large cluster. Methods The present, retrospective cohort study of nosocomial COVID-19 clusters was conducted at Tokyo Medical and Dental University Hospital from January 2022 to January 2023 using data from the hospital’s infection prevention and control team. A nosocomial COVID-19 cluster was defined as consisting of more than 2 COVID-19 cases occurring within 5 days in the same ward. Cases with a clear epidemiological link and clusters outside the ward were excluded. We collected information regarding community trends, the index case details, and each cluster's ward profile. Predictors of cluster expansion to more than 5 cases were also examined. Results 66 clusters were identified at the hospital during the study period. The median number of COVID-19 cases per cluster was 3 (range: 2-22), and their median duration was 5 days (range: 1-27). 37 (56.1%), 25 (37.9%), and 4 (6.1%) clusters comprised both inpatients and HCWs, only HCWs, and only patients, respectively. The index case of 51 clusters (77.3%) was a HCW. 18 (27.3%) and 47 (72.7%) clusters contained &amp;gt; 5 and &amp;lt; 5 cases, respectively. No significant intergroup difference was found in terms of community prevalence, index case and ward characteristics, the rate of close contact or history of previous clusters. However, “clusters occurring during the non-epidemic period” and “infections &amp;gt; 3 occurring within 3 days” tended to develop into clusters containing more than 5 cases. Conclusion Nosocomial clusters can occur anywhere, and predicting them is challenging. Further research is needed to identify the factors leading to cluster development and to establish effective infection prevention and control measures. Disclosures All Authors: No reported disclosures

Respiratory Syncytial Virus in Outpatient Children with Bronchiolitis: Continuous Virus Circulation During the Nonepidemic Period.

We aimed to estimate the respiratory syncytial virus positivity rate among ambulatory children with bronchiolitis according to the bronchiolitis epidemic period as defined by the French Public Health Institute. The positivity rate was 28.9% during the nonepidemic period and 50.6% during the epidemic period, which suggests continuous virus circulation between bronchiolitis annual peaks.

Influenza viruses circulation in a tertiary care children hospital in Rome: a comparison between 2022 and the previous 5 years

BackgroundInfluenza surveillance aims to determine onset, duration and intensity of the seasonal Influence-like Illness (ILI); data collection begins in the week 42 of a year and ends in the week 17 of the following year. In this observational study, we report the experience of a tertiary care children hospital in Rome about Influenza viruses circulation during the calendar year 2022 (January-December) in comparison with the previous five years (2017–2021), with a special focus on the weeks 18–41, usually not under surveillance.MethodsThis retrospective study involved 36782 respiratory samples referred to 21354 patients (pts), median age 2.63 years, admitted with respiratory symptoms at Bambino Gesù Children’s Hospital in the years 2017–2022. Respiratory viruses were detected by molecular Allplex™ Respiratory Panel Assays (Seegene, Korea).ResultsRegarding the pre pandemic years, 2017–2019, distribution of Flu positive patients focused in the first weeks of the year (weeks 1–17). During the pandemic period, Flu was not detected. In 2022, 239 Flu viruses were identified: 37 FluA (weeks 1–17), 29 FluA (weeks 18–41) and 168 FluA and 5 FluB (weeks 42–52). For the year 2022, during the non-epidemic period, the number of Flu viruses detected corresponded to 12.1% of total Flu detected, respect to 0-1.7% for the previous five years (p < 0.001).ConclusionsWhen compared with pre SARS-CoV-2 pandemic years, our data show a significant increase in Influenza cases during weeks 18–41/2022 and reveal an unexpected summer circulation of these viruses: just weeks 26–30 showed to be influenza virus free. A national year-round Flu surveillance could be useful to understand if changing in influenza epidemiology is transitional or likely to persist in the following years.

