Non-syndromic Supernumerary Teeth Research Articles

Non-syndromic supernumerary teeth and association with aself-reported family history of cancer.

Supernumerary teeth are an alteration of dental developmental and result in the formation of teeth above the usual number. Epidemiologic studies suggested that patients with dentofacial anomalies and their family members may present an increased risk of developing cancer, including female breast cancer and gynecologic cancers. These observations indicate that genetic alterations that result in dental anomalies may be related to cancer development. Thus, the aim of the present study was to evaluate the association between supernumerary teeth and afamily history of female breast cancer and gynecologic cancers. The diagnosis of supernumerary teeth was based on clinical and radiographic examinations. For data collection, aquestionnaire asking for information regarding ethnicity, age, gender, and self-reported family history of cancer up to the second generation was used. Statistical analysis was performed using the Χ2 test and Fisher's exact test with an established α of 5%. Atotal of 344 patients were included; 47 of them had one or more non-syndromic supernumerary teeth (not associated with any syndrome or cleft lip and palate) and 297 were control patients. Age, ethnicity, and gender distribution were not statistically different between the group with supernumerary teeth and the control group (p > 0.05). The supernumerary teeth were most commonly observed in the incisors area. Breast cancer (n = 17) was the most commonly self-reported type of cancer, followed by uterine cervical (n = 10), endometrial (n = 2), and ovarian (n = 1) cancers. Endometrial cancer was significantly associated with the diagnosis of supernumerary teeth (p = 0.017). This study suggests that patients with supernumerary teeth possess ahigher risk of having family members with endometrial cancer.

Nonsyndromic supernumerary teeth in patients in National Taiwan University Children's hospital

Background/purposeA literature review reveals limited data for supernumerary teeth in Taiwan. This study aimed to analyze the characteristics of nonsyndromic supernumerary teeth in patients in the National Taiwan University Children's Hospital. Materials and methodsThis retrospective study analyzed the nonsyndromic supernumerary teeth in 1280 patients (710 boys and 570 girls) based on examination of mainly panoramic radiographs and related radiographs. Chi-square test was used for trend analysis. ResultsThe incidence of nonsyndromic supernumerary teeth was 11.25% (179 supernumerary teeth in 144 of the 1280 patients). There was a male predominance (4.33: 1, P < 0.0001) for our 144 patients. Most supernumerary teeth were single (63.69%), conical-shaped (78.77%), and unerupted (77.09%). Supernumerary teeth also tended to be located in the premaxilla (93.85%), fully developed (51.40%), invertedly oriented (45.25%), sagittally located in a palatal/lingual position (67.60%), and adjacent to the root and root apex of permanent teeth (70.39%). The supernumerary teeth with a normal orientation (64.52%) had a high potential to erupt into the oral cavity, but the majority of the supernumerary teeth with a transverse orientation (97.22%) or an inverted orientation (100%) were unerupted. ConclusionThe nonsyndromic supernumerary teeth occur most commonly in male patients with a male to female ratio of 4.33: 1. The incidence of nonsyndromic supernumerary teeth in our 1280 patients is 11.25%, and the most frequent location of supernumerary teeth is the anterior maxillary region. More than three quarters of supernumerary teeth are conical-shaped or unerupted. Inverted supernumerary teeth are all embedded in the jawbones.

Epidemiological, clinical, radiographic characterization of non-syndromic supernumerary teeth in Chinese children and adolescents.

This retrospective study was purposed to evaluate epidemiological, clinical, and 3D radiological features of supernumerary teeth (ST) in a non-syndromic Chinese children and adolescent dental population. Original cone-beam CT (CBCT) data from 18,861 patients aged from 6 to 17years with dental maxillofacial diseases treated in a Chinese dental hospital from June 2012 to December 2018 were utilized to screen patients with ST. Diagnosis and characterizations of ST were analyzed by CBCT coupled with 3D reconstruction. All relevant epidemiological, clinical, and radiographic details about ST were collected and statistically analyzed. Among total 18,861 patients, 2,768 ST were identified in 1984 subjects with a prevalence of 10.52% and a male:female ratio of 1.86:1. Majority of ST were single, conical, inverted, impacted, and located in maxilla anterior region. ST-associated complications mainly included malposition, rotation, and impaction of adjacent teeth, which were notably associated with morphology and position of ST. The prevalence of ST in Chinese children and adolescent dental population was 10.52% and tended to present as single, conical, inverted, and impacted, which resulted in abnormalities of neighboring teeth. Our outcomes are beneficial for clinicians to more comprehensively understand the incidence, characterization, and clinical treatment planning of ST in dental children and adolescents.

