None Of Biochemical Parameters Research Articles

Effect of Thonningia sanguinea (Balanophoraceae) on zootechnical and biochemical parameters of broiler chickens

The present study was conducted to evaluate growth performance, selected biochemical serum parameters adding in broiler chickens provide with drinking water containing an aqueous extract of Thonningia sanguinea (THOS). Two hundred 1-days-old broiler chickens were acclimated for two weeks. Then they were randomly divided into two equal groups of 100 chickens. In experimental group, aqueous extracts of T. sanguinea were added to water drinkers (10 g.L-1 water) from day 15 to day 22. Through the experience, body weight, feed consumption, and number of dead birds were recorded once a week. At 15, 22, 29, 36 and 45 days of rearing, 20 birds were randomly selected in each group for serum biochemical profile analysis involving, alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), creatin phospoho-kinase (CPK) and Lactate dehydrogenase (LDH). The analyses reveal that the supplementing of aqueous extract of THOS contributed to increase in body weight (p<0.05), decrease consumption index and had a positive effect on boilers survival. In addition, none of biochemical parameters were statistically different among the treatment. These findings, indicate that drinking water supplementation at 10 g.L-1 of aqueous extract of THOS can be used as growth promoters in boiler water, and research to elucidate the mechanism for potentially enhanced growth in boilers is required.

Adrenal insufficiency in decompensated cirrhotic patients without infection: prevalence, predictors and impact on mortality.

Relative adrenal insufficiency (RAI) is common in compensated and decompensated chronic liver disease in the presence of sepsis. This study was performed to find out the prevalence of RAI in decompensated cirrhotic patients presenting with hepatic encephalopathy and variceal bleeding without any evidence of infection. The study prospectively included 75 cirrhotic patients with signs of decompensation. The short Synacthen test (SST) was performed on all patients after ruling out infection. Patients with positive blood, urine, sputum, ascitic and pleural fluid cultures or evidence of infection on chest X-ray and those with elevated procalcitonin levels (>0.05 ng/ml) were excluded. RAI in critical illness was defined by a delta cortisol level (difference between basal and post-stimulation cortisol) of ≤9 μg/dl after SST. The mean age of the study population was 54 ± 11 years. Upper gastrointestinal bleed and hepatic encephalopathy were seen in 56.6% and 41.5%, respectively, and both were seen in 1.9%. Of the 75 patients, 55 (73%) were in Child-Turcotte-Pugh (CTP) class C and the mean model for end-stage liver disease (MELD) score was 21 ± 7. Forty-five patients (60%) met our criteria for RAI. Those with RAI had lower serum albumin (2.4 ± 0.5 g/dl vs 2.7 ± 0.5 g/dl, p=0.03) and higher MELD scores (22 ± 7 vs 19 ± 6, p= 0.03). Prevalence of RAI in CTP class C was 65% (36 out of 55 patients) compared to 45% (9 out of 20 patients) in Child-Pugh stage A and B. Similarly, 82% (23 out of 28 patients) with MELD scores >25 had RAI compared to 54% with MELD scores <20. None of biochemical parameters were predictive of RAI on logistic regression analysis. Three-month mortality rate was not significantly different in patients with or without adrenal insufficiency (44% vs 28%, p = 0.11). The present study showed RAI to be common in noninfected decompensated cirrhotic patients, but did not predict 3-month mortality. There were no other predictive factors in those with RAI. Hence, in patients with cirrhosis without infection, the clinical utility of routine adrenal function testing needs further elucidation.