Clinical characteristics of alcohol-flame burns and correlation with COVID-19 epidemic: A retrospective analysis from a single center

ObjectiveTo analyze the clinical characteristics of alcohol-flame burns and the correlation with COVID-19 epidemic. MethodsA retrospective analysis was conducted on the medical records of 134 patients with alcohol-flame burns who were admitted to the Second People's Hospital of Chengdu City from January 2015 to December 2022. Demographics, time of first hospital visit, burn size, depth and site, month and place of burn, inhalation injury, surgical intervention, length of hospital stay, hospital costs were recorded annually. Data from the COVID-19 epidemic period (2020–2022) were compared to those from the non-epidemic period (2015–2019) for analysis. ResultsThe number of patients with alcohol-flame burns showed a consistent annual increase. During the epidemic period, the proportion of alcohol-flame burns among burn patients was significantly higher (2.43% ± 0.16%) than during the non-epidemic period (1.70% ± 0.15%) (P = 0.00). Alcohol-flame burns primarily affected adult men, occurring mainly in massage parlors and homes. The peak incidence was between May and August. Patients sought medical attention promptly, with a median time to first hospital visit of 2 h post-burn. Alcohol-flame burns mostly involved the trunk and upper extremities. Median total burn size was 7% TBSA, median full-thickness burn size was 1% TBSA. Over 20% of patients had combined inhalation injuries, and a similar proportion required surgical intervention. Alcohol burn patients had a median hospital stay of 14 days and incurred median medical costs of ¥16,600($2300). During the epidemic, the basic characteristics of patients with alcohol-flame burns did not change much. However, the time to first hospital visit was significantly shorter (2 h) during the epidemic period than non-epidemic period (3 h). Furthermore, alcohol-flame burn patients during the epidemic exhibited significantly larger total burn sizes, higher burn indices, and longer hospital stays compared to non-epidemic patients. The incidence of combined inhalation injuries was also significantly higher during the epidemic. Surgical requirements and medical costs were not significantly associated with the COVID-19 epidemic. ConclusionAlcohol-flame burns exhibit distinct clinical characteristics, including severe injuries, prolonged hospital stays, and elevated costs, particularly in the context of the COVID-19 pandemic.

Genetic variability of rice stripe virus after its pandemic in Jiangsu.

Rice stripe virus (RSV) caused a serious disease pandemic in rice in East China between 2001 and 2010. The continuous integrated managements reduced virus epidemic year by year until it was non-epidemic. As an RNA virus, its genetic variability after undergoing a long-term non-epidemic period was meaningful to study. While in 2019, the sudden occurrence of RSV in Jiangsu provided an opportunity for the study. The complete genome of JY2019, an RSV isolate from Jiangyan, was determined. A genotype profile of 22 isolates from China, Japan and Korea indicated that the isolates from Yunnan formed the subtype II, and other isolates clustered the subtype I. RNA 1-3 of JY2019 isolate well-clustered in the subtype I clade, and RNA 4 was also in subtype I, but it had a slight separation from other intra-group isolates. After phylogenetic analyses, it was considered NSvc4 gene contributed to the tendency, because it exhibited an obvious trend towards the subtype II (Yunnan) group. High sequence identity (100%) of NSvc4 between JY2019 and barnyardgrass isolate from different regions demonstrated genetic variation of NSvc4 was consistent in RSV natural populations in Jiangsu in the non-epidemic period. In the phylogenetic tree of all 74 NSvc4 genes, JY2019 belonged to a minor subtype Ib, suggesting the subtype Ib isolates might have existed in natural populations before the non-epidemic period, but not a dominant population. Our results suggested that NSvc4 gene was susceptible to selection pressure, and the subtype Ib might be more adaptable for the interaction between RSV and hosts in the non-epidemic ecological conditions.

Analysis model of college students' mental health based on online community topic mining and emotion analysis in novel coronavirus epidemic situation.