Associations of the microRNA gene polymorphisms with the risk of non-syndromic supernumerary teeth in a Chinese population

ObjectiveNon-syndromic supernumerary teeth (NSST) are a common type of dental anomaly. microRNAs (miRNAs) play an important role in craniofacial and tooth development. Therefore, we hypothesized that single nucleotide polymorphisms (SNPs) of miRNAs may be associated with the susceptibility of NSST. Materials and methodsFour miRNA SNPs (rs2910164, rs11614913, rs2043556, and rs2682818) were selected, and their associations with NSST susceptibility were evaluated in a case-control study (163 NSST patients and 326 healthy controls). Resultsrs2910164 was significantly associated with a risk of lower NSST (additive model: OR = 4.00, 95 % CI = 1.76–9.09, P = 0.001), and rs2682818 showed nominal association with a risk of upper NSST (additive model: OR = 1.40, 95 % CI = 1.02–1.91, P = 0.037) and NSST among male patients (additive model: OR = 1.62, 95 % CI = 1.08–2.43, P = 0.020). ConclusionGenetic variants of miR-146a/rs2910164 and miR-618/rs2682818 were likely associated with the risk of NSST in the Chinese population.

Non-syndromic cleft lip with or without palate-susceptible SNPs is associated with hyperdontia.

Non-syndromic supernumerary teeth (NSST) or hyperdontia may share common genetic determinants with non-syndromic cleft lip with or without palate (NSCL/P). The aim of this study was to test the associations between five genome-wide-associated NSCL/P-susceptible single nucleotide polymorphisms (SNPs) (rs2235371, rs7078160, rs8049367, rs4791774, and rs13041247) and the occurrence of NSST. A total of 163 cases and 326 controls were recruited and their genomic DNA was extracted from blood samples. Five NSCL/P-susceptible SNPs (rs2235371, rs7078160, rs8049367, rs4791774, and rs13041247) were genotyped by TaqMan method. Odds ratio (OR) and 95% confidence interval (CI) were used to estimate the associations between the SNPs and the risk of NSST by PLINK software. Rs4791774 (A>G) and rs13041247 (T>C) were associated with risk of NSST (rs4791774: Padd =0.011, OR, 95% CI=0.62, 0.43-0.90; rs13041247: Phomo =0.031, OR, 95% CI=1.79, 1.05-3.05) and one supernumerary tooth (rs4791774: Pdom =0.009, OR, 95% CI=0.56, 0.36-0.87; rs13041247: Phomo =0.034, OR, 95% CI=1.82, 1.05-3.15). Rs4791774 (A>G) was also showed association with risk of upper arch supernumerary teeth only (Padd =0.010, OR, 95% CI=0.60, 0.41-0.89). Non-syndromic cleft lip with or without palate-susceptible loci rs4791774 (A>G) and rs13041247 (T>C) were associated with the risk of supernumerary teeth.

Multiple supernumerary teeth in a likely syndromic individual from prehistoric Illinois

ObjectiveThis paper reports the first published case of a prehistoric human with five or more supernumerary teeth. Such cases are often neglected in paleopathology, in part due to a gap between the medicodental and anthropological literature leading to the view in anthropology that supernumerary teeth are curious anomalies rather than pathologies. DesignReconstruction and pathological description of the skeletal remains were performed according to standard osteological protocols. Each supernumerary tooth was categorized based on its morphology, location, and orientation. The dental characteristics of the individual were compared to published norms for incidences of syndromic and non-syndromic supernumerary teeth and a differential diagnosis was subsequently performed. ResultsSix supernumerary teeth and one deciduous tooth were identified. Additionally, the individual suffered from impacted teeth, dilacerated roots, and extensive sutural anomalies (including retention of the metopic suture into adulthood and an unusually high number of sutural bones). The morphology and location of the supernumerary teeth, in conjunction with the suite of other symptoms, are highly unusual among non-syndromic patients and therefore are indicative of a complex genetic disorder. ConclusionsThe individual reported here almost certainly suffered from a genetic disorder or syndrome resulting in extensive dental and sutural abnormalities. Despite a lack of post-cranial involvement, a tentative diagnosis of Cleidocranial Dysplasia was made on the basis that mutations in the RUNX2 gene may cause the dental symptoms without any pathology of the clavicle.

