The aim of this study, encompassing 146 children and 42 adults having total plasma cholesterol, triglyceride, or both (less than or the same as) age-, sex-, and race-specific 5th percentile levels, was to better define the interrelationships of low-, high-, and very low-density lipoprotein cholesterols (C-LDL, C-HDL, C-VLDL) within hypolipidemic individuals, using multivariate cluster analysis. For both children and adults, the C-LDL distribution was gaussian; the C-HDL and C-VLDL distributions were skewed to the right. The C-HDL and C-VLDL distributions were unimodal and gaussian after square root and log transformations, respectively. After consolidation of lipoprotein clusters in both children and adults into six groups by virtue of C-LDL, C-HDL, and C-VLDL in three dimensions, a numerical majority of both children (75%) and adults (95%) had predominant hypobetalipoproteinemia accounting for their hypocholesterolemia. This hypobetalipoproteinemia was accompanied by C-HDL in the 50th percentile or higher in 80% of children and in 93% of adults. Moreover, there were a nontrivial number of both children and adults having the combination of exceptionally low C-LDL and high C-HDL levels. There were few to no major cluster groups characterized by simultaneous depressions of all three lipoproteins, and only a modest number characterized by depression of both C-LDL and C-HDL with high C-VLDL. In view of the positive and negative associations of C-LDL and C-HDL, respectively, with coronary heart disease events, a majority of hypolipidemic subjects may putatively be at sharply reduced risk for development of atherosclerosis.