Under the epidemic situation of COVID-19, university students have different levels of anxiety, depression, and other psychological problems, and these differing levels present different challenges. Therefore, universities and relevant departments should carry out accurate psychological health education for university students. Through research, this paper found that students' psychological problems during the COVID-19 epidemic were mainly reflected in four aspects: depression, interpersonal relationship, sleep and eating disorders, and compulsive behavior. Through the discussion of family of origin, self-awareness and motivation attribution, and social pressure, this paper analyzed the causes of psychological problems. The information resources of the network are usually unstructured data, and the text information, as the most typical unstructured data, occupies a large proportion. Moreover, this text information often contains users' emotional response to major events. In this paper, a data preprocessing system is designed, and three data preprocessing rules are defined: expression data conversion rules, data deduplication rules and invalid data cleaning rules. The characteristics of online community text data are analyzed, and the text feature extraction method is selected according to its characteristics. The results of this study show that the proportion of university students with psychological problems is about 23%, which is slightly higher than the research results during the non-epidemic period. This paper suggests that college students should master methods of self-regulation, improve their levels of physical exercise, improve their physical fitness, and establish and improve their defense mechanisms to alleviate psychological conflicts and pressures.

Designing Mobile Epidemic Prevention Medical Stations for the COVID-19 Pandemic and International Medical Aid.

The demand for mobile epidemic prevention medical stations originated from the rapid spread of the COVID-19 pandemic. In order to reduce the infection risk of medical practitioners and provide flexible medical facilities in response to the variable needs of the pandemic, this research aimed to design mobile medical stations for COVID-19 epidemic prevention, the emergence of which began in February 2020. The mobile medical stations include a negative pressure isolation ward, a positive pressure swabbing station, a fever clinic and a laboratory. In Taiwan, many medical institutions used the mobile swabbing station design of this study to practice COVID-19 screening pre-tests. Internationally, this study assisted Palau in setting up medical stations to provide anti-epidemic goods and materials. The design of this study not only provides a highly flexible and safe medical environment but the benefits of screening can also be used as resources for medical research, forming an economic circulation for operation sustainability. In addition, the design of this study can also be used during the non-epidemic period as a healthcare station for rural areas or as a long-term community medical station.

Association between sleep disturbance and mental health of healthcare workers: A systematic review and meta-analysis.

ObjectivesSleep disturbance and mental health are challenges for healthcare workers (HCWs). Especially during the COVID-19 pandemic, they experienced more severe sleep and mental health problems. However, the association between sleep disturbance and the mental health of HCWs is still controversial. This study aimed to systematically review the relationship by conducting a systematic review and meta-analysis.MethodTwo researchers retrieved the literature from Web of Science, PubMed, EMBASE, CINAHL, Psyclnfo, and Cochrane Library from the establishment of the databases until November 20, 2021. We used the New Castle-Ottawa Scale (NOS) and Agency for Healthcare Research and Quality (AHRQ) to evaluate the risk of bias in prospective research and cross-sectional research, respectively. The major exposure was HCWs’ sleep disturbance, and the major outcome was mental health. The correlation coefficients (r), regression coefficients (β) and odds ratios (OR) of the included studies were integrated.ResultFifty-nine studies were included for qualitative analysis, of which 30 studies could be combined and entered into quantitative analysis. There were 23 studies during the COVID-19 pandemic among the 59 included studies. The results of the meta-analysis showed that the correlation coefficient between sleep disturbance and mental health was 0.43 (95% CI: 0.39–0.47). HCWs with sleep disturbance had a 3.74 (95% CI: 2.76–5.07) times higher risk of mental health problems than those without sleep disturbance. The correlation coefficient during the COVID-19 epidemic was 0.45 (95% CI: 0.37–0.53), while it was 0.40 (95% CI: 0.36–0.44) during the non-epidemic period. Subgroup analysis compared the OR results in epidemic and non-epidemic periods of COVID-19, which were 4.48 (95% CI: 2.75–5.07) and 3.74 (95% CI: 2.74–7.32), respectively.ConclusionSleep disturbance and mental health problems were positively correlated among HCWs. Particularly in the COVID-19 pandemic, more attention should be given to this issue.

Effectiveness of COVID-19 Vaccination in Preventing All-Cause Mortality among Adults during the Third Wave of the Epidemic in Hungary: Nationwide Retrospective Cohort Study.