Characteristics of nonsyndromic supernumerary teeth in children and adolescents

'Supernumerary teeth' (ST) is a term used to describe extra teeth in both dentitions than those that we are predisposed to have and considered to be one of the most significant dental anomalies affecting children and adolescents. Diagnosis and management of ST is one of the main responsibilities of dentists and also physicians. The aims of this study were to document the prevalence, characteristics, and associated clinical complications of ST among children and adolescents and to summarize the management and intervention time for ST. Materials and methods: Thirteen deciduous ST in 13 patients and 219 permanent ST in 179 patients aged up to 18 years were included in this study (in total, 192 patients with 232 ST). Results: The general prevalence of ST determined in our study was 1.148% (deciduous ST: 0.077%, permanent ST: 1.07%). Boys (66%) were affected more frequently than girls (34%). Of the permanent ST, 183 (92%) were located in the maxilla and 56.8% were conical. Most of the ST were considered fully developed (134, 67.3%), while 60 (30.2%) had partial root formation with complete crown formation. Conclusion: ST can cause a variety of complications. Early diagnosis of ST facilitates early intervention, minimal complications, and more favorable prognosis.

An Exploratory Study of Consanguinity and Dental Developmental Anomalies.

ABSTRACTBackgroundConsanguinity is known to alter the population structure but the available literature is almost silent on the association of dental conditions with consanguinity.AimThe purpose was to assess the various dental developmental anomalies in 6–9 year old children born out of consanguineous and non-consanguineous marriages and its association with their parents.DesignA cross sectional house–hold survey with a sample size of 2,000 (1,600 non-consanguineous and 400 consanguineous respondents and their parents) using systematic random sampling was planned. Six to nine-year-old children and their parents living in 1,597 households were examined and the information recorded on a pretested self prepared questionnaire. The questionnaire had questions pertaining to personal details, type of consanguineous marriages, history of trauma and examination of dental developmental anomalies.ResultsMultivariate logistic regression showed that non syndromic supernumerary teeth in fathers (p =.009); fusion in mothers (p = 0.002); fusion (p <0.001), nonsyndromic supernumerary teeth (p < 0.001), and microdontia (p = 0.002) in respondents were significantly associated with consanguinity.ConclusionA significant association of developmental anomalies in parents with consanguineous marriages and their respondents was observed.How to cite this articleKhan SY. An Exploratory Study of Consanguinity and Dental Developmental Anomalies. Int J Clin Pediatr Dent, 2018;11(6):513-518

Supernumerary teeth in non-syndromic patients

Hyperdontia or supernumerary teeth without associated syndrome is a rare phenomenon, as supernumerary teeth are usually associated with cleft lip and palate or other syndromes such as Gardner's syndrome, cleidocranial dysplasia, and so on. Five patients with supernumerary teeth visited our department. They had no familial history or other pathology, certain treatment protocols was modified due to the presence of supernumerary teeth. Non-syndromic supernumerary teeth, if asymptomatic, need to have periodical radiographic observation. If they showed no variation as they impacted in the jaw, careful examination is necessary because they may develop into pathological status such as dentigerous cysts. The importance of a precise clinical history and radiographic examination for patients with multiple supernumerary teeth should be emphasized.

Genetics and presence of non-syndromic supernumerary teeth: A mystery case report and review of literature

Presence of supernumerary teeth is well-recognized clinical phenomenon. However, it is uncommon to find multiple supernumeraries in individuals with no other associated disease or syndrome. Presence of multiple supernumerary teeth is thought to have genetic component. We report a rare case where multiple supernumerary teeth were seen without presence of any other syndrome in 3 generations; father, son, and two grandsons. We also present a review of similar cases published in literature till date. The role of genetics in development of supernumerary teeth is highlighted.

Clinical characteristics of non-syndromic supernumerary teeth in a cohort of Turkish patients

Objectives To investigate the frequency, prevalence, distribution, sex differences and characteristics of supernumerary teeth in a referred non-syndromic Turkish population.

PAX6 polymorphisms in 20 Chinese children with supernumerary teeth in the maxillary incisor area

To search for variants of PAX6 gene in patients with nonsyndromic supernumerary teeth in the maxillary incisor area (NSST) and compare genotypes and allele frequencies of the detected polymorphisms between the patients and controls. Twenty children with NSST and 31 controls were included. Genomic DNA was extracted from buccal epithelial cells of each individual. Sequencing analysis of all exons and exon/intron boundaries of PAX6 gene were performed in patients. Genotypes and allele frequencies of the single nucleotide polymorphisms detected in patients were compared between the two groups using chi-square tests. Of the 20 patients examined, six showed heterozygous for rs667773 and rs3026393 simultaneously. Among them, four possessed two supernumerary teeth and the other two possessed one. Another six patients showed heterozygous for rs3026393, five of which possessed only one supernumerary tooth and the other one possessed two. Of another six patients with homozygous rs3026393, three possessed one supernumerary tooth and the other three possessed two. The distributions of genotypes and alleles frequencies of single nucleotide polymorphisms rs667773 and rs3026393 showed no significant difference between the two groups. The present study did not find evidence of PAX6 polymorphisms being associated with supernumerary teeth in the population studied.