Our investigation aimed to describe the all-cause mortality rates by COVID-19 vaccination groups in Hungary for an epidemic period (1 April 2021–20 June 2021) and a nonepidemic period (21 June 2021–15 August 2021), and to determine the vaccines’ effectiveness in preventing all-cause mortality utilizing nonepidemic effectiveness measures to adjust for the healthy vaccinee effect (HVE). Sociodemographic status, comorbidity, primary care structural characteristics, and HVE-adjusted survival difference between fully vaccinated and unvaccinated cohorts in the epidemic period had been computed by Cox regression models, separately for each vaccine (six vaccines were available in Hungary). Hazard ratio (HR) reduction in epidemic period corrected with nonepidemic period’s HR with 95% confidence interval for each vaccine was used to describe the vaccine effectiveness (VE). The whole adult population (N = 6,404,702) of the country was followed in this study (4,026,849 fully vaccinated). Each vaccine could reduce the HVE-corrected all-cause mortality in the epidemic period (VEOxford/AstraZeneca = 0.592 [0.518–0.655], VEJanssen = 0.754 [0.628–0.838], VEModerna = 0.573 [0.526–0.615], VEPfizer-BioNTech = 0.487 [0.461–0.513], VESinopharm = 0.530 [0.496–0.561], and VESputnik V = 0.557 [0.493–0.614]). The HVE-corrected general mortality for COVID-19 vaccine cohorts demonstrated the real-life effectiveness of vaccines applied in Hungary, and the usefulness of this indicator to convince vaccine hesitants.

Construction of Continuous Dynamic Model for River Networks and Its Application in Simulation of Spatiotemporal Migration of Typical Biocides

Biocides are widely added to personal care products and enter the environment through sewage treatment plant (STP) discharge, which affects ecological health. This paper evaluated the pollution characteristics of triclosan and triclocarban in a river network during the COVID-19 epidemic. Moreover, a continuous dynamic river network model coupling a one-dimensional hydrodynamic model and four-level fugacity model was established to address the temporal and spatial heterogeneity of pollutants in the river network migration process; then, this model was applied to evaluate two biocides in the Shima River Basin. The model passed calibration and in-field concentration verification tests and yielded satisfactory simulation results. The results of the study showed that the concentration of biocides in the river network during the new crown epidemic was twice that of the non-epidemic period. The concentration of triclosan and triclocarban in the river channel first increased and then decreased with the increase of the river migration distance after STP discharge. The time variation characteristics of the concentrations were affected by the river flow. The biocide concentration in the river network of the low flow upstream area first increased and then decreased, gradually stabilizing in about 20 h. The pollution concentration in the high flow downstream area was increased, and the concentration did not stabilize at 24 h. These results indicate the necessity of evaluating the temporal and spatial characteristics of migration of typical biocides in the river network by stages and time on the premise of distinguishing the flow.

Practice and technique of using a protective mask in older adults

Objective. To assess the practice and technique of using a protective mask (surgical mask) in older adults. Methods: A convenience sample of 287 older adults aged >65 years were recruited between January and February 2017 when there was no respiratory epidemic. Their practice and technique of using a mask were assessed using a questionnaire and an observational checklist, respectively. Results: Older adults' practice and technique of using a mask were unsatisfactory. 30.1% and 26.9% indicated that they never wear a mask when taking care of family members with fever and respiratory infection, respectively. None could correctly perform all 12 steps in wearing and taking off a mask. 92.3%, 96.6%, and 93.7% did not perform hand hygiene before wearing and taking off the mask and after disposing of the mask, respectively. Conclusion: Compliance of older adults with wearing masks during a non-epidemic period was low. The commonly omitted steps of wearing and taking off a mask were related to hand hygiene. We recommend using the knowledge-attitude-practice model to rectify misconceptions and strengthen awareness on the use of masks in the required situations and on commonly omitted or incorrectly performed techniques.

Case series of &lt;em&gt;Salmonella&lt;/em&gt; spp. infections confirmed by culture test at the hospital clinical laboratory in L’Aquila (Italy), years 2011-2018

In the European Union between 2008 and 2017 there was a statistically significant decrease in the confirmed cases of salmonellosis. Nevertheless, it represents the first cause of food-borne outbreaks and the secondly most frequently reported zoonosis. Considering the pathogen diffusion and clinical consequences, monitoring the incidence of Salmonella spp. infections is a priority for public health. The study is aimed at describing the temporal trend of prevalence of Salmonella spp. positive tested and serotypes characteristics of the isolates by L’Aquila hospital laboratory microbiological analysis in 2011-2018, with a focus on the epidemic phase occurred from October 2013 to May 2014. The survey is a case series report, with a retrospective design. During the period considered, 220 infected carriers were identified, in particular 160 positive samples for Salmonella enterica serogroup B, so it was the main group causing salmonellosis in the area of L’Aquila both in the epidemic period and in the non-epidemic period. Moreover, the proportion of cases in early paediatric age (from one to five years) resulted statistically higher in the epidemic period than in the non-epidemic period. About the possible causes of the outbreak, the hypothesis of an environmental contamination seems to be plausible.

Construction of a double-scale epidemic prevention system with consideration of city and community

In the process of fighting against COVID-19, China has taken a series of measures in time, including closing down commercial and entertainment places in the city, conducting closed management of residential communities, restricting citizens’ public social gatherings, etc. During the process that these measures have successfully controlled the spread of the epidemic, new issues are also exposed in the current urban planning and construction, such as dislocation between administrative control unit and planning control unit, and the uneven distribution of urban medical facilities system, which to a large extent affect the development of urban economy and society. Therefore, under the situation that no vaccine has been developed and isolation is still needed for epidemic prevention to deal with possible repeated epidemics, it is necessary to construct an urban layout structure from the perspective of urban planning, which takes into account the needs of epidemic prevention and urban development. Specifically, the overall planning should be carried out from the two scales of city and community, so as to maintain the normal operation of urban economy, society and people’s life as much as possible on the basis of ensuring epidemic prevention. During the non-epidemic period, cities are interconnected. There is no control between the communities, and various elements interact with each other in urban space. At this time, the city can be understood as a multi system interactive “network”. After the outbreak of the epidemic, if we can only control the communities where the epidemic has occurred, it can not only effectively limit the spread of the virus, but also protect the basic living needs of citizens through the improvement of community supporting facilities. At the same time, it can also minimize the impact of space control on the city. In this way, the network characteristics of the whole city can be preserved. We can embed isolated and managed communities into the urban system through important systems and corridors, forming a “network” + “beaded” pattern. In this urban pattern, the double-scale epidemic prevention system needs to improve the ability of different urban systems to resist the impact of epidemic situation at the overall level of the city, and provide basic guarantee for the prevention and control management of communities. According to the characteristics of COVID-19, the transportation system, medical system, garbage and sewage treatment system should be adjusted, so as to realize the isolation, effective supply and timely treatment of personnel, materials and wastes. On this basis, community, as the basic unit of urban administration, is also the focal place for the outbreak, transmission and prevention and control of the epidemic. Different from the open management in the daily period, closed management must be carried out in the communities where infected persons or close contacts are found. This requires the community to be equipped with basic medical service facilities and emergency sites, and focus on the implementation of inspection and control of personnel and materials in and out, and centralized disinfection of waste. The double-scale epidemic prevention system proposed in this paper is not only a means to deal with the new epidemic situation, but also an effective way to face the unknown virus in the future. Among the two epidemic prevention levels of city and community, the city level mainly plays the role of framework support, which is an important support for the organic combination of urban systematic epidemic prevention control and community self-organization epidemic prevention management. As the core management and control unit, the community needs to have perfect social service facilities, and connect with the basic administrative unit of the city, so as to realize the organic combination and effective connection of epidemic prevention and control and daily management.

The need for additional mental health support for women in the postpartum period in the times of epidemic crisis

BackgroundThis retrospective study aimed to identify possible intensification of mental health difficulties among women seeking support in the postpartum period during the epidemic state in Poland. We assumed that the epidemic crisis, social isolation, and restrictions in hospitals which affect pregnant and postpartum women - lack of family labors, lack of the possibility to be with the newborn when he/she is hospitalized, may increase fear and reduce psychosocial resources of women, hinder their normal process of transition to motherhood and thus contribute to the intensified severity of depressive symptoms.MethodsThe study participants were women seeking support at the on-line platform of the project ‘Next Stop: Mum’, which is a part of the postpartum depression prevention’s program implemented by the Ministry of Health in Poland, and enables remote self-screening for the severity of the postpartum depression symptoms with the Edinburgh Postnatal Depression Scale developed by Cox and collaborators. The analyzed data in this study were obtained from 139 women: 61 filled forms from October 1 - November 10, 2019 (non-epidemic period), and 78 filled forms from February 20–March 30 (beginning of the COVID-19 epidemic), 2020.ResultsA statistically significant difference in the severity of postpartum depression symptoms were observed among women making a self-assessment with EPDS scale at the beginning of the COVID-19 epidemic in Poland (M = 15.71; SD = 6.23), compared to the pre-epidemic neutral period (M = 13.56; SD = 6.46).ConclusionsThe results of this study indicate that the epidemic crisis may be associated with an increased need for additional caution and support of women’s mental health in the postpartum period. We believe that recommendations for medical staff, policy, and families of women struggling with postpartum depression symptoms during crisis should be widespread as the second wave of COVID-19 disease may develop in the autumn-winter 2020 and spring 2021.

FORECASTING OF FORMATION OF PHARMACEUTICAL GLASS WASTE TAKING INTO ACCOUNT THE COVID-19 DATABASE

Subject of research: forecasting the formation of pharmaceutical glass waste in medical institutions, taking into account the peculiarities of the use of medicines during the COVID-19 epidemic in Ukraine. Research problem: Predicting the formation and accumulation of pharmaceutical glass waste in hospitals in order to implement effective environmental management and determine the resource possibilities for further waste disposal. Main scientific results: A model has been developed that can be used to predict the generation of pharmaceutical waste from glass in hospitals in the country during an epidemic, as well as in the presence of the necessary input data in a non-epidemic period. Based on regression analysis and using the Minitab-19 software, the dependences of the volume of pharmaceutical waste from glass on three variable factors were determined. Using statistical data on the incidence of COVID-19 in Ukraine, using the developed model, the PGW volume in the Volyn region for a given period of time was calculated. The scope of practical application of the research results: planning of measures to improve the environmental safety of handling pharmaceutical glass waste; development of business models for the disposal of this waste. An innovative technological product: the predictive model helps to identify the resource possibilities of using pharmaceutical glass waste for industrial waste disposal. Scope of application of the innovative technological product: medical waste management, industrial disposal of pharmaceutical glass waste.

Quantifying the impact of physical distance measures on the transmission of COVID-19 in the UK

BackgroundTo mitigate and slow the spread of COVID-19, many countries have adopted unprecedented physical distancing policies, including the UK. We evaluate whether these measures might be sufficient to control the epidemic by estimating their impact on the reproduction number (R0, the average number of secondary cases generated per case).MethodsWe asked a representative sample of UK adults about their contact patterns on the previous day. The questionnaire was conducted online via email recruitment and documents the age and location of contacts and a measure of their intimacy (whether physical contact was made or not). In addition, we asked about adherence to different physical distancing measures. The first surveys were sent on Tuesday, 24 March, 1 day after a “lockdown” was implemented across the UK. We compared measured contact patterns during the “lockdown” to patterns of social contact made during a non-epidemic period. By comparing these, we estimated the change in reproduction number as a consequence of the physical distancing measures imposed. We used a meta-analysis of published estimates to inform our estimates of the reproduction number before interventions were put in place.ResultsWe found a 74% reduction in the average daily number of contacts observed per participant (from 10.8 to 2.8). This would be sufficient to reduce R0 from 2.6 prior to lockdown to 0.62 (95% confidence interval [CI] 0.37–0.89) after the lockdown, based on all types of contact and 0.37 (95% CI = 0.22–0.53) for physical (skin to skin) contacts only.ConclusionsThe physical distancing measures adopted by the UK public have substantially reduced contact levels and will likely lead to a substantial impact and a decline in cases in the coming weeks. However, this projected decline in incidence will not occur immediately as there are significant delays between infection, the onset of symptomatic disease, and hospitalisation, as well as further delays to these events being reported. Tracking behavioural change can give a more rapid assessment of the impact of physical distancing measures than routine epidemiological surveillance.

Incidence of genes encoding vanA/vanB vancomycin resistance in rectal swabs of patients with diagnosed cancer, on the day of admission to hospital, in a non-epidemic period.

IntroductionRapid diagnosis is important for preventing infections due to vancomycin-resistant enterococci.AimTo evaluate the status of gastrointestinal colonisation with strains containing vanA/vanB genes in oncological patients.Material and methodsA total of 167 samples of rectal swabs taken from 161 patients (mean age: 63, range: 29–93 years) were examined, including 113 patients from surgical wards (70.2%) and 48 patients from non-surgical wards (29.8%), with diagnosed cancer. The tests were carried out within 24 h of admitting the patient to the department, using the Cepheid Xpert vanA/vanB test, with a CE marked GeneXpert® Instrument Systems analyser. Samples with positive vanB gene results were additionally seeded on chromogenic media.ResultsThe presence of the vanA gene was found in 2.7% and 6.3% of the examined patients, respectively, from the surgical and non-surgical departments, which accounted for 3.7% of all the patients examined. The presence of the vanB gene was detected in 21.1% of the patients, but in no case was there any growth of vancomycin-resistant enterococci on the chromogenic medium.ConclusionsPatients admitted to non-surgical wards were more often colonised with vanA/vanB genes than were patients admitted to surgical wards, but the differences were not statistically significant.

Impact of the COVID-19 Event on Trip Intensity and Air Quality in Southern China

The COVID-19 epidemic discovered and reported at the end of December 2019 and began spreading rapidly around the world. The impact of the COVID-19 event on the trip intensity, AQI (air quality index), and air pollutants, including PM2.5, PM10, SO2, CO, NO2, and O3 in Shenzhen, Guangzhou, and Foshan (the so-called ‘three cities’) from January 12 to March 27, in 2019 and 2020, are compared and discussed. In 2020, the combined trip intensity in the three cities ranged between 0.73 and 5.54 and averaged 2.57, which was 28.4% lower than that in 2019. In terms of the combined AQIs for the three cities, from January 12 to March 26, 2020, the daily AQIs ranged between 21.0 and 121.3 and averaged 56.4, which was 16.0% lower than that in 2019. The average AQIs in order were Guangzhou (57.5) > Foshan (54.1) > Shenzhen (44.1). In 2019, the distribution proportions of the six AQI classes were 45.2%, 50.4%, 4.40%, 0%, 0%, and 0%, respectively, while those in 2020 were 62.7%, 37.3%, 0%, 0%, 0% and 0%, respectively. For the combined data for the three cities, on the top five days with the highest AQIs during the epidemic period, the average concentrations of PM2.5, PM10, SO2, CO, NO2, and O3 were 76.4 μg m–3, 113.4 μg m–3, 5.14 ppb, 0.88 ppm, 36.5 ppb and 55.5 ppb, which were 55.2%, 49.4%, 55.1%, 30.0%, 45.1% and 15.5% lower than those during the non-epidemic period (from January 12 to March 27, 2017–2019). The above results revealed that the comprehensive strict epidemic prevention and control actions reduced trip intensity and improved the air quality significantly.